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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 38765

FusionGeneSummary for TMPRSS2_PHF12

check button Fusion gene summary
Fusion gene informationFusion gene name: TMPRSS2_PHF12
Fusion gene ID: 38765
HgeneTgene
Gene symbol

TMPRSS2

PHF12

Gene ID

7113

57649

Gene nametransmembrane serine protease 2PHD finger protein 12
SynonymsPP9284|PRSS10PF1
Cytomap

21q22.3

17q11.2

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protease serine 2epitheliasinserine protease 10transmembrane protease, serine 2PHD finger protein 12PHD factor 1PHD zinc finger transcription factor
Modification date2018052320180523
UniProtAcc

O15393

Q96QT6

Ensembl transtripts involved in fusion geneENST00000332149, ENST00000398585, 
ENST00000458356, ENST00000497881, 
ENST00000332830, ENST00000577226, 
ENST00000268756, ENST00000582655, 
Fusion gene scores* DoF score29 X 21 X 6=36547 X 6 X 5=210
# samples 2288
** MAII scorelog2(228/3654*10)=-0.680442809575384
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMPRSS2 [Title/Abstract] AND PHF12 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTMPRSS2

GO:0006508

proteolysis

21068237|24227843

HgeneTMPRSS2

GO:0046598

positive regulation of viral entry into host cell

21068237|24227843

TgenePHF12

GO:0000122

negative regulation of transcription by RNA polymerase II

22048773

TgenePHF12

GO:0045892

negative regulation of transcription, DNA-templated

11390640


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-G3-AAUZ-01ATMPRSS2chr21

42860321

-PHF12chr17

27235899

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000332149ENST00000332830TMPRSS2chr21

42860321

-PHF12chr17

27235899

-
5CDS-3UTRENST00000332149ENST00000577226TMPRSS2chr21

42860321

-PHF12chr17

27235899

-
5CDS-intronENST00000332149ENST00000268756TMPRSS2chr21

42860321

-PHF12chr17

27235899

-
5CDS-intronENST00000332149ENST00000582655TMPRSS2chr21

42860321

-PHF12chr17

27235899

-
In-frameENST00000398585ENST00000332830TMPRSS2chr21

42860321

-PHF12chr17

27235899

-
5CDS-3UTRENST00000398585ENST00000577226TMPRSS2chr21

42860321

-PHF12chr17

27235899

-
5CDS-intronENST00000398585ENST00000268756TMPRSS2chr21

42860321

-PHF12chr17

27235899

-
5CDS-intronENST00000398585ENST00000582655TMPRSS2chr21

42860321

-PHF12chr17

27235899

-
Frame-shiftENST00000458356ENST00000332830TMPRSS2chr21

42860321

-PHF12chr17

27235899

-
5CDS-3UTRENST00000458356ENST00000577226TMPRSS2chr21

42860321

-PHF12chr17

27235899

-
5CDS-intronENST00000458356ENST00000268756TMPRSS2chr21

42860321

-PHF12chr17

27235899

-
5CDS-intronENST00000458356ENST00000582655TMPRSS2chr21

42860321

-PHF12chr17

27235899

-
intron-3CDSENST00000497881ENST00000332830TMPRSS2chr21

42860321

-PHF12chr17

27235899

-
intron-3UTRENST00000497881ENST00000577226TMPRSS2chr21

42860321

-PHF12chr17

27235899

-
intron-intronENST00000497881ENST00000268756TMPRSS2chr21

42860321

-PHF12chr17

27235899

-
intron-intronENST00000497881ENST00000582655TMPRSS2chr21

42860321

-PHF12chr17

27235899

-

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FusionProtFeatures for TMPRSS2_PHF12


