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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38790

FusionGeneSummary for TMTC1_CANX

check button Fusion gene summary
Fusion gene informationFusion gene name: TMTC1_CANX
Fusion gene ID: 38790
HgeneTgene
Gene symbol

TMTC1

CANX

Gene ID

83857

821

Gene nametransmembrane and tetratricopeptide repeat containing 1calnexin
SynonymsARG99|OLF|TMTC1ACNX|IP90|P90
Cytomap

12p11.22

5q35.3

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane and TPR repeat-containing protein 1transmembrane and tetratricopeptide repeat containing 1Acalnexinmajor histocompatibility complex class I antigen-binding protein p88
Modification date2018051920180522
UniProtAcc

Q8IUR5

P27824

Ensembl transtripts involved in fusion geneENST00000256062, ENST00000551659, 
ENST00000552618, ENST00000319685, 
ENST00000539277, ENST00000381224, 
ENST00000504734, ENST00000415618, 
ENST00000452673, ENST00000247461, 
ENST00000512607, ENST00000503126, 
Fusion gene scores* DoF score7 X 6 X 5=2109 X 12 X 1=108
# samples 712
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/108*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TMTC1 [Title/Abstract] AND CANX [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE836489TMTC1chr12

29727036

-CANXchr5

179136873

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000256062ENST00000504734TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-3CDSENST00000256062ENST00000415618TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-3CDSENST00000256062ENST00000452673TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-3CDSENST00000256062ENST00000247461TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-3CDSENST00000256062ENST00000512607TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-intronENST00000256062ENST00000503126TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-3CDSENST00000551659ENST00000504734TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-3CDSENST00000551659ENST00000415618TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-3CDSENST00000551659ENST00000452673TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-3CDSENST00000551659ENST00000247461TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-3CDSENST00000551659ENST00000512607TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-intronENST00000551659ENST00000503126TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-3CDSENST00000552618ENST00000504734TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-3CDSENST00000552618ENST00000415618TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-3CDSENST00000552618ENST00000452673TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-3CDSENST00000552618ENST00000247461TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-3CDSENST00000552618ENST00000512607TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-intronENST00000552618ENST00000503126TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-3CDSENST00000319685ENST00000504734TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-3CDSENST00000319685ENST00000415618TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-3CDSENST00000319685ENST00000452673TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-3CDSENST00000319685ENST00000247461TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-3CDSENST00000319685ENST00000512607TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-intronENST00000319685ENST00000503126TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-3CDSENST00000539277ENST00000504734TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-3CDSENST00000539277ENST00000415618TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-3CDSENST00000539277ENST00000452673TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-3CDSENST00000539277ENST00000247461TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-3CDSENST00000539277ENST00000512607TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-intronENST00000539277ENST00000503126TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-3CDSENST00000381224ENST00000504734TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-3CDSENST00000381224ENST00000415618TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-3CDSENST00000381224ENST00000452673TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-3CDSENST00000381224ENST00000247461TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-3CDSENST00000381224ENST00000512607TMTC1chr12

29727036

-CANXchr5

179136873

+
intron-intronENST00000381224ENST00000503126TMTC1chr12

29727036

-CANXchr5

179136873

+

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FusionProtFeatures for TMTC1_CANX


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMTC1

Q8IUR5

CANX

P27824

Calcium-binding protein that interacts with newlysynthesized glycoproteins in the endoplasmic reticulum. It may actin assisting protein assembly and/or in the retention within theER of unassembled protein subunits. It seems to play a major rolein the quality control apparatus of the ER by the retention ofincorrectly folded proteins. Associated with partial T-cellantigen receptor complexes that escape the ER of immaturethymocytes, it may function as a signaling complex regulatingthymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TMTC1_CANX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMTC1_CANX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMTC1_CANX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCANXP27824DB00031TenecteplaseCalnexinbiotechapproved
TgeneCANXP27824DB11093Calcium CitrateCalnexinsmall moleculeapproved
TgeneCANXP27824DB11348Calcium PhosphateCalnexinsmall moleculeapproved
TgeneCANXP27824DB00025Antihemophilic factor, human recombinantCalnexinbiotechapproved|investigational

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RelatedDiseases for TMTC1_CANX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCANXC0151744Myocardial Ischemia1CTD_human