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Fusion gene ID: 38761 |
FusionGeneSummary for TMPRSS2_MORC3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMPRSS2_MORC3 | Fusion gene ID: 38761 | Hgene | Tgene | Gene symbol | TMPRSS2 | MORC3 | Gene ID | 7113 | 23515 |
| Gene name | transmembrane serine protease 2 | MORC family CW-type zinc finger 3 | |
| Synonyms | PP9284|PRSS10 | NXP2|ZCW5|ZCWCC3 | |
| Cytomap | 21q22.3 | 21q22.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transmembrane protease serine 2epitheliasinserine protease 10transmembrane protease, serine 2 | MORC family CW-type zinc finger protein 3nuclear matrix protein 2nuclear matrix protein NXP2zinc finger CW-type coiled-coil domain protein 3zinc finger, CW type with coiled-coil domain 3 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | O15393 | Q14149 | |
| Ensembl transtripts involved in fusion gene | ENST00000332149, ENST00000398585, ENST00000458356, ENST00000497881, | ENST00000400485, ENST00000487909, | |
| Fusion gene scores | * DoF score | 29 X 21 X 6=3654 | 5 X 5 X 3=75 |
| # samples | 228 | 5 | |
| ** MAII score | log2(228/3654*10)=-0.680442809575384 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TMPRSS2 [Title/Abstract] AND MORC3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tissue-specifically expressed gene involved fusion gene, inframe and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TMPRSS2 | GO:0006508 | proteolysis | 21068237|24227843 |
| Hgene | TMPRSS2 | GO:0046598 | positive regulation of viral entry into host cell | 21068237|24227843 |
| Tgene | MORC3 | GO:0006468 | protein phosphorylation | 17332504 |
| Tgene | MORC3 | GO:0007569 | cell aging | 17332504 |
| Tgene | MORC3 | GO:0018105 | peptidyl-serine phosphorylation | 17332504 |
| Tgene | MORC3 | GO:0048147 | negative regulation of fibroblast proliferation | 17332504 |
| Tgene | MORC3 | GO:0050821 | protein stabilization | 17332504 |
| Tgene | MORC3 | GO:0051457 | maintenance of protein location in nucleus | 17332504 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-CH-5762-01A | TMPRSS2 | chr21 | 42870046 | - | MORC3 | chr21 | 37705944 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000332149 | ENST00000400485 | TMPRSS2 | chr21 | 42870046 | - | MORC3 | chr21 | 37705944 | + |
| 5CDS-intron | ENST00000332149 | ENST00000487909 | TMPRSS2 | chr21 | 42870046 | - | MORC3 | chr21 | 37705944 | + |
| In-frame | ENST00000398585 | ENST00000400485 | TMPRSS2 | chr21 | 42870046 | - | MORC3 | chr21 | 37705944 | + |
| 5CDS-intron | ENST00000398585 | ENST00000487909 | TMPRSS2 | chr21 | 42870046 | - | MORC3 | chr21 | 37705944 | + |
| Frame-shit | ENST00000458356 | ENST00000400485 | TMPRSS2 | chr21 | 42870046 | - | MORC3 | chr21 | 37705944 | + |
| 5CDS-intron | ENST00000458356 | ENST00000487909 | TMPRSS2 | chr21 | 42870046 | - | MORC3 | chr21 | 37705944 | + |
| 5UTR-3CDS | ENST00000497881 | ENST00000400485 | TMPRSS2 | chr21 | 42870046 | - | MORC3 | chr21 | 37705944 | + |
| 5UTR-intron | ENST00000497881 | ENST00000487909 | TMPRSS2 | chr21 | 42870046 | - | MORC3 | chr21 | 37705944 | + |
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FusionProtFeatures for TMPRSS2_MORC3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TMPRSS2 | MORC3 |
