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Fusion gene ID: 38761 |
FusionGeneSummary for TMPRSS2_MORC3 |
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Fusion gene information | Fusion gene name: TMPRSS2_MORC3 | Fusion gene ID: 38761 | Hgene | Tgene | Gene symbol | TMPRSS2 | MORC3 | Gene ID | 7113 | 23515 |
Gene name | transmembrane serine protease 2 | MORC family CW-type zinc finger 3 | |
Synonyms | PP9284|PRSS10 | NXP2|ZCW5|ZCWCC3 | |
Cytomap | 21q22.3 | 21q22.12 | |
Type of gene | protein-coding | protein-coding | |
Description | transmembrane protease serine 2epitheliasinserine protease 10transmembrane protease, serine 2 | MORC family CW-type zinc finger protein 3nuclear matrix protein 2nuclear matrix protein NXP2zinc finger CW-type coiled-coil domain protein 3zinc finger, CW type with coiled-coil domain 3 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | O15393 | Q14149 | |
Ensembl transtripts involved in fusion gene | ENST00000332149, ENST00000398585, ENST00000458356, ENST00000497881, | ENST00000400485, ENST00000487909, | |
Fusion gene scores | * DoF score | 29 X 21 X 6=3654 | 5 X 5 X 3=75 |
# samples | 228 | 5 | |
** MAII score | log2(228/3654*10)=-0.680442809575384 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TMPRSS2 [Title/Abstract] AND MORC3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tissue-specifically expressed gene involved fusion gene, inframe and retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TMPRSS2 | GO:0006508 | proteolysis | 21068237|24227843 |
Hgene | TMPRSS2 | GO:0046598 | positive regulation of viral entry into host cell | 21068237|24227843 |
Tgene | MORC3 | GO:0006468 | protein phosphorylation | 17332504 |
Tgene | MORC3 | GO:0007569 | cell aging | 17332504 |
Tgene | MORC3 | GO:0018105 | peptidyl-serine phosphorylation | 17332504 |
Tgene | MORC3 | GO:0048147 | negative regulation of fibroblast proliferation | 17332504 |
Tgene | MORC3 | GO:0050821 | protein stabilization | 17332504 |
Tgene | MORC3 | GO:0051457 | maintenance of protein location in nucleus | 17332504 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-CH-5762-01A | TMPRSS2 | chr21 | 42870046 | - | MORC3 | chr21 | 37705944 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000332149 | ENST00000400485 | TMPRSS2 | chr21 | 42870046 | - | MORC3 | chr21 | 37705944 | + |
5CDS-intron | ENST00000332149 | ENST00000487909 | TMPRSS2 | chr21 | 42870046 | - | MORC3 | chr21 | 37705944 | + |
In-frame | ENST00000398585 | ENST00000400485 | TMPRSS2 | chr21 | 42870046 | - | MORC3 | chr21 | 37705944 | + |
5CDS-intron | ENST00000398585 | ENST00000487909 | TMPRSS2 | chr21 | 42870046 | - | MORC3 | chr21 | 37705944 | + |
Frame-shift | ENST00000458356 | ENST00000400485 | TMPRSS2 | chr21 | 42870046 | - | MORC3 | chr21 | 37705944 | + |
5CDS-intron | ENST00000458356 | ENST00000487909 | TMPRSS2 | chr21 | 42870046 | - | MORC3 | chr21 | 37705944 | + |
5UTR-3CDS | ENST00000497881 | ENST00000400485 | TMPRSS2 | chr21 | 42870046 | - | MORC3 | chr21 | 37705944 | + |
5UTR-intron | ENST00000497881 | ENST00000487909 | TMPRSS2 | chr21 | 42870046 | - | MORC3 | chr21 | 37705944 | + |
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FusionProtFeatures for TMPRSS2_MORC3 |
