|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 38875 |
FusionGeneSummary for TNFSF13B_RAB20 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TNFSF13B_RAB20 | Fusion gene ID: 38875 | Hgene | Tgene | Gene symbol | TNFSF13B | RAB20 | Gene ID | 10673 | 55647 |
| Gene name | TNF superfamily member 13b | RAB20, member RAS oncogene family | |
| Synonyms | BAFF|BLYS|CD257|DTL|TALL-1|TALL1|THANK|TNFSF20|TNLG7A|ZTNF4 | - | |
| Cytomap | 13q33.3 | 13q34 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tumor necrosis factor ligand superfamily member 13BApoL related ligand TALL-1B-cell-activating factorB-lymphocyte stimulatorDelta4 BAFFTNF and ApoL-related leukocyte expressed ligand 1TNF homolog that activates apoptosisdelta BAFFdendritic cell-de | ras-related protein Rab-20 | |
| Modification date | 20180520 | 20180523 | |
| UniProtAcc | Q9Y275 | Q9NX57 | |
| Ensembl transtripts involved in fusion gene | ENST00000430559, ENST00000375887, ENST00000542136, ENST00000479435, | ENST00000267328, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 1 X 3=9 |
| # samples | 1 | 3 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TNFSF13B [Title/Abstract] AND RAB20 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | COAD | TCGA-DM-A1D7-01A | TNFSF13B | chr13 | 108922772 | + | RAB20 | chr13 | 111176544 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000430559 | ENST00000267328 | TNFSF13B | chr13 | 108922772 | + | RAB20 | chr13 | 111176544 | - |
| In-frame | ENST00000375887 | ENST00000267328 | TNFSF13B | chr13 | 108922772 | + | RAB20 | chr13 | 111176544 | - |
| In-frame | ENST00000542136 | ENST00000267328 | TNFSF13B | chr13 | 108922772 | + | RAB20 | chr13 | 111176544 | - |
| 3UTR-3CDS | ENST00000479435 | ENST00000267328 | TNFSF13B | chr13 | 108922772 | + | RAB20 | chr13 | 111176544 | - |
Top |
FusionProtFeatures for TNFSF13B_RAB20 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TNFSF13B | RAB20 |
| Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA.TNFSF13/APRIL binds to the same 2 receptors. Together, they form a2 ligands -2 receptors pathway involved in the stimulation ofB- and T-cell function and the regulation of humoral immunity. Athird B-cell specific BAFF-receptor (BAFFR/BR3) promotes thesurvival of mature B-cells and the B-cell response.{ECO:0000269|PubMed:10973284}. Isoform 2 seems to inhibit isoform 1 secretion andbioactivity. {ECO:0000250}. Isoform 3: Acts as a transcription factor for its ownparent gene, in association with NF-kappa-B p50 subunit, at leastin autoimmune and proliferative B-cell diseases. The presence ofDelta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It candirectly or indirectly regulate the differential expression of alarge number of genes involved in the innate immune response andthe regulation of apoptosis. {ECO:0000269|PubMed:10973284}. | Plays a role in apical endocytosis/recycling. Plays arole in the maturation and acidification of phagosomes that engulfpathogens, such as S.aureus and M.tuberculosis. Plays a role inthe fusion of phagosomes with lysosomes.{ECO:0000269|PubMed:21255211}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TNFSF13B | chr13:108922772 | chr13:111176544 | ENST00000375887 | + | 2 | 6 | 1_46 | 141 | 286 | Topological domain | Cytoplasmic |
| Hgene | TNFSF13B | chr13:108922772 | chr13:111176544 | ENST00000430559 | + | 2 | 5 | 1_46 | 141 | 267 | Topological domain | Cytoplasmic |
| Hgene | TNFSF13B | chr13:108922772 | chr13:111176544 | ENST00000542136 | + | 2 | 4 | 1_46 | 141 | 165 | Topological domain | Cytoplasmic |
| Hgene | TNFSF13B | chr13:108922772 | chr13:111176544 | ENST00000375887 | + | 2 | 6 | 47_67 | 141 | 286 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Hgene | TNFSF13B | chr13:108922772 | chr13:111176544 | ENST00000430559 | + | 2 | 5 | 47_67 | 141 | 267 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Hgene | TNFSF13B | chr13:108922772 | chr13:111176544 | ENST00000542136 | + | 2 | 4 | 47_67 | 141 | 165 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Tgene | >RAB20 | chr13:108922772 | chr13:111176544 | ENST00000267328 | - | 0 | 2 | 113_116 | 57 | 235 | Nucleotide binding | GTP |
| Tgene | >RAB20 | chr13:108922772 | chr13:111176544 | ENST00000267328 | - | 0 | 2 | 55_59 | 57 | 235 | Nucleotide binding | GTP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TNFSF13B | chr13:108922772 | chr13:111176544 | ENST00000375887 | + | 2 | 6 | 68_285 | 141 | 286 | Topological domain | Extracellular |
