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Fusion gene ID: 38773 |
FusionGeneSummary for TMPRSS6_EME1 |
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Fusion gene information | Fusion gene name: TMPRSS6_EME1 | Fusion gene ID: 38773 | Hgene | Tgene | Gene symbol | TMPRSS6 | EME1 | Gene ID | 164656 | 146956 |
Gene name | transmembrane serine protease 6 | essential meiotic structure-specific endonuclease 1 | |
Synonyms | IRIDA | MMS4L|SLX2A | |
Cytomap | 22q12.3 | 17q21.33 | |
Type of gene | protein-coding | protein-coding | |
Description | transmembrane protease serine 6matriptase-2membrane-bound mosaic serine proteinase matriptase-2transmembrane protease, serine 6type II transmembrane serine protease 6 | crossover junction endonuclease EME1MMS4 homologSLX2 structure-specific endonuclease subunit homolog Aessential meiotic endonuclease 1 homolog 1essential meiotic endonuclease 1 homolog 2hMMS4homolog of yeast EME1 endonuclease | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8IU80 | Q96AY2 | |
Ensembl transtripts involved in fusion gene | ENST00000381792, ENST00000346753, ENST00000406725, ENST00000406856, ENST00000442782, | ENST00000393271, ENST00000338165, ENST00000511648, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 2 X 2 X 1=4 |
# samples | 4 | 2 | |
** MAII score | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: TMPRSS6 [Title/Abstract] AND EME1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TMPRSS6 | GO:0006508 | proteolysis | 12149247 |
Hgene | TMPRSS6 | GO:0042730 | fibrinolysis | 12149247 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-C8-A132-01A | TMPRSS6 | chr22 | 37485618 | - | EME1 | chr17 | 48455956 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000381792 | ENST00000393271 | TMPRSS6 | chr22 | 37485618 | - | EME1 | chr17 | 48455956 | + |
In-frame | ENST00000381792 | ENST00000338165 | TMPRSS6 | chr22 | 37485618 | - | EME1 | chr17 | 48455956 | + |
In-frame | ENST00000381792 | ENST00000511648 | TMPRSS6 | chr22 | 37485618 | - | EME1 | chr17 | 48455956 | + |
Frame-shift | ENST00000346753 | ENST00000393271 | TMPRSS6 | chr22 | 37485618 | - | EME1 | chr17 | 48455956 | + |
Frame-shift | ENST00000346753 | ENST00000338165 | TMPRSS6 | chr22 | 37485618 | - | EME1 | chr17 | 48455956 | + |
Frame-shift | ENST00000346753 | ENST00000511648 | TMPRSS6 | chr22 | 37485618 | - | EME1 | chr17 | 48455956 | + |
Frame-shift | ENST00000406725 | ENST00000393271 | TMPRSS6 | chr22 | 37485618 | - | EME1 | chr17 | 48455956 | + |
Frame-shift | ENST00000406725 | ENST00000338165 | TMPRSS6 | chr22 | 37485618 | - | EME1 | chr17 | 48455956 | + |
Frame-shift | ENST00000406725 | ENST00000511648 | TMPRSS6 | chr22 | 37485618 | - | EME1 | chr17 | 48455956 | + |
Frame-shift | ENST00000406856 | ENST00000393271 | TMPRSS6 | chr22 | 37485618 | - | EME1 | chr17 | 48455956 | + |
Frame-shift | ENST00000406856 | ENST00000338165 | TMPRSS6 | chr22 | 37485618 | - | EME1 | chr17 | 48455956 | + |
Frame-shift | ENST00000406856 | ENST00000511648 | TMPRSS6 | chr22 | 37485618 | - | EME1 | chr17 | 48455956 | + |
