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Fusion gene ID: 38892 |
FusionGeneSummary for TNIP1_CAMK2A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TNIP1_CAMK2A | Fusion gene ID: 38892 | Hgene | Tgene | Gene symbol | TNIP1 | CAMK2A | Gene ID | 10318 | 815 |
| Gene name | TNFAIP3 interacting protein 1 | calcium/calmodulin dependent protein kinase II alpha | |
| Synonyms | ABIN-1|NAF1|VAN|nip40-1 | CAMKA|MRD53 | |
| Cytomap | 5q33.1 | 5q32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | TNFAIP3-interacting protein 1A20-binding inhibitor of NF-kappa-B activation 1HIV-1 Nef-interacting proteinNef-associated factor 1 SNPvirion-associated nuclear shuttling protein | calcium/calmodulin-dependent protein kinase type II subunit alphaCaM kinase II alpha subunitCaM-kinase II alpha chainCaMK-II alpha subunitCaMKIINalphacaM kinase II subunit alphacaMK-II subunit alphacalcium/calmodulin-dependent protein kinase (CaM k | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q15025 | Q9UQM7 | |
| Ensembl transtripts involved in fusion gene | ENST00000520931, ENST00000389378, ENST00000523338, ENST00000315050, ENST00000522226, ENST00000518977, ENST00000521591, ENST00000524280, ENST00000523200, ENST00000521423, | ENST00000348628, ENST00000351010, ENST00000398376, | |
| Fusion gene scores | * DoF score | 7 X 4 X 4=112 | 3 X 3 X 3=27 |
| # samples | 5 | 3 | |
| ** MAII score | log2(5/112*10)=-1.16349873228288 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TNIP1 [Title/Abstract] AND CAMK2A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TNIP1 | GO:0009101 | glycoprotein biosynthetic process | 9923610 |
| Hgene | TNIP1 | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling | 16684768 |
| Hgene | TNIP1 | GO:0070373 | negative regulation of ERK1 and ERK2 cascade | 12220502 |
| Hgene | TNIP1 | GO:0085032 | modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade | 20010814 |
| Hgene | TNIP1 | GO:1903003 | positive regulation of protein deubiquitination | 16684768 |
| Tgene | CAMK2A | GO:0006468 | protein phosphorylation | 17052756 |
| Tgene | CAMK2A | GO:0038166 | angiotensin-activated signaling pathway | 20584908 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | KIRC | TCGA-BP-4965-01A | TNIP1 | chr5 | 150439879 | - | CAMK2A | chr5 | 149669286 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000520931 | ENST00000348628 | TNIP1 | chr5 | 150439879 | - | CAMK2A | chr5 | 149669286 | - |
| 5CDS-intron | ENST00000520931 | ENST00000351010 | TNIP1 | chr5 | 150439879 | - | CAMK2A | chr5 | 149669286 | - |
| 5CDS-intron | ENST00000520931 | ENST00000398376 | TNIP1 | chr5 | 150439879 | - | CAMK2A | chr5 | 149669286 | - |
| 5CDS-5UTR | ENST00000389378 | ENST00000348628 | TNIP1 | chr5 | 150439879 | - | CAMK2A | chr5 | 149669286 | - |
| 5CDS-intron | ENST00000389378 | ENST00000351010 | TNIP1 | chr5 | 150439879 | - | CAMK2A | chr5 | 149669286 | - |
| 5CDS-intron | ENST00000389378 | ENST00000398376 | TNIP1 | chr5 | 150439879 | - | CAMK2A | chr5 | 149669286 | - |
