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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 38768

FusionGeneSummary for TMPRSS2_TMEFF2

check button Fusion gene summary
Fusion gene informationFusion gene name: TMPRSS2_TMEFF2
Fusion gene ID: 38768
HgeneTgene
Gene symbol

TMPRSS2

TMEFF2

Gene ID

7113

23671

Gene nametransmembrane serine protease 2transmembrane protein with EGF like and two follistatin like domains 2
SynonymsPP9284|PRSS10CT120.2|HPP1|TENB2|TPEF|TR|TR-2
Cytomap

21q22.3

2q32.3

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protease serine 2epitheliasinserine protease 10transmembrane protease, serine 2tomoregulin-2cancer/testis antigen family 120, member 2hyperplastic polyposis protein 1transmembrane protein TENB2transmembrane protein with EGF-like and two follistatin-like domains
Modification date2018052320180519
UniProtAcc

O15393

Q9UIK5

Ensembl transtripts involved in fusion geneENST00000332149, ENST00000398585, 
ENST00000458356, ENST00000497881, 
ENST00000392314, ENST00000272771, 
ENST00000487771, ENST00000409056, 
Fusion gene scores* DoF score29 X 21 X 6=36542 X 2 X 1=4
# samples 2282
** MAII scorelog2(228/3654*10)=-0.680442809575384
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context

PubMed: TMPRSS2 [Title/Abstract] AND TMEFF2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
Tissue-specifically expressed gene involved fusion gene, inframe and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTMPRSS2

GO:0006508

proteolysis

21068237|24227843

HgeneTMPRSS2

GO:0046598

positive regulation of viral entry into host cell

21068237|24227843

TgeneTMEFF2

GO:0030336

negative regulation of cell migration

24632071

TgeneTMEFF2

GO:0044319

wound healing, spreading of cells

24632071

TgeneTMEFF2

GO:0051497

negative regulation of stress fiber assembly

24632071


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-KK-A59Y-01ATMPRSS2chr21

42852403

-TMEFF2chr2

192863934

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000332149ENST00000392314TMPRSS2chr21

42852403

-TMEFF2chr2

192863934

-
In-frameENST00000332149ENST00000272771TMPRSS2chr21

42852403

-TMEFF2chr2

192863934

-
Frame-shiftENST00000332149ENST00000487771TMPRSS2chr21

42852403

-TMEFF2chr2

192863934

-
5CDS-intronENST00000332149ENST00000409056TMPRSS2chr21

42852403

-TMEFF2chr2

192863934

-
In-frameENST00000398585ENST00000392314TMPRSS2chr21

42852403

-TMEFF2chr2

192863934

-
In-frameENST00000398585ENST00000272771TMPRSS2chr21

42852403

-TMEFF2chr2

192863934

-
Frame-shiftENST00000398585ENST00000487771TMPRSS2chr21

42852403

-TMEFF2chr2

192863934

-
5CDS-intronENST00000398585ENST00000409056TMPRSS2chr21

42852403

-TMEFF2chr2

192863934

-
Frame-shiftENST00000458356ENST00000392314TMPRSS2chr21

42852403

-TMEFF2chr2

192863934

-
Frame-shiftENST00000458356ENST00000272771TMPRSS2chr21

42852403

-TMEFF2chr2

192863934

-
Frame-shiftENST00000458356ENST00000487771TMPRSS2chr21

42852403

-TMEFF2chr2

192863934

-
5CDS-intronENST00000458356ENST00000409056TMPRSS2chr21

42852403

-TMEFF2chr2

192863934

-
intron-3CDSENST00000497881ENST00000392314TMPRSS2chr21

42852403

-TMEFF2chr2

192863934

-
intron-3CDSENST00000497881ENST00000272771TMPRSS2chr21

42852403

-TMEFF2chr2

192863934

-
intron-3CDSENST00000497881ENST00000487771TMPRSS2chr21

42852403

-TMEFF2chr2

192863934

-
intron-intronENST00000497881ENST00000409056TMPRSS2chr21

42852403

-TMEFF2chr2

192863934

-

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FusionProtFeatures for TMPRSS2_TMEFF2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMPRSS2