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Hgene | Tgene |
TMPRSS2 | MORC3 |
Serine protease that proteolytically cleaves andactivates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized andmaintained in precursor intermediate folding states andproteolysis permits the refolding and energy release required tocreate stable virus-cell linkages and membrane coalescence.Facilitates human SARS coronavirus (SARS-CoV) infection via twoindependent mechanisms, proteolytic cleavage of ACE2, which mightpromote viral uptake, and cleavage of coronavirus spikeglycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activatesthe spike glycoproteins of human coronavirus 229E (HCoV-229E) andhuman coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0of Sendai virus (SeV), human metapneumovirus (HMPV), humanparainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential forspread and pathogenesis of influenza A virus (strains H1N1, H3N2and H7N9); involved in proteolytic cleavage and activation ofhemagglutinin (HA) protein which is essential for viralinfectivity. {ECO:0000269|PubMed:21068237,ECO:0000269|PubMed:21325420, ECO:0000269|PubMed:23536651,ECO:0000269|PubMed:23966399, ECO:0000269|PubMed:24027332,ECO:0000269|PubMed:24227843}. | Nuclear factor which forms MORC3-NBs (nuclear bodies)via an ATP-dependent mechanism (PubMed:20501696). SumoylatedMORC3-NBs can also associate with PML-NBs (PubMed:20501696).Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity(PubMed:17332504). Binds RNA in vitro (PubMed:11927593). May berequired for influenza A transcription during viral infection(PubMed:26202233). {ECO:0000269|PubMed:11927593,ECO:0000269|PubMed:17332504, ECO:0000269|PubMed:20501696,ECO:0000269|PubMed:26202233}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >MORC3 | chr21:42870046 | chr21:37705944 | ENST00000400485 | + | 0 | 17 | 686_877 | 13 | 940 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >MORC3 | chr21:42870046 | chr21:37705944 | ENST00000400485 | + | 0 | 17 | 326_353 | 13 | 940 | Region | Nuclear matrix binding |
Tgene | >MORC3 | chr21:42870046 | chr21:37705944 | ENST00000400485 | + | 0 | 17 | 500_591 | 13 | 940 | Region | RNA binding |
Tgene | >MORC3 | chr21:42870046 | chr21:37705944 | ENST00000400485 | + | 0 | 17 | 404_454 | 13 | 940 | Zinc finger | CW-type |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000332149 | - | 2 | 14 | 112_149 | 5 | 493 | Domain | LDL-receptor class A |
Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000332149 | - | 2 | 14 | 150_242 | 5 | 493 | Domain | SRCR |
Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000332149 | - | 2 | 14 | 256_489 | 5 | 493 | Domain | Peptidase S1 |
Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000398585 | - | 2 | 14 | 112_149 | 42 | 530 | Domain | LDL-receptor class A |
Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000398585 | - | 2 | 14 | 150_242 | 42 | 530 | Domain | SRCR |
Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000398585 | - | 2 | 14 | 256_489 | 42 | 530 | Domain | Peptidase S1 |
Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000458356 | - | 2 | 14 | 112_149 | 5 | 493 | Domain | LDL-receptor class A |
Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000458356 | - | 2 | 14 | 150_242 | 5 | 493 | Domain | SRCR |
Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000458356 | - | 2 | 14 | 256_489 | 5 | 493 | Domain | Peptidase S1 |
Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000332149 | - | 2 | 14 | 106_492 | 5 | 493 | Topological domain | Extracellular |
Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000332149 | - | 2 | 14 | 1_84 | 5 | 493 | Topological domain | Cytoplasmic |
Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000398585 | - | 2 | 14 | 106_492 | 42 | 530 | Topological domain | Extracellular |
Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000398585 | - | 2 | 14 | 1_84 | 42 | 530 | Topological domain | Cytoplasmic |
Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000458356 | - | 2 | 14 | 106_492 | 5 | 493 | Topological domain | Extracellular |
Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000458356 | - | 2 | 14 | 1_84 | 5 | 493 | Topological domain | Cytoplasmic |
Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000332149 | - | 2 | 14 | 85_105 | 5 | 493 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000398585 | - | 2 | 14 | 85_105 | 42 | 530 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000458356 | - | 2 | 14 | 85_105 | 5 | 493 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
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FusionGeneSequence for TMPRSS2_MORC3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_TMPRSS2_ENST00000332149_chr21_42870046_-_MORC3_ENST00000400485_chr21_37705944_+_932aa MALNSLCPKFLHTNSTSHTWPFSAVAELIDNAYDPDVNAKQIWIDKTVINDHICLTFTDNGNGMTSDKLHKMLSFGFSDKVTMNGHVPVG LYGNGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKHRQMINLAESKASLAAILEHSLFSTEQKLLAELDAI IGKKGTRIIIWNLRSYKNATEFDFEKDKYDIRIPEDLDEITGKKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIILRGQKVKTQLV SKSLAYIERDVYRPKFLSKTVRITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQLRANNMGVGVVGIIECNFLKPTHNKQDFDYTNEYR LTITALGEKLNDYWNEMKVKKNTEYPLNLPVEDIQKRPDQTWVQCDACLKWRKLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLV HPTYEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKESVPRRHLSEGTNSYATRLLNNHQVPPQSEPESNSLKRRLSTR SSILNAKNRRLSSQFENSVYKGDDDDEDVIILEENSTPKPAVDHDIDMKSEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTA ATQTEVPSLVVKKEETVEDEIDVRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQLQELRNQLLLVTEEKENYKRQCHMFTDQIKVLQ QRILEMNDKYVKKETCHQSTETDAVFLLESINGKSESPDHMVSQYQQALEEIERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDD VFRQLDKCSIERDQYKSEVELLEMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTSSNIEESVNHMDGESLKLRSLRVNVGQLLAMIVP >In-frame_TMPRSS2_ENST00000398585_chr21_42870046_-_MORC3_ENST00000400485_chr21_37705944_+_969aa MPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSLCPKFLHTNSTSHTWPFSAVAELIDNAYDPDVNAKQIWIDKTVINDHI CLTFTDNGNGMTSDKLHKMLSFGFSDKVTMNGHVPVGLYGNGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAFN KHRQMINLAESKASLAAILEHSLFSTEQKLLAELDAIIGKKGTRIIIWNLRSYKNATEFDFEKDKYDIRIPEDLDEITGKKGYKKQERMD QIAPESDYSLRAYCSILYLKPRMQIILRGQKVKTQLVSKSLAYIERDVYRPKFLSKTVRITFGFNCRNKDHYGIMMYHRNRLIKAYEKVG