| 5CDS-5UTR | ENST00000523338 | ENST00000348628 | TNIP1 | chr5 | 150439879 | - | CAMK2A | chr5 | 149669286 | - |
| 5CDS-intron | ENST00000523338 | ENST00000351010 | TNIP1 | chr5 | 150439879 | - | CAMK2A | chr5 | 149669286 | - |
| 5CDS-intron | ENST00000523338 | ENST00000398376 | TNIP1 | chr5 | 150439879 | - | CAMK2A | chr5 | 149669286 | - |
| 5CDS-5UTR | ENST00000315050 | ENST00000348628 | TNIP1 | chr5 | 150439879 | - | CAMK2A | chr5 | 149669286 | - |
| 5CDS-intron | ENST00000315050 | ENST00000351010 | TNIP1 | chr5 | 150439879 | - | CAMK2A | chr5 | 149669286 | - |
| 5CDS-intron | ENST00000315050 | ENST00000398376 | TNIP1 | chr5 | 150439879 | - | CAMK2A | chr5 | 149669286 | - |
| 5CDS-5UTR | ENST00000522226 | ENST00000348628 | TNIP1 | chr5 | 150439879 | - | CAMK2A | chr5 | 149669286 | - |
| 5CDS-intron | ENST00000522226 | ENST00000351010 | TNIP1 | chr5 | 150439879 | - | CAMK2A | chr5 | 149669286 | - |
| 5CDS-intron | ENST00000522226 | ENST00000398376 | TNIP1 | chr5 | 150439879 | - | CAMK2A | chr5 | 149669286 | - |
| 5CDS-5UTR | ENST00000518977 | ENST00000348628 | TNIP1 | chr5 | 150439879 | - | CAMK2A | chr5 | 149669286 | - |
| 5CDS-intron | ENST00000518977 | ENST00000351010 | TNIP1 | chr5 | 150439879 | - | CAMK2A | chr5 | 149669286 | - |
| 5CDS-intron | ENST00000518977 | ENST00000398376 | TNIP1 | chr5 | 150439879 | - | CAMK2A | chr5 | 149669286 | - |
| 5CDS-5UTR | ENST00000521591 | ENST00000348628 | TNIP1 | chr5 | 150439879 | - | CAMK2A | chr5 | 149669286 | - |
| 5CDS-intron | ENST00000521591 | ENST00000351010 | TNIP1 | chr5 | 150439879 | - | CAMK2A | chr5 | 149669286 | - |
| 5CDS-intron | ENST00000521591 | ENST00000398376 | TNIP1 | chr5 | 150439879 | - | CAMK2A | chr5 | 149669286 | - |
| 5CDS-5UTR | ENST00000524280 | ENST00000348628 | TNIP1 | chr5 | 150439879 | - | CAMK2A | chr5 | 149669286 | - |
| 5CDS-intron | ENST00000524280 | ENST00000351010 | TNIP1 | chr5 | 150439879 | - | CAMK2A | chr5 | 149669286 | - |
| 5CDS-intron | ENST00000524280 | ENST00000398376 | TNIP1 | chr5 | 150439879 | - | CAMK2A | chr5 | 149669286 | - |
| 5CDS-5UTR | ENST00000523200 | ENST00000348628 | TNIP1 | chr5 | 150439879 | - | CAMK2A | chr5 | 149669286 | - |
| 5CDS-intron | ENST00000523200 | ENST00000351010 | TNIP1 | chr5 | 150439879 | - | CAMK2A | chr5 | 149669286 | - |
| 5CDS-intron | ENST00000523200 | ENST00000398376 | TNIP1 | chr5 | 150439879 | - | CAMK2A | chr5 | 149669286 | - |
| intron-5UTR | ENST00000521423 | ENST00000348628 | TNIP1 | chr5 | 150439879 | - | CAMK2A | chr5 | 149669286 | - |
| intron-intron | ENST00000521423 | ENST00000351010 | TNIP1 | chr5 | 150439879 | - | CAMK2A | chr5 | 149669286 | - |
| intron-intron | ENST00000521423 | ENST00000398376 | TNIP1 | chr5 | 150439879 | - | CAMK2A | chr5 | 149669286 | - |
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FusionProtFeatures for TNIP1_CAMK2A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TNIP1 | CAMK2A |