O15393

TMEFF2

Q9UIK5

Serine protease that proteolytically cleaves andactivates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized andmaintained in precursor intermediate folding states andproteolysis permits the refolding and energy release required tocreate stable virus-cell linkages and membrane coalescence.Facilitates human SARS coronavirus (SARS-CoV) infection via twoindependent mechanisms, proteolytic cleavage of ACE2, which mightpromote viral uptake, and cleavage of coronavirus spikeglycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activatesthe spike glycoproteins of human coronavirus 229E (HCoV-229E) andhuman coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0of Sendai virus (SeV), human metapneumovirus (HMPV), humanparainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential forspread and pathogenesis of influenza A virus (strains H1N1, H3N2and H7N9); involved in proteolytic cleavage and activation ofhemagglutinin (HA) protein which is essential for viralinfectivity. {ECO:0000269|PubMed:21068237,ECO:0000269|PubMed:21325420, ECO:0000269|PubMed:23536651,ECO:0000269|PubMed:23966399, ECO:0000269|PubMed:24027332,ECO:0000269|PubMed:24227843}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMPRSS2chr21:42852403chr2:192863934ENST00000332149-614112_149190493DomainLDL-receptor class A
HgeneTMPRSS2chr21:42852403chr2:192863934ENST00000398585-614112_149227530DomainLDL-receptor class A
HgeneTMPRSS2chr21:42852403chr2:192863934ENST00000458356-614112_149190493DomainLDL-receptor class A
HgeneTMPRSS2chr21:42852403chr2:192863934ENST00000332149-6141_84190493Topological domainCytoplasmic
HgeneTMPRSS2chr21:42852403chr2:192863934ENST00000398585-6141_84227530Topological domainCytoplasmic
HgeneTMPRSS2chr21:42852403chr2:192863934ENST00000458356-6141_84190493Topological domainCytoplasmic
HgeneTMPRSS2chr21:42852403chr2:192863934ENST00000332149-61485_105190493TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42852403chr2:192863934ENST00000398585-61485_105227530TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42852403chr2:192863934ENST00000458356-61485_105190493TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTMEFF2chr21:42852403chr2:192863934ENST00000272771-410176_229178375DomainKazal-like 2
TgeneTMEFF2chr21:42852403chr2:192863934ENST00000272771-410261_301178375DomainEGF-like
TgeneTMEFF2chr21:42852403chr2:192863934ENST00000392314-410176_229178347DomainKazal-like 2
TgeneTMEFF2chr21:42852403chr2:192863934ENST00000392314-410261_301178347DomainEGF-like
TgeneTMEFF2chr21:42852403chr2:192863934ENST00000409056-04176_2290176DomainKazal-like 2
TgeneTMEFF2chr21:42852403chr2:192863934ENST00000409056-04261_3010176DomainEGF-like
TgeneTMEFF2chr21:42852403chr2:192863934ENST00000409056-0485_1370176DomainKazal-like 1
TgeneTMEFF2chr21:42852403chr2:192863934ENST00000272771-410303_320178375RegionNote=Required for shedding
TgeneTMEFF2chr21:42852403chr2:192863934ENST00000392314-410303_320178347RegionNote=Required for shedding
TgeneTMEFF2chr21:42852403chr2:192863934ENST00000409056-04303_3200176RegionNote=Required for shedding
TgeneTMEFF2chr21:42852403chr2:192863934ENST00000272771-410342_374178375Topological domainCytoplasmic
TgeneTMEFF2chr21:42852403chr2:192863934ENST00000392314-410342_374178347Topological domainCytoplasmic
TgeneTMEFF2chr21:42852403chr2:192863934ENST00000409056-04342_3740176Topological domainCytoplasmic
TgeneTMEFF2chr21:42852403chr2:192863934ENST00000409056-0441_3200176Topological domainExtracellular
TgeneTMEFF2chr21:42852403chr2:192863934ENST00000272771-410321_341178375TransmembraneHelical
TgeneTMEFF2chr21:42852403chr2:192863934ENST00000392314-410321_341178347TransmembraneHelical
TgeneTMEFF2chr21:42852403chr2:192863934ENST00000409056-04321_3410176TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMPRSS2chr21:42852403chr2:192863934ENST00000332149-614150_242190493DomainSRCR
HgeneTMPRSS2chr21:42852403chr2:192863934ENST00000332149-614256_489190493DomainPeptidase S1
HgeneTMPRSS2chr21:42852403chr2:192863934ENST00000398585-614150_242227530DomainSRCR
HgeneTMPRSS2chr21:42852403chr2:192863934ENST00000398585-614256_489227530DomainPeptidase S1
HgeneTMPRSS2chr21:42852403chr2:192863934ENST00000458356-614150_242190493DomainSRCR
HgeneTMPRSS2chr21:42852403chr2:192863934ENST00000458356-614256_489190493DomainPeptidase S1
HgeneTMPRSS2chr21:42852403chr2:192863934ENST00000332149-614106_492190493Topological domainExtracellular
HgeneTMPRSS2chr21:42852403chr2:192863934ENST00000398585-614106_492227530Topological domainExtracellular
HgeneTMPRSS2chr21:42852403chr2:192863934ENST00000458356-614106_492190493Topological domainExtracellular
TgeneTMEFF2chr21:42852403chr2:192863934ENST00000272771-41085_137178375DomainKazal-like 1
TgeneTMEFF2chr21:42852403chr2:192863934ENST00000392314-41085_137178347DomainKazal-like 1
TgeneTMEFF2chr21:42852403chr2:192863934ENST00000272771-41041_320178375Topological domainExtracellular
TgeneTMEFF2chr21:42852403chr2:192863934ENST00000392314-41041_320178347Topological domainExtracellular


