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Fusion gene ID: 38766 |
FusionGeneSummary for TMPRSS2_SARS |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMPRSS2_SARS | Fusion gene ID: 38766 | Hgene | Tgene | Gene symbol | TMPRSS2 | SARS | Gene ID | 7113 | 54938 |
| Gene name | transmembrane serine protease 2 | seryl-tRNA synthetase 2, mitochondrial | |
| Synonyms | PP9284|PRSS10 | SARS|SARSM|SERS|SYS|SerRS|SerRSmt|mtSerRS | |
| Cytomap | 21q22.3 | 19q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transmembrane protease serine 2epitheliasinserine protease 10transmembrane protease, serine 2 | serine--tRNA ligase, mitochondrialmitochondrial seryl-tRNA synthetaseserine tRNA ligase 2, mitochondrialseryl-tRNA synthetase, mitochondrialseryl-tRNA(Ser/Sec) synthetase | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O15393 | P49591 | |
| Ensembl transtripts involved in fusion gene | ENST00000332149, ENST00000398585, ENST00000458356, ENST00000497881, | ENST00000234677, ENST00000369923, ENST00000468588, | |
| Fusion gene scores | * DoF score | 29 X 21 X 6=3654 | 6 X 5 X 4=120 |
| # samples | 228 | 7 | |
| ** MAII score | log2(228/3654*10)=-0.680442809575384 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TMPRSS2 [Title/Abstract] AND SARS [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tissue-specifically expressed gene involved fusion gene, inframe and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TMPRSS2 | GO:0006508 | proteolysis | 21068237|24227843 |
| Hgene | TMPRSS2 | GO:0046598 | positive regulation of viral entry into host cell | 21068237|24227843 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-EJ-8474-01A | TMPRSS2 | chr21 | 42860321 | - | SARS | chr1 | 109766600 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000332149 | ENST00000234677 | TMPRSS2 | chr21 | 42860321 | - | SARS | chr1 | 109766600 | + |
| In-frame | ENST00000332149 | ENST00000369923 | TMPRSS2 | chr21 | 42860321 | - | SARS | chr1 | 109766600 | + |
| 5CDS-intron | ENST00000332149 | ENST00000468588 | TMPRSS2 | chr21 | 42860321 | - | SARS | chr1 | 109766600 | + |
| In-frame | ENST00000398585 | ENST00000234677 | TMPRSS2 | chr21 | 42860321 | - | SARS | chr1 | 109766600 | + |
| In-frame | ENST00000398585 | ENST00000369923 | TMPRSS2 | chr21 | 42860321 | - | SARS | chr1 | 109766600 | + |
| 5CDS-intron | ENST00000398585 | ENST00000468588 | TMPRSS2 | chr21 | 42860321 | - | SARS | chr1 | 109766600 | + |
| Frame-shit | ENST00000458356 | ENST00000234677 | TMPRSS2 | chr21 | 42860321 | - | SARS | chr1 | 109766600 | + |
| Frame-shit | ENST00000458356 | ENST00000369923 | TMPRSS2 | chr21 | 42860321 | - | SARS | chr1 | 109766600 | + |
| 5CDS-intron | ENST00000458356 | ENST00000468588 | TMPRSS2 | chr21 | 42860321 | - | SARS | chr1 | 109766600 | + |
| intron-3CDS | ENST00000497881 | ENST00000234677 | TMPRSS2 | chr21 | 42860321 | - | SARS | chr1 | 109766600 | + |
| intron-3CDS | ENST00000497881 | ENST00000369923 | TMPRSS2 | chr21 | 42860321 | - | SARS | chr1 | 109766600 | + |
| intron-intron | ENST00000497881 | ENST00000468588 | TMPRSS2 | chr21 | 42860321 | - | SARS | chr1 | 109766600 | + |
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FusionProtFeatures for TMPRSS2_SARS |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TMPRSS2 | SARS |
