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Center for Computational Systems Medicine
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FusionGeneSummary

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Fusion gene ID: 38890

FusionGeneSummary for TNIP1_ANXA6

check button Fusion gene summary
Fusion gene informationFusion gene name: TNIP1_ANXA6
Fusion gene ID: 38890
HgeneTgene
Gene symbol

TNIP1

ANXA6

Gene ID

10318

309

Gene nameTNFAIP3 interacting protein 1annexin A6
SynonymsABIN-1|NAF1|VAN|nip40-1ANX6|CBP68|CPB-II|p68|p70
Cytomap

5q33.1

5q33.1

Type of geneprotein-codingprotein-coding
DescriptionTNFAIP3-interacting protein 1A20-binding inhibitor of NF-kappa-B activation 1HIV-1 Nef-interacting proteinNef-associated factor 1 SNPvirion-associated nuclear shuttling proteinannexin A667 kDa calelectrinannexin VI (p68)annexin-6calcium-binding protein p68calelectrincalphobindin IIchromobindin-20lipocortin VItestis secretory sperm-binding protein Li 198a
Modification date2018052220180519
UniProtAcc

Q15025

P08133

Ensembl transtripts involved in fusion geneENST00000520931, ENST00000389378, 
ENST00000523338, ENST00000315050, 
ENST00000522226, ENST00000518977, 
ENST00000521591, ENST00000524280, 
ENST00000523200, ENST00000521423, 
ENST00000354546, ENST00000523714, 
ENST00000356496, ENST00000377751, 
ENST00000521512, ENST00000519610, 
Fusion gene scores* DoF score7 X 4 X 4=1125 X 5 X 3=75
# samples 56
** MAII scorelog2(5/112*10)=-1.16349873228288
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TNIP1 [Title/Abstract] AND ANXA6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTNIP1

GO:0009101

glycoprotein biosynthetic process

9923610

HgeneTNIP1

GO:0043124

negative regulation of I-kappaB kinase/NF-kappaB signaling

16684768

HgeneTNIP1

GO:0070373

negative regulation of ERK1 and ERK2 cascade

12220502

HgeneTNIP1

GO:0085032

modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade

20010814

HgeneTNIP1

GO:1903003

positive regulation of protein deubiquitination

16684768


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-AX-A3FX-01ATNIP1chr5

150418658

-ANXA6chr5

150497398

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000520931ENST00000354546TNIP1chr5