| CaM-kinase II (CAMK2) is a prominent kinase in thecentral nervous system that may function in long-term potentiationand neurotransmitter release. Member of the NMDAR signalingcomplex in excitatory synapses it may regulate NMDAR-dependentpotentiation of the AMPAR and synaptic plasticity (By similarity).Phosphorylates transcription factor FOXO3 on 'Ser-298'(PubMed:23805378). Activates FOXO3 transcriptional activity (Bysimilarity). {ECO:0000250|UniProtKB:P11275,ECO:0000250|UniProtKB:P11798, ECO:0000269|PubMed:23805378}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TNIP1_CAMK2A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TNIP1_CAMK2A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TNIP1 | TTF2, MAGEB18, TNFAIP3, MAPK1, TNF, IKBKG, UBC, TAX1BP1, IKBKE, TBK1, TRAF3, RARA, RARG, NFKB1, MYD88, SELPLG, PIK3R1, PIK3CD, RBFOX1, RNF11, CCNG1, GIT2, OPTN, ADH6, CDKN1A, EFEMP1, FUS, GTF2H1, PIN1, MAPK10, SUMO2, TNIP1, RABAC1, NME7, BYSL, EHHADH, GTF2B, KIFC3, TCEA2, ZBTB25, AP1M1, MORF4L2, NDC80, ZNHIT1, RALBP1, MORF4L1, PNKP, GABARAPL2, FAM168A, GABARAPL1, VPS33B, MAGEH1, CDIP1, SNIP1, TNIP3, MAP1LC3B, FAM161A, NIFK, MAP1LC3A, MOB1B, TCEANC2, SYT6, MOB3C, CCDC112, TXLNA, CFAP53, HDDC3, MAP3K1, CRHBP, GRAP2, SSX2IP, OFD1, PCM1, CEP97, CEP152, CEP135, CEP44, FBF1, NINL, ODF2, CENPJ, MCM10, TYRO3, CCDC121, ABHD17A, XPO1, TRAF1, ABI2, IKBIP, PIGT, SYNC, SAMD4A, HAO2, POTEF, ERP44, NAB2, EXOC1, CORO6 | CAMK2A | CAMK2B, CAMK2D, CALM3, CHMP5, DLG3, DLG1, RIMS1, ATF1, CREB1, PARK2, GRIN2B, CDK5R1, ACTN4, YWHAB, HDAC5, GIT1, YWHAQ, PLCG1, RCHY1, NOS3, PSMC5, KCNC1, AKT1, SLC6A3, HNRNPK, MAPT, RAD23A, HSP90AA1, FKBP8, SQSTM1, ITGA2B, PTTG1, CAMK2G, ZMYM1, ARMC1, HAX1, NUFIP1, RRP7A, CDCA8, DGUOK, DNAAF2, GNAO1, PPM1F, CAMK2A, ACTN1, SMAD2, CYLD, SSBP2, NINL, ARL3, DCTN2, DCTN1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TNIP1_CAMK2A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TNIP1_CAMK2A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TNIP1 | C0024141 | Lupus Erythematosus, Systemic | 2 | CTD_human |
| Hgene | TNIP1 | C0033860 | Psoriasis | 2 | CTD_human |
| Hgene | TNIP1 | C0036421 | Systemic Scleroderma | 1 | CTD_human |
| Hgene | TNIP1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Hgene | TNIP1 | C1527336 | Sjogren's Syndrome | 1 | CTD_human |
| Tgene | CAMK2A | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
| Tgene | CAMK2A | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Tgene | CAMK2A | C0011570 | Mental Depression | 1 | PSYGENET |
| Tgene | CAMK2A | C0011581 | Depressive disorder | 1 | PSYGENET |
| Tgene | CAMK2A | C0019202 | Hepatolenticular Degeneration | 1 | CTD_human |
| Tgene | CAMK2A | C0020429 | Hyperalgesia | 1 | CTD_human |
| Tgene | CAMK2A | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Tgene | CAMK2A | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
| Tgene | CAMK2A | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
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