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Fusion gene ID: 38891 |
FusionGeneSummary for TNIP1_ARSI |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TNIP1_ARSI | Fusion gene ID: 38891 | Hgene | Tgene | Gene symbol | TNIP1 | ARSI | Gene ID | 10318 | 340075 |
| Gene name | TNFAIP3 interacting protein 1 | arylsulfatase family member I | |
| Synonyms | ABIN-1|NAF1|VAN|nip40-1 | ASI|SPG66 | |
| Cytomap | 5q33.1 | 5q32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | TNFAIP3-interacting protein 1A20-binding inhibitor of NF-kappa-B activation 1HIV-1 Nef-interacting proteinNef-associated factor 1 SNPvirion-associated nuclear shuttling protein | arylsulfatase I | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | Q15025 | Q5FYB1 | |
| Ensembl transtripts involved in fusion gene | ENST00000520931, ENST00000389378, ENST00000523338, ENST00000315050, ENST00000522226, ENST00000518977, ENST00000521591, ENST00000524280, ENST00000523200, ENST00000521423, | ENST00000328668, | |
| Fusion gene scores | * DoF score | 7 X 4 X 4=112 | 1 X 1 X 1=1 |
| # samples | 5 | 1 | |
| ** MAII score | log2(5/112*10)=-1.16349873228288 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: TNIP1 [Title/Abstract] AND ARSI [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TNIP1 | GO:0009101 | glycoprotein biosynthetic process | 9923610 |
| Hgene | TNIP1 | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling | 16684768 |
| Hgene | TNIP1 | GO:0070373 | negative regulation of ERK1 and ERK2 cascade | 12220502 |
| Hgene | TNIP1 | GO:0085032 | modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade | 20010814 |
| Hgene | TNIP1 | GO:1903003 | positive regulation of protein deubiquitination | 16684768 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | KIRC | TCGA-BP-4965-01A | TNIP1 | chr5 | 150439879 | - | ARSI | chr5 | 149678175 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000520931 | ENST00000328668 | TNIP1 | chr5 | 150439879 | - | ARSI | chr5 | 149678175 | - |
| Frame-shift | ENST00000389378 | ENST00000328668 | TNIP1 | chr5 | 150439879 | - | ARSI | chr5 | 149678175 | - |
| Frame-shift | ENST00000523338 | ENST00000328668 | TNIP1 | chr5 | 150439879 | - | ARSI | chr5 | 149678175 | - |
| Frame-shift | ENST00000315050 | ENST00000328668 | TNIP1 | chr5 | 150439879 | - | ARSI | chr5 | 149678175 | - |
| In-frame | ENST00000522226 | ENST00000328668 | TNIP1 | chr5 | 150439879 | - | ARSI | chr5 | 149678175 | - |
| In-frame | ENST00000518977 | ENST00000328668 | TNIP1 | chr5 | 150439879 | - | ARSI | chr5 | 149678175 | - |
| In-frame | ENST00000521591 | ENST00000328668 | TNIP1 | chr5 | 150439879 | - | ARSI | chr5 | 149678175 | - |