| Hgene | >TNFSF13B | chr13:108922772 | chr13:111176544 | ENST00000430559 | + | 2 | 5 | 68_285 | 141 | 267 | Topological domain | Extracellular |
| Hgene | >TNFSF13B | chr13:108922772 | chr13:111176544 | ENST00000542136 | + | 2 | 4 | 68_285 | 141 | 165 | Topological domain | Extracellular |
| Tgene | RAB20 | chr13:108922772 | chr13:111176544 | ENST00000267328 | - | 0 | 2 | 33_41 | 57 | 235 | Motif | Effector region |
| Tgene | RAB20 | chr13:108922772 | chr13:111176544 | ENST00000267328 | - | 0 | 2 | 12_19 | 57 | 235 | Nucleotide binding | GTP |
Top |
FusionGeneSequence for TNFSF13B_RAB20 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TNFSF13B_ENST00000430559_chr13_108922772_+_RAB20_ENST00000267328_chr13_111176544_-_319aa MDDSTEREQSRLTSCLKKREEMKLKECVSILPRKESPSVRSSKDGKLLAATLLLALLSCCLTVVSFYQVAALQGDLASLRAELQGHHAEK LPAGAGAPKAGLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETGREQFHGLGSMYCRGAAAIILTYDVNHRQSLVELEDRFL GLTDTASKDCLFAIVGNKVDLTEEGALAGQEKEECSPNMDAGDRVSPRAPKQVQLEDAVALYKKILKYKMLDEQDVPAAEQMCFETSAKT >In-frame_TNFSF13B_ENST00000375887_chr13_108922772_+_RAB20_ENST00000267328_chr13_111176544_-_319aa MDDSTEREQSRLTSCLKKREEMKLKECVSILPRKESPSVRSSKDGKLLAATLLLALLSCCLTVVSFYQVAALQGDLASLRAELQGHHAEK LPAGAGAPKAGLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETGREQFHGLGSMYCRGAAAIILTYDVNHRQSLVELEDRFL GLTDTASKDCLFAIVGNKVDLTEEGALAGQEKEECSPNMDAGDRVSPRAPKQVQLEDAVALYKKILKYKMLDEQDVPAAEQMCFETSAKT >In-frame_TNFSF13B_ENST00000542136_chr13_108922772_+_RAB20_ENST00000267328_chr13_111176544_-_319aa MDDSTEREQSRLTSCLKKREEMKLKECVSILPRKESPSVRSSKDGKLLAATLLLALLSCCLTVVSFYQVAALQGDLASLRAELQGHHAEK LPAGAGAPKAGLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETGREQFHGLGSMYCRGAAAIILTYDVNHRQSLVELEDRFL GLTDTASKDCLFAIVGNKVDLTEEGALAGQEKEECSPNMDAGDRVSPRAPKQVQLEDAVALYKKILKYKMLDEQDVPAAEQMCFETSAKT |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TNFSF13B_ENST00000430559_chr13_108922772_+_RAB20_ENST00000267328_chr13_111176544_-_957nt ATGGATGACTCCACAGAAAGGGAGCAGTCACGCCTTACTTCTTGCCTTAAGAAAAGAGAAGAAATGAAACTGAAGGAGTGTGTTTCCATC CTCCCACGGAAGGAAAGCCCCTCTGTCCGATCCTCCAAAGACGGAAAGCTGCTGGCTGCAACCTTGCTGCTGGCACTGCTGTCTTGCTGC CTCACGGTGGTGTCTTTCTACCAGGTGGCCGCCCTGCAAGGGGACCTGGCCAGCCTCCGGGCAGAGCTGCAGGGCCACCACGCGGAGAAG CTGCCAGCAGGAGCAGGAGCCCCCAAGGCCGGCCTGGAGGAAGCTCCAGCTGTCACCGCGGGACTGAAAATCTTTGAACCACCAGCTCCA