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FusionGeneSequence for TMPRSS2_TMEFF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TMPRSS2_ENST00000332149_chr21_42852403_-_TMEFF2_ENST00000392314_chr2_192863934_-_359aa
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLT
LGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENY
GRAACRDMGYKCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRCQDNTTTTTKSEDGHYARTDYAENANKLEESA

>In-frame_TMPRSS2_ENST00000332149_chr21_42852403_-_TMEFF2_ENST00000272771_chr2_192863934_-_387aa
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLT
LGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENY
GRAACRDMGYKCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRCQDNTTTTTKSEDGHYARTDYAENANKLEESA
REHHIPCPEHYNGFCMHGKCEHSINMQEPSCRCDAGYTGQHCEKKDYSVLYVVPGPVRFQYVLIAAVIGTIQIAVICVVVLCITRKCPRS

>In-frame_TMPRSS2_ENST00000398585_chr21_42852403_-_TMEFF2_ENST00000392314_chr2_192863934_-_396aa
MPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYA
PRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGE
DENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEV
MSLGRCQDNTTTTTKSEDGHYARTDYAENANKLEESAREHHIPCPEHYNGFCMHGKCEHSINMQEPSCRCDAGYTGQHCEKKDYSVLYVV

>In-frame_TMPRSS2_ENST00000398585_chr21_42852403_-_TMEFF2_ENST00000272771_chr2_192863934_-_424aa
MPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYA
PRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGE
DENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEV
MSLGRCQDNTTTTTKSEDGHYARTDYAENANKLEESAREHHIPCPEHYNGFCMHGKCEHSINMQEPSCRCDAGYTGQHCEKKDYSVLYVV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TMPRSS2_ENST00000332149_chr21_42852403_-_TMEFF2_ENST00000392314_chr2_192863934_-_1077nt
ATGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCC
ACTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCT
TCCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAAAGACTAAGAAAGCACTGTGCATCACCTTGACC
CTGGGGACCTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTCTGGAAGTTCATGGGCAGCAAGTGCTCCAACTCTGGGATAGAGTGC
GACTCCTCAGGTACCTGCATCAACCCCTCTAACTGGTGTGATGGCGTGTCACACTGCCCCGGCGGGGAGGACGAGAATCGGTGTGTTCGC
CTCTACGGACCAAACTTCATCCTTCAGGTGTACTCATCTCAGAGGAAGTCCTGGCACCCTGTGTGCCAAGACGACTGGAACGAGAACTAC
GGGCGGGCGGCCTGCAGGGACATGGGCTATAAGTGTGTGTGTAATATTGACTGTTCTCAAACCAACTTCAATCCCCTCTGCGCTTCTGAT
GGGAAATCTTATGATAATGCATGCCAAATCAAAGAAGCATCGTGTCAGAAACAGGAGAAAATTGAAGTCATGTCTTTGGGTCGATGTCAA
GATAACACAACTACAACTACTAAGTCTGAAGATGGGCATTATGCAAGAACAGATTATGCAGAGAATGCTAACAAATTAGAAGAAAGTGCC
AGAGAACACCACATACCTTGTCCGGAACATTACAATGGCTTCTGCATGCATGGGAAGTGTGAGCATTCTATCAATATGCAGGAGCCATCT
TGCAGGTGTGATGCTGGTTATACTGGACAACACTGTGAAAAAAAGGACTACAGTGTTCTATACGTTGTTCCCGGTCCTGTACGATTTCAG

