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Fusion gene ID: 38775 |
FusionGeneSummary for TMPRSS6_PPP6R3 |
Fusion gene summary |
Fusion gene information | Fusion gene name: TMPRSS6_PPP6R3 | Fusion gene ID: 38775 | Hgene | Tgene | Gene symbol | TMPRSS6 | PPP6R3 | Gene ID | 164656 | 55291 |
Gene name | transmembrane serine protease 6 | protein phosphatase 6 regulatory subunit 3 | |
Synonyms | IRIDA | C11orf23|PP6R3|SAP190|SAPL|SAPLa|SAPS3 | |
Cytomap | 22q12.3 | 11q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | transmembrane protease serine 6matriptase-2membrane-bound mosaic serine proteinase matriptase-2transmembrane protease, serine 6type II transmembrane serine protease 6 | serine/threonine-protein phosphatase 6 regulatory subunit 3SAPS domain family, member 3sporulation-induced transcript 4-associated protein SAPL | |
Modification date | 20180523 | 20180520 | |
UniProtAcc | Q8IU80 | Q5H9R7 | |
Ensembl transtripts involved in fusion gene | ENST00000381792, ENST00000346753, ENST00000406725, ENST00000406856, ENST00000442782, | ENST00000393799, ENST00000530427, ENST00000393800, ENST00000534534, ENST00000524845, ENST00000265637, ENST00000524904, ENST00000393801, ENST00000265636, ENST00000529710, ENST00000527403, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 15 X 15 X 6=1350 |
# samples | 4 | 19 | |
** MAII score | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(19/1350*10)=-2.82888808360725 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TMPRSS6 [Title/Abstract] AND PPP6R3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tissue-specifically expressed gene involved fusion gene, inframe and retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TMPRSS6 | GO:0006508 | proteolysis | 12149247 |
Hgene | TMPRSS6 | GO:0042730 | fibrinolysis | 12149247 |
Tgene | PPP6R3 | GO:0043666 | regulation of phosphoprotein phosphatase activity | 16716191 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LIHC | TCGA-2Y-A9GT-01A | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
TCGA | LD | LIHC | TCGA-2Y-A9H2-01A | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000381792 | ENST00000393799 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000381792 | ENST00000530427 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000381792 | ENST00000393800 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000381792 | ENST00000534534 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000381792 | ENST00000524845 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000381792 | ENST00000265637 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000381792 | ENST00000524904 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000381792 | ENST00000393801 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000381792 | ENST00000265636 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000381792 | ENST00000529710 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000381792 | ENST00000527403 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
Frame-shift | ENST00000346753 | ENST00000393799 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000346753 | ENST00000530427 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000346753 | ENST00000393800 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000346753 | ENST00000534534 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000346753 | ENST00000524845 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000346753 | ENST00000265637 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000346753 | ENST00000524904 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000346753 | ENST00000393801 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000346753 | ENST00000265636 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000346753 | ENST00000529710 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000346753 | ENST00000527403 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