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMPRSS2

O15393

PHF12

Q96QT6

Serine protease that proteolytically cleaves andactivates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized andmaintained in precursor intermediate folding states andproteolysis permits the refolding and energy release required tocreate stable virus-cell linkages and membrane coalescence.Facilitates human SARS coronavirus (SARS-CoV) infection via twoindependent mechanisms, proteolytic cleavage of ACE2, which mightpromote viral uptake, and cleavage of coronavirus spikeglycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activatesthe spike glycoproteins of human coronavirus 229E (HCoV-229E) andhuman coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0of Sendai virus (SeV), human metapneumovirus (HMPV), humanparainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential forspread and pathogenesis of influenza A virus (strains H1N1, H3N2and H7N9); involved in proteolytic cleavage and activation ofhemagglutinin (HA) protein which is essential for viralinfectivity. {ECO:0000269|PubMed:21068237,ECO:0000269|PubMed:21325420, ECO:0000269|PubMed:23536651,ECO:0000269|PubMed:23966399, ECO:0000269|PubMed:24027332,ECO:0000269|PubMed:24227843}. Acts as a transcriptional repressor. Involved inrecruitment of functional SIN3A complexes to DNA. Repressestranscription at least in part through the activity of anassociated histone deacetylase (HDAC). May also represstranscription in a SIN3A-independent manner through recruitment offunctional AES complexes to DNA. {ECO:0000269|PubMed:11390640,ECO:0000303|PubMed:11390640}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMPRSS2chr21:42860321chr17:27235899ENST00000332149-514112_149148493DomainLDL-receptor class A
HgeneTMPRSS2chr21:42860321chr17:27235899ENST00000398585-514112_149185530DomainLDL-receptor class A
HgeneTMPRSS2chr21:42860321chr17:27235899ENST00000458356-514112_149148493DomainLDL-receptor class A
HgeneTMPRSS2chr21:42860321chr17:27235899ENST00000332149-5141_84148493Topological domainCytoplasmic
HgeneTMPRSS2chr21:42860321chr17:27235899ENST00000398585-5141_84185530Topological domainCytoplasmic
HgeneTMPRSS2chr21:42860321chr17:27235899ENST00000458356-5141_84148493Topological domainCytoplasmic
HgeneTMPRSS2chr21:42860321chr17:27235899ENST00000332149-51485_105148493TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42860321chr17:27235899ENST00000398585-51485_105185530TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42860321chr17:27235899ENST00000458356-51485_105148493TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgenePHF12chr21:42860321chr17:27235899ENST00000268756-09894_897-177705Compositional biasPoly-Arg
TgenePHF12chr21:42860321chr17:27235899ENST00000268756-09929_932-177705Compositional biasPoly-Ser
TgenePHF12chr21:42860321chr17:27235899ENST00000332830-1015894_8977861005Compositional biasPoly-Arg
TgenePHF12chr21:42860321chr17:27235899ENST00000332830-1015929_9327861005Compositional biasPoly-Ser
TgenePHF12chr21:42860321chr17:27235899ENST00000268756-09815_869-177705DomainFHA
TgenePHF12chr21:42860321chr17:27235899ENST00000332830-1015815_8697861005DomainFHA
TgenePHF12chr21:42860321chr17:27235899ENST00000268756-09105_128-177705RegionNote=PBR
TgenePHF12chr21:42860321chr17:27235899ENST00000268756-09271_321-177705Zinc fingerPHD-type 2%3B atypical
TgenePHF12chr21:42860321chr17:27235899ENST00000268756-0956_105-177705Zinc fingerPHD-type 1

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMPRSS2chr21:42860321chr17:27235899ENST00000332149-514150_242148493DomainSRCR
HgeneTMPRSS2chr21:42860321chr17:27235899ENST00000332149-514256_489148493DomainPeptidase S1
HgeneTMPRSS2chr21:42860321chr17:27235899ENST00000398585-514150_242185530DomainSRCR
HgeneTMPRSS2chr21:42860321chr17:27235899ENST00000398585-514256_489185530DomainPeptidase S1
HgeneTMPRSS2chr21:42860321chr17:27235899ENST00000458356-514150_242148493DomainSRCR
HgeneTMPRSS2chr21:42860321chr17:27235899ENST00000458356-514256_489148493DomainPeptidase S1
HgeneTMPRSS2chr21:42860321chr17:27235899ENST00000332149-514106_492148493Topological domainExtracellular
HgeneTMPRSS2chr21:42860321chr17:27235899ENST00000398585-514106_492185530Topological domainExtracellular
HgeneTMPRSS2chr21:42860321chr17:27235899ENST00000458356-514106_492148493Topological domainExtracellular
TgenePHF12chr21:42860321chr17:27235899ENST00000332830-1015105_1287861005RegionNote=PBR
TgenePHF12chr21:42860321chr17:27235899ENST00000332830-1015271_3217861005Zinc fingerPHD-type 2%3B atypical
TgenePHF12chr21:42860321chr17:27235899ENST00000332830-101556_1057861005Zinc fingerPHD-type 1