| Frame-shift | ENST00000524280 | ENST00000328668 | TNIP1 | chr5 | 150439879 | - | ARSI | chr5 | 149678175 | - |
| Frame-shift | ENST00000523200 | ENST00000328668 | TNIP1 | chr5 | 150439879 | - | ARSI | chr5 | 149678175 | - |
| intron-3CDS | ENST00000521423 | ENST00000328668 | TNIP1 | chr5 | 150439879 | - | ARSI | chr5 | 149678175 | - |
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FusionProtFeatures for TNIP1_ARSI |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TNIP1 | ARSI |
| Displays arylsulfatase activity at neutral pH, when co-expressed with SUMF1; arylsulfatase activity is measured in thesecretion medium of retinal cell line, but no activity is recordedwhen measured in cell extracts. {ECO:0000269|PubMed:16500042,ECO:0000269|PubMed:19262745}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TNIP1_ARSI |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TNIP1_ENST00000522226_chr5_150439879_-_ARSI_ENST00000328668_chr5_149678175_-_611aa MEGRGPYRIYDPGGSVPSGEASAAFERLVKENSRLKEKMQGIKMLGELLEESQMEATRLRQKAEELVKDNELLPPPSPSLGSFDPLAELT GKDSNVTASPTAPACPSDKPAPVQKPPSSGTSSEFEVVTPEEQNSPESSSHANAMVPDPHRTPAFHHPPTAAQLPAPGPGDTATEAAGGR LFHPYGGQVAPGLLPEGVSAHPSGLRHLPGLAHGQCGLLHLXQLXWPRRVRLRPARGXECGLGAQRPVLHYALCPARQPYPGQPQPSASP LPLCGLPGSTHTPAVPSXVPVPLPHHGQCGPAEVRGHGDLHGXGCAQHHLGPQALRFLQQQCHHLLQXQWWPDFLGGQQLAAPRTQGHLL GRWRAGPRLCPQSPAQAKATDKPGTDAHHXLVPDPGGSGRWYHLSSRWARWLRRVAGHQRGPGLTTHGDPAQHXPTLQPCPAWLPGGRLW HLEHRRAGCHPRGXVEAADRRPRLWRLDPTADTGHLPGXLVEPGTNGQCPPGRVALQHQCXPLXTGGPGWPAAXCGPHPAGSPGRIXPHS >In-frame_TNIP1_ENST00000518977_chr5_150439879_-_ARSI_ENST00000328668_chr5_149678175_-_611aa MEGRGPYRIYDPGGSVPSGEASAAFERLVKENSRLKEKMQGIKMLGELLEESQMEATRLRQKAEELVKDNELLPPPSPSLGSFDPLAELT GKDSNVTASPTAPACPSDKPAPVQKPPSSGTSSEFEVVTPEEQNSPESSSHANAMVPDPHRTPAFHHPPTAAQLPAPGPGDTATEAAGGR LFHPYGGQVAPGLLPEGVSAHPSGLRHLPGLAHGQCGLLHLXQLXWPRRVRLRPARGXECGLGAQRPVLHYALCPARQPYPGQPQPSASP LPLCGLPGSTHTPAVPSXVPVPLPHHGQCGPAEVRGHGDLHGXGCAQHHLGPQALRFLQQQCHHLLQXQWWPDFLGGQQLAAPRTQGHLL GRWRAGPRLCPQSPAQAKATDKPGTDAHHXLVPDPGGSGRWYHLSSRWARWLRRVAGHQRGPGLTTHGDPAQHXPTLQPCPAWLPGGRLW HLEHRRAGCHPRGXVEAADRRPRLWRLDPTADTGHLPGXLVEPGTNGQCPPGRVALQHQCXPLXTGGPGWPAAXCGPHPAGSPGRIXPHS >In-frame_TNIP1_ENST00000521591_chr5_150439879_-_ARSI_ENST00000328668_chr5_149678175_-_611aa MEGRGPYRIYDPGGSVPSGEASAAFERLVKENSRLKEKMQGIKMLGELLEESQMEATRLRQKAEELVKDNELLPPPSPSLGSFDPLAELT GKDSNVTASPTAPACPSDKPAPVQKPPSSGTSSEFEVVTPEEQNSPESSSHANAMVPDPHRTPAFHHPPTAAQLPAPGPGDTATEAAGGR LFHPYGGQVAPGLLPEGVSAHPSGLRHLPGLAHGQCGLLHLXQLXWPRRVRLRPARGXECGLGAQRPVLHYALCPARQPYPGQPQPSASP LPLCGLPGSTHTPAVPSXVPVPLPHHGQCGPAEVRGHGDLHGXGCAQHHLGPQALRFLQQQCHHLLQXQWWPDFLGGQQLAAPRTQGHLL GRWRAGPRLCPQSPAQAKATDKPGTDAHHXLVPDPGGSGRWYHLSSRWARWLRRVAGHQRGPGLTTHGDPAQHXPTLQPCPAWLPGGRLW