| Serine protease that proteolytically cleaves andactivates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized andmaintained in precursor intermediate folding states andproteolysis permits the refolding and energy release required tocreate stable virus-cell linkages and membrane coalescence.Facilitates human SARS coronavirus (SARS-CoV) infection via twoindependent mechanisms, proteolytic cleavage of ACE2, which mightpromote viral uptake, and cleavage of coronavirus spikeglycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activatesthe spike glycoproteins of human coronavirus 229E (HCoV-229E) andhuman coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0of Sendai virus (SeV), human metapneumovirus (HMPV), humanparainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential forspread and pathogenesis of influenza A virus (strains H1N1, H3N2and H7N9); involved in proteolytic cleavage and activation ofhemagglutinin (HA) protein which is essential for viralinfectivity. {ECO:0000269|PubMed:21068237,ECO:0000269|PubMed:21325420, ECO:0000269|PubMed:23536651,ECO:0000269|PubMed:23966399, ECO:0000269|PubMed:24027332,ECO:0000269|PubMed:24227843}. | Nuclear factor which forms MORC3-NBs (nuclear bodies)via an ATP-dependent mechanism (PubMed:20501696). SumoylatedMORC3-NBs can also associate with PML-NBs (PubMed:20501696).Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity(PubMed:17332504). Binds RNA in vitro (PubMed:11927593). May berequired for influenza A transcription during viral infection(PubMed:26202233). {ECO:0000269|PubMed:11927593,ECO:0000269|PubMed:17332504, ECO:0000269|PubMed:20501696,ECO:0000269|PubMed:26202233}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >MORC3 | chr21:42870046 | chr21:37705944 | ENST00000400485 | + | 0 | 17 | 686_877 | 13 | 940 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >MORC3 | chr21:42870046 | chr21:37705944 | ENST00000400485 | + | 0 | 17 | 326_353 | 13 | 940 | Region | Nuclear matrix binding |
| Tgene | >MORC3 | chr21:42870046 | chr21:37705944 | ENST00000400485 | + | 0 | 17 | 500_591 | 13 | 940 | Region | RNA binding |
| Tgene | >MORC3 | chr21:42870046 | chr21:37705944 | ENST00000400485 | + | 0 | 17 | 404_454 | 13 | 940 | Zinc finger | CW-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000332149 | - | 2 | 14 | 112_149 | 5 | 493 | Domain | LDL-receptor class A |
| Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000332149 | - | 2 | 14 | 150_242 | 5 | 493 | Domain | SRCR |
| Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000332149 | - | 2 | 14 | 256_489 | 5 | 493 | Domain | Peptidase S1 |
| Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000398585 | - | 2 | 14 | 112_149 | 42 | 530 | Domain | LDL-receptor class A |
| Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000398585 | - | 2 | 14 | 150_242 | 42 | 530 | Domain | SRCR |
| Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000398585 | - | 2 | 14 | 256_489 | 42 | 530 | Domain | Peptidase S1 |
| Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000458356 | - | 2 | 14 | 112_149 | 5 | 493 | Domain | LDL-receptor class A |
| Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000458356 | - | 2 | 14 | 150_242 | 5 | 493 | Domain | SRCR |
| Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000458356 | - | 2 | 14 | 256_489 | 5 | 493 | Domain | Peptidase S1 |
| Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000332149 | - | 2 | 14 | 106_492 | 5 | 493 | Topological domain | Extracellular |
| Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000332149 | - | 2 | 14 | 1_84 | 5 | 493 | Topological domain | Cytoplasmic |
| Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000398585 | - | 2 | 14 | 106_492 | 42 | 530 | Topological domain | Extracellular |
| Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000398585 | - | 2 | 14 | 1_84 | 42 | 530 | Topological domain | Cytoplasmic |
| Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000458356 | - | 2 | 14 | 106_492 | 5 | 493 | Topological domain | Extracellular |
| Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000458356 | - | 2 | 14 | 1_84 | 5 | 493 | Topological domain | Cytoplasmic |
| Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000332149 | - | 2 | 14 | 85_105 | 5 | 493 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000398585 | - | 2 | 14 | 85_105 | 42 | 530 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Hgene | >TMPRSS2 | chr21:42870046 | chr21:37705944 | ENST00000458356 | - | 2 | 14 | 85_105 | 5 | 493 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
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FusionGeneSequence for TMPRSS2_MORC3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TMPRSS2_ENST00000332149_chr21_42870046_-_MORC3_ENST00000400485_chr21_37705944_+_932aa MALNSLCPKFLHTNSTSHTWPFSAVAELIDNATDPDVNAKQIWIDKTVINDHICLTFTDNGNGMTSDKLHKMLSFGFSDKVTMNGHVPVG LTGNGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKHRQMINLAESKASLAAILEHSLFSTEQKLLAELDAI IGKKGTRIIIWNLRSYKNATEFDFEKDKTDIRIPEDLDEITGKKGYKKQERMDQIAPESDTSLRATCSILTLKPRMQIILRGQKVKTQLV SKSLAYIERDVTRPKFLSKTVRITFGFNCRNKDHTGIMMTHRNRLIKATEKVGCQLRANNMGVGVVGIIECNFLKPTHNKQDFDTTNEYR LTITALGEKLNDYWNEMKVKKNTETPLNLPVEDIQKRPDQTWVQCDACLKWRKLPDGMDQLPEKWTCSNNPDPQFRNCEVPEEPEDEDLV HPTTEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKESVPRRHLSEGTNSTATRLLNNHQVPPQSEPESNSLKRRLSTR SSILNAKNRRLSSQFENSVTKGDDDDEDVIILEENSTPKPAVDHDIDMKSEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTA ATQTEVPSLVVKKEETVEDEIDVRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQLQELRNQLLLVTEEKENTKRQCHMFTDQIKVLQ QRILEMNDKTVKKETCHQSTETDAVFLLESINGKSESPDHMVSQTQQALEEIERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDD VFRQLDKCSIERDQTKSEVELLEMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTSSNIEESVNHMDGESLKLRSLRVNVGQLLAMIVP >In-frame_TMPRSS2_ENST00000398585_chr21_42870046_-_MORC3_ENST00000400485_chr21_37705944_+_969aa MPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSLCPKFLHTNSTSHTWPFSAVAELIDNATDPDVNAKQIWIDKTVINDHI CLTFTDNGNGMTSDKLHKMLSFGFSDKVTMNGHVPVGLTGNGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAFN KHRQMINLAESKASLAAILEHSLFSTEQKLLAELDAIIGKKGTRIIIWNLRSYKNATEFDFEKDKTDIRIPEDLDEITGKKGYKKQERMD QIAPESDTSLRATCSILTLKPRMQIILRGQKVKTQLVSKSLAYIERDVTRPKFLSKTVRITFGFNCRNKDHTGIMMTHRNRLIKATEKVG