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Fusion gene ID: 38775 |
FusionGeneSummary for TMPRSS6_PPP6R3 |
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Fusion gene information | Fusion gene name: TMPRSS6_PPP6R3 | Fusion gene ID: 38775 | Hgene | Tgene | Gene symbol | TMPRSS6 | PPP6R3 | Gene ID | 164656 | 55291 |
Gene name | transmembrane serine protease 6 | protein phosphatase 6 regulatory subunit 3 | |
Synonyms | IRIDA | C11orf23|PP6R3|SAP190|SAPL|SAPLa|SAPS3 | |
Cytomap | 22q12.3 | 11q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | transmembrane protease serine 6matriptase-2membrane-bound mosaic serine proteinase matriptase-2transmembrane protease, serine 6type II transmembrane serine protease 6 | serine/threonine-protein phosphatase 6 regulatory subunit 3SAPS domain family, member 3sporulation-induced transcript 4-associated protein SAPL | |
Modification date | 20180523 | 20180520 | |
UniProtAcc | Q8IU80 | Q5H9R7 | |
Ensembl transtripts involved in fusion gene | ENST00000381792, ENST00000346753, ENST00000406725, ENST00000406856, ENST00000442782, | ENST00000393799, ENST00000530427, ENST00000393800, ENST00000534534, ENST00000524845, ENST00000265637, ENST00000524904, ENST00000393801, ENST00000265636, ENST00000529710, ENST00000527403, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 15 X 15 X 6=1350 |
# samples | 4 | 19 | |
** MAII score | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(19/1350*10)=-2.82888808360725 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TMPRSS6 [Title/Abstract] AND PPP6R3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tissue-specifically expressed gene involved fusion gene, inframe and retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TMPRSS6 | GO:0006508 | proteolysis | 12149247 |
Hgene | TMPRSS6 | GO:0042730 | fibrinolysis | 12149247 |
Tgene | PPP6R3 | GO:0043666 | regulation of phosphoprotein phosphatase activity | 16716191 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LIHC | TCGA-2Y-A9GT-01A | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
TCGA | LD | LIHC | TCGA-2Y-A9H2-01A | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000381792 | ENST00000393799 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000381792 | ENST00000530427 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000381792 | ENST00000393800 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000381792 | ENST00000534534 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000381792 | ENST00000524845 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000381792 | ENST00000265637 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000381792 | ENST00000524904 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000381792 | ENST00000393801 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000381792 | ENST00000265636 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000381792 | ENST00000529710 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000381792 | ENST00000527403 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
Frame-shift | ENST00000346753 | ENST00000393799 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000346753 | ENST00000530427 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000346753 | ENST00000393800 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000346753 | ENST00000534534 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000346753 | ENST00000524845 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000346753 | ENST00000265637 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000346753 | ENST00000524904 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000346753 | ENST00000393801 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000346753 | ENST00000265636 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000346753 | ENST00000529710 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000346753 | ENST00000527403 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
