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Fusion gene ID: 38751 |
FusionGeneSummary for TMPRSS2_ETV5 |
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Fusion gene information | Fusion gene name: TMPRSS2_ETV5 | Fusion gene ID: 38751 | Hgene | Tgene | Gene symbol | TMPRSS2 | ETV5 | Gene ID | 7113 | 2119 |
Gene name | transmembrane serine protease 2 | ETS variant 5 | |
Synonyms | PP9284|PRSS10 | ERM | |
Cytomap | 21q22.3 | 3q27.2 | |
Type of gene | protein-coding | protein-coding | |
Description | transmembrane protease serine 2epitheliasinserine protease 10transmembrane protease, serine 2 | ETS translocation variant 5ets-related moleculeets-related protein ERM | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O15393 | P41161 | |
Ensembl transtripts involved in fusion gene | ENST00000332149, ENST00000398585, ENST00000458356, ENST00000497881, | ENST00000306376, ENST00000434744, ENST00000537818, ENST00000480706, | |
Fusion gene scores | * DoF score | 29 X 21 X 6=3654 | 6 X 6 X 4=144 |
# samples | 228 | 8 | |
** MAII score | log2(228/3654*10)=-0.680442809575384 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/144*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TMPRSS2 [Title/Abstract] AND ETV5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TMPRSS2 | GO:0006508 | proteolysis | 21068237|24227843 |
Hgene | TMPRSS2 | GO:0046598 | positive regulation of viral entry into host cell | 21068237|24227843 |
Tgene | ETV5 | GO:0034599 | cellular response to oxidative stress | 19443906 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-KK-A7AZ-01A | TMPRSS2 | chr21 | 42861434 | - | ETV5 | chr3 | 185823731 | - |
TCGA | RV | PRAD | TCGA-ZG-A9L5-01A | TMPRSS2 | chr21 | 42866283 | - | ETV5 | chr3 | 185823731 | - |
ChiTaRS3.1 | EU314929 | TMPRSS2 | chr21 | 42880007 | - | ETV5 | chr3 | 185823734 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000332149 | ENST00000306376 | TMPRSS2 | chr21 | 42861434 | - | ETV5 | chr3 | 185823731 | - |
5CDS-5UTR | ENST00000332149 | ENST00000434744 | TMPRSS2 | chr21 | 42861434 | - | ETV5 | chr3 | 185823731 | - |
5CDS-5UTR | ENST00000332149 | ENST00000537818 | TMPRSS2 | chr21 | 42861434 | - | ETV5 | chr3 | 185823731 | - |
5CDS-intron | ENST00000332149 | ENST00000480706 | TMPRSS2 | chr21 | 42861434 | - | ETV5 | chr3 | 185823731 | - |
5CDS-5UTR | ENST00000398585 | ENST00000306376 | TMPRSS2 | chr21 | 42861434 | - | ETV5 | chr3 | 185823731 | - |
5CDS-5UTR | ENST00000398585 | ENST00000434744 | TMPRSS2 | chr21 | 42861434 | - | ETV5 | chr3 | 185823731 | - |
5CDS-5UTR | ENST00000398585 | ENST00000537818 | TMPRSS2 | chr21 | 42861434 | - | ETV5 | chr3 | 185823731 | - |
5CDS-intron | ENST00000398585 | ENST00000480706 | TMPRSS2 | chr21 | 42861434 | - | ETV5 | chr3 | 185823731 | - |
5CDS-5UTR | ENST00000458356 | ENST00000306376 | TMPRSS2 | chr21 | 42861434 | - | ETV5 | chr3 | 185823731 | - |
5CDS-5UTR | ENST00000458356 | ENST00000434744 | TMPRSS2 | chr21 | 42861434 | - | ETV5 | chr3 | 185823731 | - |
5CDS-5UTR | ENST00000458356 | ENST00000537818 | TMPRSS2 | chr21 | 42861434 | - | ETV5 | chr3 | 185823731 | - |
