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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 38924

FusionGeneSummary for TNNI3_ZNF607

check button Fusion gene summary
Fusion gene informationFusion gene name: TNNI3_ZNF607
Fusion gene ID: 38924
HgeneTgene
Gene symbol

TNNI3

ZNF607

Gene ID

7137

84775

Gene nametroponin I3, cardiac typezinc finger protein 607
SynonymsCMD1FF|CMD2A|CMH7|RCM1|TNNC1|cTnI-
Cytomap

19q13.42

19q13.12

Type of geneprotein-codingprotein-coding
Descriptiontroponin I, cardiac musclecardiomyopathy, dilated 2A (autosomal recessive)troponin I type 3 (cardiac)zinc finger protein 607
Modification date2018052320180522
UniProtAcc

P19429

Q96SK3

Ensembl transtripts involved in fusion geneENST00000344887, ENST00000588882, 
ENST00000590463, 		ENST00000355202, 
ENST00000395835, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 2=8
# samples 32
** MAII scorelog2(3/8*10)=1.90689059560852log2(2/8*10)=1.32192809488736
Context

PubMed: TNNI3 [Title/Abstract] AND ZNF607 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTNNI3

GO:0032780

negative regulation of ATPase activity

7957210|11735257


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-DK-A3X2-01ATNNI3chr19

55668947

-ZNF607chr19

38200723

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000344887ENST00000355202TNNI3chr19

55668947

-ZNF607chr19

38200723

-
In-frameENST00000344887ENST00000395835TNNI3chr19

55668947

-ZNF607chr19

38200723

-
intron-3CDSENST00000588882ENST00000355202TNNI3chr19

55668947

-ZNF607chr19

38200723

-
intron-3CDSENST00000588882ENST00000395835TNNI3chr19

55668947

-ZNF607chr19

38200723

-
5UTR-3CDSENST00000590463ENST00000355202TNNI3chr19

55668947

-ZNF607chr19

38200723

-
5UTR-3CDSENST00000590463ENST00000395835TNNI3chr19

55668947

-ZNF607chr19

38200723

-

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FusionProtFeatures for TNNI3_ZNF607