150418658

-ANXA6chr5

150497398

-
In-frameENST00000520931ENST00000523714TNIP1chr5

150418658

-ANXA6chr5

150497398

-
In-frameENST00000520931ENST00000356496TNIP1chr5

150418658

-ANXA6chr5

150497398

-
In-frameENST00000520931ENST00000377751TNIP1chr5

150418658

-ANXA6chr5

150497398

-
In-frameENST00000520931ENST00000521512TNIP1chr5

150418658

-ANXA6chr5

150497398

-
5CDS-intronENST00000520931ENST00000519610TNIP1chr5

150418658

-ANXA6chr5

150497398

-
In-frameENST00000389378ENST00000354546TNIP1chr5

150418658

-ANXA6chr5

150497398

-
In-frameENST00000389378ENST00000523714TNIP1chr5

150418658

-ANXA6chr5

150497398

-
In-frameENST00000389378ENST00000356496TNIP1chr5

150418658

-ANXA6chr5

150497398

-
In-frameENST00000389378ENST00000377751TNIP1chr5

150418658

-ANXA6chr5

150497398

-
In-frameENST00000389378ENST00000521512TNIP1chr5

150418658

-ANXA6chr5

150497398

-
5CDS-intronENST00000389378ENST00000519610TNIP1chr5

150418658

-ANXA6chr5

150497398

-
In-frameENST00000523338ENST00000354546TNIP1chr5

150418658

-ANXA6chr5

150497398

-
In-frameENST00000523338ENST00000523714TNIP1chr5

150418658

-ANXA6chr5

150497398

-
In-frameENST00000523338ENST00000356496TNIP1chr5

150418658

-ANXA6chr5

150497398

-
In-frameENST00000523338ENST00000377751TNIP1chr5

150418658

-ANXA6chr5

150497398

-
In-frameENST00000523338ENST00000521512TNIP1chr5

150418658

-ANXA6chr5

150497398

-
5CDS-intronENST00000523338ENST00000519610TNIP1chr5

150418658

-ANXA6chr5

150497398

-
In-frameENST00000315050ENST00000354546TNIP1chr5

150418658

-ANXA6chr5

150497398

-
In-frameENST00000315050ENST00000523714TNIP1chr5

150418658

-ANXA6chr5

150497398

-
In-frameENST00000315050ENST00000356496TNIP1chr5

150418658

-ANXA6chr5

150497398

-
In-frameENST00000315050ENST00000377751TNIP1chr5

150418658

-ANXA6chr5

150497398

-
In-frameENST00000315050ENST00000521512TNIP1chr5

150418658

-ANXA6chr5

150497398

-
5CDS-intronENST00000315050ENST00000519610TNIP1chr5

150418658

-ANXA6chr5

150497398

-
Frame-shiftENST00000522226ENST00000354546TNIP1chr5

150418658

-ANXA6chr5

150497398

-
Frame-shiftENST00000522226ENST00000523714TNIP1chr5

150418658

-ANXA6chr5

150497398

-
Frame-shiftENST00000522226ENST00000356496TNIP1chr5

150418658

-ANXA6chr5

150497398

-
Frame-shiftENST00000522226ENST00000377751TNIP1chr5

150418658

-ANXA6chr5

150497398

-
Frame-shiftENST00000522226ENST00000521512TNIP1chr5

150418658

-ANXA6chr5

150497398

-
5CDS-intronENST00000522226ENST00000519610TNIP1chr5

150418658

-ANXA6chr5

150497398

-
Frame-shiftENST00000518977ENST00000354546TNIP1chr5

150418658

-ANXA6chr5

150497398

-
Frame-shiftENST00000518977ENST00000523714TNIP1chr5

150418658

-ANXA6chr5

150497398

-
Frame-shiftENST00000518977ENST00000356496TNIP1chr5

150418658

-ANXA6chr5

150497398

-
Frame-shiftENST00000518977ENST00000377751TNIP1chr5

150418658

-ANXA6chr5

150497398

-
Frame-shiftENST00000518977ENST00000521512TNIP1chr5

150418658

-ANXA6chr5

150497398

-
5CDS-intronENST00000518977ENST00000519610TNIP1chr5

150418658

-ANXA6chr5

150497398

-
Frame-shiftENST00000521591ENST00000354546TNIP1chr5

150418658

-ANXA6chr5

150497398

-
Frame-shiftENST00000521591ENST00000523714TNIP1chr5

150418658

-ANXA6chr5

150497398

-
Frame-shiftENST00000521591ENST00000356496TNIP1chr5

150418658

-ANXA6chr5

150497398

-
Frame-shiftENST00000521591ENST00000377751TNIP1chr5

150418658

-ANXA6chr5

150497398

-
Frame-shiftENST00000521591ENST00000521512TNIP1chr5

150418658

-ANXA6chr5

150497398

-
5CDS-intronENST00000521591ENST00000519610TNIP1chr5

150418658

-ANXA6chr5

150497398

-
Frame-shiftENST00000524280ENST00000354546TNIP1chr5

150418658

-ANXA6chr5

150497398

-