>In-frame_TMPRSS2_ENST00000332149_chr21_42852403_-_TMEFF2_ENST00000272771_chr2_192863934_-_1161nt
ATGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCC
ACTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCT
TCCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAAAGACTAAGAAAGCACTGTGCATCACCTTGACC
CTGGGGACCTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTCTGGAAGTTCATGGGCAGCAAGTGCTCCAACTCTGGGATAGAGTGC
GACTCCTCAGGTACCTGCATCAACCCCTCTAACTGGTGTGATGGCGTGTCACACTGCCCCGGCGGGGAGGACGAGAATCGGTGTGTTCGC
CTCTACGGACCAAACTTCATCCTTCAGGTGTACTCATCTCAGAGGAAGTCCTGGCACCCTGTGTGCCAAGACGACTGGAACGAGAACTAC
GGGCGGGCGGCCTGCAGGGACATGGGCTATAAGTGTGTGTGTAATATTGACTGTTCTCAAACCAACTTCAATCCCCTCTGCGCTTCTGAT
GGGAAATCTTATGATAATGCATGCCAAATCAAAGAAGCATCGTGTCAGAAACAGGAGAAAATTGAAGTCATGTCTTTGGGTCGATGTCAA
GATAACACAACTACAACTACTAAGTCTGAAGATGGGCATTATGCAAGAACAGATTATGCAGAGAATGCTAACAAATTAGAAGAAAGTGCC
AGAGAACACCACATACCTTGTCCGGAACATTACAATGGCTTCTGCATGCATGGGAAGTGTGAGCATTCTATCAATATGCAGGAGCCATCT
TGCAGGTGTGATGCTGGTTATACTGGACAACACTGTGAAAAAAAGGACTACAGTGTTCTATACGTTGTTCCCGGTCCTGTACGATTTCAG
TATGTCTTAATCGCAGCTGTGATTGGAACAATTCAGATTGCTGTCATCTGTGTGGTGGTCCTCTGCATCACAAGGAAATGCCCCAGAAGC

>In-frame_TMPRSS2_ENST00000398585_chr21_42852403_-_TMEFF2_ENST00000392314_chr2_192863934_-_1188nt
ATGCCCCCTGCCCCGCCCGGAGGTGAAAGCGGGTGTGAGGAGCGCGGCGCGGCAGGTCATATTGAACATTCCAGATACCTATCATTACTC
GATGCTGTTGATAACAGCAAGATGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAA
AACCCCTATCCCGCACAGCCCACTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCC
CCGAGGGTCCTGACGCAGGCTTCCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAAAGACTAAGAAA
GCACTGTGCATCACCTTGACCCTGGGGACCTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTCTGGAAGTTCATGGGCAGCAAGTGC
TCCAACTCTGGGATAGAGTGCGACTCCTCAGGTACCTGCATCAACCCCTCTAACTGGTGTGATGGCGTGTCACACTGCCCCGGCGGGGAG
GACGAGAATCGGTGTGTTCGCCTCTACGGACCAAACTTCATCCTTCAGGTGTACTCATCTCAGAGGAAGTCCTGGCACCCTGTGTGCCAA
GACGACTGGAACGAGAACTACGGGCGGGCGGCCTGCAGGGACATGGGCTATAAGTGTGTGTGTAATATTGACTGTTCTCAAACCAACTTC
AATCCCCTCTGCGCTTCTGATGGGAAATCTTATGATAATGCATGCCAAATCAAAGAAGCATCGTGTCAGAAACAGGAGAAAATTGAAGTC
ATGTCTTTGGGTCGATGTCAAGATAACACAACTACAACTACTAAGTCTGAAGATGGGCATTATGCAAGAACAGATTATGCAGAGAATGCT
AACAAATTAGAAGAAAGTGCCAGAGAACACCACATACCTTGTCCGGAACATTACAATGGCTTCTGCATGCATGGGAAGTGTGAGCATTCT
ATCAATATGCAGGAGCCATCTTGCAGGTGTGATGCTGGTTATACTGGACAACACTGTGAAAAAAAGGACTACAGTGTTCTATACGTTGTT
CCCGGTCCTGTACGATTTCAGTATGTCTTAATCGCAGCTGTGATTGGAACAATTCAGATTGCTGTCATCTGTGTGGTGGTCCTCTGCATC