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TNNI3

P19429

ZNF607

Q96SK3

Troponin I is the inhibitory subunit of troponin, thethin filament regulatory complex which confers calcium-sensitivityto striated muscle actomyosin ATPase activity. May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNF607chr19:55668947chr19:38200723ENST00000355202-156_783697DomainKRAB
TgeneZNF607chr19:55668947chr19:38200723ENST00000395835-156_783696DomainKRAB
TgeneZNF607chr19:55668947chr19:38200723ENST00000355202-15114_1363697Zinc fingerC2H2-type 1
TgeneZNF607chr19:55668947chr19:38200723ENST00000355202-15142_1643697Zinc fingerC2H2-type 2%3B degenerate
TgeneZNF607chr19:55668947chr19:38200723ENST00000355202-15170_1923697Zinc fingerC2H2-type 3
TgeneZNF607chr19:55668947chr19:38200723ENST00000355202-15197_2193697Zinc fingerC2H2-type 4
TgeneZNF607chr19:55668947chr19:38200723ENST00000355202-15225_2473697Zinc fingerC2H2-type 5
TgeneZNF607chr19:55668947chr19:38200723ENST00000355202-15253_2753697Zinc fingerC2H2-type 6
TgeneZNF607chr19:55668947chr19:38200723ENST00000355202-15281_3033697Zinc fingerC2H2-type 7
TgeneZNF607chr19:55668947chr19:38200723ENST00000355202-15309_3313697Zinc fingerC2H2-type 8%3B degenerate
TgeneZNF607chr19:55668947chr19:38200723ENST00000355202-15365_3873697Zinc fingerC2H2-type 9
TgeneZNF607chr19:55668947chr19:38200723ENST00000355202-15393_4153697Zinc fingerC2H2-type 10
TgeneZNF607chr19:55668947chr19:38200723ENST00000355202-15421_4433697Zinc fingerC2H2-type 11
TgeneZNF607chr19:55668947chr19:38200723ENST00000355202-15449_4713697Zinc fingerC2H2-type 12
TgeneZNF607chr19:55668947chr19:38200723ENST00000355202-15477_4993697Zinc fingerC2H2-type 13
TgeneZNF607chr19:55668947chr19:38200723ENST00000355202-15505_5273697Zinc fingerC2H2-type 14
TgeneZNF607chr19:55668947chr19:38200723ENST00000355202-15533_5553697Zinc fingerC2H2-type 15
TgeneZNF607chr19:55668947chr19:38200723ENST00000355202-15561_5833697Zinc fingerC2H2-type 16
TgeneZNF607chr19:55668947chr19:38200723ENST00000355202-15589_6113697Zinc fingerC2H2-type 17
TgeneZNF607chr19:55668947chr19:38200723ENST00000355202-15617_6393697Zinc fingerC2H2-type 18
TgeneZNF607chr19:55668947chr19:38200723ENST00000355202-15645_6673697Zinc fingerC2H2-type 19
TgeneZNF607chr19:55668947chr19:38200723ENST00000355202-15673_6953697Zinc fingerC2H2-type 20
TgeneZNF607chr19:55668947chr19:38200723ENST00000395835-15114_1363696Zinc fingerC2H2-type 1
TgeneZNF607chr19:55668947chr19:38200723ENST00000395835-15142_1643696Zinc fingerC2H2-type 2%3B degenerate
TgeneZNF607chr19:55668947chr19:38200723ENST00000395835-15170_1923696Zinc fingerC2H2-type 3
TgeneZNF607chr19:55668947chr19:38200723ENST00000395835-15197_2193696Zinc fingerC2H2-type 4
TgeneZNF607chr19:55668947chr19:38200723ENST00000395835-15225_2473696Zinc fingerC2H2-type 5
TgeneZNF607chr19:55668947chr19:38200723ENST00000395835-15253_2753696Zinc fingerC2H2-type 6
TgeneZNF607chr19:55668947chr19:38200723ENST00000395835-15281_3033696Zinc fingerC2H2-type 7
TgeneZNF607chr19:55668947chr19:38200723ENST00000395835-15309_3313696Zinc fingerC2H2-type 8%3B degenerate
TgeneZNF607chr19:55668947chr19:38200723ENST00000395835-15365_3873696Zinc fingerC2H2-type 9
TgeneZNF607chr19:55668947chr19:38200723ENST00000395835-15393_4153696Zinc fingerC2H2-type 10
TgeneZNF607chr19:55668947chr19:38200723ENST00000395835-15421_4433696Zinc fingerC2H2-type 11
TgeneZNF607chr19:55668947chr19:38200723ENST00000395835-15449_4713696Zinc fingerC2H2-type 12
TgeneZNF607chr19:55668947chr19:38200723ENST00000395835-15477_4993696Zinc fingerC2H2-type 13
TgeneZNF607chr19:55668947chr19:38200723ENST00000395835-15505_5273696Zinc fingerC2H2-type 14
TgeneZNF607chr19:55668947chr19:38200723ENST00000395835-15533_5553696Zinc fingerC2H2-type 15
TgeneZNF607chr19:55668947chr19:38200723ENST00000395835-15561_5833696Zinc fingerC2H2-type 16
TgeneZNF607chr19:55668947chr19:38200723ENST00000395835-15589_6113696Zinc fingerC2H2-type 17
TgeneZNF607chr19:55668947chr19:38200723ENST00000395835-15617_6393696Zinc fingerC2H2-type 18
TgeneZNF607chr19:55668947chr19:38200723ENST00000395835-15645_6673696Zinc fingerC2H2-type 19
TgeneZNF607chr19:55668947chr19:38200723ENST00000395835-15673_6953696Zinc fingerC2H2-type 20

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNNI3chr19:55668947chr19:38200723ENST00000344887-18137_1483211Calcium bindingOntology_term=ECO:0000250
HgeneTNNI3chr19:55668947chr19:38200723ENST00000344887-18129_1493211RegionNote=Involved in binding TNC and actin
HgeneTNNI3chr19:55668947chr19:38200723ENST00000344887-1832_793211RegionNote=Involved in binding TNC


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FusionGeneSequence for TNNI3_ZNF607


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TNNI3_ENST00000344887_chr19_55668947_-_ZNF607_ENST00000355202_chr19_38200723_-_697aa
MADGDQXHSGMWPXTSLIRSGNISAWFRRPCTRRXXWRTMTTXSHWQDIPYLSQIXSPYWSKEKSHGXLXGKKQEESVQIWIQDVKXSAM
GKCSFIGNTHVLLSIREFIMDRNHMSVSNVRSPLVILQNSWYIKQFILVRNLINVKSLGRHLAILQTLESIRKLMLVRNLMNVKNVGRSS
VILQTLLNMGKFMLRNPMNVKSVGKLLGLAVNLLYIIDFIMVRNPTNVRNVARPLVCMDDLVDIRVFTLVRSPLNVTNVGSPLGSKQALK
YIRVFILERSHMNVRNVERPFVSFPTLWVIKEFILEKNPMNARNAGRALHVGINLPCIREFIQGRNTMNVKKMGRLLVVAINLLHLIHLK
VLRNLISVRNVGKPLVCMDDLLDIRVFIVVRNPMNVTNVGSPLGSIHPLKYIKIFIPVRNPTNVRNVGRPSVSVHTLPIITEFILVTNPL
NVKNVGSPFVVPHILLYMREFIQERNPMYVKSVGRVLVIAINSLYIAEFILVRNLMNVRNVGRPLVYLDNLLSIXVFTVVRNPLNATNAG
SLLGSFLYLKPIRIFIALRNPTNVRNVARPFVMPQASYIMTELMLVKSPMNVKNVGKLLVMLHILLFMREFIPVINPMNVKDVGRHFTVP