CQLRANNMGVGVVGIIECNFLKPTHNKQDFDYTNEYRLTITALGEKLNDYWNEMKVKKNTEYPLNLPVEDIQKRPDQTWVQCDACLKWRK LPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPTYEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKESVPRR HLSEGTNSYATRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDDEDVIILEENSTPKPAVDHDIDMKSEQS HVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQTEVPSLVVKKEETVEDEIDVRNDAVILPSCVEAEAKIHETQETTDKSADD AGCQLQELRNQLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTETDAVFLLESINGKSESPDHMVSQYQQALEEIE RLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQYKSEVELLEMEKSQIRSQCEELKTEVEQLKSTNQQTATD |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_TMPRSS2_ENST00000332149_chr21_42870046_-_MORC3_ENST00000400485_chr21_37705944_+_2796nt ATGGCTTTGAACTCACTTTGCCCGAAGTTTTTACATACAAATTCTACTAGTCACACCTGGCCATTCAGTGCAGTTGCTGAATTAATAGAT AATGCTTATGATCCTGATGTGAACGCTAAACAAATATGGATTGACAAAACAGTGATAAATGACCATATATGCTTGACATTCACCGACAAT GGGAATGGTATGACTTCTGATAAATTACATAAAATGCTAAGCTTTGGCTTCAGTGACAAAGTCACCATGAATGGTCATGTCCCAGTTGGA TTATATGGGAATGGCTTCAAGTCGGGTTCTATGCGTCTGGGTAAAGACGCAATCGTTTTTACCAAAAATGGAGAAAGCATGAGCGTGGGC CTTTTGTCTCAGACCTACTTGGAAGTCATAAAAGCGGAGCATGTTGTTGTTCCAATAGTGGCATTCAACAAGCACCGACAGATGATTAAT TTAGCAGAATCAAAAGCCAGCCTTGCTGCAATTCTGGAACATTCTCTGTTTTCCACGGAACAGAAGTTACTGGCAGAACTTGATGCTATT ATAGGCAAGAAGGGGACGAGGATCATCATTTGGAATCTTAGAAGCTACAAAAATGCAACAGAGTTCGATTTTGAAAAGGATAAATATGAT ATCAGAATTCCCGAGGATTTAGATGAGATAACAGGGAAGAAGGGGTACAAGAAGCAGGAAAGGATGGACCAGATTGCCCCTGAGAGTGAC TATTCCCTGAGGGCTTATTGCAGTATATTATATCTAAAGCCAAGAATGCAGATCATCCTACGTGGACAGAAAGTGAAGACACAGCTGGTT TCGAAGAGTCTTGCCTACATCGAACGTGATGTTTATCGACCAAAATTTTTATCTAAAACAGTGAGAATTACCTTTGGATTCAACTGCAGA AATAAAGATCATTATGGGATAATGATGTATCACAGAAATAGACTCATCAAAGCTTATGAAAAAGTTGGATGTCAGTTAAGGGCAAACAAC ATGGGTGTTGGAGTGGTTGGAATTATAGAGTGTAATTTCCTTAAGCCAACTCATAATAAACAAGATTTCGACTATACTAATGAGTACAGA CTTACAATAACAGCACTAGGAGAAAAGCTGAATGATTACTGGAATGAAATGAAAGTGAAGAAAAATACAGAATATCCTCTAAATTTGCCA GTTGAAGATATACAGAAGCGTCCTGATCAGACATGGGTTCAGTGTGATGCCTGTCTAAAGTGGCGGAAATTACCTGATGGGATGGATCAA CTTCCTGAAAAATGGTATTGCTCCAATAACCCTGACCCACAGTTCAGAAATTGTGAGGTTCCAGAAGAACCTGAAGATGAGGATTTGGTA CATCCCACTTATGAAAAAACCTACAAAAAGACCAACAAGGAAAAATTCAGGATCAGACAACCGGAAATGATCCCTCGGATTAATGCTGAA CTGTTGTTTCGGCCAACTGCTCTTTCAACTCCAAGCTTTTCTTCTCCTAAGGAAAGTGTTCCAAGAAGACATCTTTCAGAAGGAACAAAT TCTTATGCGACAAGACTTCTAAATAATCATCAAGTTCCACCTCAGTCTGAACCTGAGAGCAACAGCTTGAAACGGAGACTTTCTACTCGT TCCTCAATTTTGAATGCAAAGAATCGGAGATTGAGTAGTCAGTTTGAAAATTCAGTTTATAAAGGTGATGATGATGATGAAGATGTCATC ATCTTAGAAGAAAACAGTACCCCCAAACCTGCAGTAGATCATGATATTGACATGAAATCAGAACAGAGTCACGTTGAGCAAGGTGGTGTT CAGGTTGAGTTTGTGGGTGACAGTGAACCTTGTGGCCAGACTGGTTCAACAAGCACCTCATCATCCCGATGCGACCAGGGAAATACTGCA GCTACCCAGACTGAAGTACCAAGTTTAGTTGTTAAAAAAGAAGAAACTGTTGAAGACGAGATAGACGTAAGAAATGATGCAGTGATTCTG CCCTCCTGTGTAGAAGCTGAAGCAAAGATACATGAAACCCAGGAAACCACCGATAAATCTGCAGATGATGCAGGCTGCCAATTACAAGAA CTGAGAAACCAGCTACTCCTTGTCACTGAGGAAAAAGAGAATTATAAAAGACAGTGTCATATGTTTACTGATCAAATCAAAGTGTTACAA CAGAGGATACTAGAAATGAATGACAAGTATGTTAAGAAAGAAACTTGCCATCAGTCCACTGAAACCGATGCTGTATTTTTACTTGAAAGT ATTAATGGCAAATCTGAAAGTCCAGACCATATGGTATCTCAGTATCAGCAAGCTTTGGAAGAAATAGAAAGGCTGAAAAAACAATGTAGT GCTTTGCAACATGTAAAGGCTGAATGCAGCCAGTGTTCCAATAATGAGAGTAAAAGTGAAATGGATGAGATGGCTGTGCAGCTTGACGAT