HLEHRRAGCHPRGXVEAADRRPRLWRLDPTADTGHLPGXLVEPGTNGQCPPGRVALQHQCXPLXTGGPGWPAAXCGPHPAGSPGRIXPHS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TNIP1_ENST00000522226_chr5_150439879_-_ARSI_ENST00000328668_chr5_149678175_-_1834nt ATGGAAGGGAGAGGACCGTACCGGATCTACGACCCTGGGGGCAGCGTGCCCTCAGGAGAGGCATCCGCAGCTTTTGAGCGCCTAGTGAAG GAGAATTCCCGGCTGAAGGAAAAAATGCAAGGGATAAAGATGTTAGGGGAGCTTTTGGAAGAGTCCCAGATGGAAGCGACCAGGCTCCGG CAGAAGGCAGAGGAGCTAGTGAAGGACAACGAGCTGCTCCCACCACCTTCTCCCTCCTTGGGCTCCTTCGACCCCCTGGCTGAGCTCACA GGAAAGGACTCAAATGTCACAGCATCTCCCACAGCCCCTGCATGCCCCAGTGACAAGCCAGCACCAGTCCAGAAGCCTCCATCCAGTGGC ACCTCCTCTGAATTTGAAGTGGTCACTCCTGAGGAGCAGAATTCACCAGAGAGCAGCAGCCATGCCAATGCGATGGTACCAGATCCACAC AGGACTCCAGCATTCCATCATCCGCCCACAGCAGCCCAACTGCCTGCCCCTGGACCAGGTGACACTGCCACAGAAGCTGCAGGAGGCAGG TTATTCCACCCATATGGTGGGCAAGTGGCACCTGGGCTTCTACCGGAAGGAGTGTCTGCCCACCCGTCGGGGCTTCGACACCTTCCTGGG CTCGCTCACGGGCAATGTGGACTATTACACCTATGACAACTGTGATGGCCCAGGCGTGTGCGGCTTCGACCTGCACGAGGGTGAGAATGT GGCCTGGGGGCTCAGCGGCCAGTACTCCACTATGCTTTATGCCCAGCGCGCCAGCCATATCCTGGCCAGCCACAGCCCTCAGCGTCCCCT CTTCCTCTATGTGGCCTTCCAGGCAGTACACACACCCCTGCAGTCCCCTCGTGAGTACCTGTACCGCTACCGCACCATGGGCAATGTGGC CCGGCGGAAGTACGCGGCCATGGTGACCTGCATGGATGAGGCTGTGCGCAACATCACCTGGGCCCTCAAGCGCTACGGTTTCTACAACAA CAGTGTCATCATCTTCTCCAGTGACAATGGTGGCCAGACTTTCTCGGGGGGCAGCAACTGGCCGCTCCGAGGACGCAAGGGCACTTATTG GGAAGGTGGCGTGCGGGGCCTAGGCTTTGTCCACAGTCCCCTGCTCAAGCGAAAGCAACGGACAAGCCGGGCACTGATGCACATCACTGA CTGGTACCCGACCCTGGTGGGTCTGGCAGGTGGTACCACCTCAGCAGCCGATGGGCTAGATGGCTACGACGTGTGGCCGGCCATCAGCGA GGGCCGGGCCTCACCACGCACGGAGATCCTGCACAACATTGACCCACTCTACAACCATGCCCAGCATGGCTCCCTGGAGGGCGGCTTTGG CATCTGGAACACCGCCGTGCAGGCTGCCATCCGCGTGGGTGAGTGGAAGCTGCTGACAGGAGACCCCGGCTATGGCGATTGGATCCCACC GCAGACACTGGCCACCTTCCCGGGTAGCTGGTGGAACCTGGAACGAATGGCCAGTGTCCGCCAGGCCGTGTGGCTCTTCAACATCAGTGC TGACCCTTATGAACGGGAGGACCTGGCTGGCCAGCGGCCTGATGTGGTCCGCACCCTGCTGGCTCGCCTGGCCGAATATAACCGCACAGC CATCCCGGTACGCTACCCAGCTGAGAACCCCCGGGCTCATCCTGACTTTAATGGGGGTGCTTGGGGGCCCTGGGCCAGTGATGAGGAAGA GGAGGAAGAGGAAGGGAGGGCTCGAAGCTTCTCCCGGGGTCGTCGCAAGAAAAAATGCAAGATTTGCAAGCTTCGATCCTTTTTCCGTAA >In-frame_TNIP1_ENST00000518977_chr5_150439879_-_ARSI_ENST00000328668_chr5_149678175_-_1834nt ATGGAAGGGAGAGGACCGTACCGGATCTACGACCCTGGGGGCAGCGTGCCCTCAGGAGAGGCATCCGCAGCTTTTGAGCGCCTAGTGAAG GAGAATTCCCGGCTGAAGGAAAAAATGCAAGGGATAAAGATGTTAGGGGAGCTTTTGGAAGAGTCCCAGATGGAAGCGACCAGGCTCCGG CAGAAGGCAGAGGAGCTAGTGAAGGACAACGAGCTGCTCCCACCACCTTCTCCCTCCTTGGGCTCCTTCGACCCCCTGGCTGAGCTCACA GGAAAGGACTCAAATGTCACAGCATCTCCCACAGCCCCTGCATGCCCCAGTGACAAGCCAGCACCAGTCCAGAAGCCTCCATCCAGTGGC ACCTCCTCTGAATTTGAAGTGGTCACTCCTGAGGAGCAGAATTCACCAGAGAGCAGCAGCCATGCCAATGCGATGGTACCAGATCCACAC AGGACTCCAGCATTCCATCATCCGCCCACAGCAGCCCAACTGCCTGCCCCTGGACCAGGTGACACTGCCACAGAAGCTGCAGGAGGCAGG TTATTCCACCCATATGGTGGGCAAGTGGCACCTGGGCTTCTACCGGAAGGAGTGTCTGCCCACCCGTCGGGGCTTCGACACCTTCCTGGG