Frame-shift | ENST00000442782 | ENST00000393271 | TMPRSS6 | chr22 | 37485618 | - | EME1 | chr17 | 48455956 | + |
Frame-shift | ENST00000442782 | ENST00000338165 | TMPRSS6 | chr22 | 37485618 | - | EME1 | chr17 | 48455956 | + |
Frame-shift | ENST00000442782 | ENST00000511648 | TMPRSS6 | chr22 | 37485618 | - | EME1 | chr17 | 48455956 | + |
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FusionProtFeatures for TMPRSS6_EME1 |
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Hgene | Tgene |
TMPRSS6 | EME1 |
Interacts with MUS81 to form a DNA structure-specificendonuclease with substrate preference for branched DNA structureswith a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions.May be required in mitosis for the processing of stalled orcollapsed replication forks. {ECO:0000269|PubMed:12686547,ECO:0000269|PubMed:12721304, ECO:0000269|PubMed:14617801,ECO:0000269|PubMed:17289582}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000346753 | - | 7 | 18 | 84_209 | 287 | 812 | Domain | SEA |
Hgene | TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000381792 | - | 7 | 19 | 84_209 | 278 | 825 | Domain | SEA |
Hgene | TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000406725 | - | 7 | 18 | 84_209 | 278 | 803 | Domain | SEA |
Hgene | TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000406856 | - | 7 | 19 | 84_209 | 278 | 825 | Domain | SEA |
Hgene | TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000346753 | - | 7 | 18 | 1_55 | 287 | 812 | Topological domain | Cytoplasmic |
Hgene | TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000381792 | - | 7 | 19 | 1_55 | 278 | 825 | Topological domain | Cytoplasmic |
Hgene | TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000406725 | - | 7 | 18 | 1_55 | 278 | 803 | Topological domain | Cytoplasmic |
Hgene | TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000406856 | - | 7 | 19 | 1_55 | 278 | 825 | Topological domain | Cytoplasmic |
Hgene | TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000346753 | - | 7 | 18 | 56_76 | 287 | 812 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
Hgene | TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000381792 | - | 7 | 19 | 56_76 | 278 | 825 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
Hgene | TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000406725 | - | 7 | 18 | 56_76 | 278 | 803 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
Hgene | TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000406856 | - | 7 | 19 | 56_76 | 278 | 825 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000346753 | - | 7 | 18 | 213_336 | 287 | 812 | Domain | CUB 1 |
Hgene | >TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000346753 | - | 7 | 18 | 335_452 | 287 | 812 | Domain | CUB 2 |
Hgene | >TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000346753 | - | 7 | 18 | 457_489 | 287 | 812 | Domain | LDL-receptor class A 1 |
Hgene | >TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000346753 | - | 7 | 18 | 490_526 | 287 | 812 | Domain | LDL-receptor class A 2 |
Hgene | >TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000346753 | - | 7 | 18 | 530_567 | 287 | 812 | Domain | LDL-receptor class A 3 |