Frame-shiftENST00000524280ENST00000523714TNIP1chr5

150418658

-ANXA6chr5

150497398

-
Frame-shiftENST00000524280ENST00000356496TNIP1chr5

150418658

-ANXA6chr5

150497398

-
Frame-shiftENST00000524280ENST00000377751TNIP1chr5

150418658

-ANXA6chr5

150497398

-
Frame-shiftENST00000524280ENST00000521512TNIP1chr5

150418658

-ANXA6chr5

150497398

-
5CDS-intronENST00000524280ENST00000519610TNIP1chr5

150418658

-ANXA6chr5

150497398

-
Frame-shiftENST00000523200ENST00000354546TNIP1chr5

150418658

-ANXA6chr5

150497398

-
Frame-shiftENST00000523200ENST00000523714TNIP1chr5

150418658

-ANXA6chr5

150497398

-
Frame-shiftENST00000523200ENST00000356496TNIP1chr5

150418658

-ANXA6chr5

150497398

-
Frame-shiftENST00000523200ENST00000377751TNIP1chr5

150418658

-ANXA6chr5

150497398

-
Frame-shiftENST00000523200ENST00000521512TNIP1chr5

150418658

-ANXA6chr5

150497398

-
5CDS-intronENST00000523200ENST00000519610TNIP1chr5

150418658

-ANXA6chr5

150497398

-
intron-3CDSENST00000521423ENST00000354546TNIP1chr5

150418658

-ANXA6chr5

150497398

-
intron-3CDSENST00000521423ENST00000523714TNIP1chr5

150418658

-ANXA6chr5

150497398

-
intron-3CDSENST00000521423ENST00000356496TNIP1chr5

150418658

-ANXA6chr5

150497398

-
intron-3CDSENST00000521423ENST00000377751TNIP1chr5

150418658

-ANXA6chr5

150497398

-
intron-3CDSENST00000521423ENST00000521512TNIP1chr5

150418658

-ANXA6chr5

150497398

-
intron-intronENST00000521423ENST00000519610TNIP1chr5

150418658

-ANXA6chr5

150497398

-

Top

FusionProtFeatures for TNIP1_ANXA6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TNIP1

Q15025

ANXA6

P08133

May associate with CD21. May regulate the release ofCa(2+) from intracellular stores.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNIP1chr5:150418658chr5:150497398ENST00000315050-1218196_258421637Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150418658chr5:150497398ENST00000315050-121820_73421637Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150418658chr5:150497398ENST00000389378-1218196_258421637Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150418658chr5:150497398ENST00000389378-121820_73421637Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150418658chr5:150497398ENST00000518977-1218196_258421636Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150418658chr5:150497398ENST00000518977-121820_73421636Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150418658chr5:150497398ENST00000520931-1117196_258368584Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150418658chr5:150497398ENST00000520931-111720_73368584Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150418658chr5:150497398ENST00000521591-1218196_258421637Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150418658chr5:150497398ENST00000521591-121820_73421637Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150418658chr5:150497398ENST00000522226-1218196_258421637Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150418658chr5:150497398ENST00000522226-121820_73421637Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150418658chr5:150497398ENST00000523338-1218196_258421636Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150418658chr5:150497398ENST00000523338-121820_73421636Coiled coilOntology_term=ECO:0000255
TgeneANXA6chr5:150418658chr5:150497398ENST00000354546-1726533_593479674RepeatNote=Annexin 7
TgeneANXA6chr5:150418658chr5:150497398ENST00000354546-1726608_668479674RepeatNote=Annexin 8
TgeneANXA6chr5:150418658chr5:150497398ENST00000523714-1625444_504447642RepeatNote=Annexin 6
TgeneANXA6chr5:150418658chr5:150497398ENST00000523714-1625533_593447642RepeatNote=Annexin 7
TgeneANXA6chr5:150418658chr5:150497398ENST00000523714-1625608_668447642RepeatNote=Annexin 8