>In-frame_TMPRSS2_ENST00000398585_chr21_42852403_-_TMEFF2_ENST00000272771_chr2_192863934_-_1272nt
ATGCCCCCTGCCCCGCCCGGAGGTGAAAGCGGGTGTGAGGAGCGCGGCGCGGCAGGTCATATTGAACATTCCAGATACCTATCATTACTC
GATGCTGTTGATAACAGCAAGATGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAA
AACCCCTATCCCGCACAGCCCACTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCC
CCGAGGGTCCTGACGCAGGCTTCCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAAAGACTAAGAAA
GCACTGTGCATCACCTTGACCCTGGGGACCTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTCTGGAAGTTCATGGGCAGCAAGTGC
TCCAACTCTGGGATAGAGTGCGACTCCTCAGGTACCTGCATCAACCCCTCTAACTGGTGTGATGGCGTGTCACACTGCCCCGGCGGGGAG
GACGAGAATCGGTGTGTTCGCCTCTACGGACCAAACTTCATCCTTCAGGTGTACTCATCTCAGAGGAAGTCCTGGCACCCTGTGTGCCAA
GACGACTGGAACGAGAACTACGGGCGGGCGGCCTGCAGGGACATGGGCTATAAGTGTGTGTGTAATATTGACTGTTCTCAAACCAACTTC
AATCCCCTCTGCGCTTCTGATGGGAAATCTTATGATAATGCATGCCAAATCAAAGAAGCATCGTGTCAGAAACAGGAGAAAATTGAAGTC
ATGTCTTTGGGTCGATGTCAAGATAACACAACTACAACTACTAAGTCTGAAGATGGGCATTATGCAAGAACAGATTATGCAGAGAATGCT
AACAAATTAGAAGAAAGTGCCAGAGAACACCACATACCTTGTCCGGAACATTACAATGGCTTCTGCATGCATGGGAAGTGTGAGCATTCT
ATCAATATGCAGGAGCCATCTTGCAGGTGTGATGCTGGTTATACTGGACAACACTGTGAAAAAAAGGACTACAGTGTTCTATACGTTGTT
CCCGGTCCTGTACGATTTCAGTATGTCTTAATCGCAGCTGTGATTGGAACAATTCAGATTGCTGTCATCTGTGTGGTGGTCCTCTGCATC
ACAAGGAAATGCCCCAGAAGCAACAGAATTCACAGACAGAAGCAAAATACAGGGCACTACAGTTCAGACAATACAACAAGAGCGTCCACG


* Fusion transcript sequences (Full-length transcript).
>In-frame_TMPRSS2_ENST00000332149_chr21_42852403_-_TMEFF2_ENST00000392314_chr2_192863934_-_2621nt
CGAGTAGGCGCGAGCTAAGCAGGAGGCGGAGGCGGAGGCGGAGGGCGAGGGGCGGGGAGCGCCGCCTGGAGCGCGGCAGGTCATATTGAA
CATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGATGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTAT
GAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCACTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTAC
CCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTTCCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACA
GTGTGCACCTCAAAGACTAAGAAAGCACTGTGCATCACCTTGACCCTGGGGACCTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTC
TGGAAGTTCATGGGCAGCAAGTGCTCCAACTCTGGGATAGAGTGCGACTCCTCAGGTACCTGCATCAACCCCTCTAACTGGTGTGATGGC
GTGTCACACTGCCCCGGCGGGGAGGACGAGAATCGGTGTGTTCGCCTCTACGGACCAAACTTCATCCTTCAGGTGTACTCATCTCAGAGG
AAGTCCTGGCACCCTGTGTGCCAAGACGACTGGAACGAGAACTACGGGCGGGCGGCCTGCAGGGACATGGGCTATAAGTGTGTGTGTAAT
ATTGACTGTTCTCAAACCAACTTCAATCCCCTCTGCGCTTCTGATGGGAAATCTTATGATAATGCATGCCAAATCAAAGAAGCATCGTGT
CAGAAACAGGAGAAAATTGAAGTCATGTCTTTGGGTCGATGTCAAGATAACACAACTACAACTACTAAGTCTGAAGATGGGCATTATGCA
AGAACAGATTATGCAGAGAATGCTAACAAATTAGAAGAAAGTGCCAGAGAACACCACATACCTTGTCCGGAACATTACAATGGCTTCTGC
ATGCATGGGAAGTGTGAGCATTCTATCAATATGCAGGAGCCATCTTGCAGGTGTGATGCTGGTTATACTGGACAACACTGTGAAAAAAAG
GACTACAGTGTTCTATACGTTGTTCCCGGTCCTGTACGATTTCAGTATGTCTTAATCGCAGCTGTGATTGGAACAATTCAGATTGCTGTC
ATCTGTGTGGTGGTCCTCTGCATCACAAGGGCCAAACTTTAGGTAATAGCATTGGACTGAGATTTGTAAACTTTCCAACCTTCCAGGAAA
TGCCCCAGAAGCAACAGAATTCACAGACAGAAGCAAAATACAGGGCACTACAGTTCAGACAATACAACAAGAGCGTCCACGAGGTTAATC
TAAAGGGAGCATGTTTCACAGTGGCTGGACTACCGAGAGCTTGGACTACACAATACAGTATTATAGACAAAAGAATAAGACAAGAGATCT
ACACATGTTGCCTTGCATTTGTGGTAATCTACACCAATGAAAACATGTACTACAGCTATATTTGATTATGTATGGATATATTTGAAATAG
TATACATTGTCTTGATGTTTTTTCTGTAATGTAAATAAACTATTTATATCACACAATATAGTTTTTTCTTTCCCATGTATTTGTTATATA
TAATAAATACTCAGTGATGAGAAAAAATTGGCATTCTTAAATTTGCGGTATCTCATAACTGTAAATATAATCAGACTAGTACAATCTGTA
CAGCTACCAATATTTCATGTTTCTTCTCATCTTGAGACAGCACATTAGTTCGTACAGGACTCAGTGGCTAGGTTTTGAATGATTCCAAGA
TCAAGGGAAATGATGGTTATTGGAAAAGAGAAAAAATAATTTACTTTATATCGAGTGAGGATAAAATATTTCCGATCTTTGAATCATCTC
TATTTCATCAACTTTCTTCCCTGGTCTTCCATTTTCATCCCTAGAGCAGAAAAATCTCTGGCATATAAACTAAATAAAAGAAGAAGGGGA
GGGAAAGTGTTTTATAACTCATAAAGGAGAGGGAAAGAAAATATTGGTTTTTATTGGGGAAGTAGCTTAGAATCCCCCAGTTAAGTGCAT
ATATCTGAACTTACTGAACAAGTTACATACTAGGTATACACAGAGTGGCAAAATATATTCCATTTAGGTGGGTGGAATTACCAGGGGAAA
AATGTAATAACACCACTAGATGTGAAACACCAAAATCGTGAATTCTCAAAAGCACCATACAATATGTATAGTATATAGTTCTTTGAAAAG
AAGTTAGAATCACAACCAATACCCCATGAATAGCTTTGTGGCTAATGCAGCACCATAATTTGTAATGGAACTAAGATGATGATGACGATA
TTTCATGAAAACAGAGAGATGTTTTGAGCATATTTATGTGGTGAGGTAAGAAAGAAAATTAATCCTATAGCATCTGAAAGACCTCACTGG
GAAGTTGGTATGGATTTTTGTTTGATTTGTGCATACAAATAGGTATCACAACTTGATCTGGAAAAAATAAGCTGTGAAAATTCTCAAGGA
ATAAGATGAAAATAAATCAATTATTATCATTTAGCTCTGCAAAGCTTTCCATGGCTAACACAGTAAATTTAAATAAAGCTCTCTTTGTCT