GTGTTTAGACAACTGGACAAATGCAGTATTGAGAGGGACCAGTATAAAAGTGAGGTTGAATTGCTGGAAATGGAAAAGTCACAAATCCGT TCACAGTGTGAAGAACTCAAAACTGAAGTAGAACAGTTAAAATCTACAAATCAACAGACGGCAACAGATGTTTCAACATCAAGTAACATT GAGGAGTCTGTAAATCATATGGATGGAGAAAGCCTCAAACTCCGATCTCTTCGAGTTAACGTAGGACAACTGCTGGCTATGATTGTGCCT GATCTTGATCTTCAGCAAGTGAATTACGATGTTGATGTAGTTGATGAGATTTTAGGACAAGTTGTTGAACAAATGAGTGAAATCAGTAGT >In-frame_TMPRSS2_ENST00000398585_chr21_42870046_-_MORC3_ENST00000400485_chr21_37705944_+_2907nt ATGCCCCCTGCCCCGCCCGGAGGTGAAAGCGGGTGTGAGGAGCGCGGCGCGGCAGGTCATATTGAACATTCCAGATACCTATCATTACTC GATGCTGTTGATAACAGCAAGATGGCTTTGAACTCACTTTGCCCGAAGTTTTTACATACAAATTCTACTAGTCACACCTGGCCATTCAGT GCAGTTGCTGAATTAATAGATAATGCTTATGATCCTGATGTGAACGCTAAACAAATATGGATTGACAAAACAGTGATAAATGACCATATA TGCTTGACATTCACCGACAATGGGAATGGTATGACTTCTGATAAATTACATAAAATGCTAAGCTTTGGCTTCAGTGACAAAGTCACCATG AATGGTCATGTCCCAGTTGGATTATATGGGAATGGCTTCAAGTCGGGTTCTATGCGTCTGGGTAAAGACGCAATCGTTTTTACCAAAAAT GGAGAAAGCATGAGCGTGGGCCTTTTGTCTCAGACCTACTTGGAAGTCATAAAAGCGGAGCATGTTGTTGTTCCAATAGTGGCATTCAAC AAGCACCGACAGATGATTAATTTAGCAGAATCAAAAGCCAGCCTTGCTGCAATTCTGGAACATTCTCTGTTTTCCACGGAACAGAAGTTA CTGGCAGAACTTGATGCTATTATAGGCAAGAAGGGGACGAGGATCATCATTTGGAATCTTAGAAGCTACAAAAATGCAACAGAGTTCGAT TTTGAAAAGGATAAATATGATATCAGAATTCCCGAGGATTTAGATGAGATAACAGGGAAGAAGGGGTACAAGAAGCAGGAAAGGATGGAC CAGATTGCCCCTGAGAGTGACTATTCCCTGAGGGCTTATTGCAGTATATTATATCTAAAGCCAAGAATGCAGATCATCCTACGTGGACAG AAAGTGAAGACACAGCTGGTTTCGAAGAGTCTTGCCTACATCGAACGTGATGTTTATCGACCAAAATTTTTATCTAAAACAGTGAGAATT ACCTTTGGATTCAACTGCAGAAATAAAGATCATTATGGGATAATGATGTATCACAGAAATAGACTCATCAAAGCTTATGAAAAAGTTGGA TGTCAGTTAAGGGCAAACAACATGGGTGTTGGAGTGGTTGGAATTATAGAGTGTAATTTCCTTAAGCCAACTCATAATAAACAAGATTTC GACTATACTAATGAGTACAGACTTACAATAACAGCACTAGGAGAAAAGCTGAATGATTACTGGAATGAAATGAAAGTGAAGAAAAATACA GAATATCCTCTAAATTTGCCAGTTGAAGATATACAGAAGCGTCCTGATCAGACATGGGTTCAGTGTGATGCCTGTCTAAAGTGGCGGAAA TTACCTGATGGGATGGATCAACTTCCTGAAAAATGGTATTGCTCCAATAACCCTGACCCACAGTTCAGAAATTGTGAGGTTCCAGAAGAA CCTGAAGATGAGGATTTGGTACATCCCACTTATGAAAAAACCTACAAAAAGACCAACAAGGAAAAATTCAGGATCAGACAACCGGAAATG ATCCCTCGGATTAATGCTGAACTGTTGTTTCGGCCAACTGCTCTTTCAACTCCAAGCTTTTCTTCTCCTAAGGAAAGTGTTCCAAGAAGA CATCTTTCAGAAGGAACAAATTCTTATGCGACAAGACTTCTAAATAATCATCAAGTTCCACCTCAGTCTGAACCTGAGAGCAACAGCTTG AAACGGAGACTTTCTACTCGTTCCTCAATTTTGAATGCAAAGAATCGGAGATTGAGTAGTCAGTTTGAAAATTCAGTTTATAAAGGTGAT GATGATGATGAAGATGTCATCATCTTAGAAGAAAACAGTACCCCCAAACCTGCAGTAGATCATGATATTGACATGAAATCAGAACAGAGT CACGTTGAGCAAGGTGGTGTTCAGGTTGAGTTTGTGGGTGACAGTGAACCTTGTGGCCAGACTGGTTCAACAAGCACCTCATCATCCCGA TGCGACCAGGGAAATACTGCAGCTACCCAGACTGAAGTACCAAGTTTAGTTGTTAAAAAAGAAGAAACTGTTGAAGACGAGATAGACGTA AGAAATGATGCAGTGATTCTGCCCTCCTGTGTAGAAGCTGAAGCAAAGATACATGAAACCCAGGAAACCACCGATAAATCTGCAGATGAT GCAGGCTGCCAATTACAAGAACTGAGAAACCAGCTACTCCTTGTCACTGAGGAAAAAGAGAATTATAAAAGACAGTGTCATATGTTTACT GATCAAATCAAAGTGTTACAACAGAGGATACTAGAAATGAATGACAAGTATGTTAAGAAAGAAACTTGCCATCAGTCCACTGAAACCGAT GCTGTATTTTTACTTGAAAGTATTAATGGCAAATCTGAAAGTCCAGACCATATGGTATCTCAGTATCAGCAAGCTTTGGAAGAAATAGAA AGGCTGAAAAAACAATGTAGTGCTTTGCAACATGTAAAGGCTGAATGCAGCCAGTGTTCCAATAATGAGAGTAAAAGTGAAATGGATGAG ATGGCTGTGCAGCTTGACGATGTGTTTAGACAACTGGACAAATGCAGTATTGAGAGGGACCAGTATAAAAGTGAGGTTGAATTGCTGGAA ATGGAAAAGTCACAAATCCGTTCACAGTGTGAAGAACTCAAAACTGAAGTAGAACAGTTAAAATCTACAAATCAACAGACGGCAACAGAT