CTCGCTCACGGGCAATGTGGACTATTACACCTATGACAACTGTGATGGCCCAGGCGTGTGCGGCTTCGACCTGCACGAGGGTGAGAATGT GGCCTGGGGGCTCAGCGGCCAGTACTCCACTATGCTTTATGCCCAGCGCGCCAGCCATATCCTGGCCAGCCACAGCCCTCAGCGTCCCCT CTTCCTCTATGTGGCCTTCCAGGCAGTACACACACCCCTGCAGTCCCCTCGTGAGTACCTGTACCGCTACCGCACCATGGGCAATGTGGC CCGGCGGAAGTACGCGGCCATGGTGACCTGCATGGATGAGGCTGTGCGCAACATCACCTGGGCCCTCAAGCGCTACGGTTTCTACAACAA CAGTGTCATCATCTTCTCCAGTGACAATGGTGGCCAGACTTTCTCGGGGGGCAGCAACTGGCCGCTCCGAGGACGCAAGGGCACTTATTG GGAAGGTGGCGTGCGGGGCCTAGGCTTTGTCCACAGTCCCCTGCTCAAGCGAAAGCAACGGACAAGCCGGGCACTGATGCACATCACTGA CTGGTACCCGACCCTGGTGGGTCTGGCAGGTGGTACCACCTCAGCAGCCGATGGGCTAGATGGCTACGACGTGTGGCCGGCCATCAGCGA GGGCCGGGCCTCACCACGCACGGAGATCCTGCACAACATTGACCCACTCTACAACCATGCCCAGCATGGCTCCCTGGAGGGCGGCTTTGG CATCTGGAACACCGCCGTGCAGGCTGCCATCCGCGTGGGTGAGTGGAAGCTGCTGACAGGAGACCCCGGCTATGGCGATTGGATCCCACC GCAGACACTGGCCACCTTCCCGGGTAGCTGGTGGAACCTGGAACGAATGGCCAGTGTCCGCCAGGCCGTGTGGCTCTTCAACATCAGTGC TGACCCTTATGAACGGGAGGACCTGGCTGGCCAGCGGCCTGATGTGGTCCGCACCCTGCTGGCTCGCCTGGCCGAATATAACCGCACAGC CATCCCGGTACGCTACCCAGCTGAGAACCCCCGGGCTCATCCTGACTTTAATGGGGGTGCTTGGGGGCCCTGGGCCAGTGATGAGGAAGA GGAGGAAGAGGAAGGGAGGGCTCGAAGCTTCTCCCGGGGTCGTCGCAAGAAAAAATGCAAGATTTGCAAGCTTCGATCCTTTTTCCGTAA >In-frame_TNIP1_ENST00000521591_chr5_150439879_-_ARSI_ENST00000328668_chr5_149678175_-_1834nt ATGGAAGGGAGAGGACCGTACCGGATCTACGACCCTGGGGGCAGCGTGCCCTCAGGAGAGGCATCCGCAGCTTTTGAGCGCCTAGTGAAG GAGAATTCCCGGCTGAAGGAAAAAATGCAAGGGATAAAGATGTTAGGGGAGCTTTTGGAAGAGTCCCAGATGGAAGCGACCAGGCTCCGG CAGAAGGCAGAGGAGCTAGTGAAGGACAACGAGCTGCTCCCACCACCTTCTCCCTCCTTGGGCTCCTTCGACCCCCTGGCTGAGCTCACA GGAAAGGACTCAAATGTCACAGCATCTCCCACAGCCCCTGCATGCCCCAGTGACAAGCCAGCACCAGTCCAGAAGCCTCCATCCAGTGGC ACCTCCTCTGAATTTGAAGTGGTCACTCCTGAGGAGCAGAATTCACCAGAGAGCAGCAGCCATGCCAATGCGATGGTACCAGATCCACAC AGGACTCCAGCATTCCATCATCCGCCCACAGCAGCCCAACTGCCTGCCCCTGGACCAGGTGACACTGCCACAGAAGCTGCAGGAGGCAGG TTATTCCACCCATATGGTGGGCAAGTGGCACCTGGGCTTCTACCGGAAGGAGTGTCTGCCCACCCGTCGGGGCTTCGACACCTTCCTGGG CTCGCTCACGGGCAATGTGGACTATTACACCTATGACAACTGTGATGGCCCAGGCGTGTGCGGCTTCGACCTGCACGAGGGTGAGAATGT GGCCTGGGGGCTCAGCGGCCAGTACTCCACTATGCTTTATGCCCAGCGCGCCAGCCATATCCTGGCCAGCCACAGCCCTCAGCGTCCCCT CTTCCTCTATGTGGCCTTCCAGGCAGTACACACACCCCTGCAGTCCCCTCGTGAGTACCTGTACCGCTACCGCACCATGGGCAATGTGGC CCGGCGGAAGTACGCGGCCATGGTGACCTGCATGGATGAGGCTGTGCGCAACATCACCTGGGCCCTCAAGCGCTACGGTTTCTACAACAA CAGTGTCATCATCTTCTCCAGTGACAATGGTGGCCAGACTTTCTCGGGGGGCAGCAACTGGCCGCTCCGAGGACGCAAGGGCACTTATTG GGAAGGTGGCGTGCGGGGCCTAGGCTTTGTCCACAGTCCCCTGCTCAAGCGAAAGCAACGGACAAGCCGGGCACTGATGCACATCACTGA CTGGTACCCGACCCTGGTGGGTCTGGCAGGTGGTACCACCTCAGCAGCCGATGGGCTAGATGGCTACGACGTGTGGCCGGCCATCAGCGA GGGCCGGGCCTCACCACGCACGGAGATCCTGCACAACATTGACCCACTCTACAACCATGCCCAGCATGGCTCCCTGGAGGGCGGCTTTGG