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Fusion gene ID: 38867 |
FusionGeneSummary for TNFRSF6B_CD74 |
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Fusion gene information | Fusion gene name: TNFRSF6B_CD74 | Fusion gene ID: 38867 | Hgene | Tgene | Gene symbol | TNFRSF6B | CD74 | Gene ID | 8771 | 972 |
Gene name | TNF receptor superfamily member 6b | CD74 molecule | |
Synonyms | DCR3|DJ583P15.1.1|M68|M68E|TR6 | DHLAG|HLADG|II|Ia-GAMMA | |
Cytomap | 20q13.33 | 5q33.1 | |
Type of gene | protein-coding | protein-coding | |
Description | tumor necrosis factor receptor superfamily member 6Bdecoy receptor 3 variant 1decoy receptor 3 variant 2decoy receptor for Fas ligandtumor necrosis factor receptor superfamily, member 6b, decoy | HLA class II histocompatibility antigen gamma chainCD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)CD74 molecule, major histocompatibility complex, class II invariant chainHLA-DR antigens-associated | |
Modification date | 20180522 | 20180522 | |
UniProtAcc | O95407 | P04233 | |
Ensembl transtripts involved in fusion gene | ENST00000369996, | ENST00000377795, ENST00000353334, ENST00000524315, ENST00000009530, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 16 X 15 X 5=1200 |
# samples | 2 | 27 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(27/1200*10)=-2.15200309344505 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TNFRSF6B [Title/Abstract] AND CD74 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CD74 | GO:0001516 | prostaglandin biosynthetic process | 12782713 |
Tgene | CD74 | GO:0001934 | positive regulation of protein phosphorylation | 24942581 |
Tgene | CD74 | GO:0002792 | negative regulation of peptide secretion | 19849849 |
Tgene | CD74 | GO:0007165 | signal transduction | 12782713 |
Tgene | CD74 | GO:0008283 | cell proliferation | 12782713 |
Tgene | CD74 | GO:0033674 | positive regulation of kinase activity | 24942581 |
Tgene | CD74 | GO:0043066 | negative regulation of apoptotic process | 12782713 |
Tgene | CD74 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 24942581 |
Tgene | CD74 | GO:0043410 | positive regulation of MAPK cascade | 24942581 |
Tgene | CD74 | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator | 17045821 |
Tgene | CD74 | GO:0045657 | positive regulation of monocyte differentiation | 24942581 |
Tgene | CD74 | GO:0045893 | positive regulation of transcription, DNA-templated | 24942581 |
Tgene | CD74 | GO:0046598 | positive regulation of viral entry into host cell | 24942581 |
Tgene | CD74 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 17045821 |
Tgene | CD74 | GO:0051290 | protein heterotetramerization | 24942581 |
Tgene | CD74 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 17045821|24942581 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUAD | TCGA-55-A493-01A | TNFRSF6B | chr20 | 62322300 | + | CD74 | chr5 | 149792314 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000369996 | ENST00000377795 | TNFRSF6B | chr20 | 62322300 | + | CD74 | chr5 | 149792314 | - |
intron-5UTR | ENST00000369996 | ENST00000353334 | TNFRSF6B | chr20 | 62322300 | + | CD74 | chr5 | 149792314 | - |
intron-5UTR | ENST00000369996 | ENST00000524315 | TNFRSF6B | chr20 | 62322300 | + | CD74 | chr5 | 149792314 | - |
intron-5UTR | ENST00000369996 | ENST00000009530 | TNFRSF6B | chr20 | 62322300 | + | CD74 | chr5 | 149792314 | - |
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FusionProtFeatures for TNFRSF6B_CD74 |
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Hgene | Tgene |
TNFRSF6B | CD74 |
Decoy receptor that can neutralize the cytotoxic ligandsTNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.{ECO:0000269|PubMed:21300286}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TNFRSF6B_CD74 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TNFRSF6B_CD74 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TNFRSF6B | TNFSF14, TNFSF15, FASLG, KRTAP10-9, KRTAP10-3 | CD74 | MIF, CD74, APP, HADHA, LAMTOR5, MAP3K1, TM4SF20, COPG1, COPG2, HLA-DPB1, HLA-DQA1, CD44 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TNFRSF6B_CD74 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TNFRSF6B_CD74 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CD74 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
Tgene | CD74 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | CD74 | C0162557 | Liver Failure, Acute | 1 | CTD_human |
Tgene | CD74 | C1458155 | Mammary Neoplasms | 1 | CTD_human |