Hgene | >TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000346753 | - | 7 | 18 | 577_811 | 287 | 812 | Domain | Peptidase S1 |
Hgene | >TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000381792 | - | 7 | 19 | 213_336 | 278 | 825 | Domain | CUB 1 |
Hgene | >TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000381792 | - | 7 | 19 | 335_452 | 278 | 825 | Domain | CUB 2 |
Hgene | >TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000381792 | - | 7 | 19 | 457_489 | 278 | 825 | Domain | LDL-receptor class A 1 |
Hgene | >TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000381792 | - | 7 | 19 | 490_526 | 278 | 825 | Domain | LDL-receptor class A 2 |
Hgene | >TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000381792 | - | 7 | 19 | 530_567 | 278 | 825 | Domain | LDL-receptor class A 3 |
Hgene | >TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000381792 | - | 7 | 19 | 577_811 | 278 | 825 | Domain | Peptidase S1 |
Hgene | >TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000406725 | - | 7 | 18 | 213_336 | 278 | 803 | Domain | CUB 1 |
Hgene | >TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000406725 | - | 7 | 18 | 335_452 | 278 | 803 | Domain | CUB 2 |
Hgene | >TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000406725 | - | 7 | 18 | 457_489 | 278 | 803 | Domain | LDL-receptor class A 1 |
Hgene | >TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000406725 | - | 7 | 18 | 490_526 | 278 | 803 | Domain | LDL-receptor class A 2 |
Hgene | >TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000406725 | - | 7 | 18 | 530_567 | 278 | 803 | Domain | LDL-receptor class A 3 |
Hgene | >TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000406725 | - | 7 | 18 | 577_811 | 278 | 803 | Domain | Peptidase S1 |
Hgene | >TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000406856 | - | 7 | 19 | 213_336 | 278 | 825 | Domain | CUB 1 |
Hgene | >TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000406856 | - | 7 | 19 | 335_452 | 278 | 825 | Domain | CUB 2 |
Hgene | >TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000406856 | - | 7 | 19 | 457_489 | 278 | 825 | Domain | LDL-receptor class A 1 |
Hgene | >TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000406856 | - | 7 | 19 | 490_526 | 278 | 825 | Domain | LDL-receptor class A 2 |
Hgene | >TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000406856 | - | 7 | 19 | 530_567 | 278 | 825 | Domain | LDL-receptor class A 3 |
Hgene | >TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000406856 | - | 7 | 19 | 577_811 | 278 | 825 | Domain | Peptidase S1 |
Hgene | >TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000346753 | - | 7 | 18 | 77_811 | 287 | 812 | Topological domain | Extracellular |
Hgene | >TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000381792 | - | 7 | 19 | 77_811 | 278 | 825 | Topological domain | Extracellular |
Hgene | >TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000406725 | - | 7 | 18 | 77_811 | 278 | 803 | Topological domain | Extracellular |