CATCTGGAACACCGCCGTGCAGGCTGCCATCCGCGTGGGTGAGTGGAAGCTGCTGACAGGAGACCCCGGCTATGGCGATTGGATCCCACC GCAGACACTGGCCACCTTCCCGGGTAGCTGGTGGAACCTGGAACGAATGGCCAGTGTCCGCCAGGCCGTGTGGCTCTTCAACATCAGTGC TGACCCTTATGAACGGGAGGACCTGGCTGGCCAGCGGCCTGATGTGGTCCGCACCCTGCTGGCTCGCCTGGCCGAATATAACCGCACAGC CATCCCGGTACGCTACCCAGCTGAGAACCCCCGGGCTCATCCTGACTTTAATGGGGGTGCTTGGGGGCCCTGGGCCAGTGATGAGGAAGA GGAGGAAGAGGAAGGGAGGGCTCGAAGCTTCTCCCGGGGTCGTCGCAAGAAAAAATGCAAGATTTGCAAGCTTCGATCCTTTTTCCGTAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TNIP1_ENST00000522226_chr5_150439879_-_ARSI_ENST00000328668_chr5_149678175_-_2811nt ATGCACCAAGGAAGGAGTGGGCCCCTTCTTCACTATGGATGGAGAAGCCTCAGAGAGTAAGTGGCAACAGCCAGGCGGGCACCACGGCAG GGGCTGAGCTACCCTCATGGAAGGGAGAGGACCGTACCGGATCTACGACCCTGGGGGCAGCGTGCCCTCAGGAGAGGCATCCGCAGCTTT TGAGCGCCTAGTGAAGGAGAATTCCCGGCTGAAGGAAAAAATGCAAGGGATAAAGATGTTAGGGGAGCTTTTGGAAGAGTCCCAGATGGA AGCGACCAGGCTCCGGCAGAAGGCAGAGGAGCTAGTGAAGGACAACGAGCTGCTCCCACCACCTTCTCCCTCCTTGGGCTCCTTCGACCC CCTGGCTGAGCTCACAGGAAAGGACTCAAATGTCACAGCATCTCCCACAGCCCCTGCATGCCCCAGTGACAAGCCAGCACCAGTCCAGAA GCCTCCATCCAGTGGCACCTCCTCTGAATTTGAAGTGGTCACTCCTGAGGAGCAGAATTCACCAGAGAGCAGCAGCCATGCCAATGCGAT GGTACCAGATCCACACAGGACTCCAGCATTCCATCATCCGCCCACAGCAGCCCAACTGCCTGCCCCTGGACCAGGTGACACTGCCACAGA AGCTGCAGGAGGCAGGTTATTCCACCCATATGGTGGGCAAGTGGCACCTGGGCTTCTACCGGAAGGAGTGTCTGCCCACCCGTCGGGGCT TCGACACCTTCCTGGGCTCGCTCACGGGCAATGTGGACTATTACACCTATGACAACTGTGATGGCCCAGGCGTGTGCGGCTTCGACCTGC ACGAGGGTGAGAATGTGGCCTGGGGGCTCAGCGGCCAGTACTCCACTATGCTTTATGCCCAGCGCGCCAGCCATATCCTGGCCAGCCACA GCCCTCAGCGTCCCCTCTTCCTCTATGTGGCCTTCCAGGCAGTACACACACCCCTGCAGTCCCCTCGTGAGTACCTGTACCGCTACCGCA CCATGGGCAATGTGGCCCGGCGGAAGTACGCGGCCATGGTGACCTGCATGGATGAGGCTGTGCGCAACATCACCTGGGCCCTCAAGCGCT ACGGTTTCTACAACAACAGTGTCATCATCTTCTCCAGTGACAATGGTGGCCAGACTTTCTCGGGGGGCAGCAACTGGCCGCTCCGAGGAC GCAAGGGCACTTATTGGGAAGGTGGCGTGCGGGGCCTAGGCTTTGTCCACAGTCCCCTGCTCAAGCGAAAGCAACGGACAAGCCGGGCAC TGATGCACATCACTGACTGGTACCCGACCCTGGTGGGTCTGGCAGGTGGTACCACCTCAGCAGCCGATGGGCTAGATGGCTACGACGTGT GGCCGGCCATCAGCGAGGGCCGGGCCTCACCACGCACGGAGATCCTGCACAACATTGACCCACTCTACAACCATGCCCAGCATGGCTCCC TGGAGGGCGGCTTTGGCATCTGGAACACCGCCGTGCAGGCTGCCATCCGCGTGGGTGAGTGGAAGCTGCTGACAGGAGACCCCGGCTATG GCGATTGGATCCCACCGCAGACACTGGCCACCTTCCCGGGTAGCTGGTGGAACCTGGAACGAATGGCCAGTGTCCGCCAGGCCGTGTGGC TCTTCAACATCAGTGCTGACCCTTATGAACGGGAGGACCTGGCTGGCCAGCGGCCTGATGTGGTCCGCACCCTGCTGGCTCGCCTGGCCG AATATAACCGCACAGCCATCCCGGTACGCTACCCAGCTGAGAACCCCCGGGCTCATCCTGACTTTAATGGGGGTGCTTGGGGGCCCTGGG CCAGTGATGAGGAAGAGGAGGAAGAGGAAGGGAGGGCTCGAAGCTTCTCCCGGGGTCGTCGCAAGAAAAAATGCAAGATTTGCAAGCTTC GATCCTTTTTCCGTAAACTCAACACCAGGCTAATGTCCCAACGGATCTGATGGTGGGGAGGGAGAAAACTGTCCTTTAGAGGATCTTCCC CACTCCGGCTTGGCCCTGCTGTTTCTCAGGGAGAAGCCTGTCACATCTCCATCTACAGGGAGTTGGAGGGTGTAGAGTCCCTTGGTTGAA CAGGGTAGGGAGCCTGGATAGGAGTGGGTGGGAATAAACCAGACTGGGATGCCTGTGTCTCAGTCCTGCCTCCTCACGGACTTGCTCTGT