Frame-shift | ENST00000406725 | ENST00000393799 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406725 | ENST00000530427 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406725 | ENST00000393800 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406725 | ENST00000534534 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406725 | ENST00000524845 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406725 | ENST00000265637 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406725 | ENST00000524904 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406725 | ENST00000393801 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406725 | ENST00000265636 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406725 | ENST00000529710 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406725 | ENST00000527403 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
Frame-shift | ENST00000406856 | ENST00000393799 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406856 | ENST00000530427 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406856 | ENST00000393800 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406856 | ENST00000534534 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406856 | ENST00000524845 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406856 | ENST00000265637 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406856 | ENST00000524904 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406856 | ENST00000393801 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406856 | ENST00000265636 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406856 | ENST00000529710 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406856 | ENST00000527403 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
Frame-shift | ENST00000442782 | ENST00000393799 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000442782 | ENST00000530427 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000442782 | ENST00000393800 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000442782 | ENST00000534534 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000442782 | ENST00000524845 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000442782 | ENST00000265637 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000442782 | ENST00000524904 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000442782 | ENST00000393801 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000442782 | ENST00000265636 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000442782 | ENST00000529710 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000442782 | ENST00000527403 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
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FusionProtFeatures for TMPRSS6_PPP6R3 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
TMPRSS6 | PPP6R3 |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000346753 | - | 2 | 18 | 1_55 | 76 | 812 | Topological domain | Cytoplasmic |
Hgene | TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000381792 | - | 2 | 19 | 1_55 | 67 | 825 | Topological domain | Cytoplasmic |
Hgene | TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406725 | - | 2 | 18 | 1_55 | 67 | 803 | Topological domain | Cytoplasmic |
Hgene | TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406856 | - | 2 | 19 | 1_55 | 67 | 825 | Topological domain | Cytoplasmic |
Hgene | TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000346753 | - | 2 | 18 | 56_76 | 76 | 812 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000346753 | - | 2 | 18 | 213_336 | 76 | 812 | Domain | CUB 1 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000346753 | - | 2 | 18 | 335_452 | 76 | 812 | Domain | CUB 2 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000346753 | - | 2 | 18 | 457_489 | 76 | 812 | Domain | LDL-receptor class A 1 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000346753 | - | 2 | 18 | 490_526 | 76 | 812 | Domain | LDL-receptor class A 2 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000346753 | - | 2 | 18 | 530_567 | 76 | 812 | Domain | LDL-receptor class A 3 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000346753 | - | 2 | 18 | 577_811 | 76 | 812 | Domain | Peptidase S1 