| Serine protease that proteolytically cleaves andactivates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized andmaintained in precursor intermediate folding states andproteolysis permits the refolding and energy release required tocreate stable virus-cell linkages and membrane coalescence.Facilitates human SARS coronavirus (SARS-CoV) infection via twoindependent mechanisms, proteolytic cleavage of ACE2, which mightpromote viral uptake, and cleavage of coronavirus spikeglycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activatesthe spike glycoproteins of human coronavirus 229E (HCoV-229E) andhuman coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0of Sendai virus (SeV), human metapneumovirus (HMPV), humanparainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential forspread and pathogenesis of influenza A virus (strains H1N1, H3N2and H7N9); involved in proteolytic cleavage and activation ofhemagglutinin (HA) protein which is essential for viralinfectivity. {ECO:0000269|PubMed:21068237,ECO:0000269|PubMed:21325420, ECO:0000269|PubMed:23536651,ECO:0000269|PubMed:23966399, ECO:0000269|PubMed:24027332,ECO:0000269|PubMed:24227843}. | Catalyzes the attachment of serine to tRNA(Ser) in atwo-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser)(PubMed:22353712, PubMed:24095058, PubMed:9431993,PubMed:26433229, PubMed:28236339). Is probably also able toaminoacylate tRNA(Sec) with serine, to form the misacylated tRNAL-seryl-tRNA(Sec), which will be further converted intoselenocysteinyl-tRNA(Sec) (PubMed:9431993, PubMed:26433229,PubMed:28236339). In the nucleus, binds to the VEGFA core promoterand prevents MYC binding and transcriptional activation by MYC(PubMed:24940000). Recruits SIRT2 to the VEGFA promoter, promotingdeacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibitsthe production of VEGFA and sprouting angiogenesis mediated byVEGFA (PubMed:19423848, PubMed:19423847, PubMed:24940000).{ECO:0000269|PubMed:19423847, ECO:0000269|PubMed:19423848,ECO:0000269|PubMed:22353712, ECO:0000269|PubMed:24095058,ECO:0000269|PubMed:24940000, ECO:0000269|PubMed:26433229,ECO:0000269|PubMed:28236339, ECO:0000269|PubMed:9431993}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TMPRSS2 | chr21:42860321 | chr1:109766600 | ENST00000332149 | - | 5 | 14 | 112_149 | 148 | 493 | Domain | LDL-receptor class A |
| Hgene | TMPRSS2 | chr21:42860321 | chr1:109766600 | ENST00000398585 | - | 5 | 14 | 112_149 | 185 | 530 | Domain | LDL-receptor class A |
| Hgene | TMPRSS2 | chr21:42860321 | chr1:109766600 | ENST00000458356 | - | 5 | 14 | 112_149 | 148 | 493 | Domain | LDL-receptor class A |
| Hgene | TMPRSS2 | chr21:42860321 | chr1:109766600 | ENST00000332149 | - | 5 | 14 | 1_84 | 148 | 493 | Topological domain | Cytoplasmic |
| Hgene | TMPRSS2 | chr21:42860321 | chr1:109766600 | ENST00000398585 | - | 5 | 14 | 1_84 | 185 | 530 | Topological domain | Cytoplasmic |
| Hgene | TMPRSS2 | chr21:42860321 | chr1:109766600 | ENST00000458356 | - | 5 | 14 | 1_84 | 148 | 493 | Topological domain | Cytoplasmic |
| Hgene | TMPRSS2 | chr21:42860321 | chr1:109766600 | ENST00000332149 | - | 5 | 14 | 85_105 | 148 | 493 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Hgene | TMPRSS2 | chr21:42860321 | chr1:109766600 | ENST00000398585 | - | 5 | 14 | 85_105 | 185 | 530 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Hgene | TMPRSS2 | chr21:42860321 | chr1:109766600 | ENST00000458356 | - | 5 | 14 | 85_105 | 148 | 493 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Tgene | >SARS | chr21:42860321 | chr1:109766600 | ENST00000234677 | + | 0 | 11 | 482_494 | 45 | 515 | Motif | Nuclear localization signal |
| Tgene | >SARS | chr21:42860321 | chr1:109766600 | ENST00000234677 | + | 0 | 11 | 302_304 | 45 | 515 | Nucleotide binding | ATP |
| Tgene | >SARS | chr21:42860321 | chr1:109766600 | ENST00000234677 | + | 0 | 11 | 318_321 | 45 | 515 | Nucleotide binding | ATP |
| Tgene | >SARS | chr21:42860321 | chr1:109766600 | ENST00000234677 | + | 0 | 11 | 391_394 | 45 | 515 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TMPRSS2 | chr21:42860321 | chr1:109766600 | ENST00000332149 | - | 5 | 14 | 150_242 | 148 | 493 | Domain | SRCR |