Frame-shift | ENST00000406725 | ENST00000393799 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406725 | ENST00000530427 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406725 | ENST00000393800 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406725 | ENST00000534534 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406725 | ENST00000524845 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406725 | ENST00000265637 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406725 | ENST00000524904 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406725 | ENST00000393801 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406725 | ENST00000265636 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406725 | ENST00000529710 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406725 | ENST00000527403 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
Frame-shift | ENST00000406856 | ENST00000393799 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406856 | ENST00000530427 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406856 | ENST00000393800 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406856 | ENST00000534534 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406856 | ENST00000524845 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406856 | ENST00000265637 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406856 | ENST00000524904 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406856 | ENST00000393801 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406856 | ENST00000265636 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406856 | ENST00000529710 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000406856 | ENST00000527403 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
Frame-shift | ENST00000442782 | ENST00000393799 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000442782 | ENST00000530427 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000442782 | ENST00000393800 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000442782 | ENST00000534534 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000442782 | ENST00000524845 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000442782 | ENST00000265637 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000442782 | ENST00000524904 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000442782 | ENST00000393801 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000442782 | ENST00000265636 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000442782 | ENST00000529710 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
5CDS-intron | ENST00000442782 | ENST00000527403 | TMPRSS6 | chr22 | 37499256 | - | PPP6R3 | chr11 | 68377372 | + |
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FusionProtFeatures for TMPRSS6_PPP6R3 |
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Hgene | Tgene |
TMPRSS6 | PPP6R3 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000346753 | - | 2 | 18 | 1_55 | 76 | 812 | Topological domain | Cytoplasmic |
Hgene | TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000381792 | - | 2 | 19 | 1_55 | 67 | 825 | Topological domain | Cytoplasmic |
Hgene | TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406725 | - | 2 | 18 | 1_55 | 67 | 803 | Topological domain | Cytoplasmic |
Hgene | TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406856 | - | 2 | 19 | 1_55 | 67 | 825 | Topological domain | Cytoplasmic |
Hgene | TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000346753 | - | 2 | 18 | 56_76 | 76 | 812 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000346753 | - | 2 | 18 | 213_336 | 76 | 812 | Domain | CUB 1 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000346753 | - | 2 | 18 | 335_452 | 76 | 812 | Domain | CUB 2 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000346753 | - | 2 | 18 | 457_489 | 76 | 812 | Domain | LDL-receptor class A 1 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000346753 | - | 2 | 18 | 490_526 | 76 | 812 | Domain | LDL-receptor class A 2 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000346753 | - | 2 | 18 | 530_567 | 76 | 812 | Domain | LDL-receptor class A 3 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000346753 | - | 2 | 18 | 577_811 | 76 | 812 | Domain | Peptidase S1 