>In-frame_TNNI3_ENST00000344887_chr19_55668947_-_ZNF607_ENST00000395835_chr19_38200723_-_696aa
MADGDQXHSGMWPXTSLIRSGNISAWFRRPCTRRXXWRTMTTXSHWDIPYLSQIXSPYWSKEKSHGXLXGKKQEESVQIWIQDVKXSAMG
KCSFIGNTHVLLSIREFIMDRNHMSVSNVRSPLVILQNSWYIKQFILVRNLINVKSLGRHLAILQTLESIRKLMLVRNLMNVKNVGRSSV
ILQTLLNMGKFMLRNPMNVKSVGKLLGLAVNLLYIIDFIMVRNPTNVRNVARPLVCMDDLVDIRVFTLVRSPLNVTNVGSPLGSKQALKY
IRVFILERSHMNVRNVERPFVSFPTLWVIKEFILEKNPMNARNAGRALHVGINLPCIREFIQGRNTMNVKKMGRLLVVAINLLHLIHLKV
LRNLISVRNVGKPLVCMDDLLDIRVFIVVRNPMNVTNVGSPLGSIHPLKYIKIFIPVRNPTNVRNVGRPSVSVHTLPIITEFILVTNPLN
VKNVGSPFVVPHILLYMREFIQERNPMYVKSVGRVLVIAINSLYIAEFILVRNLMNVRNVGRPLVYLDNLLSIXVFTVVRNPLNATNAGS
LLGSFLYLKPIRIFIALRNPTNVRNVARPFVMPQASYIMTELMLVKSPMNVKNVGKLLVMLHILLFMREFIPVINPMNVKDVGRHFTVPH


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TNNI3_ENST00000344887_chr19_55668947_-_ZNF607_ENST00000355202_chr19_38200723_-_2093nt
ATGGCGGATGGGGATCAATAACATTCGGGGATGTGGCCATAGACTTCTCTCATCAGGAGTGGGAATATCTCAGCCTGGTTCAGAAGACCT
TGTACCAGGAGGTGATGATGGAGAACTATGACAACTTAGTCTCATTGGCAGGACATTCCGTATCTAAGCCAGATTTAATCACCTTATTGG
AGCAAGGAAAAGAGCCATGGATGATTGTGAGGGAAGAAACAAGAGGAGAGTGTACAGATTTGGATTCAAGATGTGAAATAATCAGCGATG
GGAAAATGCAGCTTTATAGGAAACACTCATGTGTTACTCTCCATCAGAGAATTCATAATGGACAGAAACCATATGAGTGTAAGCAATGTC
AGAAGTCCTTTAGTCATCTTACAGAACTCATGGTACATCAAACAATTCATACTAGTGAGGAACCTGATCAATGTGAAAAGTTTAGGAAGG
CATTTAGCCATCTTACAGACCTTAGAAAGCATCAGAAAATTAATGCTCGTGAGAAACCTTATGAATGTGAAGAATGTGGGAAGGTCTTCA
GTTATCCTGCAAACCTTGCTCAACATGGGAAAGTTCATGTTGAGAAACCCTATGAATGTAAAGAGTGTGGGGAAGCTTTTAGGACTAGCC
GTCAACTTACTGTACATCATAGATTTCATTATGGTGAGAAACCCTACGAATGTAAGGAATGTGGCAAGGCCTTTAGTGTGTATGGACGAC
TTAGTCGACATCAGAGTATTCACACTGGTGAGAAGCCCTTTGAATGTAACAAATGTGGGAAGTCCTTTAGGCTCAAAGCAGGCCTTAAAG
TACATCAGAGTATTCATACTGGAGAGAAGCCACATGAATGTAAGGAATGTGGAAAGGCCTTTCGTCAGTTTTCCCACCTTGTGGGTCATA
AAAGAATTCATACTGGAGAAAAACCCTATGAATGCAAGGAATGCGGGAAGGGCTTTACATGTAGGTATCAACTTACCATGCATCAGAGAA
TTTATTCAGGGGAGAAACACTATGAATGTAAAGAAAATGGGGAGGCTTTTAGTAGTGGCCATCAACTTACTGCACCTCATACATTTGAAA
GTGTTGAGAAACCTTATAAGTGTGAGGAATGTGGGAAAGCCTTTAGTGTGCATGGACGACTTACTCGACATCAGGGTATTCATAGTGGTA
AGAAACCCTATGAATGTAACAAATGTGGGAAGTCCTTTAGGCTCAATTCATCCCTTAAAATACATCAAAATATTCATACCGGTGAGAAAC
CCTACAAATGTAAGGAATGTGGGAAGGCCTTCAGTCAGCGTGCACACCTTGCCCATCATAACAGAATTCATACTGGTTACAAACCCTTTG
AATGTAAAGAATGTGGGAAGTCCTTTCGTTGTGCCTCATATCTTGTTATACATGAGAGAATTCATACAGGAGAGAAACCCTATGTATGTC
AAGAGTGTGGGAAGGGTTTTAGTTATAGCCATAAACTCACTATACATCGCAGAGTTCATACTGGTGAGAAACCTTATGAATGTAAGGAAT
GTGGGAAGGCCTTTAGTGTATCTGGACAACTTACTCAGCATCTGAGTATTCACAGTGGTAAGAAACCCTTTGAATGCAACAAATGCGGGA
AGTCTTTTAGGTTCATTTCTGTACTTAAAGCCCATCAGAATATTCATAGCGCTGAGAAACCCTACGAATGTAAGGAATGTGGCAAGGCCT
TTCGTCATGCCACAAGCCTCATATATCATGACCGAACTCATGCTGGTGAAAAGTCCTATGAATGTAAAGAATGTGGGGAAACTTTTAGTC
ATGCTTCACATCTTATTATTCATGAGAGAATTCATACCAGTGATAAACCCTATGAATGTAAAAGATGTGGGAAGGCATTTCACTGTGCCT
CATATCTTGTTAGACATGAAAGCGTTCATGCTGATGGAAATCCCTATATGTGTGAAGAGTGTGGGAAAGCTTTTAATAGTAGCCATGAAC
TTAGTATACATCATAGAGTTCATACTGGTGAGAAACCCTTTAAATGTAACAAATGCAGAAGGTCCTTTAGGCTTAGATCCATCCTTGAAG