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FusionGeneSequence for TMPRSS2_PHF12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TMPRSS2_ENST00000332149_chr21_42860321_-_PHF12_ENST00000332830_chr17_27235899_-_367aa
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLT
LGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVQRKEVQARAVFYPLLGLGGAVNMCYRTLYIG
TGADMDVCLTNYGHCNYVSGKHACIFYDENTKHYELLNYSEHGTTVDNVLYSCDFSEKTPPTPPSSIVAKVQSVIRRRRHQKQDEEPSEE
AAMMSSQAQGPQRRPCNCKASSSSLIGGSGAGWEGTALLHHGSYIKLGCLQFVFSITEFATKQPKGDASLLQDGVLAEKLSLKPHQGPVL

>In-frame_TMPRSS2_ENST00000398585_chr21_42860321_-_PHF12_ENST00000332830_chr17_27235899_-_404aa
MPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYA
PRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGE
DENRCVQRKEVQARAVFYPLLGLGGAVNMCYRTLYIGTGADMDVCLTNYGHCNYVSGKHACIFYDENTKHYELLNYSEHGTTVDNVLYSC
DFSEKTPPTPPSSIVAKVQSVIRRRRHQKQDEEPSEEAAMMSSQAQGPQRRPCNCKASSSSLIGGSGAGWEGTALLHHGSYIKLGCLQFV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TMPRSS2_ENST00000332149_chr21_42860321_-_PHF12_ENST00000332830_chr17_27235899_-_1101nt
ATGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCC
ACTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCT
TCCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAAAGACTAAGAAAGCACTGTGCATCACCTTGACC
CTGGGGACCTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTCTGGAAGTTCATGGGCAGCAAGTGCTCCAACTCTGGGATAGAGTGC
GACTCCTCAGGTACCTGCATCAACCCCTCTAACTGGTGTGATGGCGTGTCACACTGCCCCGGCGGGGAGGACGAGAATCGGTGTGTGCAA
AGAAAGGAGGTACAGGCCCGAGCTGTGTTCTACCCCCTCTTAGGGTTGGGAGGAGCTGTGAACATGTGCTATCGAACCCTCTACATCGGG
ACAGGAGCTGACATGGATGTGTGCCTTACAAACTATGGTCACTGTAACTACGTGTCCGGGAAACATGCCTGCATATTCTACGATGAGAAT
ACCAAACATTATGAGCTGTTAAACTACAGTGAGCATGGGACAACGGTGGACAATGTGCTGTATTCATGTGACTTCTCGGAGAAGACCCCG
CCAACCCCCCCAAGCAGTATTGTTGCCAAAGTGCAGAGTGTCATCAGGCGCCGCCGGCACCAGAAACAGGACGAAGAGCCAAGTGAGGAG
GCAGCCATGATGAGTTCCCAGGCCCAGGGGCCGCAGCGGAGACCCTGCAATTGCAAAGCCAGCAGCTCGAGCTTGATTGGGGGCAGTGGG
GCCGGCTGGGAGGGCACAGCCTTACTGCACCATGGCAGCTACATCAAGCTGGGCTGCCTGCAGTTTGTCTTCAGCATCACTGAGTTTGCG
ACCAAACAGCCCAAAGGCGATGCCAGCCTGCTGCAGGATGGGGTCTTGGCCGAGAAGCTCTCTCTCAAGCCCCACCAGGGCCCTGTGCTG