GACCTCAGGTGACCCACATGAGCTTTTAGCCTCAGTTTCCTCATCTGTAAAATGAGCTCTAATGACTTTGTGACTCTTTGGTGTGGCCCT GGAGCCTGGGGCCACGGTGGAGTTCCTGGCCGGCCTTGCCACTTGACAACTCCTTTAAGGCTTCCCCCTTAACACGGGATCCCTGTGGTG GTGTTTGGGAGTTGCCTGGAGGCAACTCCAAGCCTGGCCCCCAGCTGAAGCATGGCAATCTGGCTGCTCTCTACAGGGACCCCCAAGCGC TGTGGGTGGAGGGCAGGGGTCGGGGGGGTTGACCTTCTTGGGTCTTCACATGGCCTAGGCCAGTCCTCCGGTCAGACTGGTGTCAGGCAC CGTGGTGCAAAATTCCTCTTCTGGCCCCTCCAGTACCCAGAGAAACTGGCTGGGCCATTAACTGCTGCAGCACCAAGGGTGGTAGAAAGA GCTGTGAAGAGCCCCCAAACCAGTACCAGGACACCTGGGTTCTCCTGTGACCTGGGGCACAGTTCTTGCCCTCTAGGCCTTGATTTCCCC ACCTGCAAGTGGGGATGCCAGCCCTGGCTCTGCCTCCTTCATGAGGCTCTGGAAGACTGGCCAAGGTTGTGGAGGAGCTTGTGAACTTGA >In-frame_TNIP1_ENST00000518977_chr5_150439879_-_ARSI_ENST00000328668_chr5_149678175_-_2936nt GACTTTCCCAGGGGTGGGGCGGCCCGGCCAGGCCCCCGGCACTTCCTCGTCCTCGGCCCGGGTGCCCTGCCCCCGTCCAGGAGCCCTAGG AGTGCTACGGGGGGCCGGAGCCTTGCCCGGGCCGCTGCCCCGTCCCTGGATTCGGGGCTGGACGCAGCAAGCGGGGCGCTGTGTCCCCAA GCTCCCCGTCCTCGGCCAGGCGGGCACCACGGCAGGGGCTGAGCTACCCTCATGGAAGGGAGAGGACCGTACCGGATCTACGACCCTGGG GGCAGCGTGCCCTCAGGAGAGGCATCCGCAGCTTTTGAGCGCCTAGTGAAGGAGAATTCCCGGCTGAAGGAAAAAATGCAAGGGATAAAG ATGTTAGGGGAGCTTTTGGAAGAGTCCCAGATGGAAGCGACCAGGCTCCGGCAGAAGGCAGAGGAGCTAGTGAAGGACAACGAGCTGCTC CCACCACCTTCTCCCTCCTTGGGCTCCTTCGACCCCCTGGCTGAGCTCACAGGAAAGGACTCAAATGTCACAGCATCTCCCACAGCCCCT GCATGCCCCAGTGACAAGCCAGCACCAGTCCAGAAGCCTCCATCCAGTGGCACCTCCTCTGAATTTGAAGTGGTCACTCCTGAGGAGCAG AATTCACCAGAGAGCAGCAGCCATGCCAATGCGATGGTACCAGATCCACACAGGACTCCAGCATTCCATCATCCGCCCACAGCAGCCCAA CTGCCTGCCCCTGGACCAGGTGACACTGCCACAGAAGCTGCAGGAGGCAGGTTATTCCACCCATATGGTGGGCAAGTGGCACCTGGGCTT CTACCGGAAGGAGTGTCTGCCCACCCGTCGGGGCTTCGACACCTTCCTGGGCTCGCTCACGGGCAATGTGGACTATTACACCTATGACAA CTGTGATGGCCCAGGCGTGTGCGGCTTCGACCTGCACGAGGGTGAGAATGTGGCCTGGGGGCTCAGCGGCCAGTACTCCACTATGCTTTA TGCCCAGCGCGCCAGCCATATCCTGGCCAGCCACAGCCCTCAGCGTCCCCTCTTCCTCTATGTGGCCTTCCAGGCAGTACACACACCCCT GCAGTCCCCTCGTGAGTACCTGTACCGCTACCGCACCATGGGCAATGTGGCCCGGCGGAAGTACGCGGCCATGGTGACCTGCATGGATGA GGCTGTGCGCAACATCACCTGGGCCCTCAAGCGCTACGGTTTCTACAACAACAGTGTCATCATCTTCTCCAGTGACAATGGTGGCCAGAC TTTCTCGGGGGGCAGCAACTGGCCGCTCCGAGGACGCAAGGGCACTTATTGGGAAGGTGGCGTGCGGGGCCTAGGCTTTGTCCACAGTCC CCTGCTCAAGCGAAAGCAACGGACAAGCCGGGCACTGATGCACATCACTGACTGGTACCCGACCCTGGTGGGTCTGGCAGGTGGTACCAC CTCAGCAGCCGATGGGCTAGATGGCTACGACGTGTGGCCGGCCATCAGCGAGGGCCGGGCCTCACCACGCACGGAGATCCTGCACAACAT TGACCCACTCTACAACCATGCCCAGCATGGCTCCCTGGAGGGCGGCTTTGGCATCTGGAACACCGCCGTGCAGGCTGCCATCCGCGTGGG TGAGTGGAAGCTGCTGACAGGAGACCCCGGCTATGGCGATTGGATCCCACCGCAGACACTGGCCACCTTCCCGGGTAGCTGGTGGAACCT GGAACGAATGGCCAGTGTCCGCCAGGCCGTGTGGCTCTTCAACATCAGTGCTGACCCTTATGAACGGGAGGACCTGGCTGGCCAGCGGCC TGATGTGGTCCGCACCCTGCTGGCTCGCCTGGCCGAATATAACCGCACAGCCATCCCGGTACGCTACCCAGCTGAGAACCCCCGGGCTCA