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Fusion gene ID: 38864 |
FusionGeneSummary for TNFRSF1B_FBXO6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TNFRSF1B_FBXO6 | Fusion gene ID: 38864 | Hgene | Tgene | Gene symbol | TNFRSF1B | FBXO6 | Gene ID | 7133 | 26270 |
| Gene name | TNF receptor superfamily member 1B | F-box protein 6 | |
| Synonyms | CD120b|TBPII|TNF-R-II|TNF-R75|TNFBR|TNFR1B|TNFR2|TNFR80|p75|p75TNFR | FBG2|FBS2|FBX6|Fbx6b | |
| Cytomap | 1p36.22 | 1p36.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tumor necrosis factor receptor superfamily member 1BTNF-R2TNF-RIIp75 TNF receptorp80 TNF-alpha receptorsoluble TNFR1B variant 1tumor necrosis factor beta receptortumor necrosis factor binding protein 2tumor necrosis factor receptor 2tumor necrosi | F-box only protein 6F-box protein FBG2F-box protein Fbx6F-box protein that recognizes sugar chains 2F-box/G-domain protein 2 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P20333 | Q9NRD1 | |
| Ensembl transtripts involved in fusion gene | ENST00000536782, ENST00000492361, ENST00000376259, | ENST00000376753, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 1 X 1 X 1=1 |
| # samples | 2 | 1 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: TNFRSF1B [Title/Abstract] AND FBXO6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | FBXO6 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 19716789 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-D3-A51E-06A | TNFRSF1B | chr1 | 12227226 | + | FBXO6 | chr1 | 11733334 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000536782 | ENST00000376753 | TNFRSF1B | chr1 | 12227226 | + | FBXO6 | chr1 | 11733334 | + |
| 3UTR-3CDS | ENST00000492361 | ENST00000376753 | TNFRSF1B | chr1 | 12227226 | + | FBXO6 | chr1 | 11733334 | + |
| Frame-shift | ENST00000376259 | ENST00000376753 | TNFRSF1B | chr1 | 12227226 | + | FBXO6 | chr1 | 11733334 | + |
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FusionProtFeatures for TNFRSF1B_FBXO6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TNFRSF1B | FBXO6 |
| Receptor with high affinity for TNFSF2/TNF-alpha andapproximately 5-fold lower affinity for homotrimericTNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits theapoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. Thisreceptor mediates most of the metabolic effects of TNF-alpha.Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests thatit regulates TNF-alpha function by antagonizing its biologicalactivity. {ECO:0000269|PubMed:12370298}. | Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved inendoplasmic reticulum-associated degradation pathway (ERAD) formisfolded lumenal proteins by recognizing and binding sugar chainson unfolded glycoproteins that are retrotranslocated into thecytosol and promoting their ubiquitination and subsequentdegradation. Able to recognize and bind denatured glycoproteins,which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Alsoinvolved in DNA damage response by specifically recognizingactivated CHEK1 (phosphorylated on 'Ser-345'), promoting itsubiquitination and degradation. Ubiquitination of CHEK1 isrequired to insure that activated CHEK1 does not accumulate ascells progress through S phase, or when replication forksencounter transient impediments during normal DNA replication.