>In-frame_TMPRSS2_ENST00000398585_chr21_42860321_-_PHF12_ENST00000332830_chr17_27235899_-_1212nt
ATGCCCCCTGCCCCGCCCGGAGGTGAAAGCGGGTGTGAGGAGCGCGGCGCGGCAGGTCATATTGAACATTCCAGATACCTATCATTACTC
GATGCTGTTGATAACAGCAAGATGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAA
AACCCCTATCCCGCACAGCCCACTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCC
CCGAGGGTCCTGACGCAGGCTTCCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAAAGACTAAGAAA
GCACTGTGCATCACCTTGACCCTGGGGACCTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTCTGGAAGTTCATGGGCAGCAAGTGC
TCCAACTCTGGGATAGAGTGCGACTCCTCAGGTACCTGCATCAACCCCTCTAACTGGTGTGATGGCGTGTCACACTGCCCCGGCGGGGAG
GACGAGAATCGGTGTGTGCAAAGAAAGGAGGTACAGGCCCGAGCTGTGTTCTACCCCCTCTTAGGGTTGGGAGGAGCTGTGAACATGTGC
TATCGAACCCTCTACATCGGGACAGGAGCTGACATGGATGTGTGCCTTACAAACTATGGTCACTGTAACTACGTGTCCGGGAAACATGCC
TGCATATTCTACGATGAGAATACCAAACATTATGAGCTGTTAAACTACAGTGAGCATGGGACAACGGTGGACAATGTGCTGTATTCATGT
GACTTCTCGGAGAAGACCCCGCCAACCCCCCCAAGCAGTATTGTTGCCAAAGTGCAGAGTGTCATCAGGCGCCGCCGGCACCAGAAACAG
GACGAAGAGCCAAGTGAGGAGGCAGCCATGATGAGTTCCCAGGCCCAGGGGCCGCAGCGGAGACCCTGCAATTGCAAAGCCAGCAGCTCG
AGCTTGATTGGGGGCAGTGGGGCCGGCTGGGAGGGCACAGCCTTACTGCACCATGGCAGCTACATCAAGCTGGGCTGCCTGCAGTTTGTC
TTCAGCATCACTGAGTTTGCGACCAAACAGCCCAAAGGCGATGCCAGCCTGCTGCAGGATGGGGTCTTGGCCGAGAAGCTCTCTCTCAAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_TMPRSS2_ENST00000332149_chr21_42860321_-_PHF12_ENST00000332830_chr17_27235899_-_2169nt
CGAGTAGGCGCGAGCTAAGCAGGAGGCGGAGGCGGAGGCGGAGGGCGAGGGGCGGGGAGCGCCGCCTGGAGCGCGGCAGGTCATATTGAA
CATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGATGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTAT
GAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCACTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTAC
CCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTTCCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACA
GTGTGCACCTCAAAGACTAAGAAAGCACTGTGCATCACCTTGACCCTGGGGACCTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTC
TGGAAGTTCATGGGCAGCAAGTGCTCCAACTCTGGGATAGAGTGCGACTCCTCAGGTACCTGCATCAACCCCTCTAACTGGTGTGATGGC
GTGTCACACTGCCCCGGCGGGGAGGACGAGAATCGGTGTGTGCAAAGAAAGGAGGTACAGGCCCGAGCTGTGTTCTACCCCCTCTTAGGG
TTGGGAGGAGCTGTGAACATGTGCTATCGAACCCTCTACATCGGGACAGGAGCTGACATGGATGTGTGCCTTACAAACTATGGTCACTGT
AACTACGTGTCCGGGAAACATGCCTGCATATTCTACGATGAGAATACCAAACATTATGAGCTGTTAAACTACAGTGAGCATGGGACAACG
GTGGACAATGTGCTGTATTCATGTGACTTCTCGGAGAAGACCCCGCCAACCCCCCCAAGCAGTATTGTTGCCAAAGTGCAGAGTGTCATC
AGGCGCCGCCGGCACCAGAAACAGGACGAAGAGCCAAGTGAGGAGGCAGCCATGATGAGTTCCCAGGCCCAGGGGCCGCAGCGGAGACCC
TGCAATTGCAAAGCCAGCAGCTCGAGCTTGATTGGGGGCAGTGGGGCCGGCTGGGAGGGCACAGCCTTACTGCACCATGGCAGCTACATC
AAGCTGGGCTGCCTGCAGTTTGTCTTCAGCATCACTGAGTTTGCGACCAAACAGCCCAAAGGCGATGCCAGCCTGCTGCAGGATGGGGTC
TTGGCCGAGAAGCTCTCTCTCAAGCCCCACCAGGGCCCTGTGCTGCGCTCCAACTCTGTTCCTTAGGACTGGCGGCTACCCCGCCACTGG
CCTGTACACCCACCCAAGACTCCTGCAATGCAAAAATGTACACAAACCAAGCCCGGGTGTTTTCTATACTCTACCAGAAACCCTTCAACT
ACAATCTTTGCATGAAATGAAGAAAACCTTTTGACTGTTTTTTAAAAATCCTTTTTCTTTTCTCAAGTTCTAGGGGGCATTTGCACATAT
ATTTGTACTCAACATTTCATGGGAAAGCGGCAGACCTGAGCTGAGGAACAGCGTGGGCAGGGAGGGAAAGACCCAGGGTCTGGACACTTC
CTCCAACACAAAACCCTTCCCCACCCACCTCCTGCTCCCTCCCCCTCGCCCACCATTGTAAAATAATCAGAAACTTGTTCTATTTTGTGG
CAGTGACAATAGTTTTATATTAAAAGAAAAAATACAGTTTTCATACAGCAAAATCTATACAATATCATTGTTTTATTTAATATAAAGATC
GCTACCCACCTTCCTTCCATGGTTCCCACCCTCCACGTTATTTTCCCTTTCTGCAGCGGTTGCACTACAGGTAGCTACTGTGTATTATGG
ACAAATGAGAAATGAATTCTTTTTCTGGCTGTCCATCTATTTTATTTCAAATAAGGAAAAGTGTATTTGGATTTTGTGTAAATACATCTA
GTGATGACATTTTTTCAATGTTTTTAAAAACCGTGTACAGTACTACATGTGGTAGAGCGTTTTCTCAAATTGTCTATTGTAGCAAAAATG
TTTTTGTCGTAAACCTGTTTTGTCTCCTTTTTTTGTTCTCTTGCCACTTCTCTCCTCTTCCTCCTGCCCCTGGTTCCCTCCTCTCCTCCC
ACCCCCACAACCAGTACCAATGTACATAGTAATTGTAATGTTTTAGACTTTACAGAAACTTTCCTGTATTCTGTATATAAAAAACAAAAA