CQLRANNMGVGVVGIIECNFLKPTHNKQDFDTTNEYRLTITALGEKLNDYWNEMKVKKNTETPLNLPVEDIQKRPDQTWVQCDACLKWRK LPDGMDQLPEKWTCSNNPDPQFRNCEVPEEPEDEDLVHPTTEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKESVPRR HLSEGTNSTATRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVTKGDDDDEDVIILEENSTPKPAVDHDIDMKSEQS HVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQTEVPSLVVKKEETVEDEIDVRNDAVILPSCVEAEAKIHETQETTDKSADD AGCQLQELRNQLLLVTEEKENTKRQCHMFTDQIKVLQQRILEMNDKTVKKETCHQSTETDAVFLLESINGKSESPDHMVSQTQQALEEIE RLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQTKSEVELLEMEKSQIRSQCEELKTEVEQLKSTNQQTATD |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TMPRSS2_ENST00000332149_chr21_42870046_-_MORC3_ENST00000400485_chr21_37705944_+_2796nt ATGGCTTTGAACTCACTTTGCCCGAAGTTTTTACATACAAATTCTACTAGTCACACCTGGCCATTCAGTGCAGTTGCTGAATTAATAGAT AATGCTTATGATCCTGATGTGAACGCTAAACAAATATGGATTGACAAAACAGTGATAAATGACCATATATGCTTGACATTCACCGACAAT GGGAATGGTATGACTTCTGATAAATTACATAAAATGCTAAGCTTTGGCTTCAGTGACAAAGTCACCATGAATGGTCATGTCCCAGTTGGA TTATATGGGAATGGCTTCAAGTCGGGTTCTATGCGTCTGGGTAAAGACGCAATCGTTTTTACCAAAAATGGAGAAAGCATGAGCGTGGGC CTTTTGTCTCAGACCTACTTGGAAGTCATAAAAGCGGAGCATGTTGTTGTTCCAATAGTGGCATTCAACAAGCACCGACAGATGATTAAT TTAGCAGAATCAAAAGCCAGCCTTGCTGCAATTCTGGAACATTCTCTGTTTTCCACGGAACAGAAGTTACTGGCAGAACTTGATGCTATT ATAGGCAAGAAGGGGACGAGGATCATCATTTGGAATCTTAGAAGCTACAAAAATGCAACAGAGTTCGATTTTGAAAAGGATAAATATGAT ATCAGAATTCCCGAGGATTTAGATGAGATAACAGGGAAGAAGGGGTACAAGAAGCAGGAAAGGATGGACCAGATTGCCCCTGAGAGTGAC TATTCCCTGAGGGCTTATTGCAGTATATTATATCTAAAGCCAAGAATGCAGATCATCCTACGTGGACAGAAAGTGAAGACACAGCTGGTT TCGAAGAGTCTTGCCTACATCGAACGTGATGTTTATCGACCAAAATTTTTATCTAAAACAGTGAGAATTACCTTTGGATTCAACTGCAGA AATAAAGATCATTATGGGATAATGATGTATCACAGAAATAGACTCATCAAAGCTTATGAAAAAGTTGGATGTCAGTTAAGGGCAAACAAC ATGGGTGTTGGAGTGGTTGGAATTATAGAGTGTAATTTCCTTAAGCCAACTCATAATAAACAAGATTTCGACTATACTAATGAGTACAGA CTTACAATAACAGCACTAGGAGAAAAGCTGAATGATTACTGGAATGAAATGAAAGTGAAGAAAAATACAGAATATCCTCTAAATTTGCCA GTTGAAGATATACAGAAGCGTCCTGATCAGACATGGGTTCAGTGTGATGCCTGTCTAAAGTGGCGGAAATTACCTGATGGGATGGATCAA CTTCCTGAAAAATGGTATTGCTCCAATAACCCTGACCCACAGTTCAGAAATTGTGAGGTTCCAGAAGAACCTGAAGATGAGGATTTGGTA CATCCCACTTATGAAAAAACCTACAAAAAGACCAACAAGGAAAAATTCAGGATCAGACAACCGGAAATGATCCCTCGGATTAATGCTGAA CTGTTGTTTCGGCCAACTGCTCTTTCAACTCCAAGCTTTTCTTCTCCTAAGGAAAGTGTTCCAAGAAGACATCTTTCAGAAGGAACAAAT TCTTATGCGACAAGACTTCTAAATAATCATCAAGTTCCACCTCAGTCTGAACCTGAGAGCAACAGCTTGAAACGGAGACTTTCTACTCGT TCCTCAATTTTGAATGCAAAGAATCGGAGATTGAGTAGTCAGTTTGAAAATTCAGTTTATAAAGGTGATGATGATGATGAAGATGTCATC ATCTTAGAAGAAAACAGTACCCCCAAACCTGCAGTAGATCATGATATTGACATGAAATCAGAACAGAGTCACGTTGAGCAAGGTGGTGTT CAGGTTGAGTTTGTGGGTGACAGTGAACCTTGTGGCCAGACTGGTTCAACAAGCACCTCATCATCCCGATGCGACCAGGGAAATACTGCA GCTACCCAGACTGAAGTACCAAGTTTAGTTGTTAAAAAAGAAGAAACTGTTGAAGACGAGATAGACGTAAGAAATGATGCAGTGATTCTG CCCTCCTGTGTAGAAGCTGAAGCAAAGATACATGAAACCCAGGAAACCACCGATAAATCTGCAGATGATGCAGGCTGCCAATTACAAGAA CTGAGAAACCAGCTACTCCTTGTCACTGAGGAAAAAGAGAATTATAAAAGACAGTGTCATATGTTTACTGATCAAATCAAAGTGTTACAA CAGAGGATACTAGAAATGAATGACAAGTATGTTAAGAAAGAAACTTGCCATCAGTCCACTGAAACCGATGCTGTATTTTTACTTGAAAGT ATTAATGGCAAATCTGAAAGTCCAGACCATATGGTATCTCAGTATCAGCAAGCTTTGGAAGAAATAGAAAGGCTGAAAAAACAATGTAGT GCTTTGCAACATGTAAAGGCTGAATGCAGCCAGTGTTCCAATAATGAGAGTAAAAGTGAAATGGATGAGATGGCTGTGCAGCTTGACGAT