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNIP1chr5:150418658chr5:150497398ENST00000315050-1218294_535421637Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150418658chr5:150497398ENST00000389378-1218294_535421637Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150418658chr5:150497398ENST00000518977-1218294_535421636Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150418658chr5:150497398ENST00000520931-1117294_535368584Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150418658chr5:150497398ENST00000521591-1218294_535421637Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150418658chr5:150497398ENST00000522226-1218294_535421637Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150418658chr5:150497398ENST00000523338-1218294_535421636Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150418658chr5:150497398ENST00000315050-1218539_636421637Compositional biasNote=Pro-rich
HgeneTNIP1chr5:150418658chr5:150497398ENST00000389378-1218539_636421637Compositional biasNote=Pro-rich
HgeneTNIP1chr5:150418658chr5:150497398ENST00000518977-1218539_636421636Compositional biasNote=Pro-rich
HgeneTNIP1chr5:150418658chr5:150497398ENST00000520931-1117539_636368584Compositional biasNote=Pro-rich
HgeneTNIP1chr5:150418658chr5:150497398ENST00000521591-1218539_636421637Compositional biasNote=Pro-rich
HgeneTNIP1chr5:150418658chr5:150497398ENST00000522226-1218539_636421637Compositional biasNote=Pro-rich
HgeneTNIP1chr5:150418658chr5:150497398ENST00000523338-1218539_636421636Compositional biasNote=Pro-rich
HgeneTNIP1chr5:150418658chr5:150497398ENST00000315050-1218524_530421637MotifNuclear localization signal
HgeneTNIP1chr5:150418658chr5:150497398ENST00000389378-1218524_530421637MotifNuclear localization signal
HgeneTNIP1chr5:150418658chr5:150497398ENST00000518977-1218524_530421636MotifNuclear localization signal
HgeneTNIP1chr5:150418658chr5:150497398ENST00000520931-1117524_530368584MotifNuclear localization signal
HgeneTNIP1chr5:150418658chr5:150497398ENST00000521591-1218524_530421637MotifNuclear localization signal
HgeneTNIP1chr5:150418658chr5:150497398ENST00000522226-1218524_530421637MotifNuclear localization signal
HgeneTNIP1chr5:150418658chr5:150497398ENST00000523338-1218524_530421636MotifNuclear localization signal
HgeneTNIP1chr5:150418658chr5:150497398ENST00000315050-1218431_588421637RegionRequired for inhibitory activity of TNF-induced NF-kappa-B activation
HgeneTNIP1chr5:150418658chr5:150497398ENST00000315050-1218452_510421637RegionNote=Ubiquitin-binding domain (UBD)
HgeneTNIP1chr5:150418658chr5:150497398ENST00000389378-1218431_588421637RegionRequired for inhibitory activity of TNF-induced NF-kappa-B activation
HgeneTNIP1chr5:150418658chr5:150497398ENST00000389378-1218452_510421637RegionNote=Ubiquitin-binding domain (UBD)
HgeneTNIP1chr5:150418658chr5:150497398ENST00000518977-1218431_588421636RegionRequired for inhibitory activity of TNF-induced NF-kappa-B activation
HgeneTNIP1chr5:150418658chr5:150497398ENST00000518977-1218452_510421636RegionNote=Ubiquitin-binding domain (UBD)
HgeneTNIP1chr5:150418658chr5:150497398ENST00000520931-1117431_588368584RegionRequired for inhibitory activity of TNF-induced NF-kappa-B activation
HgeneTNIP1chr5:150418658chr5:150497398ENST00000520931-1117452_510368584RegionNote=Ubiquitin-binding domain (UBD)
HgeneTNIP1chr5:150418658chr5:150497398ENST00000521591-1218431_588421637RegionRequired for inhibitory activity of TNF-induced NF-kappa-B activation
HgeneTNIP1chr5:150418658chr5:150497398ENST00000521591-1218452_510421637RegionNote=Ubiquitin-binding domain (UBD)
HgeneTNIP1chr5:150418658chr5:150497398ENST00000522226-1218431_588421637RegionRequired for inhibitory activity of TNF-induced NF-kappa-B activation
HgeneTNIP1chr5:150418658chr5:150497398ENST00000522226-1218452_510421637RegionNote=Ubiquitin-binding domain (UBD)
HgeneTNIP1chr5:150418658chr5:150497398ENST00000523338-1218431_588421636RegionRequired for inhibitory activity of TNF-induced NF-kappa-B activation
HgeneTNIP1chr5:150418658chr5:150497398ENST00000523338-1218452_510421636RegionNote=Ubiquitin-binding domain (UBD)
TgeneANXA6chr5:150418658chr5:150497398ENST00000354546-1726101_161479674RepeatNote=Annexin 2
TgeneANXA6chr5:150418658chr5:150497398ENST00000354546-1726185_245479674RepeatNote=Annexin 3
TgeneANXA6chr5:150418658chr5:150497398ENST00000354546-1726260_320479674RepeatNote=Annexin 4
TgeneANXA6chr5:150418658chr5:150497398ENST00000354546-172629_89479674RepeatNote=Annexin 1
TgeneANXA6chr5:150418658chr5:150497398ENST00000354546-1726372_432479674RepeatNote=Annexin 5
TgeneANXA6chr5:150418658chr5:150497398ENST00000354546-1726444_504479674RepeatNote=Annexin 6
TgeneANXA6chr5:150418658chr5:150497398ENST00000523714-1625101_161447642RepeatNote=Annexin 2
TgeneANXA6chr5:150418658chr5:150497398ENST00000523714-1625185_245447642RepeatNote=Annexin 3
TgeneANXA6chr5:150418658chr5:150497398ENST00000523714-1625260_320447642RepeatNote=Annexin 4
TgeneANXA6chr5:150418658chr5:150497398ENST00000523714-162529_89447642RepeatNote=Annexin 1
TgeneANXA6chr5:150418658chr5:150497398ENST00000523714-1625372_432447642RepeatNote=Annexin 5