5CDS-intron | ENST00000458356 | ENST00000480706 | TMPRSS2 | chr21 | 42861434 | - | ETV5 | chr3 | 185823731 | - |
intron-5UTR | ENST00000497881 | ENST00000306376 | TMPRSS2 | chr21 | 42861434 | - | ETV5 | chr3 | 185823731 | - |
intron-5UTR | ENST00000497881 | ENST00000434744 | TMPRSS2 | chr21 | 42861434 | - | ETV5 | chr3 | 185823731 | - |
intron-5UTR | ENST00000497881 | ENST00000537818 | TMPRSS2 | chr21 | 42861434 | - | ETV5 | chr3 | 185823731 | - |
intron-intron | ENST00000497881 | ENST00000480706 | TMPRSS2 | chr21 | 42861434 | - | ETV5 | chr3 | 185823731 | - |
5CDS-5UTR | ENST00000332149 | ENST00000306376 | TMPRSS2 | chr21 | 42866283 | - | ETV5 | chr3 | 185823731 | - |
5CDS-5UTR | ENST00000332149 | ENST00000434744 | TMPRSS2 | chr21 | 42866283 | - | ETV5 | chr3 | 185823731 | - |
5CDS-5UTR | ENST00000332149 | ENST00000537818 | TMPRSS2 | chr21 | 42866283 | - | ETV5 | chr3 | 185823731 | - |
5CDS-intron | ENST00000332149 | ENST00000480706 | TMPRSS2 | chr21 | 42866283 | - | ETV5 | chr3 | 185823731 | - |
5CDS-5UTR | ENST00000398585 | ENST00000306376 | TMPRSS2 | chr21 | 42866283 | - | ETV5 | chr3 | 185823731 | - |
5CDS-5UTR | ENST00000398585 | ENST00000434744 | TMPRSS2 | chr21 | 42866283 | - | ETV5 | chr3 | 185823731 | - |
5CDS-5UTR | ENST00000398585 | ENST00000537818 | TMPRSS2 | chr21 | 42866283 | - | ETV5 | chr3 | 185823731 | - |
5CDS-intron | ENST00000398585 | ENST00000480706 | TMPRSS2 | chr21 | 42866283 | - | ETV5 | chr3 | 185823731 | - |
5CDS-5UTR | ENST00000458356 | ENST00000306376 | TMPRSS2 | chr21 | 42866283 | - | ETV5 | chr3 | 185823731 | - |
5CDS-5UTR | ENST00000458356 | ENST00000434744 | TMPRSS2 | chr21 | 42866283 | - | ETV5 | chr3 | 185823731 | - |
5CDS-5UTR | ENST00000458356 | ENST00000537818 | TMPRSS2 | chr21 | 42866283 | - | ETV5 | chr3 | 185823731 | - |
5CDS-intron | ENST00000458356 | ENST00000480706 | TMPRSS2 | chr21 | 42866283 | - | ETV5 | chr3 | 185823731 | - |
intron-5UTR | ENST00000497881 | ENST00000306376 | TMPRSS2 | chr21 | 42866283 | - | ETV5 | chr3 | 185823731 | - |
intron-5UTR | ENST00000497881 | ENST00000434744 | TMPRSS2 | chr21 | 42866283 | - | ETV5 | chr3 | 185823731 | - |
intron-5UTR | ENST00000497881 | ENST00000537818 | TMPRSS2 | chr21 | 42866283 | - | ETV5 | chr3 | 185823731 | - |
intron-intron | ENST00000497881 | ENST00000480706 | TMPRSS2 | chr21 | 42866283 | - | ETV5 | chr3 | 185823731 | - |
5UTR-5UTR | ENST00000332149 | ENST00000306376 | TMPRSS2 | chr21 | 42880007 | - | ETV5 | chr3 | 185823734 | - |
5UTR-5UTR | ENST00000332149 | ENST00000434744 | TMPRSS2 | chr21 | 42880007 | - | ETV5 | chr3 | 185823734 | - |
5UTR-5UTR | ENST00000332149 | ENST00000537818 | TMPRSS2 | chr21 | 42880007 | - | ETV5 | chr3 | 185823734 | - |
5UTR-intron | ENST00000332149 | ENST00000480706 | TMPRSS2 | chr21 | 42880007 | - | ETV5 | chr3 | 185823734 | - |
intron-5UTR | ENST00000398585 | ENST00000306376 | TMPRSS2 | chr21 | 42880007 | - | ETV5 | chr3 | 185823734 | - |
intron-5UTR | ENST00000398585 | ENST00000434744 | TMPRSS2 | chr21 | 42880007 | - | ETV5 | chr3 | 185823734 | - |
intron-5UTR | ENST00000398585 | ENST00000537818 | TMPRSS2 | chr21 | 42880007 | - | ETV5 | chr3 | 185823734 | - |
