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Fusion gene ID: 38777 |
FusionGeneSummary for TMSB10_CD63 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMSB10_CD63 | Fusion gene ID: 38777 | Hgene | Tgene | Gene symbol | TMSB10 | CD63 | Gene ID | 9168 | 967 |
| Gene name | thymosin beta 10 | CD63 molecule | |
| Synonyms | MIG12|TB10 | LAMP-3|ME491|MLA1|OMA81H|TSPAN30 | |
| Cytomap | 2p11.2 | 12q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | thymosin beta-10migration-inducing gene 12migration-inducing protein 12 | CD63 antigenCD63 antigen (melanoma 1 antigen)granulophysinlysosomal-associated membrane protein 3lysosome-associated membrane glycoprotein 3melanoma-associated antigen ME491melanoma-associated antigen MLA1ocular melanoma-associated antigentetraspa | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | P63313 | P08962 | |
| Ensembl transtripts involved in fusion gene | ENST00000233143, | ENST00000548898, ENST00000552067, ENST00000420846, ENST00000548160, ENST00000546939, ENST00000552692, ENST00000549117, ENST00000257857, ENST00000552754, ENST00000550776, | |
| Fusion gene scores | * DoF score | 8 X 6 X 5=240 | 5 X 4 X 5=100 |
| # samples | 10 | 6 | |
| ** MAII score | log2(10/240*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TMSB10 [Title/Abstract] AND CD63 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CD63 | GO:0034613 | cellular protein localization | 15647390 |
| Tgene | CD63 | GO:1901379 | regulation of potassium ion transmembrane transport | 15647390 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-G9-7521-01A | TMSB10 | chr2 | 85133795 | + | CD63 | chr12 | 56123444 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000233143 | ENST00000548898 | TMSB10 | chr2 | 85133795 | + | CD63 | chr12 | 56123444 | - |
| 5CDS-intron | ENST00000233143 | ENST00000552067 | TMSB10 | chr2 | 85133795 | + | CD63 | chr12 | 56123444 | - |
| 5CDS-intron | ENST00000233143 | ENST00000420846 | TMSB10 | chr2 | 85133795 | + | CD63 | chr12 | 56123444 | - |
| 5CDS-intron | ENST00000233143 | ENST00000548160 | TMSB10 | chr2 | 85133795 | + | CD63 | chr12 | 56123444 | - |
| 5CDS-intron | ENST00000233143 | ENST00000546939 | TMSB10 | chr2 | 85133795 | + | CD63 | chr12 | 56123444 | - |
| 5CDS-intron | ENST00000233143 | ENST00000552692 | TMSB10 | chr2 | 85133795 | + | CD63 | chr12 | 56123444 | - |
| 5CDS-5UTR | ENST00000233143 | ENST00000549117 | TMSB10 | chr2 | 85133795 | + | CD63 | chr12 | 56123444 | - |
| 5CDS-intron | ENST00000233143 | ENST00000257857 | TMSB10 | chr2 | 85133795 | + | CD63 | chr12 | 56123444 | - |
| 5CDS-intron | ENST00000233143 | ENST00000552754 | TMSB10 | chr2 | 85133795 | + | CD63 | chr12 | 56123444 | - |
| 5CDS-intron | ENST00000233143 | ENST00000550776 | TMSB10 | chr2 | 85133795 | + | CD63 | chr12 | 56123444 | - |
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FusionProtFeatures for TMSB10_CD63 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TMSB10 | CD63 |
| Plays an important role in the organization of thecytoskeleton. Binds to and sequesters actin monomers (G actin) andtherefore inhibits actin polymerization (By similarity).{ECO:0000250}. | Functions as cell surface receptor for TIMP1 and plays arole in the activation of cellular signaling cascades. Plays arole in the activation of ITGB1 and integrin signaling, leading tothe activation of AKT, FAK/PTK2 and MAP kinases. Promotes cellsurvival, reorganization of the actin cytoskeleton, cell adhesion,spreading and migration, via its role in the activation of AKT andFAK/PTK2. Plays a role in VEGFA signaling via its role inregulating the internalization of KDR/VEGFR2. Plays a role inintracellular vesicular transport processes, and is required fornormal trafficking of the PMEL luminal domain that is essentialfor the development and maturation of melanocytes. Plays a role inthe adhesion of leukocytes onto endothelial cells via its role inthe regulation of SELP trafficking. May play a role in mast celldegranulation in response to Ms4a2/FceRI stimulation, but not inmast cell degranulation in response to other stimuli.{ECO:0000269|PubMed:16917503, ECO:0000269|PubMed:21803846,ECO:0000269|PubMed:21962903, ECO:0000269|PubMed:23632027,ECO:0000269|PubMed:24635319}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TMSB10_CD63 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TMSB10_CD63 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TMSB10 | TERF1, TERF2IP, POT1, TERF2, YRDC, BAG3, ALAS1, KRTAP9-2, NR2E1, LGALS3, PFN1, SRPK2, CEP170, SCLT1 | CD63 | KIT, CD9, PTGFRN, ITGB1, CD82, HLA-DRA, HLA-DMB, HLA-DOB, SRF, CD81, RNF13, ATP6V1B1, VKORC1, SDC1, SDCBP, LGALS3, TSPAN3, LGALS8, LGALS9, FAM134C, TSPAN2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMSB10_CD63 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMSB10_CD63 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TMSB10 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Hgene | TMSB10 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | TMSB10 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Hgene | TMSB10 | C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |
| Tgene | CD63 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | CD63 | C0023904 | Liver Neoplasms, Experimental | 1 | CTD_human |
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