Hgene | >TMPRSS6 | chr22:37485618 | chr17:48455956 | ENST00000406856 | - | 7 | 19 | 77_811 | 278 | 825 | Topological domain | Extracellular |
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FusionGeneSequence for TMPRSS6_EME1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_TMPRSS6_ENST00000381792_chr22_37485618_-_EME1_ENST00000393271_chr17_48455956_+_561aa MPVAEAPQVAGGQGDGGDGEEAEPEGMFKACEDSKRKARGYLRLVPLFVLLALLVLASAGVLLWYFLGYKAEVMVSQVYSGSLRVLNRHF SQDLTRRESSAFRSETAKAQKMLKELITSTRLGTYYNSSSVYSFGEGPLTCFFWFILQIPEHRRLMLSPEVVQALLVEELLSTVNSSAAV PYRAEYEVDPEGLVILEASVKDIAALNSTLGCYRYSYVGQGQVLRLKGPDHLASSCLWHLQGPKDLMLKLRLEWTLAECRDRLAMYDVAG PLEKRLITSTERTGWRSQQYWCCSGQRHLCPXSTMESREAWTALXKGRKRFRALXLTSQQRQQGKLCHWXLWIRRNASAWSCCSLISSPA PVLRILQEEGNREQINRPRSSSRDNQRPAXGPWYPGXTLKRHWWICSYTQKPRLKLCRAGKSWPTSHAHSQRLWLRRPSRSSEMKLPSPS VWRVTGLEGXRWTLLAGDSHXSGGDRFSSXTESAWKWPVQLXMPIPPHSSWYRLISSVFRIKNARICSQTYRCAVGKVXHPLLAALDQNY >In-frame_TMPRSS6_ENST00000381792_chr22_37485618_-_EME1_ENST00000338165_chr17_48455956_+_548aa MPVAEAPQVAGGQGDGGDGEEAEPEGMFKACEDSKRKARGYLRLVPLFVLLALLVLASAGVLLWYFLGYKAEVMVSQVYSGSLRVLNRHF SQDLTRRESSAFRSETAKAQKMLKELITSTRLGTYYNSSSVYSFGEGPLTCFFWFILQIPEHRRLMLSPEVVQALLVEELLSTVNSSAAV PYRAEYEVDPEGLVILEASVKDIAALNSTLGCYRYSYVGQGQVLRLKGPDHLASSCLWHLQGPKDLMLKLRLEWTLAECRDRLAMYDVAG PLEKRLITSTERTGWRSQQYWCCSGQRHLCPXSTMESREAWTALXKGRKRFRALXLTSQQRQQGKLCHWXLWIRRNASVLRILQEEGNRE QINRPRSSSRDNQRPAXGPWYPGXTLKRHWWICSYTQKPRLKLCRAGKSWPTSHAHSQRLWLRRPSRSSEMKLPSPSVWRVTGLEGXRWT LLAGDSHXSGGDRFSSXTESAWKWPVQLXMPIPPHSSWYRLISSVFRIKNARICSQTYRCAVGKVXHPLLAALDQNYPGVSTFRXPLYSH >In-frame_TMPRSS6_ENST00000381792_chr22_37485618_-_EME1_ENST00000511648_chr17_48455956_+_561aa MPVAEAPQVAGGQGDGGDGEEAEPEGMFKACEDSKRKARGYLRLVPLFVLLALLVLASAGVLLWYFLGYKAEVMVSQVYSGSLRVLNRHF SQDLTRRESSAFRSETAKAQKMLKELITSTRLGTYYNSSSVYSFGEGPLTCFFWFILQIPEHRRLMLSPEVVQALLVEELLSTVNSSAAV PYRAEYEVDPEGLVILEASVKDIAALNSTLGCYRYSYVGQGQVLRLKGPDHLASSCLWHLQGPKDLMLKLRLEWTLAECRDRLAMYDVAG PLEKRLITSTERTGWRSQQYWCCSGQRHLCPXSTMESREAWTALXKGRKRFRALXLTSQQRQQGKLCHWXLWIRRNASAWSCCSLISSPA PVLRILQEEGNREQINRPRSSSRDNQRPAXGPWYPGXTLKRHWWICSYTQKPRLKLCRAGKSWPTSHAHSQRLWLRRPSRSSEMKLPSPS VWRVTGLEGXRWTLLAGDSHXSGGDRFSSXTESAWKWPVQLXMPIPPHSSWYRLISSVFRIKNARICSQTYRCAVGKVXHPLLAALDQNY |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_TMPRSS6_ENST00000381792_chr22_37485618_-_EME1_ENST00000393271_chr17_48455956_+_1685nt ATGCCCGTGGCCGAGGCCCCCCAGGTGGCTGGCGGGCAGGGGGACGGAGGTGATGGCGAGGAAGCGGAGCCGGAGGGGATGTTCAAGGCC TGTGAGGACTCCAAGAGAAAAGCCCGGGGCTACCTCCGCCTGGTGCCCCTGTTTGTGCTGCTGGCCCTGCTCGTGCTGGCTTCGGCGGGG GTGCTACTCTGGTATTTCCTAGGGTACAAGGCGGAGGTGATGGTCAGCCAGGTGTACTCAGGCAGTCTGCGTGTACTCAATCGCCACTTC TCCCAGGATCTTACCCGCCGGGAATCTAGTGCCTTCCGCAGTGAAACCGCCAAAGCCCAGAAGATGCTCAAGGAGCTCATCACCAGCACC CGCCTGGGAACTTACTACAACTCCAGCTCCGTCTATTCCTTTGGGGAGGGACCCCTCACCTGCTTCTTCTGGTTCATTCTCCAAATCCCC GAGCACCGCCGGCTGATGCTGAGCCCCGAGGTGGTGCAGGCACTGCTGGTGGAGGAGCTGCTGTCCACAGTCAACAGCTCGGCTGCCGTC CCCTACAGGGCCGAGTACGAAGTGGACCCCGAGGGCCTAGTGATCCTGGAAGCCAGTGTGAAAGACATAGCTGCATTGAATTCCACGCTG GGTTGTTACCGCTACAGCTACGTGGGCCAGGGCCAGGTCCTCCGGCTGAAGGGGCCTGACCACCTGGCCTCCAGCTGCCTGTGGCACCTG CAGGGCCCCAAGGACCTCATGCTCAAACTCCGGCTGGAGTGGACGCTGGCAGAGTGCCGGGACCGACTGGCCATGTATGACGTGGCCGGG