>In-frame_TMPRSS2_ENST00000332149_chr21_42852403_-_TMEFF2_ENST00000272771_chr2_192863934_-_1590nt
CGAGTAGGCGCGAGCTAAGCAGGAGGCGGAGGCGGAGGCGGAGGGCGAGGGGCGGGGAGCGCCGCCTGGAGCGCGGCAGGTCATATTGAA
CATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGATGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTAT
GAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCACTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTAC
CCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTTCCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACA
GTGTGCACCTCAAAGACTAAGAAAGCACTGTGCATCACCTTGACCCTGGGGACCTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTC
TGGAAGTTCATGGGCAGCAAGTGCTCCAACTCTGGGATAGAGTGCGACTCCTCAGGTACCTGCATCAACCCCTCTAACTGGTGTGATGGC
GTGTCACACTGCCCCGGCGGGGAGGACGAGAATCGGTGTGTTCGCCTCTACGGACCAAACTTCATCCTTCAGGTGTACTCATCTCAGAGG
AAGTCCTGGCACCCTGTGTGCCAAGACGACTGGAACGAGAACTACGGGCGGGCGGCCTGCAGGGACATGGGCTATAAGTGTGTGTGTAAT
ATTGACTGTTCTCAAACCAACTTCAATCCCCTCTGCGCTTCTGATGGGAAATCTTATGATAATGCATGCCAAATCAAAGAAGCATCGTGT
CAGAAACAGGAGAAAATTGAAGTCATGTCTTTGGGTCGATGTCAAGATAACACAACTACAACTACTAAGTCTGAAGATGGGCATTATGCA
AGAACAGATTATGCAGAGAATGCTAACAAATTAGAAGAAAGTGCCAGAGAACACCACATACCTTGTCCGGAACATTACAATGGCTTCTGC
ATGCATGGGAAGTGTGAGCATTCTATCAATATGCAGGAGCCATCTTGCAGGTGTGATGCTGGTTATACTGGACAACACTGTGAAAAAAAG
GACTACAGTGTTCTATACGTTGTTCCCGGTCCTGTACGATTTCAGTATGTCTTAATCGCAGCTGTGATTGGAACAATTCAGATTGCTGTC
ATCTGTGTGGTGGTCCTCTGCATCACAAGGAAATGCCCCAGAAGCAACAGAATTCACAGACAGAAGCAAAATACAGGGCACTACAGTTCA
GACAATACAACAAGAGCGTCCACGAGGTTAATCTAAAGGGAGCATGTTTCACAGTGGCTGGACTACCGAGAGCTTGGACTACACAATACA
GTATTATAGACAAAAGAATAAGACAAGAGATCTACACATGTTGCCTTGCATTTGTGGTAATCTACACCAATGAAAACATGTACTACAGCT
ATATTTGATTATGTATGGATATATTTGAAATAGTATACATTGTCTTGATGTTTTTTCTGTAATGTAAATAAACTATTTATATCACACAAT