GGAGAAGGCAACTCCAGTCAGAACAGCAGAAATAAGCGTGCCGTTCAGGGTCCAGAAGAAACAGGGCGGGAGCAGTTCCACGGCCTGGGC TCCATGTACTGCCGGGGGGCGGCCGCCATCATCCTCACCTATGATGTGAATCACCGGCAGAGCCTGGTGGAGCTGGAGGACCGGTTCCTG GGCCTGACAGACACAGCCAGCAAAGACTGCCTCTTTGCCATCGTGGGGAACAAAGTGGACCTCACTGAGGAGGGGGCCTTGGCGGGCCAG GAGAAGGAAGAGTGCAGTCCCAATATGGACGCTGGGGACCGTGTCTCCCCAAGGGCACCTAAGCAGGTGCAGCTGGAGGATGCGGTGGCC CTTTATAAAAAGATCCTCAAGTACAAGATGCTGGATGAGCAGGATGTGCCGGCCGCTGAGCAAATGTGCTTTGAGACCAGCGCCAAGACC GGCTACAATGTGGACCTCCTGTTTGAGACCCTCTTTGACCTGGTGGTGCCAATGATCTTACAGCAGAGAGCTGAGAGGCCGTCACACACA >In-frame_TNFSF13B_ENST00000375887_chr13_108922772_+_RAB20_ENST00000267328_chr13_111176544_-_957nt ATGGATGACTCCACAGAAAGGGAGCAGTCACGCCTTACTTCTTGCCTTAAGAAAAGAGAAGAAATGAAACTGAAGGAGTGTGTTTCCATC CTCCCACGGAAGGAAAGCCCCTCTGTCCGATCCTCCAAAGACGGAAAGCTGCTGGCTGCAACCTTGCTGCTGGCACTGCTGTCTTGCTGC CTCACGGTGGTGTCTTTCTACCAGGTGGCCGCCCTGCAAGGGGACCTGGCCAGCCTCCGGGCAGAGCTGCAGGGCCACCACGCGGAGAAG CTGCCAGCAGGAGCAGGAGCCCCCAAGGCCGGCCTGGAGGAAGCTCCAGCTGTCACCGCGGGACTGAAAATCTTTGAACCACCAGCTCCA GGAGAAGGCAACTCCAGTCAGAACAGCAGAAATAAGCGTGCCGTTCAGGGTCCAGAAGAAACAGGGCGGGAGCAGTTCCACGGCCTGGGC TCCATGTACTGCCGGGGGGCGGCCGCCATCATCCTCACCTATGATGTGAATCACCGGCAGAGCCTGGTGGAGCTGGAGGACCGGTTCCTG GGCCTGACAGACACAGCCAGCAAAGACTGCCTCTTTGCCATCGTGGGGAACAAAGTGGACCTCACTGAGGAGGGGGCCTTGGCGGGCCAG GAGAAGGAAGAGTGCAGTCCCAATATGGACGCTGGGGACCGTGTCTCCCCAAGGGCACCTAAGCAGGTGCAGCTGGAGGATGCGGTGGCC CTTTATAAAAAGATCCTCAAGTACAAGATGCTGGATGAGCAGGATGTGCCGGCCGCTGAGCAAATGTGCTTTGAGACCAGCGCCAAGACC GGCTACAATGTGGACCTCCTGTTTGAGACCCTCTTTGACCTGGTGGTGCCAATGATCTTACAGCAGAGAGCTGAGAGGCCGTCACACACA >In-frame_TNFSF13B_ENST00000542136_chr13_108922772_+_RAB20_ENST00000267328_chr13_111176544_-_957nt ATGGATGACTCCACAGAAAGGGAGCAGTCACGCCTTACTTCTTGCCTTAAGAAAAGAGAAGAAATGAAACTGAAGGAGTGTGTTTCCATC CTCCCACGGAAGGAAAGCCCCTCTGTCCGATCCTCCAAAGACGGAAAGCTGCTGGCTGCAACCTTGCTGCTGGCACTGCTGTCTTGCTGC CTCACGGTGGTGTCTTTCTACCAGGTGGCCGCCCTGCAAGGGGACCTGGCCAGCCTCCGGGCAGAGCTGCAGGGCCACCACGCGGAGAAG CTGCCAGCAGGAGCAGGAGCCCCCAAGGCCGGCCTGGAGGAAGCTCCAGCTGTCACCGCGGGACTGAAAATCTTTGAACCACCAGCTCCA GGAGAAGGCAACTCCAGTCAGAACAGCAGAAATAAGCGTGCCGTTCAGGGTCCAGAAGAAACAGGGCGGGAGCAGTTCCACGGCCTGGGC TCCATGTACTGCCGGGGGGCGGCCGCCATCATCCTCACCTATGATGTGAATCACCGGCAGAGCCTGGTGGAGCTGGAGGACCGGTTCCTG GGCCTGACAGACACAGCCAGCAAAGACTGCCTCTTTGCCATCGTGGGGAACAAAGTGGACCTCACTGAGGAGGGGGCCTTGGCGGGCCAG