TCCTGACTTTAATGGGGGTGCTTGGGGGCCCTGGGCCAGTGATGAGGAAGAGGAGGAAGAGGAAGGGAGGGCTCGAAGCTTCTCCCGGGG TCGTCGCAAGAAAAAATGCAAGATTTGCAAGCTTCGATCCTTTTTCCGTAAACTCAACACCAGGCTAATGTCCCAACGGATCTGATGGTG GGGAGGGAGAAAACTGTCCTTTAGAGGATCTTCCCCACTCCGGCTTGGCCCTGCTGTTTCTCAGGGAGAAGCCTGTCACATCTCCATCTA CAGGGAGTTGGAGGGTGTAGAGTCCCTTGGTTGAACAGGGTAGGGAGCCTGGATAGGAGTGGGTGGGAATAAACCAGACTGGGATGCCTG TGTCTCAGTCCTGCCTCCTCACGGACTTGCTCTGTGACCTCAGGTGACCCACATGAGCTTTTAGCCTCAGTTTCCTCATCTGTAAAATGA GCTCTAATGACTTTGTGACTCTTTGGTGTGGCCCTGGAGCCTGGGGCCACGGTGGAGTTCCTGGCCGGCCTTGCCACTTGACAACTCCTT TAAGGCTTCCCCCTTAACACGGGATCCCTGTGGTGGTGTTTGGGAGTTGCCTGGAGGCAACTCCAAGCCTGGCCCCCAGCTGAAGCATGG CAATCTGGCTGCTCTCTACAGGGACCCCCAAGCGCTGTGGGTGGAGGGCAGGGGTCGGGGGGGTTGACCTTCTTGGGTCTTCACATGGCC TAGGCCAGTCCTCCGGTCAGACTGGTGTCAGGCACCGTGGTGCAAAATTCCTCTTCTGGCCCCTCCAGTACCCAGAGAAACTGGCTGGGC CATTAACTGCTGCAGCACCAAGGGTGGTAGAAAGAGCTGTGAAGAGCCCCCAAACCAGTACCAGGACACCTGGGTTCTCCTGTGACCTGG GGCACAGTTCTTGCCCTCTAGGCCTTGATTTCCCCACCTGCAAGTGGGGATGCCAGCCCTGGCTCTGCCTCCTTCATGAGGCTCTGGAAG >In-frame_TNIP1_ENST00000521591_chr5_150439879_-_ARSI_ENST00000328668_chr5_149678175_-_2936nt GACTTTCCCAGGGGTGGGGCGGCCCGGCCAGGCCCCCGGCACTTCCTCGTCCTCGGCCCGGGTGCCCTGCCCCCGTCCAGGAGCCCTAGG AGTGCTACGGGGGGCCGGAGCCTTGCCCGGGCCGCTGCCCCGTCCCTGGATTCGGGGCTGGACGCAGCAAGCGGGGCGCTGTGTCCCCAA GCTCCCCGTCCTCGGCCAGGCGGGCACCACGGCAGGGGCTGAGCTACCCTCATGGAAGGGAGAGGACCGTACCGGATCTACGACCCTGGG GGCAGCGTGCCCTCAGGAGAGGCATCCGCAGCTTTTGAGCGCCTAGTGAAGGAGAATTCCCGGCTGAAGGAAAAAATGCAAGGGATAAAG ATGTTAGGGGAGCTTTTGGAAGAGTCCCAGATGGAAGCGACCAGGCTCCGGCAGAAGGCAGAGGAGCTAGTGAAGGACAACGAGCTGCTC CCACCACCTTCTCCCTCCTTGGGCTCCTTCGACCCCCTGGCTGAGCTCACAGGAAAGGACTCAAATGTCACAGCATCTCCCACAGCCCCT GCATGCCCCAGTGACAAGCCAGCACCAGTCCAGAAGCCTCCATCCAGTGGCACCTCCTCTGAATTTGAAGTGGTCACTCCTGAGGAGCAG AATTCACCAGAGAGCAGCAGCCATGCCAATGCGATGGTACCAGATCCACACAGGACTCCAGCATTCCATCATCCGCCCACAGCAGCCCAA CTGCCTGCCCCTGGACCAGGTGACACTGCCACAGAAGCTGCAGGAGGCAGGTTATTCCACCCATATGGTGGGCAAGTGGCACCTGGGCTT CTACCGGAAGGAGTGTCTGCCCACCCGTCGGGGCTTCGACACCTTCCTGGGCTCGCTCACGGGCAATGTGGACTATTACACCTATGACAA CTGTGATGGCCCAGGCGTGTGCGGCTTCGACCTGCACGAGGGTGAGAATGTGGCCTGGGGGCTCAGCGGCCAGTACTCCACTATGCTTTA TGCCCAGCGCGCCAGCCATATCCTGGCCAGCCACAGCCCTCAGCGTCCCCTCTTCCTCTATGTGGCCTTCCAGGCAGTACACACACCCCT GCAGTCCCCTCGTGAGTACCTGTACCGCTACCGCACCATGGGCAATGTGGCCCGGCGGAAGTACGCGGCCATGGTGACCTGCATGGATGA GGCTGTGCGCAACATCACCTGGGCCCTCAAGCGCTACGGTTTCTACAACAACAGTGTCATCATCTTCTCCAGTGACAATGGTGGCCAGAC TTTCTCGGGGGGCAGCAACTGGCCGCTCCGAGGACGCAAGGGCACTTATTGGGAAGGTGGCGTGCGGGGCCTAGGCTTTGTCCACAGTCC CCTGCTCAAGCGAAAGCAACGGACAAGCCGGGCACTGATGCACATCACTGACTGGTACCCGACCCTGGTGGGTCTGGCAGGTGGTACCAC CTCAGCAGCCGATGGGCTAGATGGCTACGACGTGTGGCCGGCCATCAGCGAGGGCCGGGCCTCACCACGCACGGAGATCCTGCACAACAT TGACCCACTCTACAACCATGCCCAGCATGGCTCCCTGGAGGGCGGCTTTGGCATCTGGAACACCGCCGTGCAGGCTGCCATCCGCGTGGG