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FusionGeneSequence for TNIP1_ANXA6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TNIP1_ANXA6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TNIP1TTF2, MAGEB18, TNFAIP3, MAPK1, TNF, IKBKG, UBC, TAX1BP1, IKBKE, TBK1, TRAF3, RARA, RARG, NFKB1, MYD88, SELPLG, PIK3R1, PIK3CD, RBFOX1, RNF11, CCNG1, GIT2, OPTN, ADH6, CDKN1A, EFEMP1, FUS, GTF2H1, PIN1, MAPK10, SUMO2, TNIP1, RABAC1, NME7, BYSL, EHHADH, GTF2B, KIFC3, TCEA2, ZBTB25, AP1M1, MORF4L2, NDC80, ZNHIT1, RALBP1, MORF4L1, PNKP, GABARAPL2, FAM168A, GABARAPL1, VPS33B, MAGEH1, CDIP1, SNIP1, TNIP3, MAP1LC3B, FAM161A, NIFK, MAP1LC3A, MOB1B, TCEANC2, SYT6, MOB3C, CCDC112, TXLNA, CFAP53, HDDC3, MAP3K1, CRHBP, GRAP2, SSX2IP, OFD1, PCM1, CEP97, CEP152, CEP135, CEP44, FBF1, NINL, ODF2, CENPJ, MCM10, TYRO3, CCDC121, ABHD17A, XPO1, TRAF1, ABI2, IKBIP, PIGT, SYNC, SAMD4A, HAO2, POTEF, ERP44, NAB2, EXOC1, CORO6ANXA6CDC73, S100A1, S100B, RASA1, CR2, H2AFX, CD4, TJP1, SIRT7, PRKCA, CUL5, SNCA, MLH1, METTL18, ATP4A, ADSS, GOT1, MTAP, PLS3, POLE3, THOP1, UBE2H, HPRT1, IDH1, NAMPT, CCDC8, MSH2, TBCB, TXN2, NTRK1, ERBB2, EWSR1, PPME1, RHOU, U2AF2, SMURF1, ATP6V0A2, MTNR1B, TRIM25, G3BP1, UBE2A, LMNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneTNIP1chr5:150418658chr5:150497398ENST00000315050-121894_412421637Nef
HgeneTNIP1chr5:150418658chr5:150497398ENST00000389378-121894_412421637Nef
HgeneTNIP1chr5:150418658chr5:150497398ENST00000518977-121894_412421636Nef
HgeneTNIP1chr5:150418658chr5:150497398ENST00000521591-121894_412421637Nef
HgeneTNIP1chr5:150418658chr5:150497398ENST00000522226-121894_412421637Nef
HgeneTNIP1chr5:150418658chr5:150497398ENST00000523338-121894_412421636Nef
HgeneTNIP1chr5:150418658chr5:150497398ENST00000315050-1218351_367421637Shigella flexneri ipah9.8
HgeneTNIP1chr5:150418658chr5:150497398ENST00000389378-1218351_367421637Shigella flexneri ipah9.8
HgeneTNIP1chr5:150418658chr5:150497398ENST00000518977-1218351_367421636Shigella flexneri ipah9.8
HgeneTNIP1chr5:150418658chr5:150497398ENST00000520931-1117351_367368584Shigella flexneri ipah9.8
HgeneTNIP1chr5:150418658chr5:150497398ENST00000521591-1218351_367421637Shigella flexneri ipah9.8
HgeneTNIP1chr5:150418658chr5:150497398ENST00000522226-1218351_367421637Shigella flexneri ipah9.8
HgeneTNIP1chr5:150418658chr5:150497398ENST00000523338-1218351_367421636Shigella flexneri ipah9.8


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTNIP1chr5:150418658chr5:150497398ENST00000520931-111794_412368584Nef


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TNIP1_ANXA6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TNIP1_ANXA6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTNIP1C0024141Lupus Erythematosus, Systemic2CTD_human
HgeneTNIP1C0033860Psoriasis2CTD_human
HgeneTNIP1C0036421Systemic Scleroderma1CTD_human
HgeneTNIP1C1458155Mammary Neoplasms1CTD_human
HgeneTNIP1C1527336Sjogren's Syndrome1CTD_human
TgeneANXA6C0023467Leukemia, Myelocytic, Acute1CTD_human