>In-frame_TNNI3_ENST00000344887_chr19_55668947_-_ZNF607_ENST00000395835_chr19_38200723_-_2090nt
ATGGCGGATGGGGATCAATAACATTCGGGGATGTGGCCATAGACTTCTCTCATCAGGAGTGGGAATATCTCAGCCTGGTTCAGAAGACCT
TGTACCAGGAGGTGATGATGGAGAACTATGACAACTTAGTCTCATTGGGACATTCCGTATCTAAGCCAGATTTAATCACCTTATTGGAGC
AAGGAAAAGAGCCATGGATGATTGTGAGGGAAGAAACAAGAGGAGAGTGTACAGATTTGGATTCAAGATGTGAAATAATCAGCGATGGGA
AAATGCAGCTTTATAGGAAACACTCATGTGTTACTCTCCATCAGAGAATTCATAATGGACAGAAACCATATGAGTGTAAGCAATGTCAGA
AGTCCTTTAGTCATCTTACAGAACTCATGGTACATCAAACAATTCATACTAGTGAGGAACCTGATCAATGTGAAAAGTTTAGGAAGGCAT
TTAGCCATCTTACAGACCTTAGAAAGCATCAGAAAATTAATGCTCGTGAGAAACCTTATGAATGTGAAGAATGTGGGAAGGTCTTCAGTT
ATCCTGCAAACCTTGCTCAACATGGGAAAGTTCATGTTGAGAAACCCTATGAATGTAAAGAGTGTGGGGAAGCTTTTAGGACTAGCCGTC
AACTTACTGTACATCATAGATTTCATTATGGTGAGAAACCCTACGAATGTAAGGAATGTGGCAAGGCCTTTAGTGTGTATGGACGACTTA
GTCGACATCAGAGTATTCACACTGGTGAGAAGCCCTTTGAATGTAACAAATGTGGGAAGTCCTTTAGGCTCAAAGCAGGCCTTAAAGTAC
ATCAGAGTATTCATACTGGAGAGAAGCCACATGAATGTAAGGAATGTGGAAAGGCCTTTCGTCAGTTTTCCCACCTTGTGGGTCATAAAA
GAATTCATACTGGAGAAAAACCCTATGAATGCAAGGAATGCGGGAAGGGCTTTACATGTAGGTATCAACTTACCATGCATCAGAGAATTT
ATTCAGGGGAGAAACACTATGAATGTAAAGAAAATGGGGAGGCTTTTAGTAGTGGCCATCAACTTACTGCACCTCATACATTTGAAAGTG
TTGAGAAACCTTATAAGTGTGAGGAATGTGGGAAAGCCTTTAGTGTGCATGGACGACTTACTCGACATCAGGGTATTCATAGTGGTAAGA
AACCCTATGAATGTAACAAATGTGGGAAGTCCTTTAGGCTCAATTCATCCCTTAAAATACATCAAAATATTCATACCGGTGAGAAACCCT
ACAAATGTAAGGAATGTGGGAAGGCCTTCAGTCAGCGTGCACACCTTGCCCATCATAACAGAATTCATACTGGTTACAAACCCTTTGAAT
GTAAAGAATGTGGGAAGTCCTTTCGTTGTGCCTCATATCTTGTTATACATGAGAGAATTCATACAGGAGAGAAACCCTATGTATGTCAAG
AGTGTGGGAAGGGTTTTAGTTATAGCCATAAACTCACTATACATCGCAGAGTTCATACTGGTGAGAAACCTTATGAATGTAAGGAATGTG
GGAAGGCCTTTAGTGTATCTGGACAACTTACTCAGCATCTGAGTATTCACAGTGGTAAGAAACCCTTTGAATGCAACAAATGCGGGAAGT
CTTTTAGGTTCATTTCTGTACTTAAAGCCCATCAGAATATTCATAGCGCTGAGAAACCCTACGAATGTAAGGAATGTGGCAAGGCCTTTC
GTCATGCCACAAGCCTCATATATCATGACCGAACTCATGCTGGTGAAAAGTCCTATGAATGTAAAGAATGTGGGGAAACTTTTAGTCATG
CTTCACATCTTATTATTCATGAGAGAATTCATACCAGTGATAAACCCTATGAATGTAAAAGATGTGGGAAGGCATTTCACTGTGCCTCAT
ATCTTGTTAGACATGAAAGCGTTCATGCTGATGGAAATCCCTATATGTGTGAAGAGTGTGGGAAAGCTTTTAATAGTAGCCATGAACTTA
GTATACATCATAGAGTTCATACTGGTGAGAAACCCTTTAAATGTAACAAATGCAGAAGGTCCTTTAGGCTTAGATCCATCCTTGAAGTAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_TNNI3_ENST00000344887_chr19_55668947_-_ZNF607_ENST00000355202_chr19_38200723_-_3913nt
AGTGTCCTCGGGGAGTCTCAAGCAGCCCGGAGGAGACTGACGGTCCCTGGGACCCTGAAGGTCACCCGGGCGGCCCCCTCACTGACCCTC
CAAACGCCCCTGTCCTCGCCCTGCCTCCTGCCATTCCCGGCCTGAGTCTCAGCATGGCGGATGGGGATCAATAACATTCGGGGATGTGGC
CATAGACTTCTCTCATCAGGAGTGGGAATATCTCAGCCTGGTTCAGAAGACCTTGTACCAGGAGGTGATGATGGAGAACTATGACAACTT
AGTCTCATTGGCAGGACATTCCGTATCTAAGCCAGATTTAATCACCTTATTGGAGCAAGGAAAAGAGCCATGGATGATTGTGAGGGAAGA
AACAAGAGGAGAGTGTACAGATTTGGATTCAAGATGTGAAATAATCAGCGATGGGAAAATGCAGCTTTATAGGAAACACTCATGTGTTAC
TCTCCATCAGAGAATTCATAATGGACAGAAACCATATGAGTGTAAGCAATGTCAGAAGTCCTTTAGTCATCTTACAGAACTCATGGTACA
TCAAACAATTCATACTAGTGAGGAACCTGATCAATGTGAAAAGTTTAGGAAGGCATTTAGCCATCTTACAGACCTTAGAAAGCATCAGAA
AATTAATGCTCGTGAGAAACCTTATGAATGTGAAGAATGTGGGAAGGTCTTCAGTTATCCTGCAAACCTTGCTCAACATGGGAAAGTTCA
TGTTGAGAAACCCTATGAATGTAAAGAGTGTGGGGAAGCTTTTAGGACTAGCCGTCAACTTACTGTACATCATAGATTTCATTATGGTGA
