	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 38823

FusionGeneSummary for TMUB2_TMUB2

Fusion gene summary

Fusion gene information	Fusion gene name: TMUB2_TMUB2
	Fusion gene ID: 38823
		Hgene	Tgene
	Gene symbol	TMUB2	TMUB2
	Gene ID	79089	79089
	Gene name	transmembrane and ubiquitin like domain containing 2	transmembrane and ubiquitin like domain containing 2
	Synonyms	FP2653	FP2653
	Cytomap	17q21.31	17q21.31
	Type of gene	protein-coding	protein-coding
	Description	transmembrane and ubiquitin-like domain-containing protein 2	transmembrane and ubiquitin-like domain-containing protein 2
	Modification date	20180519	20180519
	UniProtAcc	Q71RG4	Q71RG4
	Ensembl transtripts involved in fusion gene	ENST00000446571, ENST00000357984, ENST00000538716, ENST00000587989, ENST00000590235, ENST00000319511, ENST00000589785, ENST00000592825, ENST00000589184, ENST00000589856, ENST00000587172,	ENST00000446571, ENST00000357984, ENST00000538716, ENST00000587989, ENST00000590235, ENST00000319511, ENST00000589785, ENST00000592825, ENST00000589184, ENST00000589856, ENST00000587172,
Fusion gene scores	* DoF score	1 X 1 X 1=1	1 X 1 X 1=1
	# samples	1	1
	** MAII score	log2(1/1*10)=3.32192809488736	log2(1/1*10)=3.32192809488736
Context	PubMed: TMUB2 [Title/Abstract] AND TMUB2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BF754907	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000446571	ENST00000446571	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
In-frame	ENST00000446571	ENST00000357984	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
In-frame	ENST00000446571	ENST00000538716	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
In-frame	ENST00000446571	ENST00000587989	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000446571	ENST00000590235	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000446571	ENST00000319511	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000446571	ENST00000589785	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000446571	ENST00000592825	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000446571	ENST00000589184	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000446571	ENST00000589856	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000446571	ENST00000587172	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
Frame-shift	ENST00000357984	ENST00000446571	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
In-frame	ENST00000357984	ENST00000357984	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
In-frame	ENST00000357984	ENST00000538716	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
In-frame	ENST00000357984	ENST00000587989	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000357984	ENST00000590235	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000357984	ENST00000319511	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000357984	ENST00000589785	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000357984	ENST00000592825	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000357984	ENST00000589184	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000357984	ENST00000589856	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000357984	ENST00000587172	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
Frame-shift	ENST00000538716	ENST00000446571	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
Frame-shift	ENST00000538716	ENST00000357984	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
Frame-shift	ENST00000538716	ENST00000538716	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
Frame-shift	ENST00000538716	ENST00000587989	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000538716	ENST00000590235	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000538716	ENST00000319511	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000538716	ENST00000589785	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000538716	ENST00000592825	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000538716	ENST00000589184	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000538716	ENST00000589856	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000538716	ENST00000587172	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
In-frame	ENST00000587989	ENST00000446571	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
Frame-shift	ENST00000587989	ENST00000357984	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
Frame-shift	ENST00000587989	ENST00000538716	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
Frame-shift	ENST00000587989	ENST00000587989	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000587989	ENST00000590235	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000587989	ENST00000319511	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000587989	ENST00000589785	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000587989	ENST00000592825	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000587989	ENST00000589184	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000587989	ENST00000589856	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000587989	ENST00000587172	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
3UTR-3CDS	ENST00000590235	ENST00000446571	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
3UTR-3CDS	ENST00000590235	ENST00000357984	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
3UTR-3CDS	ENST00000590235	ENST00000538716	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
3UTR-3CDS	ENST00000590235	ENST00000587989	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
3UTR-intron	ENST00000590235	ENST00000590235	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
3UTR-intron	ENST00000590235	ENST00000319511	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
3UTR-intron	ENST00000590235	ENST00000589785	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
3UTR-intron	ENST00000590235	ENST00000592825	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
3UTR-intron	ENST00000590235	ENST00000589184	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
3UTR-intron	ENST00000590235	ENST00000589856	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
3UTR-intron	ENST00000590235	ENST00000587172	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
In-frame	ENST00000319511	ENST00000446571	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
Frame-shift	ENST00000319511	ENST00000357984	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
Frame-shift	ENST00000319511	ENST00000538716	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