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000346753 | - | 2 | 18 | 84_209 | 76 | 812 | Domain | SEA |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000381792 | - | 2 | 19 | 213_336 | 67 | 825 | Domain | CUB 1 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000381792 | - | 2 | 19 | 335_452 | 67 | 825 | Domain | CUB 2 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000381792 | - | 2 | 19 | 457_489 | 67 | 825 | Domain | LDL-receptor class A 1 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000381792 | - | 2 | 19 | 490_526 | 67 | 825 | Domain | LDL-receptor class A 2 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000381792 | - | 2 | 19 | 530_567 | 67 | 825 | Domain | LDL-receptor class A 3 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000381792 | - | 2 | 19 | 577_811 | 67 | 825 | Domain | Peptidase S1 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000381792 | - | 2 | 19 | 84_209 | 67 | 825 | Domain | SEA |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406725 | - | 2 | 18 | 213_336 | 67 | 803 | Domain | CUB 1 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406725 | - | 2 | 18 | 335_452 | 67 | 803 | Domain | CUB 2 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406725 | - | 2 | 18 | 457_489 | 67 | 803 | Domain | LDL-receptor class A 1 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406725 | - | 2 | 18 | 490_526 | 67 | 803 | Domain | LDL-receptor class A 2 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406725 | - | 2 | 18 | 530_567 | 67 | 803 | Domain | LDL-receptor class A 3 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406725 | - | 2 | 18 | 577_811 | 67 | 803 | Domain | Peptidase S1 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406725 | - | 2 | 18 | 84_209 | 67 | 803 | Domain | SEA |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406856 | - | 2 | 19 | 213_336 | 67 | 825 | Domain | CUB 1 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406856 | - | 2 | 19 | 335_452 | 67 | 825 | Domain | CUB 2 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406856 | - | 2 | 19 | 457_489 | 67 | 825 | Domain | LDL-receptor class A 1 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406856 | - | 2 | 19 | 490_526 | 67 | 825 | Domain | LDL-receptor class A 2 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406856 | - | 2 | 19 | 530_567 | 67 | 825 | Domain | LDL-receptor class A 3 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406856 | - | 2 | 19 | 577_811 | 67 | 825 | Domain | Peptidase S1 |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406856 | - | 2 | 19 | 84_209 | 67 | 825 | Domain | SEA |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000346753 | - | 2 | 18 | 77_811 | 76 | 812 | Topological domain | Extracellular |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000381792 | - | 2 | 19 | 77_811 | 67 | 825 | Topological domain | Extracellular |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406725 | - | 2 | 18 | 77_811 | 67 | 803 | Topological domain | Extracellular |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406856 | - | 2 | 19 | 77_811 | 67 | 825 | Topological domain | Extracellular |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000381792 | - | 2 | 19 | 56_76 | 67 | 825 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406725 | - | 2 | 18 | 56_76 | 67 | 803 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
Hgene | >TMPRSS6 | chr22:37499256 | chr11:68377372 | ENST00000406856 | - | 2 | 19 | 56_76 | 67 | 825 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