TGAGTGGAAGCTGCTGACAGGAGACCCCGGCTATGGCGATTGGATCCCACCGCAGACACTGGCCACCTTCCCGGGTAGCTGGTGGAACCT GGAACGAATGGCCAGTGTCCGCCAGGCCGTGTGGCTCTTCAACATCAGTGCTGACCCTTATGAACGGGAGGACCTGGCTGGCCAGCGGCC TGATGTGGTCCGCACCCTGCTGGCTCGCCTGGCCGAATATAACCGCACAGCCATCCCGGTACGCTACCCAGCTGAGAACCCCCGGGCTCA TCCTGACTTTAATGGGGGTGCTTGGGGGCCCTGGGCCAGTGATGAGGAAGAGGAGGAAGAGGAAGGGAGGGCTCGAAGCTTCTCCCGGGG TCGTCGCAAGAAAAAATGCAAGATTTGCAAGCTTCGATCCTTTTTCCGTAAACTCAACACCAGGCTAATGTCCCAACGGATCTGATGGTG GGGAGGGAGAAAACTGTCCTTTAGAGGATCTTCCCCACTCCGGCTTGGCCCTGCTGTTTCTCAGGGAGAAGCCTGTCACATCTCCATCTA CAGGGAGTTGGAGGGTGTAGAGTCCCTTGGTTGAACAGGGTAGGGAGCCTGGATAGGAGTGGGTGGGAATAAACCAGACTGGGATGCCTG TGTCTCAGTCCTGCCTCCTCACGGACTTGCTCTGTGACCTCAGGTGACCCACATGAGCTTTTAGCCTCAGTTTCCTCATCTGTAAAATGA GCTCTAATGACTTTGTGACTCTTTGGTGTGGCCCTGGAGCCTGGGGCCACGGTGGAGTTCCTGGCCGGCCTTGCCACTTGACAACTCCTT TAAGGCTTCCCCCTTAACACGGGATCCCTGTGGTGGTGTTTGGGAGTTGCCTGGAGGCAACTCCAAGCCTGGCCCCCAGCTGAAGCATGG CAATCTGGCTGCTCTCTACAGGGACCCCCAAGCGCTGTGGGTGGAGGGCAGGGGTCGGGGGGGTTGACCTTCTTGGGTCTTCACATGGCC TAGGCCAGTCCTCCGGTCAGACTGGTGTCAGGCACCGTGGTGCAAAATTCCTCTTCTGGCCCCTCCAGTACCCAGAGAAACTGGCTGGGC CATTAACTGCTGCAGCACCAAGGGTGGTAGAAAGAGCTGTGAAGAGCCCCCAAACCAGTACCAGGACACCTGGGTTCTCCTGTGACCTGG GGCACAGTTCTTGCCCTCTAGGCCTTGATTTCCCCACCTGCAAGTGGGGATGCCAGCCCTGGCTCTGCCTCCTTCATGAGGCTCTGGAAG |
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FusionGenePPI for TNIP1_ARSI |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TNIP1 | TTF2, MAGEB18, TNFAIP3, MAPK1, TNF, IKBKG, UBC, TAX1BP1, IKBKE, TBK1, TRAF3, RARA, RARG, NFKB1, MYD88, SELPLG, PIK3R1, PIK3CD, RBFOX1, RNF11, CCNG1, GIT2, OPTN, ADH6, CDKN1A, EFEMP1, FUS, GTF2H1, PIN1, MAPK10, SUMO2, TNIP1, RABAC1, NME7, BYSL, EHHADH, GTF2B, KIFC3, TCEA2, ZBTB25, AP1M1, MORF4L2, NDC80, ZNHIT1, RALBP1, MORF4L1, PNKP, GABARAPL2, FAM168A, GABARAPL1, VPS33B, MAGEH1, CDIP1, SNIP1, TNIP3, MAP1LC3B, FAM161A, NIFK, MAP1LC3A, MOB1B, TCEANC2, SYT6, MOB3C, CCDC112, TXLNA, CFAP53, HDDC3, MAP3K1, CRHBP, GRAP2, SSX2IP, OFD1, PCM1, CEP97, CEP152, CEP135, CEP44, FBF1, NINL, ODF2, CENPJ, MCM10, TYRO3, CCDC121, ABHD17A, XPO1, TRAF1, ABI2, IKBIP, PIGT, SYNC, SAMD4A, HAO2, POTEF, ERP44, NAB2, EXOC1, CORO6 | ARSI | KRT40, NOL11, AHCYL2, HSPA5 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TNIP1_ARSI |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TNIP1_ARSI |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TNIP1 | C0024141 | Lupus Erythematosus, Systemic | 2 | CTD_human |
| Hgene | TNIP1 | C0033860 | Psoriasis | 2 | CTD_human |
| Hgene | TNIP1 | C0036421 | Systemic Scleroderma | 1 | CTD_human |
| Hgene | TNIP1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Hgene | TNIP1 | C1527336 | Sjogren's Syndrome | 1 | CTD_human |
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