Frame-shift	ENST00000319511	ENST00000587989	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000319511	ENST00000590235	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000319511	ENST00000319511	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000319511	ENST00000589785	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000319511	ENST00000592825	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000319511	ENST00000589184	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000319511	ENST00000589856	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000319511	ENST00000587172	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
Frame-shift	ENST00000589785	ENST00000446571	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
In-frame	ENST00000589785	ENST00000357984	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
In-frame	ENST00000589785	ENST00000538716	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
In-frame	ENST00000589785	ENST00000587989	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000589785	ENST00000590235	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000589785	ENST00000319511	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000589785	ENST00000589785	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000589785	ENST00000592825	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000589785	ENST00000589184	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000589785	ENST00000589856	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000589785	ENST00000587172	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
3UTR-3CDS	ENST00000592825	ENST00000446571	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
3UTR-3CDS	ENST00000592825	ENST00000357984	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
3UTR-3CDS	ENST00000592825	ENST00000538716	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
3UTR-3CDS	ENST00000592825	ENST00000587989	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
3UTR-intron	ENST00000592825	ENST00000590235	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
3UTR-intron	ENST00000592825	ENST00000319511	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
3UTR-intron	ENST00000592825	ENST00000589785	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
3UTR-intron	ENST00000592825	ENST00000592825	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
3UTR-intron	ENST00000592825	ENST00000589184	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
3UTR-intron	ENST00000592825	ENST00000589856	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
3UTR-intron	ENST00000592825	ENST00000587172	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
Frame-shift	ENST00000589184	ENST00000446571	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
In-frame	ENST00000589184	ENST00000357984	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
In-frame	ENST00000589184	ENST00000538716	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
In-frame	ENST00000589184	ENST00000587989	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000589184	ENST00000590235	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000589184	ENST00000319511	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000589184	ENST00000589785	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000589184	ENST00000592825	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000589184	ENST00000589184	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000589184	ENST00000589856	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
5CDS-intron	ENST00000589184	ENST00000587172	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
intron-3CDS	ENST00000589856	ENST00000446571	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
intron-3CDS	ENST00000589856	ENST00000357984	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
intron-3CDS	ENST00000589856	ENST00000538716	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
intron-3CDS	ENST00000589856	ENST00000587989	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
intron-intron	ENST00000589856	ENST00000590235	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
intron-intron	ENST00000589856	ENST00000319511	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
intron-intron	ENST00000589856	ENST00000589785	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
intron-intron	ENST00000589856	ENST00000592825	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
intron-intron	ENST00000589856	ENST00000589184	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
intron-intron	ENST00000589856	ENST00000589856	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
intron-intron	ENST00000589856	ENST00000587172	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
3UTR-3CDS	ENST00000587172	ENST00000446571	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
3UTR-3CDS	ENST00000587172	ENST00000357984	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
3UTR-3CDS	ENST00000587172	ENST00000538716	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
3UTR-3CDS	ENST00000587172	ENST00000587989	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
3UTR-intron	ENST00000587172	ENST00000590235	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
3UTR-intron	ENST00000587172	ENST00000319511	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
3UTR-intron	ENST00000587172	ENST00000589785	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
3UTR-intron	ENST00000587172	ENST00000592825	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
3UTR-intron	ENST00000587172	ENST00000589184	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
3UTR-intron	ENST00000587172	ENST00000589856	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+
3UTR-intron	ENST00000587172	ENST00000587172	TMUB2	chr17	42268019	+	TMUB2	chr17	42266803	+

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FusionProtFeatures for TMUB2_TMUB2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TMUB2 Q71RG4	TMUB2 Q71RG4

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for TMUB2_TMUB2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMUB2_TMUB2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for TMUB2_TMUB2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for TMUB2_TMUB2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

Home

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Statistics

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Fusion gene ID: 38823

FusionGeneSummary for TMUB2_TMUB2

FusionProtFeatures for TMUB2_TMUB2

FusionGeneSequence for TMUB2_TMUB2

FusionGenePPI for TMUB2_TMUB2

RelatedDrugs for TMUB2_TMUB2

RelatedDiseases for TMUB2_TMUB2