>In-frame_TMPRSS2_ENST00000398585_chr21_42860321_-_PHF12_ENST00000332830_chr17_27235899_-_2206nt
ACCAGGGTCCCGGCTCGGGGTCCGGGCTGGGGAGGGGAACCTGGGCGCCTGGGACCCGCCGATGCCCCCTGCCCCGCCCGGAGGTGAAAG
CGGGTGTGAGGAGCGCGGCGCGGCAGGTCATATTGAACATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGATGGCTTT
GAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCACTGTGGT
CCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTTCCAACCC
CGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAAAGACTAAGAAAGCACTGTGCATCACCTTGACCCTGGGGAC
CTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTCTGGAAGTTCATGGGCAGCAAGTGCTCCAACTCTGGGATAGAGTGCGACTCCTC
AGGTACCTGCATCAACCCCTCTAACTGGTGTGATGGCGTGTCACACTGCCCCGGCGGGGAGGACGAGAATCGGTGTGTGCAAAGAAAGGA
GGTACAGGCCCGAGCTGTGTTCTACCCCCTCTTAGGGTTGGGAGGAGCTGTGAACATGTGCTATCGAACCCTCTACATCGGGACAGGAGC
TGACATGGATGTGTGCCTTACAAACTATGGTCACTGTAACTACGTGTCCGGGAAACATGCCTGCATATTCTACGATGAGAATACCAAACA
TTATGAGCTGTTAAACTACAGTGAGCATGGGACAACGGTGGACAATGTGCTGTATTCATGTGACTTCTCGGAGAAGACCCCGCCAACCCC
CCCAAGCAGTATTGTTGCCAAAGTGCAGAGTGTCATCAGGCGCCGCCGGCACCAGAAACAGGACGAAGAGCCAAGTGAGGAGGCAGCCAT
GATGAGTTCCCAGGCCCAGGGGCCGCAGCGGAGACCCTGCAATTGCAAAGCCAGCAGCTCGAGCTTGATTGGGGGCAGTGGGGCCGGCTG
GGAGGGCACAGCCTTACTGCACCATGGCAGCTACATCAAGCTGGGCTGCCTGCAGTTTGTCTTCAGCATCACTGAGTTTGCGACCAAACA
GCCCAAAGGCGATGCCAGCCTGCTGCAGGATGGGGTCTTGGCCGAGAAGCTCTCTCTCAAGCCCCACCAGGGCCCTGTGCTGCGCTCCAA
CTCTGTTCCTTAGGACTGGCGGCTACCCCGCCACTGGCCTGTACACCCACCCAAGACTCCTGCAATGCAAAAATGTACACAAACCAAGCC
CGGGTGTTTTCTATACTCTACCAGAAACCCTTCAACTACAATCTTTGCATGAAATGAAGAAAACCTTTTGACTGTTTTTTAAAAATCCTT
TTTCTTTTCTCAAGTTCTAGGGGGCATTTGCACATATATTTGTACTCAACATTTCATGGGAAAGCGGCAGACCTGAGCTGAGGAACAGCG
TGGGCAGGGAGGGAAAGACCCAGGGTCTGGACACTTCCTCCAACACAAAACCCTTCCCCACCCACCTCCTGCTCCCTCCCCCTCGCCCAC
CATTGTAAAATAATCAGAAACTTGTTCTATTTTGTGGCAGTGACAATAGTTTTATATTAAAAGAAAAAATACAGTTTTCATACAGCAAAA
TCTATACAATATCATTGTTTTATTTAATATAAAGATCGCTACCCACCTTCCTTCCATGGTTCCCACCCTCCACGTTATTTTCCCTTTCTG
CAGCGGTTGCACTACAGGTAGCTACTGTGTATTATGGACAAATGAGAAATGAATTCTTTTTCTGGCTGTCCATCTATTTTATTTCAAATA
AGGAAAAGTGTATTTGGATTTTGTGTAAATACATCTAGTGATGACATTTTTTCAATGTTTTTAAAAACCGTGTACAGTACTACATGTGGT
AGAGCGTTTTCTCAAATTGTCTATTGTAGCAAAAATGTTTTTGTCGTAAACCTGTTTTGTCTCCTTTTTTTGTTCTCTTGCCACTTCTCT
CCTCTTCCTCCTGCCCCTGGTTCCCTCCTCTCCTCCCACCCCCACAACCAGTACCAATGTACATAGTAATTGTAATGTTTTAGACTTTAC


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FusionGenePPI for TMPRSS2_PHF12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMPRSS2CLK1PHF12SIN3A, HDAC1, SAP30, MORF4L1, MORF4L2, BRCA1, HIST3H3, GATAD1, RBBP7, HDAC2, KDM5A, S100A4, SIN3B, C11orf30, SPICE1, ZNF281, ZNF131, QSER1, CHD9, PHF12, TUBA4A, ZNF143, DPM1, ZNF335, RBFOX2, RBFOX1, H2AFY, BAG2, HSPB1, NFE2L1, TUBB8, DNAJA3, SENP1, ABCF2, GPATCH8, ABCG2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgenePHF12chr21:42860321chr17:27235899ENST00000268756-09102_273-177705SIN3A
TgenePHF12chr21:42860321chr17:27235899ENST00000268756-09300_704-177705SIN3A


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgenePHF12chr21:42860321chr17:27235899ENST00000332830-1015102_2737861005SIN3A
TgenePHF12chr21:42860321chr17:27235899ENST00000332830-1015300_7047861005SIN3A


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMPRSS2_PHF12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMPRSS2_PHF12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTMPRSS2C0033578Prostatic Neoplasms2CTD_human