FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 38855

FusionGeneSummary for TNFRSF13B_MPRIP

check button Fusion gene summary
Fusion gene informationFusion gene name: TNFRSF13B_MPRIP
Fusion gene ID: 38855
HgeneTgene
Gene symbol

TNFRSF13B

MPRIP

Gene ID

23495

23164

Gene nameTNF receptor superfamily member 13Bmyosin phosphatase Rho interacting protein
SynonymsCD267|CVID|CVID2|IGAD2|RYZN|TACI|TNFRSF14BM-RIP|MRIP|RHOIP3|RIP3|p116Rip
Cytomap

17p11.2

17p11.2

Type of geneprotein-codingprotein-coding
Descriptiontumor necrosis factor receptor superfamily member 13Btransmembrane activator and CAML interactortumor necrosis factor receptor 13Bmyosin phosphatase Rho-interacting proteinRho interacting protein 3
Modification date2018052320180522
UniProtAcc

O14836

Q6WCQ1

Ensembl transtripts involved in fusion geneENST00000437538, ENST00000579315, 
ENST00000261652, ENST00000583789, 
ENST00000581616, 		ENST00000395811, 
ENST00000444976, ENST00000395804, 
ENST00000341712, ENST00000395806, 
ENST00000395807, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 3 X 4=48
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TNFRSF13B [Title/Abstract] AND MPRIP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A3M1-01ATNFRSF13Bchr17

16852052

-MPRIPchr17

16960950

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000437538ENST00000395811TNFRSF13Bchr17