CCCCTGGAGAAGAGGCTCATCACCTCGACAGAGAGGACTGGGTGGAGGAGCCAACAGTACTGGTGTTGCTCCGGGCAGAGGCATTTGTGT CCATGATCGACAATGGAAAGCAGGGAAGCCTGGACAGCACTATGAAAGGGAAGGAAACGCTTCAGGGCTTTGTAACTGACATCACAGCAA AGACAGCAGGGAAAGCTCTGTCACTGGTGATTGTGGATCAGGAGAAATGCTTCAGCCTGGAGCTGCTGTTCTTTGATTTCCTCCCCTGCA CCAGTGCTCAGAATCCTCCAAGAAGAGGGAAACAGGGAGCAAATAAACAGACCAAGAAGCAGCAGCAGAGACAACCAGAGGCCAGCATAG GGTCCATGGTATCCAGGGTAGACGCTGAAGAGGCATTGGTGGATCTGCAGCTACACACAGAAGCCCAGGCTCAAATTGTGCAGAGCTGGA AAGAGCTGGCCGACTTCACATGCGCATTCACAAAGGCTGTGGCTGAGGCGCCCTTCAAGAAGCTCCGAGATGAAACTACCTTCTCCTTCT GTCTGGAGAGTGACTGGGCTGGAGGGGTGAAGGTGGACCTTGCTGGCAGGGGACTCGCACTAGTCTGGAGGAGACAGATTCAGCAGCTGA ACCGAGTCAGCCTGGAAATGGCCAGTGCAGTTGTGAATGCCTATCCCTCCCCACAGCTCCTGGTACAGGCTTATCAGCAGTGTTTTTCGG ATAAAGAACGCCAGAATTTGCTCGCAGACATACAGGTGCGCCGTGGGGAAGGTGTGACATCCACTTCTCGCCGCATTGGACCAGAACTAT >In-frame_TMPRSS6_ENST00000381792_chr22_37485618_-_EME1_ENST00000338165_chr17_48455956_+_1646nt ATGCCCGTGGCCGAGGCCCCCCAGGTGGCTGGCGGGCAGGGGGACGGAGGTGATGGCGAGGAAGCGGAGCCGGAGGGGATGTTCAAGGCC TGTGAGGACTCCAAGAGAAAAGCCCGGGGCTACCTCCGCCTGGTGCCCCTGTTTGTGCTGCTGGCCCTGCTCGTGCTGGCTTCGGCGGGG GTGCTACTCTGGTATTTCCTAGGGTACAAGGCGGAGGTGATGGTCAGCCAGGTGTACTCAGGCAGTCTGCGTGTACTCAATCGCCACTTC TCCCAGGATCTTACCCGCCGGGAATCTAGTGCCTTCCGCAGTGAAACCGCCAAAGCCCAGAAGATGCTCAAGGAGCTCATCACCAGCACC CGCCTGGGAACTTACTACAACTCCAGCTCCGTCTATTCCTTTGGGGAGGGACCCCTCACCTGCTTCTTCTGGTTCATTCTCCAAATCCCC GAGCACCGCCGGCTGATGCTGAGCCCCGAGGTGGTGCAGGCACTGCTGGTGGAGGAGCTGCTGTCCACAGTCAACAGCTCGGCTGCCGTC CCCTACAGGGCCGAGTACGAAGTGGACCCCGAGGGCCTAGTGATCCTGGAAGCCAGTGTGAAAGACATAGCTGCATTGAATTCCACGCTG GGTTGTTACCGCTACAGCTACGTGGGCCAGGGCCAGGTCCTCCGGCTGAAGGGGCCTGACCACCTGGCCTCCAGCTGCCTGTGGCACCTG CAGGGCCCCAAGGACCTCATGCTCAAACTCCGGCTGGAGTGGACGCTGGCAGAGTGCCGGGACCGACTGGCCATGTATGACGTGGCCGGG CCCCTGGAGAAGAGGCTCATCACCTCGACAGAGAGGACTGGGTGGAGGAGCCAACAGTACTGGTGTTGCTCCGGGCAGAGGCATTTGTGT CCATGATCGACAATGGAAAGCAGGGAAGCCTGGACAGCACTATGAAAGGGAAGGAAACGCTTCAGGGCTTTGTAACTGACATCACAGCAA AGACAGCAGGGAAAGCTCTGTCACTGGTGATTGTGGATCAGGAGAAATGCTTCAGTGCTCAGAATCCTCCAAGAAGAGGGAAACAGGGAG CAAATAAACAGACCAAGAAGCAGCAGCAGAGACAACCAGAGGCCAGCATAGGGTCCATGGTATCCAGGGTAGACGCTGAAGAGGCATTGG TGGATCTGCAGCTACACACAGAAGCCCAGGCTCAAATTGTGCAGAGCTGGAAAGAGCTGGCCGACTTCACATGCGCATTCACAAAGGCTG TGGCTGAGGCGCCCTTCAAGAAGCTCCGAGATGAAACTACCTTCTCCTTCTGTCTGGAGAGTGACTGGGCTGGAGGGGTGAAGGTGGACC TTGCTGGCAGGGGACTCGCACTAGTCTGGAGGAGACAGATTCAGCAGCTGAACCGAGTCAGCCTGGAAATGGCCAGTGCAGTTGTGAATG CCTATCCCTCCCCACAGCTCCTGGTACAGGCTTATCAGCAGTGTTTTTCGGATAAAGAACGCCAGAATTTGCTCGCAGACATACAGGTGC GCCGTGGGGAAGGTGTGACATCCACTTCTCGCCGCATTGGACCAGAACTATCCAGGCGTATCTACCTTCAGATGACCACTTTACAGCCAC >In-frame_TMPRSS6_ENST00000381792_chr22_37485618_-_EME1_ENST00000511648_chr17_48455956_+_1685nt ATGCCCGTGGCCGAGGCCCCCCAGGTGGCTGGCGGGCAGGGGGACGGAGGTGATGGCGAGGAAGCGGAGCCGGAGGGGATGTTCAAGGCC TGTGAGGACTCCAAGAGAAAAGCCCGGGGCTACCTCCGCCTGGTGCCCCTGTTTGTGCTGCTGGCCCTGCTCGTGCTGGCTTCGGCGGGG GTGCTACTCTGGTATTTCCTAGGGTACAAGGCGGAGGTGATGGTCAGCCAGGTGTACTCAGGCAGTCTGCGTGTACTCAATCGCCACTTC TCCCAGGATCTTACCCGCCGGGAATCTAGTGCCTTCCGCAGTGAAACCGCCAAAGCCCAGAAGATGCTCAAGGAGCTCATCACCAGCACC CGCCTGGGAACTTACTACAACTCCAGCTCCGTCTATTCCTTTGGGGAGGGACCCCTCACCTGCTTCTTCTGGTTCATTCTCCAAATCCCC