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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38848

FusionGeneSummary for TNFAIP8_NRXN3

check button Fusion gene summary
Fusion gene informationFusion gene name: TNFAIP8_NRXN3
Fusion gene ID: 38848
HgeneTgene
Gene symbol

TNFAIP8

NRXN3

Gene ID

25816

9369

Gene nameTNF alpha induced protein 8neurexin 3
SynonymsGG2-1|MDC-3.13|NDED|SCC-S2|SCCS2C14orf60
Cytomap

5q23.1

14q24.3-q31.1

Type of geneprotein-codingprotein-coding
Descriptiontumor necrosis factor alpha-induced protein 8NF-kappa-B-inducible DED-containing proteinTNF-induced protein GG2-1head and neck tumor and metastasis-related proteintumor necrosis factor, alpha induced protein 8neurexin 3neurexin IIIneurexin-3-alpha
Modification date2018052320180519
UniProtAcc

O95379

Q9Y4C0

Ensembl transtripts involved in fusion geneENST00000274456, ENST00000513374, 
ENST00000504771, ENST00000503646, 
ENST00000504642, ENST00000415806, 
ENST00000554719, ENST00000335750, 
ENST00000557594, ENST00000281127, 
ENST00000428277, ENST00000556003, 
Fusion gene scores* DoF score6 X 5 X 4=1204 X 4 X 2=32
# samples 74
** MAII scorelog2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TNFAIP8 [Title/Abstract] AND NRXN3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW894889TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000274456ENST00000554719TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000274456ENST00000335750TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000274456ENST00000557594TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000274456ENST00000281127TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000274456ENST00000428277TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000274456ENST00000556003TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000513374ENST00000554719TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000513374ENST00000335750TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000513374ENST00000557594TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000513374ENST00000281127TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000513374ENST00000428277TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000513374ENST00000556003TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000504771ENST00000554719TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000504771ENST00000335750TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000504771ENST00000557594TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000504771ENST00000281127TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000504771ENST00000428277TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000504771ENST00000556003TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000503646ENST00000554719TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000503646ENST00000335750TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000503646ENST00000557594TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000503646ENST00000281127TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000503646ENST00000428277TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000503646ENST00000556003TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000504642ENST00000554719TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000504642ENST00000335750TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000504642ENST00000557594TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000504642ENST00000281127TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000504642ENST00000428277TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000504642ENST00000556003TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000415806ENST00000554719TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000415806ENST00000335750TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000415806ENST00000557594TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000415806ENST00000281127TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000415806ENST00000428277TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+
intron-intronENST00000415806ENST00000556003TNFAIP8chr5

118677861

+NRXN3chr14

80158542

+

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FusionProtFeatures for TNFAIP8_NRXN3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TNFAIP8

O95379

NRXN3

Q9Y4C0

Acts as a negative mediator of apoptosis and may play arole in tumor progression. Suppresses the TNF-mediated apoptosisby inhibiting caspase-8 activity but not the processing ofprocaspase-8, subsequently resulting in inhibition of BID cleavageand caspase-3 activation. {ECO:0000269|PubMed:10644768,ECO:0000269|PubMed:11346652, ECO:0000269|PubMed:14724590}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TNFAIP8_NRXN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TNFAIP8_NRXN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TNFAIP8_NRXN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TNFAIP8_NRXN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTNFAIP8C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneTNFAIP8C0027627Neoplasm Metastasis1CTD_human
HgeneTNFAIP8C0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneTNFAIP8C3495559Juvenile arthritis1CTD_human
TgeneNRXN3C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneNRXN3C0036341Schizophrenia1PSYGENET
TgeneNRXN3C0236969Substance-Related Disorders1CTD_human
TgeneNRXN3C0853193Bipolar I disorder1PSYGENET