GAGAAGGAAGAGTGCAGTCCCAATATGGACGCTGGGGACCGTGTCTCCCCAAGGGCACCTAAGCAGGTGCAGCTGGAGGATGCGGTGGCC CTTTATAAAAAGATCCTCAAGTACAAGATGCTGGATGAGCAGGATGTGCCGGCCGCTGAGCAAATGTGCTTTGAGACCAGCGCCAAGACC GGCTACAATGTGGACCTCCTGTTTGAGACCCTCTTTGACCTGGTGGTGCCAATGATCTTACAGCAGAGAGCTGAGAGGCCGTCACACACA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TNFSF13B_ENST00000430559_chr13_108922772_+_RAB20_ENST00000267328_chr13_111176544_-_1819nt GAAATTCTTACAAAAACTGAAAGTGAAATGAGGAAGACAGATTGAGCAATCCAATCGGAGGGTAAATGCCAGCAAACCTACTGTACAGTA GGGGTAGAGATGCAGAAAGGCAGAAAGGAGAAAATTCAGGATAACTCTCCTGAGGGGTGAGCCAAGCCCTGCCATGTAGTGCACGCAGGA CATCAACAAACACAGATAACAGGAAATGATCCATTCCCTGTGGTCACTTATTCTAAAGGCCCCAACCTTCAAAGTTCAAGTAGTGATATG GATGACTCCACAGAAAGGGAGCAGTCACGCCTTACTTCTTGCCTTAAGAAAAGAGAAGAAATGAAACTGAAGGAGTGTGTTTCCATCCTC CCACGGAAGGAAAGCCCCTCTGTCCGATCCTCCAAAGACGGAAAGCTGCTGGCTGCAACCTTGCTGCTGGCACTGCTGTCTTGCTGCCTC ACGGTGGTGTCTTTCTACCAGGTGGCCGCCCTGCAAGGGGACCTGGCCAGCCTCCGGGCAGAGCTGCAGGGCCACCACGCGGAGAAGCTG CCAGCAGGAGCAGGAGCCCCCAAGGCCGGCCTGGAGGAAGCTCCAGCTGTCACCGCGGGACTGAAAATCTTTGAACCACCAGCTCCAGGA GAAGGCAACTCCAGTCAGAACAGCAGAAATAAGCGTGCCGTTCAGGGTCCAGAAGAAACAGGGCGGGAGCAGTTCCACGGCCTGGGCTCC ATGTACTGCCGGGGGGCGGCCGCCATCATCCTCACCTATGATGTGAATCACCGGCAGAGCCTGGTGGAGCTGGAGGACCGGTTCCTGGGC CTGACAGACACAGCCAGCAAAGACTGCCTCTTTGCCATCGTGGGGAACAAAGTGGACCTCACTGAGGAGGGGGCCTTGGCGGGCCAGGAG AAGGAAGAGTGCAGTCCCAATATGGACGCTGGGGACCGTGTCTCCCCAAGGGCACCTAAGCAGGTGCAGCTGGAGGATGCGGTGGCCCTT TATAAAAAGATCCTCAAGTACAAGATGCTGGATGAGCAGGATGTGCCGGCCGCTGAGCAAATGTGCTTTGAGACCAGCGCCAAGACCGGC TACAATGTGGACCTCCTGTTTGAGACCCTCTTTGACCTGGTGGTGCCAATGATCTTACAGCAGAGAGCTGAGAGGCCGTCACACACAGTG GATATATCCAGTCATAAGCCACCCAAGAGGACCAGATCTGGGTGTTGTGCCTGACTTTCGAGGGCCTCCTGGACTCAGACTGTGCATGTT GGGAAGGGGTCTGACCAGGCAAGCTGTGATCTGAAAGGAGCAAGGAACAGCAAGGAATTATTTTCCAGAATGACACCCGCAGCAGAATGT TGGAGTGGAAATGATGGCTGGCTATGAAGAGGAGGTCAACGTGTGTGGTCTCCTCAGTCTCTGTCAGAGGGGTGGGGAGGTGGGAAACAG GAATCCTCTGCAAAGCCCAATCTGCAGAGTCGAGACCCCTGGTGCTCTCTGCCCCGCTGCCTGGCACTGGTCCTTTGCAGCCAGCCACCA ACGGCCCCCTTGCCCTTGCAGAGGCAGAAGCCTGCGTCTGCACCTGCACCTCTGACCGTTTCAGCACCCTGGGTTGTTACCACGTCCTAC AACTCTGACATTTCTTGTTCTCAAGCGTTTCTCTTCACTGTGAGTTGTCTTTGGTCCTCCCACTTGGTACTTGTATCTTGATGCTTTATA ATCCTGACTCTCGACGTGTTCATTTATACAAAATCAGGAATAACTTTGTTTTTATACTGATTGCAGCAATGTTGGCTACATGTATTATTA >In-frame_TNFSF13B_ENST00000375887_chr13_108922772_+_RAB20_ENST00000267328_chr13_111176544_-_1730nt AGGGGTAGAGATGCAGAAAGGCAGAAAGGAGAAAATTCAGGATAACTCTCCTGAGGGGTGAGCCAAGCCCTGCCATGTAGTGCACGCAGG ACATCAACAAACACAGATAACAGGAAATGATCCATTCCCTGTGGTCACTTATTCTAAAGGCCCCAACCTTCAAAGTTCAAGTAGTGATAT GGATGACTCCACAGAAAGGGAGCAGTCACGCCTTACTTCTTGCCTTAAGAAAAGAGAAGAAATGAAACTGAAGGAGTGTGTTTCCATCCT CCCACGGAAGGAAAGCCCCTCTGTCCGATCCTCCAAAGACGGAAAGCTGCTGGCTGCAACCTTGCTGCTGGCACTGCTGTCTTGCTGCCT CACGGTGGTGTCTTTCTACCAGGTGGCCGCCCTGCAAGGGGACCTGGCCAGCCTCCGGGCAGAGCTGCAGGGCCACCACGCGGAGAAGCT GCCAGCAGGAGCAGGAGCCCCCAAGGCCGGCCTGGAGGAAGCTCCAGCTGTCACCGCGGGACTGAAAATCTTTGAACCACCAGCTCCAGG AGAAGGCAACTCCAGTCAGAACAGCAGAAATAAGCGTGCCGTTCAGGGTCCAGAAGAAACAGGGCGGGAGCAGTTCCACGGCCTGGGCTC CATGTACTGCCGGGGGGCGGCCGCCATCATCCTCACCTATGATGTGAATCACCGGCAGAGCCTGGTGGAGCTGGAGGACCGGTTCCTGGG CCTGACAGACACAGCCAGCAAAGACTGCCTCTTTGCCATCGTGGGGAACAAAGTGGACCTCACTGAGGAGGGGGCCTTGGCGGGCCAGGA GAAGGAAGAGTGCAGTCCCAATATGGACGCTGGGGACCGTGTCTCCCCAAGGGCACCTAAGCAGGTGCAGCTGGAGGATGCGGTGGCCCT TTATAAAAAGATCCTCAAGTACAAGATGCTGGATGAGCAGGATGTGCCGGCCGCTGAGCAAATGTGCTTTGAGACCAGCGCCAAGACCGG CTACAATGTGGACCTCCTGTTTGAGACCCTCTTTGACCTGGTGGTGCCAATGATCTTACAGCAGAGAGCTGAGAGGCCGTCACACACAGT GGATATATCCAGTCATAAGCCACCCAAGAGGACCAGATCTGGGTGTTGTGCCTGACTTTCGAGGGCCTCCTGGACTCAGACTGTGCATGT TGGGAAGGGGTCTGACCAGGCAAGCTGTGATCTGAAAGGAGCAAGGAACAGCAAGGAATTATTTTCCAGAATGACACCCGCAGCAGAATG TTGGAGTGGAAATGATGGCTGGCTATGAAGAGGAGGTCAACGTGTGTGGTCTCCTCAGTCTCTGTCAGAGGGGTGGGGAGGTGGGAAACA GGAATCCTCTGCAAAGCCCAATCTGCAGAGTCGAGACCCCTGGTGCTCTCTGCCCCGCTGCCTGGCACTGGTCCTTTGCAGCCAGCCACC AACGGCCCCCTTGCCCTTGCAGAGGCAGAAGCCTGCGTCTGCACCTGCACCTCTGACCGTTTCAGCACCCTGGGTTGTTACCACGTCCTA CAACTCTGACATTTCTTGTTCTCAAGCGTTTCTCTTCACTGTGAGTTGTCTTTGGTCCTCCCACTTGGTACTTGTATCTTGATGCTTTAT AATCCTGACTCTCGACGTGTTCATTTATACAAAATCAGGAATAACTTTGTTTTTATACTGATTGCAGCAATGTTGGCTACATGTATTATT >In-frame_TNFSF13B_ENST00000542136_chr13_108922772_+_RAB20_ENST00000267328_chr13_111176544_-_1552nt ATGGATGACTCCACAGAAAGGGAGCAGTCACGCCTTACTTCTTGCCTTAAGAAAAGAGAAGAAATGAAACTGAAGGAGTGTGTTTCCATC CTCCCACGGAAGGAAAGCCCCTCTGTCCGATCCTCCAAAGACGGAAAGCTGCTGGCTGCAACCTTGCTGCTGGCACTGCTGTCTTGCTGC CTCACGGTGGTGTCTTTCTACCAGGTGGCCGCCCTGCAAGGGGACCTGGCCAGCCTCCGGGCAGAGCTGCAGGGCCACCACGCGGAGAAG CTGCCAGCAGGAGCAGGAGCCCCCAAGGCCGGCCTGGAGGAAGCTCCAGCTGTCACCGCGGGACTGAAAATCTTTGAACCACCAGCTCCA