| Hgene | >TMPRSS2 | chr21:42860321 | chr1:109766600 | ENST00000332149 | - | 5 | 14 | 256_489 | 148 | 493 | Domain | Peptidase S1 |
| Hgene | >TMPRSS2 | chr21:42860321 | chr1:109766600 | ENST00000398585 | - | 5 | 14 | 150_242 | 185 | 530 | Domain | SRCR |
| Hgene | >TMPRSS2 | chr21:42860321 | chr1:109766600 | ENST00000398585 | - | 5 | 14 | 256_489 | 185 | 530 | Domain | Peptidase S1 |
| Hgene | >TMPRSS2 | chr21:42860321 | chr1:109766600 | ENST00000458356 | - | 5 | 14 | 150_242 | 148 | 493 | Domain | SRCR |
| Hgene | >TMPRSS2 | chr21:42860321 | chr1:109766600 | ENST00000458356 | - | 5 | 14 | 256_489 | 148 | 493 | Domain | Peptidase S1 |
| Hgene | >TMPRSS2 | chr21:42860321 | chr1:109766600 | ENST00000332149 | - | 5 | 14 | 106_492 | 148 | 493 | Topological domain | Extracellular |
| Hgene | >TMPRSS2 | chr21:42860321 | chr1:109766600 | ENST00000398585 | - | 5 | 14 | 106_492 | 185 | 530 | Topological domain | Extracellular |
| Hgene | >TMPRSS2 | chr21:42860321 | chr1:109766600 | ENST00000458356 | - | 5 | 14 | 106_492 | 148 | 493 | Topological domain | Extracellular |
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FusionGeneSequence for TMPRSS2_SARS |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TMPRSS2_ENST00000332149_chr21_42860321_-_SARS_ENST00000234677_chr1_109766600_+_618aa MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLT LGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCGRFRADNLNKLKNLCSKTIGEKMKKKEPVGDD ESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAERIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKK YSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEK SDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITT AEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTI >In-frame_TMPRSS2_ENST00000332149_chr21_42860321_-_SARS_ENST00000369923_chr1_109766600_+_640aa MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLT LGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCGRFRADNLNKLKNLCSKTIGEKMKKKEPVGDD ESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAERIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKK YSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEK SDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITT AEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKRKNNLHLSTQNKLEASLF SPKKVEFVHMLNATMCATTRTICAILENYQTEKGITVPEKLKEFMPPGLQELIPFVKPAPIEQEPSKKQKKQHEGSKKKAAARDVTLENR >In-frame_TMPRSS2_ENST00000398585_chr21_42860321_-_SARS_ENST00000234677_chr1_109766600_+_655aa MPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYA PRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGE DENRCGRFRADNLNKLKNLCSKTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAERIKLEAERFE NLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKKYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGY IPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGR DTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTD YQARRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTICAILENYQTEKGITVPEKLKEFMPPGLQELIPFVKPAPIEQEPSKKQKKQHEG >In-frame_TMPRSS2_ENST00000398585_chr21_42860321_-_SARS_ENST00000369923_chr1_109766600_+_677aa MPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYA PRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGE DENRCGRFRADNLNKLKNLCSKTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAERIKLEAERFE NLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKKYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGY IPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGR DTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTD YQARRLRIRYGQTKKMMDKRKNNLHLSTQNKLEASLFSPKKVEFVHMLNATMCATTRTICAILENYQTEKGITVPEKLKEFMPPGLQELI |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TMPRSS2_ENST00000332149_chr21_42860321_-_SARS_ENST00000234677_chr1_109766600_+_1854nt ATGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCC ACTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCT TCCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAAAGACTAAGAAAGCACTGTGCATCACCTTGACC CTGGGGACCTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTCTGGAAGTTCATGGGCAGCAAGTGCTCCAACTCTGGGATAGAGTGC GACTCCTCAGGTACCTGCATCAACCCCTCTAACTGGTGTGATGGCGTGTCACACTGCCCCGGCGGGGAGGACGAGAATCGGTGTGGTAGA TTTCGGGCAGACAACTTGAACAAGCTGAAGAACCTATGCAGCAAGACAATCGGAGAGAAAATGAAGAAAAAAGAGCCAGTGGGAGATGAT GAGTCTGTCCCAGAGAATGTGCTGAGTTTCGATGACCTTACTGCAGACGCTTTAGCTAACCTGAAAGTCTCACAAATCAAAAAAGTCCGA CTCCTCATTGATGAAGCCATCCTGAAGTGTGACGCGGAGCGGATAAAGTTGGAAGCAGAGCGGTTTGAGAACCTCCGAGAGATTGGGAAC CTTCTGCACCCTTCTGTACCCATCAGTAACGATGAGGATGTGGACAACAAAGTAGAGAGGATTTGGGGTGATTGTACAGTCAGGAAGAAG TACTCTCATGTGGACCTGGTGGTGATGGTAGATGGCTTTGAAGGCGAAAAGGGGGCCGTGGTGGCTGGGAGTCGAGGGTACTTCTTGAAG GGGGTCCTGGTGTTCCTGGAACAGGCTCTCATCCAGTATGCCCTTCGCACCTTGGGAAGTCGGGGCTACATTCCCATTTATACCCCCTTT TTCATGAGGAAGGAGGTCATGCAGGAGGTGGCACAGCTCAGCCAGTTTGATGAAGAACTTTATAAGGTGATTGGCAAAGGCAGTGAAAAG TCTGATGACAACTCCTATGATGAGAAGTACCTGATTGCCACCTCAGAGCAGCCCATTGCTGCCCTGCACCGGGATGAGTGGCTCCGGCCG GAGGACCTGCCCATCAAGTATGCTGGCCTGTCTACCTGCTTCCGTCAGGAGGTGGGCTCCCATGGCCGTGACACCCGTGGCATCTTCCGA GTCCATCAGTTTGAGAAGATTGAACAGTTTGTGTACTCATCACCCCATGACAACAAGTCATGGGAGATGTTTGAAGAGATGATTACCACC GCAGAGGAGTTCTACCAGTCCCTGGGGATTCCTTACCACATTGTGAATATTGTCTCAGGTTCTTTGAATCATGCTGCCAGTAAGAAGCTT GACCTGGAGGCCTGGTTTCCGGGCTCAGGAGCCTTCCGTGAGTTGGTCTCCTGTTCTAATTGCACGGATTACCAGGCTCGCCGGCTTCGA ATCCGATATGGGCAAACCAAGAAGATGATGGACAAGGTGGAGTTTGTCCATATGCTCAATGCTACCATGTGCGCCACTACCCGTACCATC TGCGCCATCCTGGAGAACTACCAGACAGAGAAGGGCATCACTGTGCCTGAGAAATTGAAGGAGTTCATGCCGCCAGGACTGCAAGAACTG ATCCCCTTTGTGAAGCCTGCGCCCATTGAGCAGGAGCCATCAAAGAAGCAGAAGAAGCAACATGAGGGCAGCAAAAAGAAAGCAGCAGCA >In-frame_TMPRSS2_ENST00000332149_chr21_42860321_-_SARS_ENST00000369923_chr1_109766600_+_1920nt ATGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCC ACTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCT TCCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAAAGACTAAGAAAGCACTGTGCATCACCTTGACC CTGGGGACCTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTCTGGAAGTTCATGGGCAGCAAGTGCTCCAACTCTGGGATAGAGTGC GACTCCTCAGGTACCTGCATCAACCCCTCTAACTGGTGTGATGGCGTGTCACACTGCCCCGGCGGGGAGGACGAGAATCGGTGTGGTAGA TTTCGGGCAGACAACTTGAACAAGCTGAAGAACCTATGCAGCAAGACAATCGGAGAGAAAATGAAGAAAAAAGAGCCAGTGGGAGATGAT GAGTCTGTCCCAGAGAATGTGCTGAGTTTCGATGACCTTACTGCAGACGCTTTAGCTAACCTGAAAGTCTCACAAATCAAAAAAGTCCGA CTCCTCATTGATGAAGCCATCCTGAAGTGTGACGCGGAGCGGATAAAGTTGGAAGCAGAGCGGTTTGAGAACCTCCGAGAGATTGGGAAC CTTCTGCACCCTTCTGTACCCATCAGTAACGATGAGGATGTGGACAACAAAGTAGAGAGGATTTGGGGTGATTGTACAGTCAGGAAGAAG TACTCTCATGTGGACCTGGTGGTGATGGTAGATGGCTTTGAAGGCGAAAAGGGGGCCGTGGTGGCTGGGAGTCGAGGGTACTTCTTGAAG GGGGTCCTGGTGTTCCTGGAACAGGCTCTCATCCAGTATGCCCTTCGCACCTTGGGAAGTCGGGGCTACATTCCCATTTATACCCCCTTT TTCATGAGGAAGGAGGTCATGCAGGAGGTGGCACAGCTCAGCCAGTTTGATGAAGAACTTTATAAGGTGATTGGCAAAGGCAGTGAAAAG TCTGATGACAACTCCTATGATGAGAAGTACCTGATTGCCACCTCAGAGCAGCCCATTGCTGCCCTGCACCGGGATGAGTGGCTCCGGCCG GAGGACCTGCCCATCAAGTATGCTGGCCTGTCTACCTGCTTCCGTCAGGAGGTGGGCTCCCATGGCCGTGACACCCGTGGCATCTTCCGA GTCCATCAGTTTGAGAAGATTGAACAGTTTGTGTACTCATCACCCCATGACAACAAGTCATGGGAGATGTTTGAAGAGATGATTACCACC GCAGAGGAGTTCTACCAGTCCCTGGGGATTCCTTACCACATTGTGAATATTGTCTCAGGTTCTTTGAATCATGCTGCCAGTAAGAAGCTT GACCTGGAGGCCTGGTTTCCGGGCTCAGGAGCCTTCCGTGAGTTGGTCTCCTGTTCTAATTGCACGGATTACCAGGCTCGCCGGCTTCGA ATCCGATATGGGCAAACCAAGAAGATGATGGACAAGAGAAAGAATAATCTCCATTTATCTACACAGAACAAGTTGGAGGCTTCCCTCTTC TCACCCAAGAAGGTGGAGTTTGTCCATATGCTCAATGCTACCATGTGCGCCACTACCCGTACCATCTGCGCCATCCTGGAGAACTACCAG ACAGAGAAGGGCATCACTGTGCCTGAGAAATTGAAGGAGTTCATGCCGCCAGGACTGCAAGAACTGATCCCCTTTGTGAAGCCTGCGCCC