GTTTCAACATCAAGTAACATTGAGGAGTCTGTAAATCATATGGATGGAGAAAGCCTCAAACTCCGATCTCTTCGAGTTAACGTAGGACAA CTGCTGGCTATGATTGTGCCTGATCTTGATCTTCAGCAAGTGAATTACGATGTTGATGTAGTTGATGAGATTTTAGGACAAGTTGTTGAA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_TMPRSS2_ENST00000332149_chr21_42870046_-_MORC3_ENST00000400485_chr21_37705944_+_4281nt CGAGTAGGCGCGAGCTAAGCAGGAGGCGGAGGCGGAGGCGGAGGGCGAGGGGCGGGGAGCGCCGCCTGGAGCGCGGCAGGTCATATTGAA CATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGATGGCTTTGAACTCACTTTGCCCGAAGTTTTTACATACAAATTCT ACTAGTCACACCTGGCCATTCAGTGCAGTTGCTGAATTAATAGATAATGCTTATGATCCTGATGTGAACGCTAAACAAATATGGATTGAC AAAACAGTGATAAATGACCATATATGCTTGACATTCACCGACAATGGGAATGGTATGACTTCTGATAAATTACATAAAATGCTAAGCTTT GGCTTCAGTGACAAAGTCACCATGAATGGTCATGTCCCAGTTGGATTATATGGGAATGGCTTCAAGTCGGGTTCTATGCGTCTGGGTAAA GACGCAATCGTTTTTACCAAAAATGGAGAAAGCATGAGCGTGGGCCTTTTGTCTCAGACCTACTTGGAAGTCATAAAAGCGGAGCATGTT GTTGTTCCAATAGTGGCATTCAACAAGCACCGACAGATGATTAATTTAGCAGAATCAAAAGCCAGCCTTGCTGCAATTCTGGAACATTCT CTGTTTTCCACGGAACAGAAGTTACTGGCAGAACTTGATGCTATTATAGGCAAGAAGGGGACGAGGATCATCATTTGGAATCTTAGAAGC TACAAAAATGCAACAGAGTTCGATTTTGAAAAGGATAAATATGATATCAGAATTCCCGAGGATTTAGATGAGATAACAGGGAAGAAGGGG TACAAGAAGCAGGAAAGGATGGACCAGATTGCCCCTGAGAGTGACTATTCCCTGAGGGCTTATTGCAGTATATTATATCTAAAGCCAAGA ATGCAGATCATCCTACGTGGACAGAAAGTGAAGACACAGCTGGTTTCGAAGAGTCTTGCCTACATCGAACGTGATGTTTATCGACCAAAA TTTTTATCTAAAACAGTGAGAATTACCTTTGGATTCAACTGCAGAAATAAAGATCATTATGGGATAATGATGTATCACAGAAATAGACTC ATCAAAGCTTATGAAAAAGTTGGATGTCAGTTAAGGGCAAACAACATGGGTGTTGGAGTGGTTGGAATTATAGAGTGTAATTTCCTTAAG CCAACTCATAATAAACAAGATTTCGACTATACTAATGAGTACAGACTTACAATAACAGCACTAGGAGAAAAGCTGAATGATTACTGGAAT GAAATGAAAGTGAAGAAAAATACAGAATATCCTCTAAATTTGCCAGTTGAAGATATACAGAAGCGTCCTGATCAGACATGGGTTCAGTGT GATGCCTGTCTAAAGTGGCGGAAATTACCTGATGGGATGGATCAACTTCCTGAAAAATGGTATTGCTCCAATAACCCTGACCCACAGTTC AGAAATTGTGAGGTTCCAGAAGAACCTGAAGATGAGGATTTGGTACATCCCACTTATGAAAAAACCTACAAAAAGACCAACAAGGAAAAA TTCAGGATCAGACAACCGGAAATGATCCCTCGGATTAATGCTGAACTGTTGTTTCGGCCAACTGCTCTTTCAACTCCAAGCTTTTCTTCT CCTAAGGAAAGTGTTCCAAGAAGACATCTTTCAGAAGGAACAAATTCTTATGCGACAAGACTTCTAAATAATCATCAAGTTCCACCTCAG TCTGAACCTGAGAGCAACAGCTTGAAACGGAGACTTTCTACTCGTTCCTCAATTTTGAATGCAAAGAATCGGAGATTGAGTAGTCAGTTT GAAAATTCAGTTTATAAAGGTGATGATGATGATGAAGATGTCATCATCTTAGAAGAAAACAGTACCCCCAAACCTGCAGTAGATCATGAT ATTGACATGAAATCAGAACAGAGTCACGTTGAGCAAGGTGGTGTTCAGGTTGAGTTTGTGGGTGACAGTGAACCTTGTGGCCAGACTGGT TCAACAAGCACCTCATCATCCCGATGCGACCAGGGAAATACTGCAGCTACCCAGACTGAAGTACCAAGTTTAGTTGTTAAAAAAGAAGAA ACTGTTGAAGACGAGATAGACGTAAGAAATGATGCAGTGATTCTGCCCTCCTGTGTAGAAGCTGAAGCAAAGATACATGAAACCCAGGAA ACCACCGATAAATCTGCAGATGATGCAGGCTGCCAATTACAAGAACTGAGAAACCAGCTACTCCTTGTCACTGAGGAAAAAGAGAATTAT AAAAGACAGTGTCATATGTTTACTGATCAAATCAAAGTGTTACAACAGAGGATACTAGAAATGAATGACAAGTATGTTAAGAAAGAAACT TGCCATCAGTCCACTGAAACCGATGCTGTATTTTTACTTGAAAGTATTAATGGCAAATCTGAAAGTCCAGACCATATGGTATCTCAGTAT CAGCAAGCTTTGGAAGAAATAGAAAGGCTGAAAAAACAATGTAGTGCTTTGCAACATGTAAAGGCTGAATGCAGCCAGTGTTCCAATAAT GAGAGTAAAAGTGAAATGGATGAGATGGCTGTGCAGCTTGACGATGTGTTTAGACAACTGGACAAATGCAGTATTGAGAGGGACCAGTAT AAAAGTGAGGTTGAATTGCTGGAAATGGAAAAGTCACAAATCCGTTCACAGTGTGAAGAACTCAAAACTGAAGTAGAACAGTTAAAATCT ACAAATCAACAGACGGCAACAGATGTTTCAACATCAAGTAACATTGAGGAGTCTGTAAATCATATGGATGGAGAAAGCCTCAAACTCCGA TCTCTTCGAGTTAACGTAGGACAACTGCTGGCTATGATTGTGCCTGATCTTGATCTTCAGCAAGTGAATTACGATGTTGATGTAGTTGAT