intron-intron | ENST00000398585 | ENST00000480706 | TMPRSS2 | chr21 | 42880007 | - | ETV5 | chr3 | 185823734 | - |
intron-5UTR | ENST00000458356 | ENST00000306376 | TMPRSS2 | chr21 | 42880007 | - | ETV5 | chr3 | 185823734 | - |
intron-5UTR | ENST00000458356 | ENST00000434744 | TMPRSS2 | chr21 | 42880007 | - | ETV5 | chr3 | 185823734 | - |
intron-5UTR | ENST00000458356 | ENST00000537818 | TMPRSS2 | chr21 | 42880007 | - | ETV5 | chr3 | 185823734 | - |
intron-intron | ENST00000458356 | ENST00000480706 | TMPRSS2 | chr21 | 42880007 | - | ETV5 | chr3 | 185823734 | - |
5UTR-5UTR | ENST00000497881 | ENST00000306376 | TMPRSS2 | chr21 | 42880007 | - | ETV5 | chr3 | 185823734 | - |
5UTR-5UTR | ENST00000497881 | ENST00000434744 | TMPRSS2 | chr21 | 42880007 | - | ETV5 | chr3 | 185823734 | - |
5UTR-5UTR | ENST00000497881 | ENST00000537818 | TMPRSS2 | chr21 | 42880007 | - | ETV5 | chr3 | 185823734 | - |
5UTR-intron | ENST00000497881 | ENST00000480706 | TMPRSS2 | chr21 | 42880007 | - | ETV5 | chr3 | 185823734 | - |
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FusionProtFeatures for TMPRSS2_ETV5 |
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Hgene | Tgene |
TMPRSS2 | ETV5 |
Serine protease that proteolytically cleaves andactivates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized andmaintained in precursor intermediate folding states andproteolysis permits the refolding and energy release required tocreate stable virus-cell linkages and membrane coalescence.Facilitates human SARS coronavirus (SARS-CoV) infection via twoindependent mechanisms, proteolytic cleavage of ACE2, which mightpromote viral uptake, and cleavage of coronavirus spikeglycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activatesthe spike glycoproteins of human coronavirus 229E (HCoV-229E) andhuman coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0of Sendai virus (SeV), human metapneumovirus (HMPV), humanparainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential forspread and pathogenesis of influenza A virus (strains H1N1, H3N2and H7N9); involved in proteolytic cleavage and activation ofhemagglutinin (HA) protein which is essential for viralinfectivity. {ECO:0000269|PubMed:21068237,ECO:0000269|PubMed:21325420, ECO:0000269|PubMed:23536651,ECO:0000269|PubMed:23966399, ECO:0000269|PubMed:24027332,ECO:0000269|PubMed:24227843}. | Binds to DNA sequences containing the consensusnucleotide core sequence 5'-GGAA.-3'.{ECO:0000269|PubMed:8152800}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TMPRSS2_ETV5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TMPRSS2_ETV5 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TMPRSS2 | CLK1 | ETV5 | AR, RFWD2, ELAVL1, BRCA1, APP, HDAC11, DHRS7, SEZ6L2, SLC22A2, AMH, CISH, CCR5, CYP3A5, HOXD9, MOV10, NXF1, STK40, MYH14, UBE2E3, DET1, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMPRSS2_ETV5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMPRSS2_ETV5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TMPRSS2 | C0033578 | Prostatic Neoplasms | 2 | CTD_human |