GAAACCCTACGAATGTAAGGAATGTGGCAAGGCCTTTAGTGTGTATGGACGACTTAGTCGACATCAGAGTATTCACACTGGTGAGAAGCC
CTTTGAATGTAACAAATGTGGGAAGTCCTTTAGGCTCAAAGCAGGCCTTAAAGTACATCAGAGTATTCATACTGGAGAGAAGCCACATGA
ATGTAAGGAATGTGGAAAGGCCTTTCGTCAGTTTTCCCACCTTGTGGGTCATAAAAGAATTCATACTGGAGAAAAACCCTATGAATGCAA
GGAATGCGGGAAGGGCTTTACATGTAGGTATCAACTTACCATGCATCAGAGAATTTATTCAGGGGAGAAACACTATGAATGTAAAGAAAA
TGGGGAGGCTTTTAGTAGTGGCCATCAACTTACTGCACCTCATACATTTGAAAGTGTTGAGAAACCTTATAAGTGTGAGGAATGTGGGAA
AGCCTTTAGTGTGCATGGACGACTTACTCGACATCAGGGTATTCATAGTGGTAAGAAACCCTATGAATGTAACAAATGTGGGAAGTCCTT
TAGGCTCAATTCATCCCTTAAAATACATCAAAATATTCATACCGGTGAGAAACCCTACAAATGTAAGGAATGTGGGAAGGCCTTCAGTCA
GCGTGCACACCTTGCCCATCATAACAGAATTCATACTGGTTACAAACCCTTTGAATGTAAAGAATGTGGGAAGTCCTTTCGTTGTGCCTC
ATATCTTGTTATACATGAGAGAATTCATACAGGAGAGAAACCCTATGTATGTCAAGAGTGTGGGAAGGGTTTTAGTTATAGCCATAAACT
CACTATACATCGCAGAGTTCATACTGGTGAGAAACCTTATGAATGTAAGGAATGTGGGAAGGCCTTTAGTGTATCTGGACAACTTACTCA
GCATCTGAGTATTCACAGTGGTAAGAAACCCTTTGAATGCAACAAATGCGGGAAGTCTTTTAGGTTCATTTCTGTACTTAAAGCCCATCA
GAATATTCATAGCGCTGAGAAACCCTACGAATGTAAGGAATGTGGCAAGGCCTTTCGTCATGCCACAAGCCTCATATATCATGACCGAAC
TCATGCTGGTGAAAAGTCCTATGAATGTAAAGAATGTGGGGAAACTTTTAGTCATGCTTCACATCTTATTATTCATGAGAGAATTCATAC
CAGTGATAAACCCTATGAATGTAAAAGATGTGGGAAGGCATTTCACTGTGCCTCATATCTTGTTAGACATGAAAGCGTTCATGCTGATGG
AAATCCCTATATGTGTGAAGAGTGTGGGAAAGCTTTTAATAGTAGCCATGAACTTAGTATACATCATAGAGTTCATACTGGTGAGAAACC
CTTTAAATGTAACAAATGCAGAAGGTCCTTTAGGCTTAGATCCATCCTTGAAGTACATCAGAGAATTCATATTTGATAGAGAAATTGTGG
CATATACAGGTAGTAAAGAAAGCACATTGTGTCAATGGATTTATCCCACTGAACAATTTGAATGAAGACAATGTGGAATGGCTTTGAGAT
ACAGTTCAGTTTTTATTAGGCATCAATTTGTATTGGTGTGAACTTTTCAAAATGTAAATCATATATGCAGTTTCTTTGGTATGACCTGTG
TTAACTCAGATTCAGAGAATTTATAATGTATTTTTTTAATAACATAAGAAAACTTTTCTGATATTCCTCTAGTTTTGGATTGCCAAAATA
TTCACAGTAGAGGAAAACTGAGAAAACGTAGGAAACCATTCTTTATACTTGCATGTAAACATCTTCCAGCAACAATCATTTATTGTTAAA
CCTGGAAAAAGCCATTACACAGGAAACCTCTGTTGATATAAGCGATGATGGGAAAGGCTATTTAGCCACTCTGCATATTTAATGCTCATG
ATCAACATCTGCTTCCTATAGCTGGGATGATATGGGGGAAGATATTTATCCCTTCTGGGGATCATATATAAATGATGATAGTAGTACCTA
CAGTATAGTGCTGTTAGAATTACATGAGTTAGATGTGGAGGTCAGAGTGGAAGCAGGTGTGAGAGGGTCCCGCAGAAGAAAACATGGCTG
CCAAAGTGTTTGAGTCCATCGGCAAGTTTGGCCTGGCCTTAGCTGTTGCAGGAGGCATGGTGAACTCTGCCTTATGTAATGTGGATGCTG
GGCACAGAGCTGCCATCTTTGACCAATTCCGTGGAGTACAGAACATTGTGGTAGGGGAAGGGACTCACTTTCTCATCCCATGTGTACAAA
AACCAATTATCTTTGACTGCTGTTCTCAACCACGTAGTGCGCCAGTCATCACTGGTAGCAAAGATTTACAGAATGTCAACATCACACTGT
GCATCCTCTTCCGGCCCATCACTAGCCAGCTTCCTCGCATCTTCACCAGCATTGGAGAGGACTACGATGAGTGTGTGCTGCCGTTCATTA
CCACGGAGATCCTCAAGTCACTGGTGGCTCGCTTTGATGCTGGAGAACTAATCACCCAGAGGGAGCTGGTCTCCAGCCAGGTGAGCAACA
ACCTTATGGAGTGAGCAGCCACCTTTGGGCTCATTCTGGACGACGTGTCTTTGACACATCTGACCTTCTTGAAGGAGTTAACAGACAGGT
GGCCCCCCAGGAAGCAGAGAGCGCCAGATTTGTGGTGGAAAAGGCGGCCATCATCTCTGCTGAGGGTGACTCCAAGGCAGCTGAGCTGAT
CGCCAACTCACTGGCCACTGCAGGGGACGGCCAGAGCGAGCTGTGCAAGCTGGAAGCTGCAGAAGACATTGCATACCAGCTCTCATGCTC
TCGGAACATCACCTGCCTGCCGGCAGGGCAGTCCGTGCTCCTCCAGCTGCCCTAGTGAGGCCCCAGCCTACCTGCACCTCCGTGAGGCAA
CTGGGCCACAGCCCCGATGATTCGTAACACCACCTTTCGCCCTCACCCCAGAAATCACTGAAATTTCATGATTGGCTTAAAGTGAAGGAA
GTAAAGGTAAAATCACTTCAGATCTCTAAAAAACAAAGAATTACATGAGTTAGTACATGAAAAAATTATGGGAAACTACATGAAATATAC