GTGTTTAGACAACTGGACAAATGCAGTATTGAGAGGGACCAGTATAAAAGTGAGGTTGAATTGCTGGAAATGGAAAAGTCACAAATCCGT TCACAGTGTGAAGAACTCAAAACTGAAGTAGAACAGTTAAAATCTACAAATCAACAGACGGCAACAGATGTTTCAACATCAAGTAACATT GAGGAGTCTGTAAATCATATGGATGGAGAAAGCCTCAAACTCCGATCTCTTCGAGTTAACGTAGGACAACTGCTGGCTATGATTGTGCCT GATCTTGATCTTCAGCAAGTGAATTACGATGTTGATGTAGTTGATGAGATTTTAGGACAAGTTGTTGAACAAATGAGTGAAATCAGTAGT >In-frame_TMPRSS2_ENST00000398585_chr21_42870046_-_MORC3_ENST00000400485_chr21_37705944_+_2907nt ATGCCCCCTGCCCCGCCCGGAGGTGAAAGCGGGTGTGAGGAGCGCGGCGCGGCAGGTCATATTGAACATTCCAGATACCTATCATTACTC GATGCTGTTGATAACAGCAAGATGGCTTTGAACTCACTTTGCCCGAAGTTTTTACATACAAATTCTACTAGTCACACCTGGCCATTCAGT GCAGTTGCTGAATTAATAGATAATGCTTATGATCCTGATGTGAACGCTAAACAAATATGGATTGACAAAACAGTGATAAATGACCATATA TGCTTGACATTCACCGACAATGGGAATGGTATGACTTCTGATAAATTACATAAAATGCTAAGCTTTGGCTTCAGTGACAAAGTCACCATG AATGGTCATGTCCCAGTTGGATTATATGGGAATGGCTTCAAGTCGGGTTCTATGCGTCTGGGTAAAGACGCAATCGTTTTTACCAAAAAT GGAGAAAGCATGAGCGTGGGCCTTTTGTCTCAGACCTACTTGGAAGTCATAAAAGCGGAGCATGTTGTTGTTCCAATAGTGGCATTCAAC AAGCACCGACAGATGATTAATTTAGCAGAATCAAAAGCCAGCCTTGCTGCAATTCTGGAACATTCTCTGTTTTCCACGGAACAGAAGTTA CTGGCAGAACTTGATGCTATTATAGGCAAGAAGGGGACGAGGATCATCATTTGGAATCTTAGAAGCTACAAAAATGCAACAGAGTTCGAT TTTGAAAAGGATAAATATGATATCAGAATTCCCGAGGATTTAGATGAGATAACAGGGAAGAAGGGGTACAAGAAGCAGGAAAGGATGGAC CAGATTGCCCCTGAGAGTGACTATTCCCTGAGGGCTTATTGCAGTATATTATATCTAAAGCCAAGAATGCAGATCATCCTACGTGGACAG AAAGTGAAGACACAGCTGGTTTCGAAGAGTCTTGCCTACATCGAACGTGATGTTTATCGACCAAAATTTTTATCTAAAACAGTGAGAATT ACCTTTGGATTCAACTGCAGAAATAAAGATCATTATGGGATAATGATGTATCACAGAAATAGACTCATCAAAGCTTATGAAAAAGTTGGA TGTCAGTTAAGGGCAAACAACATGGGTGTTGGAGTGGTTGGAATTATAGAGTGTAATTTCCTTAAGCCAACTCATAATAAACAAGATTTC GACTATACTAATGAGTACAGACTTACAATAACAGCACTAGGAGAAAAGCTGAATGATTACTGGAATGAAATGAAAGTGAAGAAAAATACA GAATATCCTCTAAATTTGCCAGTTGAAGATATACAGAAGCGTCCTGATCAGACATGGGTTCAGTGTGATGCCTGTCTAAAGTGGCGGAAA TTACCTGATGGGATGGATCAACTTCCTGAAAAATGGTATTGCTCCAATAACCCTGACCCACAGTTCAGAAATTGTGAGGTTCCAGAAGAA CCTGAAGATGAGGATTTGGTACATCCCACTTATGAAAAAACCTACAAAAAGACCAACAAGGAAAAATTCAGGATCAGACAACCGGAAATG ATCCCTCGGATTAATGCTGAACTGTTGTTTCGGCCAACTGCTCTTTCAACTCCAAGCTTTTCTTCTCCTAAGGAAAGTGTTCCAAGAAGA CATCTTTCAGAAGGAACAAATTCTTATGCGACAAGACTTCTAAATAATCATCAAGTTCCACCTCAGTCTGAACCTGAGAGCAACAGCTTG AAACGGAGACTTTCTACTCGTTCCTCAATTTTGAATGCAAAGAATCGGAGATTGAGTAGTCAGTTTGAAAATTCAGTTTATAAAGGTGAT GATGATGATGAAGATGTCATCATCTTAGAAGAAAACAGTACCCCCAAACCTGCAGTAGATCATGATATTGACATGAAATCAGAACAGAGT CACGTTGAGCAAGGTGGTGTTCAGGTTGAGTTTGTGGGTGACAGTGAACCTTGTGGCCAGACTGGTTCAACAAGCACCTCATCATCCCGA TGCGACCAGGGAAATACTGCAGCTACCCAGACTGAAGTACCAAGTTTAGTTGTTAAAAAAGAAGAAACTGTTGAAGACGAGATAGACGTA AGAAATGATGCAGTGATTCTGCCCTCCTGTGTAGAAGCTGAAGCAAAGATACATGAAACCCAGGAAACCACCGATAAATCTGCAGATGAT GCAGGCTGCCAATTACAAGAACTGAGAAACCAGCTACTCCTTGTCACTGAGGAAAAAGAGAATTATAAAAGACAGTGTCATATGTTTACT GATCAAATCAAAGTGTTACAACAGAGGATACTAGAAATGAATGACAAGTATGTTAAGAAAGAAACTTGCCATCAGTCCACTGAAACCGAT GCTGTATTTTTACTTGAAAGTATTAATGGCAAATCTGAAAGTCCAGACCATATGGTATCTCAGTATCAGCAAGCTTTGGAAGAAATAGAA AGGCTGAAAAAACAATGTAGTGCTTTGCAACATGTAAAGGCTGAATGCAGCCAGTGTTCCAATAATGAGAGTAAAAGTGAAATGGATGAG ATGGCTGTGCAGCTTGACGATGTGTTTAGACAACTGGACAAATGCAGTATTGAGAGGGACCAGTATAAAAGTGAGGTTGAATTGCTGGAA ATGGAAAAGTCACAAATCCGTTCACAGTGTGAAGAACTCAAAACTGAAGTAGAACAGTTAAAATCTACAAATCAACAGACGGCAACAGAT