GAGATTTTAGGACAAGTTGTTGAACAAATGAGTGAAATCAGTAGTACTTAAAGTATATGTTATGTAAGATAAAATATTTGCTCAATTCTT TTGGTTGTACAGCTTTCAAAATATAATTAATTTTGTTTTATAGATATGATAGGCAACAGACTGAAAACCATAATCTTTACTGTATTCTAT GCATTCAAATGTGGTCACAAATATTGTGGACACATTATCTTATGTTTTGAAATACCTGTGAATTGTTGGCATTGAGCAGCTGAAGCTAAC TCATGACTCTGTTTTGAATGTAAATATTTGTAATTAAGCCTGCACATATTTTTTTATTGCCCTAGAGTACTCAAGTGTTTTTCACCAAGA GCTTTTCAGGTTGCCCCTAAGCTTTGTGCAATTTTTTCTGGTTCCCCAAAGTGTATTTTTCTCTAAGTCGAGGGCTATGCCATAATACAA ATGGAAATGTTACCTTTGATTTTCTTATAAAGGAGTTTAAATAGGATTTTTAAATAATGTAGTAACACTCCTGATACAACTCTGGTTATA AGTGAATTGAGCATTAATGTTTCTTTTGTATAAATTCCTGTCCTGAAATATTTTATTCATGAAAATAAGGTAAGCAAAAACCAACTCCAT TTTGCCAGGATTTTGTTGTGCTGAGATTGCCAATCACGGTTAAACACAAAGTGTTTTTATAGAATGAAGAAACAGTCTTTAACAGAAAAA AGGTATTGAAATATTAAATGGCCACCAAGTTTACTTTGAAGCCCATTTTTGGCTGTTTAGTCAGCATGAAGTGGGCATGATAATTTTTTA ATATTTCTTTTTGTGAAATTTCCTGTACAGCCTTTTGTAGGATTACTACAGGTTAATGTGAGTTGAGGAAGACAGTCTTTCTCAAACAAT ACTACATACCTTTTATTATATTACAAACCTAAGTGTTTTATATCCTAGAGTCAAGGAACAAATTTCCTTAGGATTATAGTATTACATGCC ATAAAATACTATGCTTTATTGGTCCCATGTTTTGTGCAATTTTAAAGAGATGGCTTTCTATTAAGTATAAACTATGTATATATAAGAACC ATATTTTCCACAACTAAAATGTGCATTATTTTTTCCAAAGTTTTATCATTGCTATTTATTTTTACCTTTGTTTTTGAACATTCAATCCGT TCATTTTGTATGTATGCTTAATACGTGTCGGTCATATACAGTATTGAATTTTTACTGTATAGTAATTCTGGAAAGAGCAAATAAATGAAG ATTGTTTTTATTTGCCTGATAAAGTAATTGAAAGTGTATTTTTGGTATGAAGCTGGTTTTCTGTCACAATTGTAATTTCCCAAATTTTAA >In-frame_TMPRSS2_ENST00000398585_chr21_42870046_-_MORC3_ENST00000400485_chr21_37705944_+_4318nt ACCAGGGTCCCGGCTCGGGGTCCGGGCTGGGGAGGGGAACCTGGGCGCCTGGGACCCGCCGATGCCCCCTGCCCCGCCCGGAGGTGAAAG CGGGTGTGAGGAGCGCGGCGCGGCAGGTCATATTGAACATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGATGGCTTT GAACTCACTTTGCCCGAAGTTTTTACATACAAATTCTACTAGTCACACCTGGCCATTCAGTGCAGTTGCTGAATTAATAGATAATGCTTA TGATCCTGATGTGAACGCTAAACAAATATGGATTGACAAAACAGTGATAAATGACCATATATGCTTGACATTCACCGACAATGGGAATGG TATGACTTCTGATAAATTACATAAAATGCTAAGCTTTGGCTTCAGTGACAAAGTCACCATGAATGGTCATGTCCCAGTTGGATTATATGG GAATGGCTTCAAGTCGGGTTCTATGCGTCTGGGTAAAGACGCAATCGTTTTTACCAAAAATGGAGAAAGCATGAGCGTGGGCCTTTTGTC TCAGACCTACTTGGAAGTCATAAAAGCGGAGCATGTTGTTGTTCCAATAGTGGCATTCAACAAGCACCGACAGATGATTAATTTAGCAGA ATCAAAAGCCAGCCTTGCTGCAATTCTGGAACATTCTCTGTTTTCCACGGAACAGAAGTTACTGGCAGAACTTGATGCTATTATAGGCAA GAAGGGGACGAGGATCATCATTTGGAATCTTAGAAGCTACAAAAATGCAACAGAGTTCGATTTTGAAAAGGATAAATATGATATCAGAAT TCCCGAGGATTTAGATGAGATAACAGGGAAGAAGGGGTACAAGAAGCAGGAAAGGATGGACCAGATTGCCCCTGAGAGTGACTATTCCCT GAGGGCTTATTGCAGTATATTATATCTAAAGCCAAGAATGCAGATCATCCTACGTGGACAGAAAGTGAAGACACAGCTGGTTTCGAAGAG TCTTGCCTACATCGAACGTGATGTTTATCGACCAAAATTTTTATCTAAAACAGTGAGAATTACCTTTGGATTCAACTGCAGAAATAAAGA TCATTATGGGATAATGATGTATCACAGAAATAGACTCATCAAAGCTTATGAAAAAGTTGGATGTCAGTTAAGGGCAAACAACATGGGTGT TGGAGTGGTTGGAATTATAGAGTGTAATTTCCTTAAGCCAACTCATAATAAACAAGATTTCGACTATACTAATGAGTACAGACTTACAAT AACAGCACTAGGAGAAAAGCTGAATGATTACTGGAATGAAATGAAAGTGAAGAAAAATACAGAATATCCTCTAAATTTGCCAGTTGAAGA TATACAGAAGCGTCCTGATCAGACATGGGTTCAGTGTGATGCCTGTCTAAAGTGGCGGAAATTACCTGATGGGATGGATCAACTTCCTGA AAAATGGTATTGCTCCAATAACCCTGACCCACAGTTCAGAAATTGTGAGGTTCCAGAAGAACCTGAAGATGAGGATTTGGTACATCCCAC TTATGAAAAAACCTACAAAAAGACCAACAAGGAAAAATTCAGGATCAGACAACCGGAAATGATCCCTCGGATTAATGCTGAACTGTTGTT