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000346753 | - | 2 | 18 | 84_209 | 76 | 812 | Domain | SEA |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000381792 | - | 2 | 19 | 213_336 | 67 | 825 | Domain | CUB 1 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000381792 | - | 2 | 19 | 335_452 | 67 | 825 | Domain | CUB 2 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000381792 | - | 2 | 19 | 457_489 | 67 | 825 | Domain | LDL-receptor class A 1 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000381792 | - | 2 | 19 | 490_526 | 67 | 825 | Domain | LDL-receptor class A 2 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000381792 | - | 2 | 19 | 530_567 | 67 | 825 | Domain | LDL-receptor class A 3 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000381792 | - | 2 | 19 | 577_811 | 67 | 825 | Domain | Peptidase S1 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000381792 | - | 2 | 19 | 84_209 | 67 | 825 | Domain | SEA |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406725 | - | 2 | 18 | 213_336 | 67 | 803 | Domain | CUB 1 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406725 | - | 2 | 18 | 335_452 | 67 | 803 | Domain | CUB 2 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406725 | - | 2 | 18 | 457_489 | 67 | 803 | Domain | LDL-receptor class A 1 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406725 | - | 2 | 18 | 490_526 | 67 | 803 | Domain | LDL-receptor class A 2 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406725 | - | 2 | 18 | 530_567 | 67 | 803 | Domain | LDL-receptor class A 3 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406725 | - | 2 | 18 | 577_811 | 67 | 803 | Domain | Peptidase S1 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406725 | - | 2 | 18 | 84_209 | 67 | 803 | Domain | SEA |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406856 | - | 2 | 19 | 213_336 | 67 | 825 | Domain | CUB 1 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406856 | - | 2 | 19 | 335_452 | 67 | 825 | Domain | CUB 2 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406856 | - | 2 | 19 | 457_489 | 67 | 825 | Domain | LDL-receptor class A 1 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406856 | - | 2 | 19 | 490_526 | 67 | 825 | Domain | LDL-receptor class A 2 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406856 | - | 2 | 19 | 530_567 | 67 | 825 | Domain | LDL-receptor class A 3 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406856 | - | 2 | 19 | 577_811 | 67 | 825 | Domain | Peptidase S1 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406856 | - | 2 | 19 | 84_209 | 67 | 825 | Domain | SEA |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000346753 | - | 2 | 18 | 77_811 | 76 | 812 | Topological domain | Extracellular |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000381792 | - | 2 | 19 | 77_811 | 67 | 825 | Topological domain | Extracellular |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406725 | - | 2 | 18 | 77_811 | 67 | 803 | Topological domain | Extracellular |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406856 | - | 2 | 19 | 77_811 | 67 | 825 | Topological domain | Extracellular |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000381792 | - | 2 | 19 | 56_76 | 67 | 825 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406725 | - | 2 | 18 | 56_76 | 67 | 803 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406856 | - | 2 | 19 | 56_76 | 67 | 825 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