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FusionGeneSequence for TMPRSS6_PPP6R3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_TMPRSS6_ENST00000381792_chr22_37499256_-_PPP6R3_ENST00000393799_chr11_68377372_+_125aa MPVAEAPQVAGGQGDGGDGEEAEPEGMFKACEDSKRKARGYLRLVPLFVLLALLVLASAGVLLWYFLAVRKGNCLPLKMLLVKTQRSVPR |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_TMPRSS6_ENST00000381792_chr22_37499256_-_PPP6R3_ENST00000393799_chr11_68377372_+_377nt ATGCCCGTGGCCGAGGCCCCCCAGGTGGCTGGCGGGCAGGGGGACGGAGGTGATGGCGAGGAAGCGGAGCCGGAGGGGATGTTCAAGGCC TGTGAGGACTCCAAGAGAAAAGCCCGGGGCTACCTCCGCCTGGTGCCCCTGTTTGTGCTGCTGGCCCTGCTCGTGCTGGCTTCGGCGGGG GTGCTACTCTGGTATTTCCTAGCAGTGAGGAAGGGAAACTGTCTACCTCTCAAGATGCTGCTTGTAAAGACGCAGAGGAGTGTCCCGAGA CTGCAGAGGCGAAGTGCGCGGCGCCCAGGCCTCCCAGCAGCAGTCCCGAGCAGAGGACTGGCCAACCAAGCGCACCAGGTGACACTTCAG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_TMPRSS6_ENST00000381792_chr22_37499256_-_PPP6R3_ENST00000393799_chr11_68377372_+_2730nt CTTGAGCCAGACCCAGTCCAGCTCTGGTGCCTGCCCTCTGGTGCGAGCTGACCTGAGATGCACTTCCCTCCTCTGTGAGCTGTCTCGGCA CCCACTTGCAGTCACTGCCGCCTGATGTTGTTACTCTTCCACTCCAAAAGGATGCCCGTGGCCGAGGCCCCCCAGGTGGCTGGCGGGCAG GGGGACGGAGGTGATGGCGAGGAAGCGGAGCCGGAGGGGATGTTCAAGGCCTGTGAGGACTCCAAGAGAAAAGCCCGGGGCTACCTCCGC CTGGTGCCCCTGTTTGTGCTGCTGGCCCTGCTCGTGCTGGCTTCGGCGGGGGTGCTACTCTGGTATTTCCTAGCAGTGAGGAAGGGAAAC TGTCTACCTCTCAAGATGCTGCTTGTAAAGACGCAGAGGAGTGTCCCGAGACTGCAGAGGCGAAGTGCGCGGCGCCCAGGCCTCCCAGCA GCAGTCCCGAGCAGAGGACTGGCCAACCAAGCGCACCAGGTGACACTTCAGTGAATGGCCCTGTATGACGGGTGACGTCTGCTGCTGCTG ACTGAGGACTGCAGACCGCCACCACTCAGGGGCTCTGGAGGGGTCAGCTGGAGCCCACCAAGCTGTCACTGCTGCACTCACTCTGCAAGG GATCAGGACCAGCAACCTTTATATTCTAGATTCTAAGACATTGTACAGAGAAATTCAGAAGTGTAAAAATATTGCACATTGACAAATACC AAGAATTTTTGCGTATGTTTATATTGTATTGTTCTAAATAATGGGTAGCCTGTGAAATAAGATCTTGCCACCCATGTAATAATAGTAGTA ATACTATAGTTAAAATGGCTGTAAGAATAGTTTTATAAAAGTGAATACACAGATCTATTGTATTTGAAACATAACTTTGACAATTATTAG TGTGACCAAAGTATTAGGCGGTTTTCATACATTTTTCACCTTGTACAAAATTATGAATTCATTTTTCCTCCAGGCCGACAAGGAGTTGTA GAATGAAAATGCCCTCTAAGTGTTATTTTGGTTGTTCTAACTTACAAAAGTGATTTTGAATAAGAAATATTTGGTGTTCTTTTTATAACC AGTTTTTGATTGGTAATTGTTTTCTGTATTGTTTAAAACGGATCAAAAATGTAAGTCTATTGGTAGAGATTAAGTAAAGTATTTATTGCT ACATCATAGTTGATAAATTGATGTTATCGTAAAGCCATATGTTCTGTTCAAGTCTTGTTTGCTTGAAATGATTATTCCTACAAGTGAAAC ACTAGACTATTTGGAGTGTATATGGCTTGTGTTTTGGGATTTTTTTTTTTTTTTTTTGGCTTTTGTTTTTGTTTGTTTTTTTGTTTCATT TGGTAGTTCATCTGCCTTTTAACCCATTCACCAAAATTTACCTTGTTAACAAGCATCACCAATGAACATTTCAGAGCAATCTGCATATTT AACAGACCTAAAATAAATCCTATTAGGCAAGTCAGTTGAAAATGCTCGTGCTGCTAATGGAATTAGAGTGCGTTCATTTTACAGGCTAGT ATTTTAAAAGTAGAAATCAAAATCTGGCACCGAAGCATGCTAATTGTTTACTGTACCTTGTGAGGTTTTCACTCATAAATTTAAACCAGT GTATTTTTTTAGAACTGGTTTGTGTATATATATAGTGATTATGGATACTAATTCAATGTAATTTATAATTTTCTATGTCAATACAAAAAT ACATCACAGCCTTCTCAAACAGCTCAAGCAATATATTGTATATTGCCATATCGTCTGGTGAAAGGGTTAAATTACTTCACCTCTTGCACT TTTAGATGCAAATCAGTTTTTCATTTCTGTAATAGAAAATTATTCACGTATTTTTACATCATTTGTTTTTCCTGACCAGTATTTAAAACC AAAAGGATATTCTGAAAAATGGCCAACAATTTTTTTAGAAGTAGCATCCCAAGCAGCGTGCCTAAACATTACATTGCATATGGAAATAAA AGAATCAAACGTCTAATGCCTTATTATTTCTGATTTCCTTTTTCATTTTAAGTGGTGTGGAGATTCCAGCACTCCCAGGACAGTGGAGTC AGCAGTAAGCCCTGGGACAGGTGGCAAGGGTGGGTCCCTTGACCTTTGCACGCCTCCTCAGGAACCCCCTTTCCCGGGTGAGCCCCTCTC TGAAGAGACTGTCCTTGGGCCTCCTCTGGAAGCAGCACCCCCAGAGGACAGGGCTCCTCCTGCTTGCCTCAGGGCTGCCTGACTTGAATG GCGTTGGACCTCGGGGATTACTGGTAGATAATATGCTCTGGTCTCGCCTGGTGGTGAGTTTTGCCAGCCATGGCCAGGGTTTGGCTCCAC TGGTGGCACACGTGGCCTCCGTGGTATGGACCTGGTGGCTTCTCCATCCCACTGTGGCCTCTGTGGTATGGACCTGGTGGCTTCTCCATC CTACCCAAGGTAACAGTGTCTTGCTTCATCCCACTGACTGCTGGGAGAGAGCCTCTGGGACTTTTCTTTGGGGCATCATTTTGTTTTGTC TTTCGTAGCAGGGAAAGGATATGACAATGGGGAGGACAGTTCTTTTGGAGGTTGGAGGGGCCAAGCCAAGGACAGGAGCAAGTGTGCCCT CATTTTGTTTCTACTTTTAATTTCTGTGTGTTGGCCATACTGAATTATGAGACTAACAGATGTCTACAATACAATACCTGTATTCAAAAT |
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FusionGenePPI for TMPRSS6_PPP6R3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TMPRSS6 | PPP6R3 | KDM6A, TNFAIP3, USP21, USP36, USP49, PPP6C, PRKDC, HDAC1, HDAC2, ELAVL1, SIRT7, TERF2IP, TINF2, TFAP4, GRK5, PFAS, BRCA1, ECT2, NOTCH1, LATS1, GPSM1, HDAC11, USP10, ANKRD28, MOB1A, MOB1B, ACAD11, ANKRD44, ANKRD52, AP1B1, AP2A1, AP2A2, AURKA, DNAJC11, ECH1, ERLIN2, PPP6R1, PPP6R2, CDC37, ENAH, ETFA, HSP90AA1, HSP90AB1, RUVBL2, SRRT, TPM1, USP7, CSNK1E, SNAI2, RNF2, GPHA2, RPS6KB2, UNK, DIEXF, NSUN5, EIF4A3, TIPRL, NTRK1, CEP44, CEP19, XPO1, ZNRF2, ZNF746, TRMT2A, TRIM25, TES |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMPRSS6_PPP6R3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMPRSS6_PPP6R3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TMPRSS6 | C0085576 | Iron-Refractory Iron Deficiency Anemia | 7 | CTD_human;ORPHANET;UNIPROT |
Hgene | TMPRSS6 | C0162316 | Iron deficiency anemia | 2 | CTD_human |