>In-frame_TMPRSS2_ENST00000398585_chr21_42852403_-_TMEFF2_ENST00000392314_chr2_192863934_-_2658nt
ACCAGGGTCCCGGCTCGGGGTCCGGGCTGGGGAGGGGAACCTGGGCGCCTGGGACCCGCCGATGCCCCCTGCCCCGCCCGGAGGTGAAAG
CGGGTGTGAGGAGCGCGGCGCGGCAGGTCATATTGAACATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGATGGCTTT
GAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCACTGTGGT
CCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTTCCAACCC
CGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAAAGACTAAGAAAGCACTGTGCATCACCTTGACCCTGGGGAC
CTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTCTGGAAGTTCATGGGCAGCAAGTGCTCCAACTCTGGGATAGAGTGCGACTCCTC
AGGTACCTGCATCAACCCCTCTAACTGGTGTGATGGCGTGTCACACTGCCCCGGCGGGGAGGACGAGAATCGGTGTGTTCGCCTCTACGG
ACCAAACTTCATCCTTCAGGTGTACTCATCTCAGAGGAAGTCCTGGCACCCTGTGTGCCAAGACGACTGGAACGAGAACTACGGGCGGGC
GGCCTGCAGGGACATGGGCTATAAGTGTGTGTGTAATATTGACTGTTCTCAAACCAACTTCAATCCCCTCTGCGCTTCTGATGGGAAATC
TTATGATAATGCATGCCAAATCAAAGAAGCATCGTGTCAGAAACAGGAGAAAATTGAAGTCATGTCTTTGGGTCGATGTCAAGATAACAC
AACTACAACTACTAAGTCTGAAGATGGGCATTATGCAAGAACAGATTATGCAGAGAATGCTAACAAATTAGAAGAAAGTGCCAGAGAACA
CCACATACCTTGTCCGGAACATTACAATGGCTTCTGCATGCATGGGAAGTGTGAGCATTCTATCAATATGCAGGAGCCATCTTGCAGGTG
TGATGCTGGTTATACTGGACAACACTGTGAAAAAAAGGACTACAGTGTTCTATACGTTGTTCCCGGTCCTGTACGATTTCAGTATGTCTT
AATCGCAGCTGTGATTGGAACAATTCAGATTGCTGTCATCTGTGTGGTGGTCCTCTGCATCACAAGGGCCAAACTTTAGGTAATAGCATT
GGACTGAGATTTGTAAACTTTCCAACCTTCCAGGAAATGCCCCAGAAGCAACAGAATTCACAGACAGAAGCAAAATACAGGGCACTACAG
TTCAGACAATACAACAAGAGCGTCCACGAGGTTAATCTAAAGGGAGCATGTTTCACAGTGGCTGGACTACCGAGAGCTTGGACTACACAA
TACAGTATTATAGACAAAAGAATAAGACAAGAGATCTACACATGTTGCCTTGCATTTGTGGTAATCTACACCAATGAAAACATGTACTAC
AGCTATATTTGATTATGTATGGATATATTTGAAATAGTATACATTGTCTTGATGTTTTTTCTGTAATGTAAATAAACTATTTATATCACA
CAATATAGTTTTTTCTTTCCCATGTATTTGTTATATATAATAAATACTCAGTGATGAGAAAAAATTGGCATTCTTAAATTTGCGGTATCT
CATAACTGTAAATATAATCAGACTAGTACAATCTGTACAGCTACCAATATTTCATGTTTCTTCTCATCTTGAGACAGCACATTAGTTCGT
ACAGGACTCAGTGGCTAGGTTTTGAATGATTCCAAGATCAAGGGAAATGATGGTTATTGGAAAAGAGAAAAAATAATTTACTTTATATCG
AGTGAGGATAAAATATTTCCGATCTTTGAATCATCTCTATTTCATCAACTTTCTTCCCTGGTCTTCCATTTTCATCCCTAGAGCAGAAAA
ATCTCTGGCATATAAACTAAATAAAAGAAGAAGGGGAGGGAAAGTGTTTTATAACTCATAAAGGAGAGGGAAAGAAAATATTGGTTTTTA
TTGGGGAAGTAGCTTAGAATCCCCCAGTTAAGTGCATATATCTGAACTTACTGAACAAGTTACATACTAGGTATACACAGAGTGGCAAAA
TATATTCCATTTAGGTGGGTGGAATTACCAGGGGAAAAATGTAATAACACCACTAGATGTGAAACACCAAAATCGTGAATTCTCAAAAGC
ACCATACAATATGTATAGTATATAGTTCTTTGAAAAGAAGTTAGAATCACAACCAATACCCCATGAATAGCTTTGTGGCTAATGCAGCAC
CATAATTTGTAATGGAACTAAGATGATGATGACGATATTTCATGAAAACAGAGAGATGTTTTGAGCATATTTATGTGGTGAGGTAAGAAA
GAAAATTAATCCTATAGCATCTGAAAGACCTCACTGGGAAGTTGGTATGGATTTTTGTTTGATTTGTGCATACAAATAGGTATCACAACT
TGATCTGGAAAAAATAAGCTGTGAAAATTCTCAAGGAATAAGATGAAAATAAATCAATTATTATCATTTAGCTCTGCAAAGCTTTCCATG