GAGCACCGCCGGCTGATGCTGAGCCCCGAGGTGGTGCAGGCACTGCTGGTGGAGGAGCTGCTGTCCACAGTCAACAGCTCGGCTGCCGTC CCCTACAGGGCCGAGTACGAAGTGGACCCCGAGGGCCTAGTGATCCTGGAAGCCAGTGTGAAAGACATAGCTGCATTGAATTCCACGCTG GGTTGTTACCGCTACAGCTACGTGGGCCAGGGCCAGGTCCTCCGGCTGAAGGGGCCTGACCACCTGGCCTCCAGCTGCCTGTGGCACCTG CAGGGCCCCAAGGACCTCATGCTCAAACTCCGGCTGGAGTGGACGCTGGCAGAGTGCCGGGACCGACTGGCCATGTATGACGTGGCCGGG CCCCTGGAGAAGAGGCTCATCACCTCGACAGAGAGGACTGGGTGGAGGAGCCAACAGTACTGGTGTTGCTCCGGGCAGAGGCATTTGTGT CCATGATCGACAATGGAAAGCAGGGAAGCCTGGACAGCACTATGAAAGGGAAGGAAACGCTTCAGGGCTTTGTAACTGACATCACAGCAA AGACAGCAGGGAAAGCTCTGTCACTGGTGATTGTGGATCAGGAGAAATGCTTCAGCCTGGAGCTGCTGTTCTTTGATTTCCTCCCCTGCA CCAGTGCTCAGAATCCTCCAAGAAGAGGGAAACAGGGAGCAAATAAACAGACCAAGAAGCAGCAGCAGAGACAACCAGAGGCCAGCATAG GGTCCATGGTATCCAGGGTAGACGCTGAAGAGGCATTGGTGGATCTGCAGCTACACACAGAAGCCCAGGCTCAAATTGTGCAGAGCTGGA AAGAGCTGGCCGACTTCACATGCGCATTCACAAAGGCTGTGGCTGAGGCGCCCTTCAAGAAGCTCCGAGATGAAACTACCTTCTCCTTCT GTCTGGAGAGTGACTGGGCTGGAGGGGTGAAGGTGGACCTTGCTGGCAGGGGACTCGCACTAGTCTGGAGGAGACAGATTCAGCAGCTGA ACCGAGTCAGCCTGGAAATGGCCAGTGCAGTTGTGAATGCCTATCCCTCCCCACAGCTCCTGGTACAGGCTTATCAGCAGTGTTTTTCGG ATAAAGAACGCCAGAATTTGCTCGCAGACATACAGGTGCGCCGTGGGGAAGGTGTGACATCCACTTCTCGCCGCATTGGACCAGAACTAT |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_TMPRSS6_ENST00000381792_chr22_37485618_-_EME1_ENST00000393271_chr17_48455956_+_2346nt CTTGAGCCAGACCCAGTCCAGCTCTGGTGCCTGCCCTCTGGTGCGAGCTGACCTGAGATGCACTTCCCTCCTCTGTGAGCTGTCTCGGCA CCCACTTGCAGTCACTGCCGCCTGATGTTGTTACTCTTCCACTCCAAAAGGATGCCCGTGGCCGAGGCCCCCCAGGTGGCTGGCGGGCAG GGGGACGGAGGTGATGGCGAGGAAGCGGAGCCGGAGGGGATGTTCAAGGCCTGTGAGGACTCCAAGAGAAAAGCCCGGGGCTACCTCCGC CTGGTGCCCCTGTTTGTGCTGCTGGCCCTGCTCGTGCTGGCTTCGGCGGGGGTGCTACTCTGGTATTTCCTAGGGTACAAGGCGGAGGTG ATGGTCAGCCAGGTGTACTCAGGCAGTCTGCGTGTACTCAATCGCCACTTCTCCCAGGATCTTACCCGCCGGGAATCTAGTGCCTTCCGC AGTGAAACCGCCAAAGCCCAGAAGATGCTCAAGGAGCTCATCACCAGCACCCGCCTGGGAACTTACTACAACTCCAGCTCCGTCTATTCC TTTGGGGAGGGACCCCTCACCTGCTTCTTCTGGTTCATTCTCCAAATCCCCGAGCACCGCCGGCTGATGCTGAGCCCCGAGGTGGTGCAG GCACTGCTGGTGGAGGAGCTGCTGTCCACAGTCAACAGCTCGGCTGCCGTCCCCTACAGGGCCGAGTACGAAGTGGACCCCGAGGGCCTA GTGATCCTGGAAGCCAGTGTGAAAGACATAGCTGCATTGAATTCCACGCTGGGTTGTTACCGCTACAGCTACGTGGGCCAGGGCCAGGTC CTCCGGCTGAAGGGGCCTGACCACCTGGCCTCCAGCTGCCTGTGGCACCTGCAGGGCCCCAAGGACCTCATGCTCAAACTCCGGCTGGAG TGGACGCTGGCAGAGTGCCGGGACCGACTGGCCATGTATGACGTGGCCGGGCCCCTGGAGAAGAGGCTCATCACCTCGACAGAGAGGACT GGGTGGAGGAGCCAACAGTACTGGTGTTGCTCCGGGCAGAGGCATTTGTGTCCATGATCGACAATGGAAAGCAGGGAAGCCTGGACAGCA CTATGAAAGGGAAGGAAACGCTTCAGGGCTTTGTAACTGACATCACAGCAAAGACAGCAGGGAAAGCTCTGTCACTGGTGATTGTGGATC AGGAGAAATGCTTCAGCCTGGAGCTGCTGTTCTTTGATTTCCTCCCCTGCACCAGTGCTCAGAATCCTCCAAGAAGAGGGAAACAGGGAG CAAATAAACAGACCAAGAAGCAGCAGCAGAGACAACCAGAGGCCAGCATAGGGTCCATGGTATCCAGGGTAGACGCTGAAGAGGCATTGG TGGATCTGCAGCTACACACAGAAGCCCAGGCTCAAATTGTGCAGAGCTGGAAAGAGCTGGCCGACTTCACATGCGCATTCACAAAGGCTG TGGCTGAGGCGCCCTTCAAGAAGCTCCGAGATGAAACTACCTTCTCCTTCTGTCTGGAGAGTGACTGGGCTGGAGGGGTGAAGGTGGACC TTGCTGGCAGGGGACTCGCACTAGTCTGGAGGAGACAGATTCAGCAGCTGAACCGAGTCAGCCTGGAAATGGCCAGTGCAGTTGTGAATG CCTATCCCTCCCCACAGCTCCTGGTACAGGCTTATCAGCAGTGTTTTTCGGATAAAGAACGCCAGAATTTGCTCGCAGACATACAGGTGC