GGAGAAGGCAACTCCAGTCAGAACAGCAGAAATAAGCGTGCCGTTCAGGGTCCAGAAGAAACAGGGCGGGAGCAGTTCCACGGCCTGGGC TCCATGTACTGCCGGGGGGCGGCCGCCATCATCCTCACCTATGATGTGAATCACCGGCAGAGCCTGGTGGAGCTGGAGGACCGGTTCCTG GGCCTGACAGACACAGCCAGCAAAGACTGCCTCTTTGCCATCGTGGGGAACAAAGTGGACCTCACTGAGGAGGGGGCCTTGGCGGGCCAG GAGAAGGAAGAGTGCAGTCCCAATATGGACGCTGGGGACCGTGTCTCCCCAAGGGCACCTAAGCAGGTGCAGCTGGAGGATGCGGTGGCC CTTTATAAAAAGATCCTCAAGTACAAGATGCTGGATGAGCAGGATGTGCCGGCCGCTGAGCAAATGTGCTTTGAGACCAGCGCCAAGACC GGCTACAATGTGGACCTCCTGTTTGAGACCCTCTTTGACCTGGTGGTGCCAATGATCTTACAGCAGAGAGCTGAGAGGCCGTCACACACA GTGGATATATCCAGTCATAAGCCACCCAAGAGGACCAGATCTGGGTGTTGTGCCTGACTTTCGAGGGCCTCCTGGACTCAGACTGTGCAT GTTGGGAAGGGGTCTGACCAGGCAAGCTGTGATCTGAAAGGAGCAAGGAACAGCAAGGAATTATTTTCCAGAATGACACCCGCAGCAGAA TGTTGGAGTGGAAATGATGGCTGGCTATGAAGAGGAGGTCAACGTGTGTGGTCTCCTCAGTCTCTGTCAGAGGGGTGGGGAGGTGGGAAA CAGGAATCCTCTGCAAAGCCCAATCTGCAGAGTCGAGACCCCTGGTGCTCTCTGCCCCGCTGCCTGGCACTGGTCCTTTGCAGCCAGCCA CCAACGGCCCCCTTGCCCTTGCAGAGGCAGAAGCCTGCGTCTGCACCTGCACCTCTGACCGTTTCAGCACCCTGGGTTGTTACCACGTCC TACAACTCTGACATTTCTTGTTCTCAAGCGTTTCTCTTCACTGTGAGTTGTCTTTGGTCCTCCCACTTGGTACTTGTATCTTGATGCTTT ATAATCCTGACTCTCGACGTGTTCATTTATACAAAATCAGGAATAACTTTGTTTTTATACTGATTGCAGCAATGTTGGCTACATGTATTA |
Top |
FusionGenePPI for TNFSF13B_RAB20 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TNFSF13B | TNFRSF17, TNFRSF13C, TNFSF13B, TNFSF13, TNFRSF13B, APP, TNFSF12, CAND2, IPO7, PDSS1, MON2, FANCD2, RANBP6, MFAP3, FAM160B1, IMPAD1, HOOK2, TTC17, HOOK1, BRAT1, NUP85, LRIG3, IPO8, XPO4, MAP3K6, MAP3K5, MAP3K15, IPO11, TMEM131, HEATR1, TNPO2, NF1, IPO9, ITGB1, ITGA7, NCAPG, FAM118A, SAAL1, BTAF1, HOOK3, AKTIP, FAM160A2, PIGQ, TMEM39A, ARSK, CHST12, VTI1B, HLA-DPB1, ITGAV, PXYLP1, DYM | RAB20 | NXF1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for TNFSF13B_RAB20 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | TNFSF13B | Q9Y275 | DB08879 | Belimumab | Tumor necrosis factor ligand superfamily member 13B | biotech | approved |
| Hgene | TNFSF13B | Q9Y275 | DB04272 | Citric Acid | Tumor necrosis factor ligand superfamily member 13B | small molecule | approved|nutraceutical|vet_approved |
Top |
RelatedDiseases for TNFSF13B_RAB20 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TNFSF13B | C0525045 | Mood Disorders | 1 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|