>In-frame_TMPRSS2_ENST00000398585_chr21_42852403_-_TMEFF2_ENST00000272771_chr2_192863934_-_1627nt
ACCAGGGTCCCGGCTCGGGGTCCGGGCTGGGGAGGGGAACCTGGGCGCCTGGGACCCGCCGATGCCCCCTGCCCCGCCCGGAGGTGAAAG
CGGGTGTGAGGAGCGCGGCGCGGCAGGTCATATTGAACATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGATGGCTTT
GAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCACTGTGGT
CCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTTCCAACCC
CGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAAAGACTAAGAAAGCACTGTGCATCACCTTGACCCTGGGGAC
CTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTCTGGAAGTTCATGGGCAGCAAGTGCTCCAACTCTGGGATAGAGTGCGACTCCTC
AGGTACCTGCATCAACCCCTCTAACTGGTGTGATGGCGTGTCACACTGCCCCGGCGGGGAGGACGAGAATCGGTGTGTTCGCCTCTACGG
ACCAAACTTCATCCTTCAGGTGTACTCATCTCAGAGGAAGTCCTGGCACCCTGTGTGCCAAGACGACTGGAACGAGAACTACGGGCGGGC
GGCCTGCAGGGACATGGGCTATAAGTGTGTGTGTAATATTGACTGTTCTCAAACCAACTTCAATCCCCTCTGCGCTTCTGATGGGAAATC
TTATGATAATGCATGCCAAATCAAAGAAGCATCGTGTCAGAAACAGGAGAAAATTGAAGTCATGTCTTTGGGTCGATGTCAAGATAACAC
AACTACAACTACTAAGTCTGAAGATGGGCATTATGCAAGAACAGATTATGCAGAGAATGCTAACAAATTAGAAGAAAGTGCCAGAGAACA
CCACATACCTTGTCCGGAACATTACAATGGCTTCTGCATGCATGGGAAGTGTGAGCATTCTATCAATATGCAGGAGCCATCTTGCAGGTG
TGATGCTGGTTATACTGGACAACACTGTGAAAAAAAGGACTACAGTGTTCTATACGTTGTTCCCGGTCCTGTACGATTTCAGTATGTCTT
AATCGCAGCTGTGATTGGAACAATTCAGATTGCTGTCATCTGTGTGGTGGTCCTCTGCATCACAAGGAAATGCCCCAGAAGCAACAGAAT
TCACAGACAGAAGCAAAATACAGGGCACTACAGTTCAGACAATACAACAAGAGCGTCCACGAGGTTAATCTAAAGGGAGCATGTTTCACA
GTGGCTGGACTACCGAGAGCTTGGACTACACAATACAGTATTATAGACAAAAGAATAAGACAAGAGATCTACACATGTTGCCTTGCATTT
GTGGTAATCTACACCAATGAAAACATGTACTACAGCTATATTTGATTATGTATGGATATATTTGAAATAGTATACATTGTCTTGATGTTT
TTTCTGTAATGTAAATAAACTATTTATATCACACAATATAGTTTTTTCTTTCCCATGTATTTGTTATATATAATAAATACTCAGTGATGA


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FusionGenePPI for TMPRSS2_TMEFF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMPRSS2CLK1TMEFF2AGO2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMPRSS2_TMEFF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMPRSS2_TMEFF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTMPRSS2C0033578Prostatic Neoplasms2CTD_human
TgeneTMEFF2C0032460Polycystic Ovary Syndrome1CTD_human
TgeneTMEFF2C0033578Prostatic Neoplasms1CTD_human