ATTGAGCAGGAGCCATCAAAGAAGCAGAAGAAGCAACATGAGGGCAGCAAAAAGAAAGCAGCAGCAAGAGACGTCACCCTAGAAAACAGG >In-frame_TMPRSS2_ENST00000398585_chr21_42860321_-_SARS_ENST00000234677_chr1_109766600_+_1965nt ATGCCCCCTGCCCCGCCCGGAGGTGAAAGCGGGTGTGAGGAGCGCGGCGCGGCAGGTCATATTGAACATTCCAGATACCTATCATTACTC GATGCTGTTGATAACAGCAAGATGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAA AACCCCTATCCCGCACAGCCCACTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCC CCGAGGGTCCTGACGCAGGCTTCCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAAAGACTAAGAAA GCACTGTGCATCACCTTGACCCTGGGGACCTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTCTGGAAGTTCATGGGCAGCAAGTGC TCCAACTCTGGGATAGAGTGCGACTCCTCAGGTACCTGCATCAACCCCTCTAACTGGTGTGATGGCGTGTCACACTGCCCCGGCGGGGAG GACGAGAATCGGTGTGGTAGATTTCGGGCAGACAACTTGAACAAGCTGAAGAACCTATGCAGCAAGACAATCGGAGAGAAAATGAAGAAA AAAGAGCCAGTGGGAGATGATGAGTCTGTCCCAGAGAATGTGCTGAGTTTCGATGACCTTACTGCAGACGCTTTAGCTAACCTGAAAGTC TCACAAATCAAAAAAGTCCGACTCCTCATTGATGAAGCCATCCTGAAGTGTGACGCGGAGCGGATAAAGTTGGAAGCAGAGCGGTTTGAG AACCTCCGAGAGATTGGGAACCTTCTGCACCCTTCTGTACCCATCAGTAACGATGAGGATGTGGACAACAAAGTAGAGAGGATTTGGGGT GATTGTACAGTCAGGAAGAAGTACTCTCATGTGGACCTGGTGGTGATGGTAGATGGCTTTGAAGGCGAAAAGGGGGCCGTGGTGGCTGGG AGTCGAGGGTACTTCTTGAAGGGGGTCCTGGTGTTCCTGGAACAGGCTCTCATCCAGTATGCCCTTCGCACCTTGGGAAGTCGGGGCTAC ATTCCCATTTATACCCCCTTTTTCATGAGGAAGGAGGTCATGCAGGAGGTGGCACAGCTCAGCCAGTTTGATGAAGAACTTTATAAGGTG ATTGGCAAAGGCAGTGAAAAGTCTGATGACAACTCCTATGATGAGAAGTACCTGATTGCCACCTCAGAGCAGCCCATTGCTGCCCTGCAC CGGGATGAGTGGCTCCGGCCGGAGGACCTGCCCATCAAGTATGCTGGCCTGTCTACCTGCTTCCGTCAGGAGGTGGGCTCCCATGGCCGT GACACCCGTGGCATCTTCCGAGTCCATCAGTTTGAGAAGATTGAACAGTTTGTGTACTCATCACCCCATGACAACAAGTCATGGGAGATG TTTGAAGAGATGATTACCACCGCAGAGGAGTTCTACCAGTCCCTGGGGATTCCTTACCACATTGTGAATATTGTCTCAGGTTCTTTGAAT CATGCTGCCAGTAAGAAGCTTGACCTGGAGGCCTGGTTTCCGGGCTCAGGAGCCTTCCGTGAGTTGGTCTCCTGTTCTAATTGCACGGAT TACCAGGCTCGCCGGCTTCGAATCCGATATGGGCAAACCAAGAAGATGATGGACAAGGTGGAGTTTGTCCATATGCTCAATGCTACCATG TGCGCCACTACCCGTACCATCTGCGCCATCCTGGAGAACTACCAGACAGAGAAGGGCATCACTGTGCCTGAGAAATTGAAGGAGTTCATG CCGCCAGGACTGCAAGAACTGATCCCCTTTGTGAAGCCTGCGCCCATTGAGCAGGAGCCATCAAAGAAGCAGAAGAAGCAACATGAGGGC >In-frame_TMPRSS2_ENST00000398585_chr21_42860321_-_SARS_ENST00000369923_chr1_109766600_+_2031nt ATGCCCCCTGCCCCGCCCGGAGGTGAAAGCGGGTGTGAGGAGCGCGGCGCGGCAGGTCATATTGAACATTCCAGATACCTATCATTACTC GATGCTGTTGATAACAGCAAGATGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAA AACCCCTATCCCGCACAGCCCACTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCC CCGAGGGTCCTGACGCAGGCTTCCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAAAGACTAAGAAA GCACTGTGCATCACCTTGACCCTGGGGACCTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTCTGGAAGTTCATGGGCAGCAAGTGC TCCAACTCTGGGATAGAGTGCGACTCCTCAGGTACCTGCATCAACCCCTCTAACTGGTGTGATGGCGTGTCACACTGCCCCGGCGGGGAG GACGAGAATCGGTGTGGTAGATTTCGGGCAGACAACTTGAACAAGCTGAAGAACCTATGCAGCAAGACAATCGGAGAGAAAATGAAGAAA AAAGAGCCAGTGGGAGATGATGAGTCTGTCCCAGAGAATGTGCTGAGTTTCGATGACCTTACTGCAGACGCTTTAGCTAACCTGAAAGTC TCACAAATCAAAAAAGTCCGACTCCTCATTGATGAAGCCATCCTGAAGTGTGACGCGGAGCGGATAAAGTTGGAAGCAGAGCGGTTTGAG AACCTCCGAGAGATTGGGAACCTTCTGCACCCTTCTGTACCCATCAGTAACGATGAGGATGTGGACAACAAAGTAGAGAGGATTTGGGGT GATTGTACAGTCAGGAAGAAGTACTCTCATGTGGACCTGGTGGTGATGGTAGATGGCTTTGAAGGCGAAAAGGGGGCCGTGGTGGCTGGG AGTCGAGGGTACTTCTTGAAGGGGGTCCTGGTGTTCCTGGAACAGGCTCTCATCCAGTATGCCCTTCGCACCTTGGGAAGTCGGGGCTAC ATTCCCATTTATACCCCCTTTTTCATGAGGAAGGAGGTCATGCAGGAGGTGGCACAGCTCAGCCAGTTTGATGAAGAACTTTATAAGGTG ATTGGCAAAGGCAGTGAAAAGTCTGATGACAACTCCTATGATGAGAAGTACCTGATTGCCACCTCAGAGCAGCCCATTGCTGCCCTGCAC CGGGATGAGTGGCTCCGGCCGGAGGACCTGCCCATCAAGTATGCTGGCCTGTCTACCTGCTTCCGTCAGGAGGTGGGCTCCCATGGCCGT GACACCCGTGGCATCTTCCGAGTCCATCAGTTTGAGAAGATTGAACAGTTTGTGTACTCATCACCCCATGACAACAAGTCATGGGAGATG TTTGAAGAGATGATTACCACCGCAGAGGAGTTCTACCAGTCCCTGGGGATTCCTTACCACATTGTGAATATTGTCTCAGGTTCTTTGAAT