TCGGCCAACTGCTCTTTCAACTCCAAGCTTTTCTTCTCCTAAGGAAAGTGTTCCAAGAAGACATCTTTCAGAAGGAACAAATTCTTATGC GACAAGACTTCTAAATAATCATCAAGTTCCACCTCAGTCTGAACCTGAGAGCAACAGCTTGAAACGGAGACTTTCTACTCGTTCCTCAAT TTTGAATGCAAAGAATCGGAGATTGAGTAGTCAGTTTGAAAATTCAGTTTATAAAGGTGATGATGATGATGAAGATGTCATCATCTTAGA AGAAAACAGTACCCCCAAACCTGCAGTAGATCATGATATTGACATGAAATCAGAACAGAGTCACGTTGAGCAAGGTGGTGTTCAGGTTGA GTTTGTGGGTGACAGTGAACCTTGTGGCCAGACTGGTTCAACAAGCACCTCATCATCCCGATGCGACCAGGGAAATACTGCAGCTACCCA GACTGAAGTACCAAGTTTAGTTGTTAAAAAAGAAGAAACTGTTGAAGACGAGATAGACGTAAGAAATGATGCAGTGATTCTGCCCTCCTG TGTAGAAGCTGAAGCAAAGATACATGAAACCCAGGAAACCACCGATAAATCTGCAGATGATGCAGGCTGCCAATTACAAGAACTGAGAAA CCAGCTACTCCTTGTCACTGAGGAAAAAGAGAATTATAAAAGACAGTGTCATATGTTTACTGATCAAATCAAAGTGTTACAACAGAGGAT ACTAGAAATGAATGACAAGTATGTTAAGAAAGAAACTTGCCATCAGTCCACTGAAACCGATGCTGTATTTTTACTTGAAAGTATTAATGG CAAATCTGAAAGTCCAGACCATATGGTATCTCAGTATCAGCAAGCTTTGGAAGAAATAGAAAGGCTGAAAAAACAATGTAGTGCTTTGCA ACATGTAAAGGCTGAATGCAGCCAGTGTTCCAATAATGAGAGTAAAAGTGAAATGGATGAGATGGCTGTGCAGCTTGACGATGTGTTTAG ACAACTGGACAAATGCAGTATTGAGAGGGACCAGTATAAAAGTGAGGTTGAATTGCTGGAAATGGAAAAGTCACAAATCCGTTCACAGTG TGAAGAACTCAAAACTGAAGTAGAACAGTTAAAATCTACAAATCAACAGACGGCAACAGATGTTTCAACATCAAGTAACATTGAGGAGTC TGTAAATCATATGGATGGAGAAAGCCTCAAACTCCGATCTCTTCGAGTTAACGTAGGACAACTGCTGGCTATGATTGTGCCTGATCTTGA TCTTCAGCAAGTGAATTACGATGTTGATGTAGTTGATGAGATTTTAGGACAAGTTGTTGAACAAATGAGTGAAATCAGTAGTACTTAAAG TATATGTTATGTAAGATAAAATATTTGCTCAATTCTTTTGGTTGTACAGCTTTCAAAATATAATTAATTTTGTTTTATAGATATGATAGG CAACAGACTGAAAACCATAATCTTTACTGTATTCTATGCATTCAAATGTGGTCACAAATATTGTGGACACATTATCTTATGTTTTGAAAT ACCTGTGAATTGTTGGCATTGAGCAGCTGAAGCTAACTCATGACTCTGTTTTGAATGTAAATATTTGTAATTAAGCCTGCACATATTTTT TTATTGCCCTAGAGTACTCAAGTGTTTTTCACCAAGAGCTTTTCAGGTTGCCCCTAAGCTTTGTGCAATTTTTTCTGGTTCCCCAAAGTG TATTTTTCTCTAAGTCGAGGGCTATGCCATAATACAAATGGAAATGTTACCTTTGATTTTCTTATAAAGGAGTTTAAATAGGATTTTTAA ATAATGTAGTAACACTCCTGATACAACTCTGGTTATAAGTGAATTGAGCATTAATGTTTCTTTTGTATAAATTCCTGTCCTGAAATATTT TATTCATGAAAATAAGGTAAGCAAAAACCAACTCCATTTTGCCAGGATTTTGTTGTGCTGAGATTGCCAATCACGGTTAAACACAAAGTG TTTTTATAGAATGAAGAAACAGTCTTTAACAGAAAAAAGGTATTGAAATATTAAATGGCCACCAAGTTTACTTTGAAGCCCATTTTTGGC TGTTTAGTCAGCATGAAGTGGGCATGATAATTTTTTAATATTTCTTTTTGTGAAATTTCCTGTACAGCCTTTTGTAGGATTACTACAGGT TAATGTGAGTTGAGGAAGACAGTCTTTCTCAAACAATACTACATACCTTTTATTATATTACAAACCTAAGTGTTTTATATCCTAGAGTCA AGGAACAAATTTCCTTAGGATTATAGTATTACATGCCATAAAATACTATGCTTTATTGGTCCCATGTTTTGTGCAATTTTAAAGAGATGG CTTTCTATTAAGTATAAACTATGTATATATAAGAACCATATTTTCCACAACTAAAATGTGCATTATTTTTTCCAAAGTTTTATCATTGCT ATTTATTTTTACCTTTGTTTTTGAACATTCAATCCGTTCATTTTGTATGTATGCTTAATACGTGTCGGTCATATACAGTATTGAATTTTT ACTGTATAGTAATTCTGGAAAGAGCAAATAAATGAAGATTGTTTTTATTTGCCTGATAAAGTAATTGAAAGTGTATTTTTGGTATGAAGC |
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FusionGenePPI for TMPRSS2_MORC3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TMPRSS2 | CLK1 | MORC3 | RAD23A, ROR1, KPNA2, HIST1H2BG, HIST1H3A, HTT, SNTB1, MOGS, DYNLL1, CRIPT, TRIB1, SYNE2, DEPDC1, DOCK8, RDH10, C6orf141, UBC, DYNLL2, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMPRSS2_MORC3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMPRSS2_MORC3 |
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Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TMPRSS2 | C0033578 | Prostatic Neoplasms | 2 | CTD_human |