GTTTCAACATCAAGTAACATTGAGGAGTCTGTAAATCATATGGATGGAGAAAGCCTCAAACTCCGATCTCTTCGAGTTAACGTAGGACAA CTGCTGGCTATGATTGTGCCTGATCTTGATCTTCAGCAAGTGAATTACGATGTTGATGTAGTTGATGAGATTTTAGGACAAGTTGTTGAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TMPRSS2_ENST00000332149_chr21_42870046_-_MORC3_ENST00000400485_chr21_37705944_+_4281nt CGAGTAGGCGCGAGCTAAGCAGGAGGCGGAGGCGGAGGCGGAGGGCGAGGGGCGGGGAGCGCCGCCTGGAGCGCGGCAGGTCATATTGAA CATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGATGGCTTTGAACTCACTTTGCCCGAAGTTTTTACATACAAATTCT ACTAGTCACACCTGGCCATTCAGTGCAGTTGCTGAATTAATAGATAATGCTTATGATCCTGATGTGAACGCTAAACAAATATGGATTGAC AAAACAGTGATAAATGACCATATATGCTTGACATTCACCGACAATGGGAATGGTATGACTTCTGATAAATTACATAAAATGCTAAGCTTT GGCTTCAGTGACAAAGTCACCATGAATGGTCATGTCCCAGTTGGATTATATGGGAATGGCTTCAAGTCGGGTTCTATGCGTCTGGGTAAA GACGCAATCGTTTTTACCAAAAATGGAGAAAGCATGAGCGTGGGCCTTTTGTCTCAGACCTACTTGGAAGTCATAAAAGCGGAGCATGTT GTTGTTCCAATAGTGGCATTCAACAAGCACCGACAGATGATTAATTTAGCAGAATCAAAAGCCAGCCTTGCTGCAATTCTGGAACATTCT CTGTTTTCCACGGAACAGAAGTTACTGGCAGAACTTGATGCTATTATAGGCAAGAAGGGGACGAGGATCATCATTTGGAATCTTAGAAGC TACAAAAATGCAACAGAGTTCGATTTTGAAAAGGATAAATATGATATCAGAATTCCCGAGGATTTAGATGAGATAACAGGGAAGAAGGGG TACAAGAAGCAGGAAAGGATGGACCAGATTGCCCCTGAGAGTGACTATTCCCTGAGGGCTTATTGCAGTATATTATATCTAAAGCCAAGA ATGCAGATCATCCTACGTGGACAGAAAGTGAAGACACAGCTGGTTTCGAAGAGTCTTGCCTACATCGAACGTGATGTTTATCGACCAAAA TTTTTATCTAAAACAGTGAGAATTACCTTTGGATTCAACTGCAGAAATAAAGATCATTATGGGATAATGATGTATCACAGAAATAGACTC ATCAAAGCTTATGAAAAAGTTGGATGTCAGTTAAGGGCAAACAACATGGGTGTTGGAGTGGTTGGAATTATAGAGTGTAATTTCCTTAAG CCAACTCATAATAAACAAGATTTCGACTATACTAATGAGTACAGACTTACAATAACAGCACTAGGAGAAAAGCTGAATGATTACTGGAAT GAAATGAAAGTGAAGAAAAATACAGAATATCCTCTAAATTTGCCAGTTGAAGATATACAGAAGCGTCCTGATCAGACATGGGTTCAGTGT GATGCCTGTCTAAAGTGGCGGAAATTACCTGATGGGATGGATCAACTTCCTGAAAAATGGTATTGCTCCAATAACCCTGACCCACAGTTC AGAAATTGTGAGGTTCCAGAAGAACCTGAAGATGAGGATTTGGTACATCCCACTTATGAAAAAACCTACAAAAAGACCAACAAGGAAAAA TTCAGGATCAGACAACCGGAAATGATCCCTCGGATTAATGCTGAACTGTTGTTTCGGCCAACTGCTCTTTCAACTCCAAGCTTTTCTTCT CCTAAGGAAAGTGTTCCAAGAAGACATCTTTCAGAAGGAACAAATTCTTATGCGACAAGACTTCTAAATAATCATCAAGTTCCACCTCAG TCTGAACCTGAGAGCAACAGCTTGAAACGGAGACTTTCTACTCGTTCCTCAATTTTGAATGCAAAGAATCGGAGATTGAGTAGTCAGTTT GAAAATTCAGTTTATAAAGGTGATGATGATGATGAAGATGTCATCATCTTAGAAGAAAACAGTACCCCCAAACCTGCAGTAGATCATGAT ATTGACATGAAATCAGAACAGAGTCACGTTGAGCAAGGTGGTGTTCAGGTTGAGTTTGTGGGTGACAGTGAACCTTGTGGCCAGACTGGT TCAACAAGCACCTCATCATCCCGATGCGACCAGGGAAATACTGCAGCTACCCAGACTGAAGTACCAAGTTTAGTTGTTAAAAAAGAAGAA ACTGTTGAAGACGAGATAGACGTAAGAAATGATGCAGTGATTCTGCCCTCCTGTGTAGAAGCTGAAGCAAAGATACATGAAACCCAGGAA ACCACCGATAAATCTGCAGATGATGCAGGCTGCCAATTACAAGAACTGAGAAACCAGCTACTCCTTGTCACTGAGGAAAAAGAGAATTAT AAAAGACAGTGTCATATGTTTACTGATCAAATCAAAGTGTTACAACAGAGGATACTAGAAATGAATGACAAGTATGTTAAGAAAGAAACT TGCCATCAGTCCACTGAAACCGATGCTGTATTTTTACTTGAAAGTATTAATGGCAAATCTGAAAGTCCAGACCATATGGTATCTCAGTAT CAGCAAGCTTTGGAAGAAATAGAAAGGCTGAAAAAACAATGTAGTGCTTTGCAACATGTAAAGGCTGAATGCAGCCAGTGTTCCAATAAT GAGAGTAAAAGTGAAATGGATGAGATGGCTGTGCAGCTTGACGATGTGTTTAGACAACTGGACAAATGCAGTATTGAGAGGGACCAGTAT AAAAGTGAGGTTGAATTGCTGGAAATGGAAAAGTCACAAATCCGTTCACAGTGTGAAGAACTCAAAACTGAAGTAGAACAGTTAAAATCT ACAAATCAACAGACGGCAACAGATGTTTCAACATCAAGTAACATTGAGGAGTCTGTAAATCATATGGATGGAGAAAGCCTCAAACTCCGA TCTCTTCGAGTTAACGTAGGACAACTGCTGGCTATGATTGTGCCTGATCTTGATCTTCAGCAAGTGAATTACGATGTTGATGTAGTTGAT