CATGCTGCCAGTAAGAAGCTTGACCTGGAGGCCTGGTTTCCGGGCTCAGGAGCCTTCCGTGAGTTGGTCTCCTGTTCTAATTGCACGGAT TACCAGGCTCGCCGGCTTCGAATCCGATATGGGCAAACCAAGAAGATGATGGACAAGAGAAAGAATAATCTCCATTTATCTACACAGAAC AAGTTGGAGGCTTCCCTCTTCTCACCCAAGAAGGTGGAGTTTGTCCATATGCTCAATGCTACCATGTGCGCCACTACCCGTACCATCTGC GCCATCCTGGAGAACTACCAGACAGAGAAGGGCATCACTGTGCCTGAGAAATTGAAGGAGTTCATGCCGCCAGGACTGCAAGAACTGATC CCCTTTGTGAAGCCTGCGCCCATTGAGCAGGAGCCATCAAAGAAGCAGAAGAAGCAACATGAGGGCAGCAAAAAGAAAGCAGCAGCAAGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TMPRSS2_ENST00000332149_chr21_42860321_-_SARS_ENST00000234677_chr1_109766600_+_2221nt CGAGTAGGCGCGAGCTAAGCAGGAGGCGGAGGCGGAGGCGGAGGGCGAGGGGCGGGGAGCGCCGCCTGGAGCGCGGCAGGTCATATTGAA CATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGATGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTAT GAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCACTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTAC CCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTTCCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACA GTGTGCACCTCAAAGACTAAGAAAGCACTGTGCATCACCTTGACCCTGGGGACCTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTC TGGAAGTTCATGGGCAGCAAGTGCTCCAACTCTGGGATAGAGTGCGACTCCTCAGGTACCTGCATCAACCCCTCTAACTGGTGTGATGGC GTGTCACACTGCCCCGGCGGGGAGGACGAGAATCGGTGTGGTAGATTTCGGGCAGACAACTTGAACAAGCTGAAGAACCTATGCAGCAAG ACAATCGGAGAGAAAATGAAGAAAAAAGAGCCAGTGGGAGATGATGAGTCTGTCCCAGAGAATGTGCTGAGTTTCGATGACCTTACTGCA GACGCTTTAGCTAACCTGAAAGTCTCACAAATCAAAAAAGTCCGACTCCTCATTGATGAAGCCATCCTGAAGTGTGACGCGGAGCGGATA AAGTTGGAAGCAGAGCGGTTTGAGAACCTCCGAGAGATTGGGAACCTTCTGCACCCTTCTGTACCCATCAGTAACGATGAGGATGTGGAC AACAAAGTAGAGAGGATTTGGGGTGATTGTACAGTCAGGAAGAAGTACTCTCATGTGGACCTGGTGGTGATGGTAGATGGCTTTGAAGGC GAAAAGGGGGCCGTGGTGGCTGGGAGTCGAGGGTACTTCTTGAAGGGGGTCCTGGTGTTCCTGGAACAGGCTCTCATCCAGTATGCCCTT CGCACCTTGGGAAGTCGGGGCTACATTCCCATTTATACCCCCTTTTTCATGAGGAAGGAGGTCATGCAGGAGGTGGCACAGCTCAGCCAG TTTGATGAAGAACTTTATAAGGTGATTGGCAAAGGCAGTGAAAAGTCTGATGACAACTCCTATGATGAGAAGTACCTGATTGCCACCTCA GAGCAGCCCATTGCTGCCCTGCACCGGGATGAGTGGCTCCGGCCGGAGGACCTGCCCATCAAGTATGCTGGCCTGTCTACCTGCTTCCGT CAGGAGGTGGGCTCCCATGGCCGTGACACCCGTGGCATCTTCCGAGTCCATCAGTTTGAGAAGATTGAACAGTTTGTGTACTCATCACCC CATGACAACAAGTCATGGGAGATGTTTGAAGAGATGATTACCACCGCAGAGGAGTTCTACCAGTCCCTGGGGATTCCTTACCACATTGTG AATATTGTCTCAGGTTCTTTGAATCATGCTGCCAGTAAGAAGCTTGACCTGGAGGCCTGGTTTCCGGGCTCAGGAGCCTTCCGTGAGTTG GTCTCCTGTTCTAATTGCACGGATTACCAGGCTCGCCGGCTTCGAATCCGATATGGGCAAACCAAGAAGATGATGGACAAGGTGGAGTTT GTCCATATGCTCAATGCTACCATGTGCGCCACTACCCGTACCATCTGCGCCATCCTGGAGAACTACCAGACAGAGAAGGGCATCACTGTG CCTGAGAAATTGAAGGAGTTCATGCCGCCAGGACTGCAAGAACTGATCCCCTTTGTGAAGCCTGCGCCCATTGAGCAGGAGCCATCAAAG AAGCAGAAGAAGCAACATGAGGGCAGCAAAAAGAAAGCAGCAGCAAGAGACGTCACCCTAGAAAACAGGCTGCAGAACATGGAGGTCACC GATGCTTGAACATTCCTGCCTCCCTATTTGCCAGGCTTTCATTTCTGTCTGCTGAGATCTCAGAGCCTGCCCAACAGCAGGGAAGCCAAG CACCCATTCATCCCCCTGCCCCCATCTGACTGCGTAGCTGAGAGGGGAACAGTGCCATGTACCACACAGATGTTCCTGTCTCCTCGCATG >In-frame_TMPRSS2_ENST00000332149_chr21_42860321_-_SARS_ENST00000369923_chr1_109766600_+_2315nt CGAGTAGGCGCGAGCTAAGCAGGAGGCGGAGGCGGAGGCGGAGGGCGAGGGGCGGGGAGCGCCGCCTGGAGCGCGGCAGGTCATATTGAA CATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGATGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTAT GAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCACTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTAC CCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTTCCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACA GTGTGCACCTCAAAGACTAAGAAAGCACTGTGCATCACCTTGACCCTGGGGACCTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTC TGGAAGTTCATGGGCAGCAAGTGCTCCAACTCTGGGATAGAGTGCGACTCCTCAGGTACCTGCATCAACCCCTCTAACTGGTGTGATGGC GTGTCACACTGCCCCGGCGGGGAGGACGAGAATCGGTGTGGTAGATTTCGGGCAGACAACTTGAACAAGCTGAAGAACCTATGCAGCAAG