GCCGTGGGGAAGGTGTGACATCCACTTCTCGCCGCATTGGACCAGAACTATCCAGGCGTATCTACCTTCAGATGACCACTTTACAGCCAC ATCTCTCTTTAGATAGTGCTGACTGATTCTAGCCCTCAGGGATGAGGATGAAAAGCTGGAAACTTCCACTTCCCCAACCTCAGAGCCTGA CTGTAATGAAGAGACTGGCAGCACCTCCTGGAACACAAGCCTAGGTGAGGCCCAGTCTTTCTTGGGTCTTATTATTTGTGAAGGTCTCTC TGCCTGTCGGCTGGGGCAGAGACTGAAATACTGCCACCTACCTTTGGCATTTAATGTTCCTCTCCTGGCAAAAATTCACTGCCACAGACA AACCACCCCCACTCCTACCCAGCCAGCCCTCAAAACACAAAGGAACAAAGACAGTCCACTCAGACACTTATTTAATAACTGTAGAAATCC AAAAGAATTAGCATCAAATCTTGAAGTCGTGAGTGAAGCTGCGGGTTGGCTTGACTGGGCTCAGCCACTGAGCTGCCTCAACCGGCCAAG GAACGGGATTATGATGACTATGCGGACTTCTATATTGTCTTCATCTCATTGTGTGTATTATGTATTTAGTTTCAATAAAGCATTTGTACC >In-frame_TMPRSS6_ENST00000381792_chr22_37485618_-_EME1_ENST00000338165_chr17_48455956_+_2331nt CTTGAGCCAGACCCAGTCCAGCTCTGGTGCCTGCCCTCTGGTGCGAGCTGACCTGAGATGCACTTCCCTCCTCTGTGAGCTGTCTCGGCA CCCACTTGCAGTCACTGCCGCCTGATGTTGTTACTCTTCCACTCCAAAAGGATGCCCGTGGCCGAGGCCCCCCAGGTGGCTGGCGGGCAG GGGGACGGAGGTGATGGCGAGGAAGCGGAGCCGGAGGGGATGTTCAAGGCCTGTGAGGACTCCAAGAGAAAAGCCCGGGGCTACCTCCGC CTGGTGCCCCTGTTTGTGCTGCTGGCCCTGCTCGTGCTGGCTTCGGCGGGGGTGCTACTCTGGTATTTCCTAGGGTACAAGGCGGAGGTG ATGGTCAGCCAGGTGTACTCAGGCAGTCTGCGTGTACTCAATCGCCACTTCTCCCAGGATCTTACCCGCCGGGAATCTAGTGCCTTCCGC AGTGAAACCGCCAAAGCCCAGAAGATGCTCAAGGAGCTCATCACCAGCACCCGCCTGGGAACTTACTACAACTCCAGCTCCGTCTATTCC TTTGGGGAGGGACCCCTCACCTGCTTCTTCTGGTTCATTCTCCAAATCCCCGAGCACCGCCGGCTGATGCTGAGCCCCGAGGTGGTGCAG GCACTGCTGGTGGAGGAGCTGCTGTCCACAGTCAACAGCTCGGCTGCCGTCCCCTACAGGGCCGAGTACGAAGTGGACCCCGAGGGCCTA GTGATCCTGGAAGCCAGTGTGAAAGACATAGCTGCATTGAATTCCACGCTGGGTTGTTACCGCTACAGCTACGTGGGCCAGGGCCAGGTC CTCCGGCTGAAGGGGCCTGACCACCTGGCCTCCAGCTGCCTGTGGCACCTGCAGGGCCCCAAGGACCTCATGCTCAAACTCCGGCTGGAG TGGACGCTGGCAGAGTGCCGGGACCGACTGGCCATGTATGACGTGGCCGGGCCCCTGGAGAAGAGGCTCATCACCTCGACAGAGAGGACT GGGTGGAGGAGCCAACAGTACTGGTGTTGCTCCGGGCAGAGGCATTTGTGTCCATGATCGACAATGGAAAGCAGGGAAGCCTGGACAGCA CTATGAAAGGGAAGGAAACGCTTCAGGGCTTTGTAACTGACATCACAGCAAAGACAGCAGGGAAAGCTCTGTCACTGGTGATTGTGGATC AGGAGAAATGCTTCAGTGCTCAGAATCCTCCAAGAAGAGGGAAACAGGGAGCAAATAAACAGACCAAGAAGCAGCAGCAGAGACAACCAG AGGCCAGCATAGGGTCCATGGTATCCAGGGTAGACGCTGAAGAGGCATTGGTGGATCTGCAGCTACACACAGAAGCCCAGGCTCAAATTG TGCAGAGCTGGAAAGAGCTGGCCGACTTCACATGCGCATTCACAAAGGCTGTGGCTGAGGCGCCCTTCAAGAAGCTCCGAGATGAAACTA CCTTCTCCTTCTGTCTGGAGAGTGACTGGGCTGGAGGGGTGAAGGTGGACCTTGCTGGCAGGGGACTCGCACTAGTCTGGAGGAGACAGA TTCAGCAGCTGAACCGAGTCAGCCTGGAAATGGCCAGTGCAGTTGTGAATGCCTATCCCTCCCCACAGCTCCTGGTACAGGCTTATCAGC AGTGTTTTTCGGATAAAGAACGCCAGAATTTGCTCGCAGACATACAGGTGCGCCGTGGGGAAGGTGTGACATCCACTTCTCGCCGCATTG GACCAGAACTATCCAGGCGTATCTACCTTCAGATGACCACTTTACAGCCACATCTCTCTTTAGATAGTGCTGACTGATTCTAGCCCTCAG GGATGAGGATGAAAAGCTGGAAACTTCCACTTCCCCAACCTCAGAGCCTGACTGTAATGAAGAGACTGGCAGCACCTCCTGGAACACAAG CCTAGGTGAGGCCCAGTCTTTCTTGGGTCTTATTATTTGTGAAGGTCTCTCTGCCTGTCGGCTGGGGCAGAGACTGAAATACTGCCACCT ACCTTTGGCATTTAATGTTCCTCTCCTGGCAAAAATTCACTGCCACAGACAAACCACCCCCACTCCTACCCAGCCAGCCCTCAAAACACA AAGGAACAAAGACAGTCCACTCAGACACTTATTTAATAACTGTAGAAATCCAAAAGAATTAGCATCAAATCTTGAAGTCGTGAGTGAAGC TGCGGGTTGGCTTGACTGGGCTCAGCCACTGAGCTGCCTCAACCGGCCAAGGAACGGGATTATGATGACTATGCGGACTTCTATATTGTC >In-frame_TMPRSS6_ENST00000381792_chr22_37485618_-_EME1_ENST00000511648_chr17_48455956_+_2346nt