>In-frame_TNNI3_ENST00000344887_chr19_55668947_-_ZNF607_ENST00000395835_chr19_38200723_-_3900nt
AGTGTCCTCGGGGAGTCTCAAGCAGCCCGGAGGAGACTGACGGTCCCTGGGACCCTGAAGGTCACCCGGGCGGCCCCCTCACTGACCCTC
CAAACGCCCCTGTCCTCGCCCTGCCTCCTGCCATTCCCGGCCTGAGTCTCAGCATGGCGGATGGGGATCAATAACATTCGGGGATGTGGC
CATAGACTTCTCTCATCAGGAGTGGGAATATCTCAGCCTGGTTCAGAAGACCTTGTACCAGGAGGTGATGATGGAGAACTATGACAACTT
AGTCTCATTGGGACATTCCGTATCTAAGCCAGATTTAATCACCTTATTGGAGCAAGGAAAAGAGCCATGGATGATTGTGAGGGAAGAAAC
AAGAGGAGAGTGTACAGATTTGGATTCAAGATGTGAAATAATCAGCGATGGGAAAATGCAGCTTTATAGGAAACACTCATGTGTTACTCT
CCATCAGAGAATTCATAATGGACAGAAACCATATGAGTGTAAGCAATGTCAGAAGTCCTTTAGTCATCTTACAGAACTCATGGTACATCA
AACAATTCATACTAGTGAGGAACCTGATCAATGTGAAAAGTTTAGGAAGGCATTTAGCCATCTTACAGACCTTAGAAAGCATCAGAAAAT
TAATGCTCGTGAGAAACCTTATGAATGTGAAGAATGTGGGAAGGTCTTCAGTTATCCTGCAAACCTTGCTCAACATGGGAAAGTTCATGT
TGAGAAACCCTATGAATGTAAAGAGTGTGGGGAAGCTTTTAGGACTAGCCGTCAACTTACTGTACATCATAGATTTCATTATGGTGAGAA
ACCCTACGAATGTAAGGAATGTGGCAAGGCCTTTAGTGTGTATGGACGACTTAGTCGACATCAGAGTATTCACACTGGTGAGAAGCCCTT
TGAATGTAACAAATGTGGGAAGTCCTTTAGGCTCAAAGCAGGCCTTAAAGTACATCAGAGTATTCATACTGGAGAGAAGCCACATGAATG
TAAGGAATGTGGAAAGGCCTTTCGTCAGTTTTCCCACCTTGTGGGTCATAAAAGAATTCATACTGGAGAAAAACCCTATGAATGCAAGGA
ATGCGGGAAGGGCTTTACATGTAGGTATCAACTTACCATGCATCAGAGAATTTATTCAGGGGAGAAACACTATGAATGTAAAGAAAATGG
GGAGGCTTTTAGTAGTGGCCATCAACTTACTGCACCTCATACATTTGAAAGTGTTGAGAAACCTTATAAGTGTGAGGAATGTGGGAAAGC
CTTTAGTGTGCATGGACGACTTACTCGACATCAGGGTATTCATAGTGGTAAGAAACCCTATGAATGTAACAAATGTGGGAAGTCCTTTAG
GCTCAATTCATCCCTTAAAATACATCAAAATATTCATACCGGTGAGAAACCCTACAAATGTAAGGAATGTGGGAAGGCCTTCAGTCAGCG
TGCACACCTTGCCCATCATAACAGAATTCATACTGGTTACAAACCCTTTGAATGTAAAGAATGTGGGAAGTCCTTTCGTTGTGCCTCATA
TCTTGTTATACATGAGAGAATTCATACAGGAGAGAAACCCTATGTATGTCAAGAGTGTGGGAAGGGTTTTAGTTATAGCCATAAACTCAC
TATACATCGCAGAGTTCATACTGGTGAGAAACCTTATGAATGTAAGGAATGTGGGAAGGCCTTTAGTGTATCTGGACAACTTACTCAGCA
TCTGAGTATTCACAGTGGTAAGAAACCCTTTGAATGCAACAAATGCGGGAAGTCTTTTAGGTTCATTTCTGTACTTAAAGCCCATCAGAA
TATTCATAGCGCTGAGAAACCCTACGAATGTAAGGAATGTGGCAAGGCCTTTCGTCATGCCACAAGCCTCATATATCATGACCGAACTCA