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FusionGeneSequence for TMPRSS6_PPP6R3 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_TMPRSS6_ENST00000381792_chr22_37499256_-_PPP6R3_ENST00000393799_chr11_68377372_+_125aa MPVAEAPQVAGGQGDGGDGEEAEPEGMFKACEDSKRKARGYLRLVPLFVLLALLVLASAGVLLWYFLAVRKGNCLPLKMLLVKTQRSVPR |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_TMPRSS6_ENST00000381792_chr22_37499256_-_PPP6R3_ENST00000393799_chr11_68377372_+_377nt ATGCCCGTGGCCGAGGCCCCCCAGGTGGCTGGCGGGCAGGGGGACGGAGGTGATGGCGAGGAAGCGGAGCCGGAGGGGATGTTCAAGGCC TGTGAGGACTCCAAGAGAAAAGCCCGGGGCTACCTCCGCCTGGTGCCCCTGTTTGTGCTGCTGGCCCTGCTCGTGCTGGCTTCGGCGGGG GTGCTACTCTGGTATTTCCTAGCAGTGAGGAAGGGAAACTGTCTACCTCTCAAGATGCTGCTTGTAAAGACGCAGAGGAGTGTCCCGAGA CTGCAGAGGCGAAGTGCGCGGCGCCCAGGCCTCCCAGCAGCAGTCCCGAGCAGAGGACTGGCCAACCAAGCGCACCAGGTGACACTTCAG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_TMPRSS6_ENST00000381792_chr22_37499256_-_PPP6R3_ENST00000393799_chr11_68377372_+_2730nt CTTGAGCCAGACCCAGTCCAGCTCTGGTGCCTGCCCTCTGGTGCGAGCTGACCTGAGATGCACTTCCCTCCTCTGTGAGCTGTCTCGGCA CCCACTTGCAGTCACTGCCGCCTGATGTTGTTACTCTTCCACTCCAAAAGGATGCCCGTGGCCGAGGCCCCCCAGGTGGCTGGCGGGCAG GGGGACGGAGGTGATGGCGAGGAAGCGGAGCCGGAGGGGATGTTCAAGGCCTGTGAGGACTCCAAGAGAAAAGCCCGGGGCTACCTCCGC CTGGTGCCCCTGTTTGTGCTGCTGGCCCTGCTCGTGCTGGCTTCGGCGGGGGTGCTACTCTGGTATTTCCTAGCAGTGAGGAAGGGAAAC TGTCTACCTCTCAAGATGCTGCTTGTAAAGACGCAGAGGAGTGTCCCGAGACTGCAGAGGCGAAGTGCGCGGCGCCCAGGCCTCCCAGCA GCAGTCCCGAGCAGAGGACTGGCCAACCAAGCGCACCAGGTGACACTTCAGTGAATGGCCCTGTATGACGGGTGACGTCTGCTGCTGCTG ACTGAGGACTGCAGACCGCCACCACTCAGGGGCTCTGGAGGGGTCAGCTGGAGCCCACCAAGCTGTCACTGCTGCACTCACTCTGCAAGG GATCAGGACCAGCAACCTTTATATTCTAGATTCTAAGACATTGTACAGAGAAATTCAGAAGTGTAAAAATATTGCACATTGACAAATACC AAGAATTTTTGCGTATGTTTATATTGTATTGTTCTAAATAATGGGTAGCCTGTGAAATAAGATCTTGCCACCCATGTAATAATAGTAGTA ATACTATAGTTAAAATGGCTGTAAGAATAGTTTTATAAAAGTGAATACACAGATCTATTGTATTTGAAACATAACTTTGACAATTATTAG TGTGACCAAAGTATTAGGCGGTTTTCATACATTTTTCACCTTGTACAAAATTATGAATTCATTTTTCCTCCAGGCCGACAAGGAGTTGTA GAATGAAAATGCCCTCTAAGTGTTATTTTGGTTGTTCTAACTTACAAAAGTGATTTTGAATAAGAAATATTTGGTGTTCTTTTTATAACC AGTTTTTGATTGGTAATTGTTTTCTGTATTGTTTAAAACGGATCAAAAATGTAAGTCTATTGGTAGAGATTAAGTAAAGTATTTATTGCT ACATCATAGTTGATAAATTGATGTTATCGTAAAGCCATATGTTCTGTTCAAGTCTTGTTTGCTTGAAATGATTATTCCTACAAGTGAAAC ACTAGACTATTTGGAGTGTATATGGCTTGTGTTTTGGGATTTTTTTTTTTTTTTTTTGGCTTTTGTTTTTGTTTGTTTTTTTGTTTCATT TGGTAGTTCATCTGCCTTTTAACCCATTCACCAAAATTTACCTTGTTAACAAGCATCACCAATGAACATTTCAGAGCAATCTGCATATTT AACAGACCTAAAATAAATCCTATTAGGCAAGTCAGTTGAAAATGCTCGTGCTGCTAATGGAATTAGAGTGCGTTCATTTTACAGGCTAGT ATTTTAAAAGTAGAAATCAAAATCTGGCACCGAAGCATGCTAATTGTTTACTGTACCTTGTGAGGTTTTCACTCATAAATTTAAACCAGT GTATTTTTTTAGAACTGGTTTGTGTATATATATAGTGATTATGGATACTAATTCAATGTAATTTATAATTTTCTATGTCAATACAAAAAT ACATCACAGCCTTCTCAAACAGCTCAAGCAATATATTGTATATTGCCATATCGTCTGGTGAAAGGGTTAAATTACTTCACCTCTTGCACT TTTAGATGCAAATCAGTTTTTCATTTCTGTAATAGAAAATTATTCACGTATTTTTACATCATTTGTTTTTCCTGACCAGTATTTAAAACC AAAAGGATATTCTGAAAAATGGCCAACAATTTTTTTAGAAGTAGCATCCCAAGCAGCGTGCCTAAACATTACATTGCATATGGAAATAAA AGAATCAAACGTCTAATGCCTTATTATTTCTGATTTCCTTTTTCATTTTAAGTGGTGTGGAGATTCCAGCACTCCCAGGACAGTGGAGTC AGCAGTAAGCCCTGGGACAGGTGGCAAGGGTGGGTCCCTTGACCTTTGCACGCCTCCTCAGGAACCCCCTTTCCCGGGTGAGCCCCTCTC TGAAGAGACTGTCCTTGGGCCTCCTCTGGAAGCAGCACCCCCAGAGGACAGGGCTCCTCCTGCTTGCCTCAGGGCTGCCTGACTTGAATG GCGTTGGACCTCGGGGATTACTGGTAGATAATATGCTCTGGTCTCGCCTGGTGGTGAGTTTTGCCAGCCATGGCCAGGGTTTGGCTCCAC TGGTGGCACACGTGGCCTCCGTGGTATGGACCTGGTGGCTTCTCCATCCCACTGTGGCCTCTGTGGTATGGACCTGGTGGCTTCTCCATC CTACCCAAGGTAACAGTGTCTTGCTTCATCCCACTGACTGCTGGGAGAGAGCCTCTGGGACTTTTCTTTGGGGCATCATTTTGTTTTGTC TTTCGTAGCAGGGAAAGGATATGACAATGGGGAGGACAGTTCTTTTGGAGGTTGGAGGGGCCAAGCCAAGGACAGGAGCAAGTGTGCCCT CATTTTGTTTCTACTTTTAATTTCTGTGTGTTGGCCATACTGAATTATGAGACTAACAGATGTCTACAATACAATACCTGTATTCAAAAT |
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FusionGenePPI for TMPRSS6_PPP6R3 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TMPRSS6 | PPP6R3 | KDM6A, TNFAIP3, USP21, USP36, USP49, PPP6C, PRKDC, HDAC1, HDAC2, ELAVL1, SIRT7, TERF2IP, TINF2, TFAP4, GRK5, PFAS, BRCA1, ECT2, NOTCH1, LATS1, GPSM1, HDAC11, USP10, ANKRD28, MOB1A, MOB1B, ACAD11, ANKRD44, ANKRD52, AP1B1, AP2A1, AP2A2, AURKA, DNAJC11, ECH1, ERLIN2, PPP6R1, PPP6R2, CDC37, ENAH, ETFA, HSP90AA1, HSP90AB1, RUVBL2, SRRT, TPM1, USP7, CSNK1E, SNAI2, RNF2, GPHA2, RPS6KB2, UNK, DIEXF, NSUN5, EIF4A3, TIPRL, NTRK1, CEP44, CEP19, XPO1, ZNRF2, ZNF746, TRMT2A, TRIM25, TES |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMPRSS6_PPP6R3 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMPRSS6_PPP6R3 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TMPRSS6 | C0085576 | Iron-Refractory Iron Deficiency Anemia | 7 | CTD_human;ORPHANET;UNIPROT |
Hgene | TMPRSS6 | C0162316 | Iron deficiency anemia | 2 | CTD_human |