GAGATTTTAGGACAAGTTGTTGAACAAATGAGTGAAATCAGTAGTACTTAAAGTATATGTTATGTAAGATAAAATATTTGCTCAATTCTT TTGGTTGTACAGCTTTCAAAATATAATTAATTTTGTTTTATAGATATGATAGGCAACAGACTGAAAACCATAATCTTTACTGTATTCTAT GCATTCAAATGTGGTCACAAATATTGTGGACACATTATCTTATGTTTTGAAATACCTGTGAATTGTTGGCATTGAGCAGCTGAAGCTAAC TCATGACTCTGTTTTGAATGTAAATATTTGTAATTAAGCCTGCACATATTTTTTTATTGCCCTAGAGTACTCAAGTGTTTTTCACCAAGA GCTTTTCAGGTTGCCCCTAAGCTTTGTGCAATTTTTTCTGGTTCCCCAAAGTGTATTTTTCTCTAAGTCGAGGGCTATGCCATAATACAA ATGGAAATGTTACCTTTGATTTTCTTATAAAGGAGTTTAAATAGGATTTTTAAATAATGTAGTAACACTCCTGATACAACTCTGGTTATA AGTGAATTGAGCATTAATGTTTCTTTTGTATAAATTCCTGTCCTGAAATATTTTATTCATGAAAATAAGGTAAGCAAAAACCAACTCCAT TTTGCCAGGATTTTGTTGTGCTGAGATTGCCAATCACGGTTAAACACAAAGTGTTTTTATAGAATGAAGAAACAGTCTTTAACAGAAAAA AGGTATTGAAATATTAAATGGCCACCAAGTTTACTTTGAAGCCCATTTTTGGCTGTTTAGTCAGCATGAAGTGGGCATGATAATTTTTTA ATATTTCTTTTTGTGAAATTTCCTGTACAGCCTTTTGTAGGATTACTACAGGTTAATGTGAGTTGAGGAAGACAGTCTTTCTCAAACAAT ACTACATACCTTTTATTATATTACAAACCTAAGTGTTTTATATCCTAGAGTCAAGGAACAAATTTCCTTAGGATTATAGTATTACATGCC ATAAAATACTATGCTTTATTGGTCCCATGTTTTGTGCAATTTTAAAGAGATGGCTTTCTATTAAGTATAAACTATGTATATATAAGAACC ATATTTTCCACAACTAAAATGTGCATTATTTTTTCCAAAGTTTTATCATTGCTATTTATTTTTACCTTTGTTTTTGAACATTCAATCCGT TCATTTTGTATGTATGCTTAATACGTGTCGGTCATATACAGTATTGAATTTTTACTGTATAGTAATTCTGGAAAGAGCAAATAAATGAAG ATTGTTTTTATTTGCCTGATAAAGTAATTGAAAGTGTATTTTTGGTATGAAGCTGGTTTTCTGTCACAATTGTAATTTCCCAAATTTTAA >In-frame_TMPRSS2_ENST00000398585_chr21_42870046_-_MORC3_ENST00000400485_chr21_37705944_+_4318nt ACCAGGGTCCCGGCTCGGGGTCCGGGCTGGGGAGGGGAACCTGGGCGCCTGGGACCCGCCGATGCCCCCTGCCCCGCCCGGAGGTGAAAG CGGGTGTGAGGAGCGCGGCGCGGCAGGTCATATTGAACATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGATGGCTTT GAACTCACTTTGCCCGAAGTTTTTACATACAAATTCTACTAGTCACACCTGGCCATTCAGTGCAGTTGCTGAATTAATAGATAATGCTTA TGATCCTGATGTGAACGCTAAACAAATATGGATTGACAAAACAGTGATAAATGACCATATATGCTTGACATTCACCGACAATGGGAATGG TATGACTTCTGATAAATTACATAAAATGCTAAGCTTTGGCTTCAGTGACAAAGTCACCATGAATGGTCATGTCCCAGTTGGATTATATGG GAATGGCTTCAAGTCGGGTTCTATGCGTCTGGGTAAAGACGCAATCGTTTTTACCAAAAATGGAGAAAGCATGAGCGTGGGCCTTTTGTC TCAGACCTACTTGGAAGTCATAAAAGCGGAGCATGTTGTTGTTCCAATAGTGGCATTCAACAAGCACCGACAGATGATTAATTTAGCAGA ATCAAAAGCCAGCCTTGCTGCAATTCTGGAACATTCTCTGTTTTCCACGGAACAGAAGTTACTGGCAGAACTTGATGCTATTATAGGCAA GAAGGGGACGAGGATCATCATTTGGAATCTTAGAAGCTACAAAAATGCAACAGAGTTCGATTTTGAAAAGGATAAATATGATATCAGAAT TCCCGAGGATTTAGATGAGATAACAGGGAAGAAGGGGTACAAGAAGCAGGAAAGGATGGACCAGATTGCCCCTGAGAGTGACTATTCCCT GAGGGCTTATTGCAGTATATTATATCTAAAGCCAAGAATGCAGATCATCCTACGTGGACAGAAAGTGAAGACACAGCTGGTTTCGAAGAG TCTTGCCTACATCGAACGTGATGTTTATCGACCAAAATTTTTATCTAAAACAGTGAGAATTACCTTTGGATTCAACTGCAGAAATAAAGA TCATTATGGGATAATGATGTATCACAGAAATAGACTCATCAAAGCTTATGAAAAAGTTGGATGTCAGTTAAGGGCAAACAACATGGGTGT TGGAGTGGTTGGAATTATAGAGTGTAATTTCCTTAAGCCAACTCATAATAAACAAGATTTCGACTATACTAATGAGTACAGACTTACAAT AACAGCACTAGGAGAAAAGCTGAATGATTACTGGAATGAAATGAAAGTGAAGAAAAATACAGAATATCCTCTAAATTTGCCAGTTGAAGA TATACAGAAGCGTCCTGATCAGACATGGGTTCAGTGTGATGCCTGTCTAAAGTGGCGGAAATTACCTGATGGGATGGATCAACTTCCTGA AAAATGGTATTGCTCCAATAACCCTGACCCACAGTTCAGAAATTGTGAGGTTCCAGAAGAACCTGAAGATGAGGATTTGGTACATCCCAC TTATGAAAAAACCTACAAAAAGACCAACAAGGAAAAATTCAGGATCAGACAACCGGAAATGATCCCTCGGATTAATGCTGAACTGTTGTT TCGGCCAACTGCTCTTTCAACTCCAAGCTTTTCTTCTCCTAAGGAAAGTGTTCCAAGAAGACATCTTTCAGAAGGAACAAATTCTTATGC