TGCTGGTGAAAAGTCCTATGAATGTAAAGAATGTGGGGAAACTTTTAGTCATGCTTCACATCTTATTATTCATGAGAGAATTCATACCAG
TGATAAACCCTATGAATGTAAAAGATGTGGGAAGGCATTTCACTGTGCCTCATATCTTGTTAGACATGAAAGCGTTCATGCTGATGGAAA
TCCCTATATGTGTGAAGAGTGTGGGAAAGCTTTTAATAGTAGCCATGAACTTAGTATACATCATAGAGTTCATACTGGTGAGAAACCCTT
TAAATGTAACAAATGCAGAAGGTCCTTTAGGCTTAGATCCATCCTTGAAGTACATCAGAGAATTCATATTTGATAGAGAAATTGTGGCAT
ATACAGGTAGTAAAGAAAGCACATTGTGTCAATGGATTTATCCCACTGAACAATTTGAATGAAGACAATGTGGAATGGCTTTGAGATACA
GTTCAGTTTTTATTAGGCATCAATTTGTATTGGTGTGAACTTTTCAAAATGTAAATCATATATGCAGTTTCTTTGGTATGACCTGTGTTA
ACTCAGATTCAGAGAATTTATAATGTATTTTTTTAATAACATAAGAAAACTTTTCTGATATTCCTCTAGTTTTGGATTGCCAAAATATTC
ACAGTAGAGGAAAACTGAGAAAACGTAGGAAACCATTCTTTATACTTGCATGTAAACATCTTCCAGCAACAATCATTTATTGTTAAACCT
GGAAAAAGCCATTACACAGGAAACCTCTGTTGATATAAGCGATGATGGGAAAGGCTATTTAGCCACTCTGCATATTTAATGCTCATGATC
AACATCTGCTTCCTATAGCTGGGATGATATGGGGGAAGATATTTATCCCTTCTGGGGATCATATATAAATGATGATAGTAGTACCTACAG
TATAGTGCTGTTAGAATTACATGAGTTAGATGTGGAGGTCAGAGTGGAAGCAGGTGTGAGAGGGTCCCGCAGAAGAAAACATGGCTGCCA
AAGTGTTTGAGTCCATCGGCAAGTTTGGCCTGGCCTTAGCTGTTGCAGGAGGCATGGTGAACTCTGCCTTATGTAATGTGGATGCTGGGC
ACAGAGCTGCCATCTTTGACCAATTCCGTGGAGTACAGAACATTGTGGTAGGGGAAGGGACTCACTTTCTCATCCCATGTGTACAAAAAC
CAATTATCTTTGACTGCTGTTCTCAACCACGTAGTGCGCCAGTCATCACTGGTAGCAAAGATTTACAGAATGTCAACATCACACTGTGCA
TCCTCTTCCGGCCCATCACTAGCCAGCTTCCTCGCATCTTCACCAGCATTGGAGAGGACTACGATGAGTGTGTGCTGCCGTTCATTACCA
CGGAGATCCTCAAGTCACTGGTGGCTCGCTTTGATGCTGGAGAACTAATCACCCAGAGGGAGCTGGTCTCCAGCCAGGTGAGCAACAACC
TTATGGAGTGAGCAGCCACCTTTGGGCTCATTCTGGACGACGTGTCTTTGACACATCTGACCTTCTTGAAGGAGTTAACAGACAGGTGGC
CCCCCAGGAAGCAGAGAGCGCCAGATTTGTGGTGGAAAAGGCGGCCATCATCTCTGCTGAGGGTGACTCCAAGGCAGCTGAGCTGATCGC
CAACTCACTGGCCACTGCAGGGGACGGCCAGAGCGAGCTGTGCAAGCTGGAAGCTGCAGAAGACATTGCATACCAGCTCTCATGCTCTCG
GAACATCACCTGCCTGCCGGCAGGGCAGTCCGTGCTCCTCCAGCTGCCCTAGTGAGGCCCCAGCCTACCTGCACCTCCGTGAGGCAACTG
GGCCACAGCCCCGATGATTCGTAACACCACCTTTCGCCCTCACCCCAGAAATCACTGAAATTTCATGATTGGCTTAAAGTGAAGGAAGTA
AAGGTAAAATCACTTCAGATCTCTAAAAAACAAAGAATTACATGAGTTAGTACATGAAAAAATTATGGGAAACTACATGAAATATACTGT