ACAATCGGAGAGAAAATGAAGAAAAAAGAGCCAGTGGGAGATGATGAGTCTGTCCCAGAGAATGTGCTGAGTTTCGATGACCTTACTGCA GACGCTTTAGCTAACCTGAAAGTCTCACAAATCAAAAAAGTCCGACTCCTCATTGATGAAGCCATCCTGAAGTGTGACGCGGAGCGGATA AAGTTGGAAGCAGAGCGGTTTGAGAACCTCCGAGAGATTGGGAACCTTCTGCACCCTTCTGTACCCATCAGTAACGATGAGGATGTGGAC AACAAAGTAGAGAGGATTTGGGGTGATTGTACAGTCAGGAAGAAGTACTCTCATGTGGACCTGGTGGTGATGGTAGATGGCTTTGAAGGC GAAAAGGGGGCCGTGGTGGCTGGGAGTCGAGGGTACTTCTTGAAGGGGGTCCTGGTGTTCCTGGAACAGGCTCTCATCCAGTATGCCCTT CGCACCTTGGGAAGTCGGGGCTACATTCCCATTTATACCCCCTTTTTCATGAGGAAGGAGGTCATGCAGGAGGTGGCACAGCTCAGCCAG TTTGATGAAGAACTTTATAAGGTGATTGGCAAAGGCAGTGAAAAGTCTGATGACAACTCCTATGATGAGAAGTACCTGATTGCCACCTCA GAGCAGCCCATTGCTGCCCTGCACCGGGATGAGTGGCTCCGGCCGGAGGACCTGCCCATCAAGTATGCTGGCCTGTCTACCTGCTTCCGT CAGGAGGTGGGCTCCCATGGCCGTGACACCCGTGGCATCTTCCGAGTCCATCAGTTTGAGAAGATTGAACAGTTTGTGTACTCATCACCC CATGACAACAAGTCATGGGAGATGTTTGAAGAGATGATTACCACCGCAGAGGAGTTCTACCAGTCCCTGGGGATTCCTTACCACATTGTG AATATTGTCTCAGGTTCTTTGAATCATGCTGCCAGTAAGAAGCTTGACCTGGAGGCCTGGTTTCCGGGCTCAGGAGCCTTCCGTGAGTTG GTCTCCTGTTCTAATTGCACGGATTACCAGGCTCGCCGGCTTCGAATCCGATATGGGCAAACCAAGAAGATGATGGACAAGAGAAAGAAT AATCTCCATTTATCTACACAGAACAAGTTGGAGGCTTCCCTCTTCTCACCCAAGAAGGTGGAGTTTGTCCATATGCTCAATGCTACCATG TGCGCCACTACCCGTACCATCTGCGCCATCCTGGAGAACTACCAGACAGAGAAGGGCATCACTGTGCCTGAGAAATTGAAGGAGTTCATG CCGCCAGGACTGCAAGAACTGATCCCCTTTGTGAAGCCTGCGCCCATTGAGCAGGAGCCATCAAAGAAGCAGAAGAAGCAACATGAGGGC AGCAAAAAGAAAGCAGCAGCAAGAGACGTCACCCTAGAAAACAGGCTGCAGAACATGGAGGTCACCGATGCTTGAACATTCCTGCCTCCC TATTTGCCAGGCTTTCATTTCTGTCTGCTGAGATCTCAGAGCCTGCCCAACAGCAGGGAAGCCAAGCACCCATTCATCCCCCTGCCCCCA TCTGACTGCGTAGCTGAGAGGGGAACAGTGCCATGTACCACACAGATGTTCCTGTCTCCTCGCATGGGCATAGGGACCCATCATTGATGA >In-frame_TMPRSS2_ENST00000398585_chr21_42860321_-_SARS_ENST00000234677_chr1_109766600_+_2258nt ACCAGGGTCCCGGCTCGGGGTCCGGGCTGGGGAGGGGAACCTGGGCGCCTGGGACCCGCCGATGCCCCCTGCCCCGCCCGGAGGTGAAAG CGGGTGTGAGGAGCGCGGCGCGGCAGGTCATATTGAACATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGATGGCTTT GAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCACTGTGGT CCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTTCCAACCC CGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAAAGACTAAGAAAGCACTGTGCATCACCTTGACCCTGGGGAC CTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTCTGGAAGTTCATGGGCAGCAAGTGCTCCAACTCTGGGATAGAGTGCGACTCCTC AGGTACCTGCATCAACCCCTCTAACTGGTGTGATGGCGTGTCACACTGCCCCGGCGGGGAGGACGAGAATCGGTGTGGTAGATTTCGGGC AGACAACTTGAACAAGCTGAAGAACCTATGCAGCAAGACAATCGGAGAGAAAATGAAGAAAAAAGAGCCAGTGGGAGATGATGAGTCTGT CCCAGAGAATGTGCTGAGTTTCGATGACCTTACTGCAGACGCTTTAGCTAACCTGAAAGTCTCACAAATCAAAAAAGTCCGACTCCTCAT TGATGAAGCCATCCTGAAGTGTGACGCGGAGCGGATAAAGTTGGAAGCAGAGCGGTTTGAGAACCTCCGAGAGATTGGGAACCTTCTGCA CCCTTCTGTACCCATCAGTAACGATGAGGATGTGGACAACAAAGTAGAGAGGATTTGGGGTGATTGTACAGTCAGGAAGAAGTACTCTCA TGTGGACCTGGTGGTGATGGTAGATGGCTTTGAAGGCGAAAAGGGGGCCGTGGTGGCTGGGAGTCGAGGGTACTTCTTGAAGGGGGTCCT GGTGTTCCTGGAACAGGCTCTCATCCAGTATGCCCTTCGCACCTTGGGAAGTCGGGGCTACATTCCCATTTATACCCCCTTTTTCATGAG GAAGGAGGTCATGCAGGAGGTGGCACAGCTCAGCCAGTTTGATGAAGAACTTTATAAGGTGATTGGCAAAGGCAGTGAAAAGTCTGATGA CAACTCCTATGATGAGAAGTACCTGATTGCCACCTCAGAGCAGCCCATTGCTGCCCTGCACCGGGATGAGTGGCTCCGGCCGGAGGACCT GCCCATCAAGTATGCTGGCCTGTCTACCTGCTTCCGTCAGGAGGTGGGCTCCCATGGCCGTGACACCCGTGGCATCTTCCGAGTCCATCA GTTTGAGAAGATTGAACAGTTTGTGTACTCATCACCCCATGACAACAAGTCATGGGAGATGTTTGAAGAGATGATTACCACCGCAGAGGA GTTCTACCAGTCCCTGGGGATTCCTTACCACATTGTGAATATTGTCTCAGGTTCTTTGAATCATGCTGCCAGTAAGAAGCTTGACCTGGA GGCCTGGTTTCCGGGCTCAGGAGCCTTCCGTGAGTTGGTCTCCTGTTCTAATTGCACGGATTACCAGGCTCGCCGGCTTCGAATCCGATA TGGGCAAACCAAGAAGATGATGGACAAGGTGGAGTTTGTCCATATGCTCAATGCTACCATGTGCGCCACTACCCGTACCATCTGCGCCAT CCTGGAGAACTACCAGACAGAGAAGGGCATCACTGTGCCTGAGAAATTGAAGGAGTTCATGCCGCCAGGACTGCAAGAACTGATCCCCTT TGTGAAGCCTGCGCCCATTGAGCAGGAGCCATCAAAGAAGCAGAAGAAGCAACATGAGGGCAGCAAAAAGAAAGCAGCAGCAAGAGACGT