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Fusion gene ID: 38878 |
FusionGeneSummary for TNFSF4_CIR1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TNFSF4_CIR1 | Fusion gene ID: 38878 | Hgene | Tgene | Gene symbol | TNFSF4 | CIR1 | Gene ID | 7292 | 9541 |
| Gene name | TNF superfamily member 4 | corepressor interacting with RBPJ, 1 | |
| Synonyms | CD134L|CD252|GP34|OX-40L|OX4OL|TNLG2B|TXGP1 | CIR | |
| Cytomap | 1q25.1 | 2q31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tumor necrosis factor ligand superfamily member 4CD134 ligandOX40 antigen ligandglycoprotein Gp34tax-transcriptionally activated glycoprotein 1 (34kD)tumor necrosis factor (ligand) superfamily member 4tumor necrosis factor ligand 2Btumor necrosis f | corepressor interacting with RBPJ 1CBF1-interacting corepressorrecepin | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | P23510 | Q86X95 | |
| Ensembl transtripts involved in fusion gene | ENST00000367718, ENST00000281834, ENST00000488053, | ENST00000342016, ENST00000362053, | |
| Fusion gene scores | * DoF score | 4 X 4 X 1=16 | 7 X 4 X 3=84 |
| # samples | 4 | 4 | |
| ** MAII score | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/84*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TNFSF4 [Title/Abstract] AND CIR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TNFSF4 | GO:0032700 | negative regulation of interleukin-17 production | 18501882 |
| Hgene | TNFSF4 | GO:0032729 | positive regulation of interferon-gamma production | 18501882 |
| Hgene | TNFSF4 | GO:0032753 | positive regulation of interleukin-4 production | 18501882 |
| Hgene | TNFSF4 | GO:0032755 | positive regulation of interleukin-6 production | 20844189 |
| Hgene | TNFSF4 | GO:0050729 | positive regulation of inflammatory response | 20844189 |
| Hgene | TNFSF4 | GO:0071222 | cellular response to lipopolysaccharide | 20844189 |
| Hgene | TNFSF4 | GO:0071380 | cellular response to prostaglandin E stimulus | 19029446 |
| Tgene | CIR1 | GO:0045892 | negative regulation of transcription, DNA-templated | 9874765 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF826300 | TNFSF4 | chr1 | 173157970 | + | CIR1 | chr2 | 175216380 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000367718 | ENST00000342016 | TNFSF4 | chr1 | 173157970 | + | CIR1 | chr2 | 175216380 | + |
| intron-3CDS | ENST00000367718 | ENST00000362053 | TNFSF4 | chr1 | 173157970 | + | CIR1 | chr2 | 175216380 | + |
| intron-3CDS | ENST00000281834 | ENST00000342016 | TNFSF4 | chr1 | 173157970 | + | CIR1 | chr2 | 175216380 | + |
| intron-3CDS | ENST00000281834 | ENST00000362053 | TNFSF4 | chr1 | 173157970 | + | CIR1 | chr2 | 175216380 | + |
| intron-3CDS | ENST00000488053 | ENST00000342016 | TNFSF4 | chr1 | 173157970 | + | CIR1 | chr2 | 175216380 | + |
| intron-3CDS | ENST00000488053 | ENST00000362053 | TNFSF4 | chr1 | 173157970 | + | CIR1 | chr2 | 175216380 | + |
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FusionProtFeatures for TNFSF4_CIR1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TNFSF4 | CIR1 |
| Cytokine that binds to TNFRSF4. Co-stimulates T-cellproliferation and cytokine production. | May modulate splice site selection during alternativesplicing of pre-mRNAs (By similarity). Regulates transcription andacts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histonedeacetylase complex (HDAC). Required for RBPJ-mediated repressionof transcription. {ECO:0000250, ECO:0000269|PubMed:19409814,ECO:0000269|PubMed:9874765}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TNFSF4_CIR1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TNFSF4_CIR1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TNFSF4_CIR1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TNFSF4_CIR1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TNFSF4 | C0024141 | Lupus Erythematosus, Systemic | 2 | CTD_human |
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