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FusionGenePPI for TNNI3_ZNF607


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TNNI3PKD2L1, TNNI3K, TNNC1, PKD2, LYST, TNNT2, RCAN3, TRIM63, TRIM55, TNNC2, SOX4, PSMC5, HSPB2, AKAP1, IFNA4ZNF607MDFI, MTUS2, CEP70


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TNNI3_ZNF607


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TNNI3_ZNF607


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTNNI3C1860752CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 76CTD_human;UNIPROT
HgeneTNNI3C0949658Cardiomyopathy, Hypertrophic, Familial3CTD_human
HgeneTNNI3C2750091Cardiomyopathy, Dilated, 1FF2CTD_human;UNIPROT
HgeneTNNI3C0007193Cardiomyopathy, Dilated1CTD_human;HPO
HgeneTNNI3C0007196Restrictive cardiomyopathy1CTD_human;HPO
HgeneTNNI3C0018799Heart Diseases1CTD_human
HgeneTNNI3C0027051Myocardial Infarction1CTD_human
HgeneTNNI3C0878544Cardiomyopathies1CTD_human;HPO
HgeneTNNI3C0948089Acute Coronary Syndrome1CTD_human
HgeneTNNI3C1861861CARDIOMYOPATHY, FAMILIAL RESTRICTIVE, 1 (disorder)1CTD_human;UNIPROT
HgeneTNNI3C2678474CARDIOMYOPATHY, DILATED, 2A (disorder)1CTD_human;UNIPROT