CACCCTAGAAAACAGGCTGCAGAACATGGAGGTCACCGATGCTTGAACATTCCTGCCTCCCTATTTGCCAGGCTTTCATTTCTGTCTGCT GAGATCTCAGAGCCTGCCCAACAGCAGGGAAGCCAAGCACCCATTCATCCCCCTGCCCCCATCTGACTGCGTAGCTGAGAGGGGAACAGT GCCATGTACCACACAGATGTTCCTGTCTCCTCGCATGGGCATAGGGACCCATCATTGATGACTGATGAAACCATGTAATAAAGCATCTCT >In-frame_TMPRSS2_ENST00000398585_chr21_42860321_-_SARS_ENST00000369923_chr1_109766600_+_2352nt ACCAGGGTCCCGGCTCGGGGTCCGGGCTGGGGAGGGGAACCTGGGCGCCTGGGACCCGCCGATGCCCCCTGCCCCGCCCGGAGGTGAAAG CGGGTGTGAGGAGCGCGGCGCGGCAGGTCATATTGAACATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGATGGCTTT GAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCACTGTGGT CCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTTCCAACCC CGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAAAGACTAAGAAAGCACTGTGCATCACCTTGACCCTGGGGAC CTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTCTGGAAGTTCATGGGCAGCAAGTGCTCCAACTCTGGGATAGAGTGCGACTCCTC AGGTACCTGCATCAACCCCTCTAACTGGTGTGATGGCGTGTCACACTGCCCCGGCGGGGAGGACGAGAATCGGTGTGGTAGATTTCGGGC AGACAACTTGAACAAGCTGAAGAACCTATGCAGCAAGACAATCGGAGAGAAAATGAAGAAAAAAGAGCCAGTGGGAGATGATGAGTCTGT CCCAGAGAATGTGCTGAGTTTCGATGACCTTACTGCAGACGCTTTAGCTAACCTGAAAGTCTCACAAATCAAAAAAGTCCGACTCCTCAT TGATGAAGCCATCCTGAAGTGTGACGCGGAGCGGATAAAGTTGGAAGCAGAGCGGTTTGAGAACCTCCGAGAGATTGGGAACCTTCTGCA CCCTTCTGTACCCATCAGTAACGATGAGGATGTGGACAACAAAGTAGAGAGGATTTGGGGTGATTGTACAGTCAGGAAGAAGTACTCTCA TGTGGACCTGGTGGTGATGGTAGATGGCTTTGAAGGCGAAAAGGGGGCCGTGGTGGCTGGGAGTCGAGGGTACTTCTTGAAGGGGGTCCT GGTGTTCCTGGAACAGGCTCTCATCCAGTATGCCCTTCGCACCTTGGGAAGTCGGGGCTACATTCCCATTTATACCCCCTTTTTCATGAG GAAGGAGGTCATGCAGGAGGTGGCACAGCTCAGCCAGTTTGATGAAGAACTTTATAAGGTGATTGGCAAAGGCAGTGAAAAGTCTGATGA CAACTCCTATGATGAGAAGTACCTGATTGCCACCTCAGAGCAGCCCATTGCTGCCCTGCACCGGGATGAGTGGCTCCGGCCGGAGGACCT GCCCATCAAGTATGCTGGCCTGTCTACCTGCTTCCGTCAGGAGGTGGGCTCCCATGGCCGTGACACCCGTGGCATCTTCCGAGTCCATCA GTTTGAGAAGATTGAACAGTTTGTGTACTCATCACCCCATGACAACAAGTCATGGGAGATGTTTGAAGAGATGATTACCACCGCAGAGGA GTTCTACCAGTCCCTGGGGATTCCTTACCACATTGTGAATATTGTCTCAGGTTCTTTGAATCATGCTGCCAGTAAGAAGCTTGACCTGGA GGCCTGGTTTCCGGGCTCAGGAGCCTTCCGTGAGTTGGTCTCCTGTTCTAATTGCACGGATTACCAGGCTCGCCGGCTTCGAATCCGATA TGGGCAAACCAAGAAGATGATGGACAAGAGAAAGAATAATCTCCATTTATCTACACAGAACAAGTTGGAGGCTTCCCTCTTCTCACCCAA GAAGGTGGAGTTTGTCCATATGCTCAATGCTACCATGTGCGCCACTACCCGTACCATCTGCGCCATCCTGGAGAACTACCAGACAGAGAA GGGCATCACTGTGCCTGAGAAATTGAAGGAGTTCATGCCGCCAGGACTGCAAGAACTGATCCCCTTTGTGAAGCCTGCGCCCATTGAGCA GGAGCCATCAAAGAAGCAGAAGAAGCAACATGAGGGCAGCAAAAAGAAAGCAGCAGCAAGAGACGTCACCCTAGAAAACAGGCTGCAGAA CATGGAGGTCACCGATGCTTGAACATTCCTGCCTCCCTATTTGCCAGGCTTTCATTTCTGTCTGCTGAGATCTCAGAGCCTGCCCAACAG CAGGGAAGCCAAGCACCCATTCATCCCCCTGCCCCCATCTGACTGCGTAGCTGAGAGGGGAACAGTGCCATGTACCACACAGATGTTCCT GTCTCCTCGCATGGGCATAGGGACCCATCATTGATGACTGATGAAACCATGTAATAAAGCATCTCTGGGGAGGGCTTAGGACTCTTCCTC |
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FusionGenePPI for TMPRSS2_SARS |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TMPRSS2 | CLK1 | SARS | SIRT2, TRS-AGA2-4, UBA5, MYC, TERF1, TINF2, POT1, CDK2, PALLD, TARS, GATC, ANP32E, EFTUD2, GTF2A1, ACBD3, ASF1A, ATG7, ATP6V1C1, CTTN, DUS3L, ELAC2, GTF2E1, STAT1, TTC1, XPO5, SNX5, TBCD, FRMPD2, R3HCC1L, C12orf45, ARFIP1, ARFIP2, C9orf78, CAD, CCDC6, GFPT2, HARS, HARS2, HIP1R, HSPB1, NUP210, PAPOLA, PFDN2, PFKM, PPM1G, PRRC1, PTGES3, MESDC2, TSG101, SEC13, SNW1, TRIM25, WARS, NTRK1, XPO1, MCM2, DUSP21, SOD1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | SARS | chr21:42860321 | chr1:109766600 | ENST00000234677 | + | 0 | 11 | 9_61 | 45 | 515 | tRNA |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMPRSS2_SARS |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMPRSS2_SARS |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TMPRSS2 | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
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