CTTGAGCCAGACCCAGTCCAGCTCTGGTGCCTGCCCTCTGGTGCGAGCTGACCTGAGATGCACTTCCCTCCTCTGTGAGCTGTCTCGGCA CCCACTTGCAGTCACTGCCGCCTGATGTTGTTACTCTTCCACTCCAAAAGGATGCCCGTGGCCGAGGCCCCCCAGGTGGCTGGCGGGCAG GGGGACGGAGGTGATGGCGAGGAAGCGGAGCCGGAGGGGATGTTCAAGGCCTGTGAGGACTCCAAGAGAAAAGCCCGGGGCTACCTCCGC CTGGTGCCCCTGTTTGTGCTGCTGGCCCTGCTCGTGCTGGCTTCGGCGGGGGTGCTACTCTGGTATTTCCTAGGGTACAAGGCGGAGGTG ATGGTCAGCCAGGTGTACTCAGGCAGTCTGCGTGTACTCAATCGCCACTTCTCCCAGGATCTTACCCGCCGGGAATCTAGTGCCTTCCGC AGTGAAACCGCCAAAGCCCAGAAGATGCTCAAGGAGCTCATCACCAGCACCCGCCTGGGAACTTACTACAACTCCAGCTCCGTCTATTCC TTTGGGGAGGGACCCCTCACCTGCTTCTTCTGGTTCATTCTCCAAATCCCCGAGCACCGCCGGCTGATGCTGAGCCCCGAGGTGGTGCAG GCACTGCTGGTGGAGGAGCTGCTGTCCACAGTCAACAGCTCGGCTGCCGTCCCCTACAGGGCCGAGTACGAAGTGGACCCCGAGGGCCTA GTGATCCTGGAAGCCAGTGTGAAAGACATAGCTGCATTGAATTCCACGCTGGGTTGTTACCGCTACAGCTACGTGGGCCAGGGCCAGGTC CTCCGGCTGAAGGGGCCTGACCACCTGGCCTCCAGCTGCCTGTGGCACCTGCAGGGCCCCAAGGACCTCATGCTCAAACTCCGGCTGGAG TGGACGCTGGCAGAGTGCCGGGACCGACTGGCCATGTATGACGTGGCCGGGCCCCTGGAGAAGAGGCTCATCACCTCGACAGAGAGGACT GGGTGGAGGAGCCAACAGTACTGGTGTTGCTCCGGGCAGAGGCATTTGTGTCCATGATCGACAATGGAAAGCAGGGAAGCCTGGACAGCA CTATGAAAGGGAAGGAAACGCTTCAGGGCTTTGTAACTGACATCACAGCAAAGACAGCAGGGAAAGCTCTGTCACTGGTGATTGTGGATC AGGAGAAATGCTTCAGCCTGGAGCTGCTGTTCTTTGATTTCCTCCCCTGCACCAGTGCTCAGAATCCTCCAAGAAGAGGGAAACAGGGAG CAAATAAACAGACCAAGAAGCAGCAGCAGAGACAACCAGAGGCCAGCATAGGGTCCATGGTATCCAGGGTAGACGCTGAAGAGGCATTGG TGGATCTGCAGCTACACACAGAAGCCCAGGCTCAAATTGTGCAGAGCTGGAAAGAGCTGGCCGACTTCACATGCGCATTCACAAAGGCTG TGGCTGAGGCGCCCTTCAAGAAGCTCCGAGATGAAACTACCTTCTCCTTCTGTCTGGAGAGTGACTGGGCTGGAGGGGTGAAGGTGGACC TTGCTGGCAGGGGACTCGCACTAGTCTGGAGGAGACAGATTCAGCAGCTGAACCGAGTCAGCCTGGAAATGGCCAGTGCAGTTGTGAATG CCTATCCCTCCCCACAGCTCCTGGTACAGGCTTATCAGCAGTGTTTTTCGGATAAAGAACGCCAGAATTTGCTCGCAGACATACAGGTGC GCCGTGGGGAAGGTGTGACATCCACTTCTCGCCGCATTGGACCAGAACTATCCAGGCGTATCTACCTTCAGATGACCACTTTACAGCCAC ATCTCTCTTTAGATAGTGCTGACTGATTCTAGCCCTCAGGGATGAGGATGAAAAGCTGGAAACTTCCACTTCCCCAACCTCAGAGCCTGA CTGTAATGAAGAGACTGGCAGCACCTCCTGGAACACAAGCCTAGGTGAGGCCCAGTCTTTCTTGGGTCTTATTATTTGTGAAGGTCTCTC TGCCTGTCGGCTGGGGCAGAGACTGAAATACTGCCACCTACCTTTGGCATTTAATGTTCCTCTCCTGGCAAAAATTCACTGCCACAGACA AACCACCCCCACTCCTACCCAGCCAGCCCTCAAAACACAAAGGAACAAAGACAGTCCACTCAGACACTTATTTAATAACTGTAGAAATCC AAAAGAATTAGCATCAAATCTTGAAGTCGTGAGTGAAGCTGCGGGTTGGCTTGACTGGGCTCAGCCACTGAGCTGCCTCAACCGGCCAAG GAACGGGATTATGATGACTATGCGGACTTCTATATTGTCTTCATCTCATTGTGTGTATTATGTATTTAGTTTCAATAAAGCATTTGTACC |
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FusionGenePPI for TMPRSS6_EME1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TMPRSS6 | EME1 | MUS81, SLX4, SLX1B, SLX1A, APP, SUMO2, RBM33, KLK5, UHRF1, HIST1H2BG, HERC2, HNRNPU, PML, SORT1, YEATS4, CCDC88A, UGGT1, VWA9, KIF18A, PARD6B, CNTROB, USF1, CCL22, SNX21, INTU, NEUROG3, IDO2, DDB1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMPRSS6_EME1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMPRSS6_EME1 |
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Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TMPRSS6 | C0085576 | Iron-Refractory Iron Deficiency Anemia | 7 | CTD_human;ORPHANET;UNIPROT |
Hgene | TMPRSS6 | C0162316 | Iron deficiency anemia | 2 | CTD_human |