16852052

-MPRIPchr17

16960950

+
5CDS-intronENST00000437538ENST00000444976TNFRSF13Bchr17

16852052

-MPRIPchr17

16960950

+
5CDS-intronENST00000437538ENST00000395804TNFRSF13Bchr17

16852052

-MPRIPchr17

16960950

+
5CDS-intronENST00000437538ENST00000341712TNFRSF13Bchr17

16852052

-MPRIPchr17

16960950

+
5CDS-intronENST00000437538ENST00000395806TNFRSF13Bchr17

16852052

-MPRIPchr17

16960950

+
5CDS-intronENST00000437538ENST00000395807TNFRSF13Bchr17

16852052

-MPRIPchr17

16960950

+
5CDS-intronENST00000579315ENST00000395811TNFRSF13Bchr17

16852052

-MPRIPchr17

16960950

+
5CDS-intronENST00000579315ENST00000444976TNFRSF13Bchr17

16852052

-MPRIPchr17

16960950

+
5CDS-intronENST00000579315ENST00000395804TNFRSF13Bchr17

16852052

-MPRIPchr17

16960950

+
5CDS-intronENST00000579315ENST00000341712TNFRSF13Bchr17

16852052

-MPRIPchr17

16960950

+
5CDS-intronENST00000579315ENST00000395806TNFRSF13Bchr17

16852052

-MPRIPchr17

16960950

+
5CDS-intronENST00000579315ENST00000395807TNFRSF13Bchr17

16852052

-MPRIPchr17

16960950

+
5CDS-intronENST00000261652ENST00000395811TNFRSF13Bchr17

16852052

-MPRIPchr17

16960950

+
5CDS-intronENST00000261652ENST00000444976TNFRSF13Bchr17

16852052

-MPRIPchr17

16960950

+
5CDS-intronENST00000261652ENST00000395804TNFRSF13Bchr17

16852052

-MPRIPchr17

16960950

+
5CDS-intronENST00000261652ENST00000341712TNFRSF13Bchr17

16852052

-MPRIPchr17

16960950

+
5CDS-intronENST00000261652ENST00000395806TNFRSF13Bchr17

16852052

-MPRIPchr17

16960950

+
5CDS-intronENST00000261652ENST00000395807TNFRSF13Bchr17

16852052

-MPRIPchr17

16960950

+
5CDS-intronENST00000583789ENST00000395811TNFRSF13Bchr17

16852052

-MPRIPchr17

16960950

+
5CDS-intronENST00000583789ENST00000444976TNFRSF13Bchr17

16852052

-MPRIPchr17

16960950

+
5CDS-intronENST00000583789ENST00000395804TNFRSF13Bchr17

16852052

-MPRIPchr17

16960950

+
5CDS-intronENST00000583789ENST00000341712TNFRSF13Bchr17

16852052

-MPRIPchr17

16960950

+
5CDS-intronENST00000583789ENST00000395806TNFRSF13Bchr17

16852052

-MPRIPchr17

16960950

+
5CDS-intronENST00000583789ENST00000395807TNFRSF13Bchr17

16852052

-MPRIPchr17

16960950

+
5UTR-intronENST00000581616ENST00000395811TNFRSF13Bchr17

16852052

-MPRIPchr17

16960950

+
5UTR-intronENST00000581616ENST00000444976TNFRSF13Bchr17

16852052

-MPRIPchr17

16960950

+
5UTR-intronENST00000581616ENST00000395804TNFRSF13Bchr17

16852052

-MPRIPchr17

16960950

+
5UTR-intronENST00000581616ENST00000341712TNFRSF13Bchr17

16852052

-MPRIPchr17

16960950

+
5UTR-intronENST00000581616ENST00000395806TNFRSF13Bchr17

16852052

-MPRIPchr17

16960950

+
5UTR-intronENST00000581616ENST00000395807TNFRSF13Bchr17

16852052

-MPRIPchr17

16960950

+

Top

FusionProtFeatures for TNFRSF13B_MPRIP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TNFRSF13B

O14836

MPRIP

Q6WCQ1

Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYSthat binds both ligands with similar high affinity. Mediatescalcineurin-dependent activation of NF-AT, as well as activationof NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.{ECO:0000269|PubMed:10956646, ECO:0000269|PubMed:10973284}. Targets myosin phosphatase to the actin cytoskeleton.Required for the regulation of the actin cytoskeleton by RhoA andROCK1. Depletion leads to an increased number of stress fibers insmooth muscle cells through stabilization of actin fibers byphosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers inneuronal cells. {ECO:0000250|UniProtKB:P97434,ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TNFRSF13B_MPRIP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TNFRSF13B_MPRIP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TNFRSF13BCAMLG, TNFSF13B, TNFSF13, TRAF2, TRAF5, TRAF6, TRAF3, MYD88, IRAK4, IRAK1, SGTA, FIZ1, ZNF579, ZNF646, CD70, RBM26, RBM27, ZFP91, RRP1, ZNF638, RBM23, RNF166, TEX10, C1QBP, CHCHD2P9, THRAP3, CHTOP, TNFRSF10B, EHD4, MRPL44, TYK2, SENP3, DDX50, RRP12MPRIPPPP1R12C, YWHAB, YWHAG, YWHAQ, SFN, RHOA, ATXN7, ARRB1, FBXO25, LRRK2, NOS3, AGAP2, PAN2, IKBKG, RACGAP1, PIAS4, LSM8, YTHDC1, RPA3, RPA2, RPA1, CCDC101, WDR83, PSAT1, TCP10L2, PSMC3, FNDC4, PACSIN2, ZFP41, PTEN, PCM1, RPGRIP1L, CAPZA2, CDK2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, IQGAP1, PDLIM7, SYNPO, LIMA1, ANLN, MYO19, MYO18A, ESR1, ARMC7, CDH1, VAPB, BTRC, JPH4, VAPA, PACSIN1, PLK1, VTN, NECAB1, CTAGE5, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TNFRSF13B_MPRIP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TNFRSF13B_MPRIP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTNFRSF13BC0026764Multiple Myeloma1CTD_human
HgeneTNFRSF13BC3150354IMMUNODEFICIENCY, COMMON VARIABLE, 21UNIPROT
TgeneMPRIPC0043094Weight Gain1CTD_human