GACAAGACTTCTAAATAATCATCAAGTTCCACCTCAGTCTGAACCTGAGAGCAACAGCTTGAAACGGAGACTTTCTACTCGTTCCTCAAT TTTGAATGCAAAGAATCGGAGATTGAGTAGTCAGTTTGAAAATTCAGTTTATAAAGGTGATGATGATGATGAAGATGTCATCATCTTAGA AGAAAACAGTACCCCCAAACCTGCAGTAGATCATGATATTGACATGAAATCAGAACAGAGTCACGTTGAGCAAGGTGGTGTTCAGGTTGA GTTTGTGGGTGACAGTGAACCTTGTGGCCAGACTGGTTCAACAAGCACCTCATCATCCCGATGCGACCAGGGAAATACTGCAGCTACCCA GACTGAAGTACCAAGTTTAGTTGTTAAAAAAGAAGAAACTGTTGAAGACGAGATAGACGTAAGAAATGATGCAGTGATTCTGCCCTCCTG TGTAGAAGCTGAAGCAAAGATACATGAAACCCAGGAAACCACCGATAAATCTGCAGATGATGCAGGCTGCCAATTACAAGAACTGAGAAA CCAGCTACTCCTTGTCACTGAGGAAAAAGAGAATTATAAAAGACAGTGTCATATGTTTACTGATCAAATCAAAGTGTTACAACAGAGGAT ACTAGAAATGAATGACAAGTATGTTAAGAAAGAAACTTGCCATCAGTCCACTGAAACCGATGCTGTATTTTTACTTGAAAGTATTAATGG CAAATCTGAAAGTCCAGACCATATGGTATCTCAGTATCAGCAAGCTTTGGAAGAAATAGAAAGGCTGAAAAAACAATGTAGTGCTTTGCA ACATGTAAAGGCTGAATGCAGCCAGTGTTCCAATAATGAGAGTAAAAGTGAAATGGATGAGATGGCTGTGCAGCTTGACGATGTGTTTAG ACAACTGGACAAATGCAGTATTGAGAGGGACCAGTATAAAAGTGAGGTTGAATTGCTGGAAATGGAAAAGTCACAAATCCGTTCACAGTG TGAAGAACTCAAAACTGAAGTAGAACAGTTAAAATCTACAAATCAACAGACGGCAACAGATGTTTCAACATCAAGTAACATTGAGGAGTC TGTAAATCATATGGATGGAGAAAGCCTCAAACTCCGATCTCTTCGAGTTAACGTAGGACAACTGCTGGCTATGATTGTGCCTGATCTTGA TCTTCAGCAAGTGAATTACGATGTTGATGTAGTTGATGAGATTTTAGGACAAGTTGTTGAACAAATGAGTGAAATCAGTAGTACTTAAAG TATATGTTATGTAAGATAAAATATTTGCTCAATTCTTTTGGTTGTACAGCTTTCAAAATATAATTAATTTTGTTTTATAGATATGATAGG CAACAGACTGAAAACCATAATCTTTACTGTATTCTATGCATTCAAATGTGGTCACAAATATTGTGGACACATTATCTTATGTTTTGAAAT ACCTGTGAATTGTTGGCATTGAGCAGCTGAAGCTAACTCATGACTCTGTTTTGAATGTAAATATTTGTAATTAAGCCTGCACATATTTTT TTATTGCCCTAGAGTACTCAAGTGTTTTTCACCAAGAGCTTTTCAGGTTGCCCCTAAGCTTTGTGCAATTTTTTCTGGTTCCCCAAAGTG TATTTTTCTCTAAGTCGAGGGCTATGCCATAATACAAATGGAAATGTTACCTTTGATTTTCTTATAAAGGAGTTTAAATAGGATTTTTAA ATAATGTAGTAACACTCCTGATACAACTCTGGTTATAAGTGAATTGAGCATTAATGTTTCTTTTGTATAAATTCCTGTCCTGAAATATTT TATTCATGAAAATAAGGTAAGCAAAAACCAACTCCATTTTGCCAGGATTTTGTTGTGCTGAGATTGCCAATCACGGTTAAACACAAAGTG TTTTTATAGAATGAAGAAACAGTCTTTAACAGAAAAAAGGTATTGAAATATTAAATGGCCACCAAGTTTACTTTGAAGCCCATTTTTGGC TGTTTAGTCAGCATGAAGTGGGCATGATAATTTTTTAATATTTCTTTTTGTGAAATTTCCTGTACAGCCTTTTGTAGGATTACTACAGGT TAATGTGAGTTGAGGAAGACAGTCTTTCTCAAACAATACTACATACCTTTTATTATATTACAAACCTAAGTGTTTTATATCCTAGAGTCA AGGAACAAATTTCCTTAGGATTATAGTATTACATGCCATAAAATACTATGCTTTATTGGTCCCATGTTTTGTGCAATTTTAAAGAGATGG CTTTCTATTAAGTATAAACTATGTATATATAAGAACCATATTTTCCACAACTAAAATGTGCATTATTTTTTCCAAAGTTTTATCATTGCT ATTTATTTTTACCTTTGTTTTTGAACATTCAATCCGTTCATTTTGTATGTATGCTTAATACGTGTCGGTCATATACAGTATTGAATTTTT ACTGTATAGTAATTCTGGAAAGAGCAAATAAATGAAGATTGTTTTTATTTGCCTGATAAAGTAATTGAAAGTGTATTTTTGGTATGAAGC |
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FusionGenePPI for TMPRSS2_MORC3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TMPRSS2 | CLK1 | MORC3 | RAD23A, ROR1, KPNA2, HIST1H2BG, HIST1H3A, HTT, SNTB1, MOGS, DYNLL1, CRIPT, TRIB1, SYNE2, DEPDC1, DOCK8, RDH10, C6orf141, UBC, DYNLL2, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMPRSS2_MORC3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMPRSS2_MORC3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TMPRSS2 | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
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