{ECO:0000269|PubMed:18203720, ECO:0000269|PubMed:19716789}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TNFRSF1B_FBXO6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TNFRSF1B_FBXO6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TNFRSF1B | FANCD2, TNF, TRAF2, CAV1, KRT18, TDP2, TRAF1, TNFRSF1B, CSNK1A1, TRIM37, TRAIP, SMURF2, ASB3, TRAF3, TRAF6, TNFRSF1A, CHUK, RIPK1, TRADD, PKN1, LTA, CD14, UBQLN1, ZNF420, ADAM17, CSNK1A1L | FBXO6 | VCP, SKP1, CUL1, ASGR2, RBX1, ATP5A1, ATP5B, ATRN, CCT3, COPS2, CRTAP, DDOST, ERLIN2, ERO1L, GLA, GLB1, COLGALT1, GNS, GRN, GUSB, H6PD, HSPA9, IGF2R, IKBIP, LAMB2, P3H1, LMNB1, MCM7, NAGLU, NOMO2, HYOU1, PIGS, PLOD1, PLOD3, PON2, PRCP, RPN1, RPN2, STT3A, STT3B, TFRC, UQCRC2, SMC1A, SMC3, ADAM17, AIFM1, ALDH1B1, ASAH1, ATP6AP1, B3GALNT2, CACHD1, CLU, CNTNAP1, COL6A1, COPA, CTPS1, DDX39A, DDX3X, EDEM3, EMILIN2, ERLIN1, ERO1LB, FARSA, FBN2, FOXRED2, FUCA2, GAA, GANAB, GBA, GGCX, GGH, HADHB, HLA-C, HNRNPC, HNRNPM, HRNR, HSP90AA1, HSP90B1, IMPDH2, ITGAV, ITGB1, EMC1, KIAA1161, LAMB1, LAMC1, LGALS3BP, LGMN, LMF2, LRIG2, MCM3, MCM5, MEGF8, MGRN1, NAGA, NCLN, NCSTN, NEDD8, NPM1, NPTN, NUP210, OAT, P4HB, PABPC1, PCBP2, PDHB, PDIA6, PLD3, PLOD2, PLXNA1, PPM1B, PPP1CC, PPT1, PRMT5, PTBP1, PTGFRN, PXDN, SCARB1, SERPINH1, SGSH, SLC25A5, SORL1, SSR1, TCTN3, TMPO, TOR1AIP2, TTC13, TUBB6, TUBG1, ACAT1, GARS, LRP1, NPC1, ASGR1, CLN5, EGFR, ORC4, A2M, ACP2, AFG3L2, ALPL, ALPP, ASS1, C1RL, CCT5, CCT6A, CCT8, CHPF2, COL4A2, COPS3, COPS7B, CPS1, CPT1A, CTSA, CTSZ, DDX3Y, ECEL1, EIF4A1, ENO1, EPRS, FLG2, GAPDH, GPR126, HSDL2, HSPA5, IGF1R, ITGA3, L1CAM, MAGT1, MET, MIR671, MRC2, PFKM, PFKP, PHB, PHGDH, PRSS21, PSMC1, PSMC3, RARS, RRM1, SLC25A1, SLC25A13, SLC25A3, SMCHD1, TCP1, TGFB1, TKT, TMEM2, TRIP13, UBA52, UGGT1, YBX1, YWHAG, YWHAQ, YWHAZ, ACACA, AASDHPPT, ABCE1, ABCF2, ABCF3, ACOT9, ACTL6A, ADAM10, ADAM15, ADAMTSL4, ADAR, AGA, AGK, AHCY, AHSA1, ALG1, ANKRD28, ARAF, ARF1, ARF4, ARHGEF2, ARIH1, ATAD3A, ATAD3B, ATF6, ATP5C1, ATP6V1A, AUP1, B4GAT1, B4GALT3, BSG, EMC7, C1QBP, APMAP, POMGNT2, C6orf89, TMEM245, CAD, CALU, CANX, CAPRIN1, CCT2, CDC37, CDC45, CDK1, CERCAM, CHPF, CHST10, CILP2, CKAP5, CLIC1, CLNS1A, CLPX, CLTC, CMAS, CNNM3, COCH, COL18A1, COMT, COPB1, COPB2, COPG2, COPS4, COPS5, COPS6, COPS7A, COPS8, CPD, CREG1, CSE1L, CTSB, CTSC, CTSD, CYC1, DARS, DDX17, DDX18, DDX21, DDX5, DDX6, DHX15, DHX9, DNAJA1, DNAJA2, DNAJB11, DNAJC11, DNASE2, DNM2, DPM1, DPP7, ECE1, EEF1B2, EEF1D, EIF2B3, EIF3A, EIF3B, EIF3E, EIF3F, EIF4A3, EIF4B, EMD, ENPP3, EPB41L3, ERLEC1, EZR, FAF2, FASN, FASTKD5, FBXW2, FDFT1, FECH, GART, GCAT, GCDH, GCN1L1, GEMIN5, COLGALT2, GMPS, GNB2L1, GNB4, GPS1, GTF2I, HEPH, HEXA, HEXB, HIST1H1D, HK2, HNRNPA2B1, HNRNPF, HNRNPH2, HNRNPL, HNRNPR, HNRNPDL, HSD17B11, HSPA1A, HSPA1B, HSPG2, HSPH1, IARS, ICAM4, ICAM5, IGF2BP1, IGF2BP3, IGSF8, ILF2, ILF3, IMMT, IPO11, IPO5, IPO7, ITFG1, ITFG3, ITGA2B, ITGA5, ITPRIP, IVNS1ABP, KARS, KDELC2, TTI1, KIAA0922, KPNB1, POGLUT1, LAMA5, LAMP1, LDHA, LEPR, LIFR, LMNA, LNPEP, SPCS2P4, LRFN4, LRPPRC, NRROS, LRRC47, LTBP1, LTBP3, LTBP4, M6PR, MAN2A2, MAN2B1, MAN2B2, MANBA, MAP2K7, MARS, MAT2A, MGAT3, MIR1181, MIR1257, MTCH2, MTHFD1, NAAA, NAMPTP1, NDUFA9, NDUFS1, NDUFS2, NDUFS7, NEU1, NGLY1, NME1, NOB1, NPEPPS, NRM, NUP133, NUP155, NUP205, NUP214, NUP85, NUP93, NUP98, OS9, PCNA, PCYOX1L, PFKL, PIGK, PLA2G15, PLBD2, PLK1, PLXNB2, POFUT1, POLR2B, PPA1, PPIB, PPM1F, PPP6C, PPT2, PRF1, PRKDC, PROS1, PRPF8, PRPS1, PSAP, PSMA1, PSMA3, PSMA4, PSMC2, PSMC5, PSMC6, PSMD3, PSMD4, PSMD7, PTGS1, PTPMT1, PTPRC, PTPRJ, PTPRS, PUM1, QPCTL, RAB27A, RAC2, RAD50, RBBP4, RBM10, RBMX, RFC3, RFC5, RHOG, RHOT2, RNASET2, RPA1, RPF2, RPL18, RPL23, RPL28, RPL32, RPL4, RPL5, RPL6, RPL7A, RPL8, RPLP2, RPS10, RPS20, RPS3, RPS4X, RPS5, RPS6, RPS7, RPS9, RUVBL1, SCAMP3, SCYL2, SDF2L1, SDHA, SEC11A, SEL1L, SEL1L3, SEMA4C, SERPINB1, SF3B1, SF3B2, SF3B3, SRSF1, SIAE, SIL1, SLC25A11, SLC25A12, SLC25A21, SLC25A22, SLC25A24, SLC25A6, SMARCA4, SMC2, SMC4, SNORA41, SNORD21, SNORD24, SNORD36C, SNORD36A, SNORD36B, SNRNP200, SPCS3, SPTLC1, SRPRB, SSR4, STK38, STOM, STOML2, STRAP, SUN1, SUSD1, SYNCRIP, TAF4, TARDBP, TCTN2, TFB2M, TFR2, TGM2, ALYREF, TIMM23, TIMM50, TIMP1, TMCO1, TMED10, EMC3, TMEM131, TMEM201, TMEM214, TMEM231, TOR1B, TPP1, TRAP1, TRIM28, TSR1, TTC17, TTC27, EMC2, TTC4, TUBA1A, TUBA1B, TUBB3, TUFM, TUSC3, TUT1, TXNDC11, TXNDC15, UCK2, UGGT2, UGT8, VAPA, VARS, VDAC2, VDAC3, VPS4A, VWDE, XPOT, YTHDF2, YWHAE, ACTG1, AMOT, ATP1A1, CAPZA1, CAPZB, CCT4, CCT7, HSPD1, CPVL, DBN1, EEF1A1, EEF1G, EFHD2, GALK1, HIST1H4A, HIST1H4D, HIST1H4E, HIST1H4H, HIST1H4I, HIST2H4A, HIST2H4B, HIST4H4, HNRNPA1, HNRNPH1, HNRNPK, HSP90AB1, HSPA8, HUWE1, IGSF3, ILK, KIF11, MIR7-1, MYO6, NOMO1, NOMO3, PCBP1, PKM, RIOK1, RUVBL2, SLC25A10, SPTBN1, STK38L, TRIM21, TUBA1C, TUBB, TUBB2B, TUBB4A, TUBG2, VIM, WDR77, UBB, HSPA13, ENTPD5, NUDT9, BTD, JMJD8, MINPP1, FAM168A, FSTL1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TNFRSF1B_FBXO6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | TNFRSF1B | P20333 | DB11626 | Tasonermin | Tumor necrosis factor receptor superfamily member 1B | biotech | approved |
| Hgene | TNFRSF1B | P20333 | DB00005 | Etanercept | Tumor necrosis factor receptor superfamily member 1B | biotech | approved|investigational |
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RelatedDiseases for TNFRSF1B_FBXO6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TNFRSF1B | C0011570 | Mental Depression | 4 | PSYGENET |
| Hgene | TNFRSF1B | C0011581 | Depressive disorder | 4 | PSYGENET |
| Hgene | TNFRSF1B | C0036341 | Schizophrenia | 2 | PSYGENET |
| Hgene | TNFRSF1B | C0004352 | Autistic Disorder | 1 | CTD_human |
| Hgene | TNFRSF1B | C0007786 | Brain Ischemia | 1 | CTD_human |
| Hgene | TNFRSF1B | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
| Hgene | TNFRSF1B | C0020517 | Hypersensitivity | 1 | CTD_human |
| Hgene | TNFRSF1B | C0023890 | Liver Cirrhosis | 1 | CTD_human |
| Hgene | TNFRSF1B | C0026948 | Mycosis Fungoides | 1 | CTD_human;ORPHANET |
| Hgene | TNFRSF1B | C0028754 | Obesity | 1 | CTD_human |
| Hgene | TNFRSF1B | C0032285 | Pneumonia | 1 | CTD_human |
| Hgene | TNFRSF1B | C0036349 | Paranoid Schizophrenia | 1 | PSYGENET |
| Hgene | TNFRSF1B | C0036920 | Sezary Syndrome | 1 | CTD_human;ORPHANET |
| Hgene | TNFRSF1B | C0239981 | Hypoalbuminemia | 1 | CTD_human |
| Hgene | TNFRSF1B | C0400966 | Non-alcoholic Fatty Liver Disease | 1 | CTD_human |
| Tgene | FBXO6 | C0038325 | Stevens-Johnson Syndrome | 1 | CTD_human |
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