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Fusion gene ID: 38738 |
FusionGeneSummary for TMPRSS11D_SPINK2 |
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Fusion gene information | Fusion gene name: TMPRSS11D_SPINK2 | Fusion gene ID: 38738 | Hgene | Tgene | Gene symbol | TMPRSS11D | SPINK2 | Gene ID | 9407 | 6691 |
Gene name | transmembrane serine protease 11D | serine peptidase inhibitor, Kazal type 2 | |
Synonyms | HAT | HUSI-II | |
Cytomap | 4q13.2 | 4q12 | |
Type of gene | protein-coding | protein-coding | |
Description | transmembrane protease serine 11Dairway trypsin-like proteasetransmembrane protease, serine 11D | serine protease inhibitor Kazal-type 2epididymis tissue protein Li 172serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) | |
Modification date | 20180403 | 20180523 | |
UniProtAcc | O60235 | P20155 | |
Ensembl transtripts involved in fusion gene | ENST00000283916, ENST00000545541, ENST00000509584, | ENST00000248701, ENST00000506738, ENST00000504762, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 3 X 5=75 |
# samples | 1 | 5 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TMPRSS11D [Title/Abstract] AND SPINK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TMPRSS11D | GO:0006508 | proteolysis | 24227843 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | HNSC | TCGA-F7-7848-01A | TMPRSS11D | chr4 | 68749644 | - | SPINK2 | chr4 | 57677960 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000283916 | ENST00000248701 | TMPRSS11D | chr4 | 68749644 | - | SPINK2 | chr4 | 57677960 | - |
In-frame | ENST00000283916 | ENST00000506738 | TMPRSS11D | chr4 | 68749644 | - | SPINK2 | chr4 | 57677960 | - |
In-frame | ENST00000283916 | ENST00000504762 | TMPRSS11D | chr4 | 68749644 | - | SPINK2 | chr4 | 57677960 | - |
5UTR-3CDS | ENST00000545541 | ENST00000248701 | TMPRSS11D | chr4 | 68749644 | - | SPINK2 | chr4 | 57677960 | - |
5UTR-3CDS | ENST00000545541 | ENST00000506738 | TMPRSS11D | chr4 | 68749644 | - | SPINK2 | chr4 | 57677960 | - |
5UTR-3CDS | ENST00000545541 | ENST00000504762 | TMPRSS11D | chr4 | 68749644 | - | SPINK2 | chr4 | 57677960 | - |
5UTR-3CDS | ENST00000509584 | ENST00000248701 | TMPRSS11D | chr4 | 68749644 | - | SPINK2 | chr4 | 57677960 | - |
5UTR-3CDS | ENST00000509584 | ENST00000506738 | TMPRSS11D | chr4 | 68749644 | - | SPINK2 | chr4 | 57677960 | - |
5UTR-3CDS | ENST00000509584 | ENST00000504762 | TMPRSS11D | chr4 | 68749644 | - | SPINK2 | chr4 | 57677960 | - |
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FusionProtFeatures for TMPRSS11D_SPINK2 |
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Hgene | Tgene |
TMPRSS11D | SPINK2 |
May play some biological role in the host defense systemon the mucous membrane independently of or in cooperation withother substances in airway mucous or bronchial secretions. Plays arole in the proteolytic processing of ACE2. Proteolyticallycleaves and activates the human coronavirus 229E (HCoV-229E) spikeglycoprotein which facilitate virus-cell membrane fusions; spikeproteins are synthesized and maintained in precursor intermediatefolding states and proteolysis permits the refolding and energyrelease required to create stable virus-cell linkages and membranecoalescence. Preferentially cleaves the C-terminal side ofarginine residues at the P1 position of certain peptides, cleavingBoc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently andhaving an optimum pH of 8.6 with this substrate.{ECO:0000269|PubMed:23536651, ECO:0000269|PubMed:24227843}. | Strong inhibitor of acrosin in male and/or femalegenital tract. Also inhibits trypsin.{ECO:0000269|PubMed:19422058}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >SPINK2 | chr4:68749644 | chr4:57677960 | ENST00000248701 | - | 1 | 4 | 30_84 | 33 | 85 | Domain | Kazal-like |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >TMPRSS11D | chr4:68749644 | chr4:57677960 | ENST00000283916 | - | 1 | 10 | 187_417 | 2 | 419 | Domain | Peptidase S1 |
Hgene | >TMPRSS11D | chr4:68749644 | chr4:57677960 | ENST00000283916 | - | 1 | 10 | 46_163 | 2 | 419 | Domain | SEA |
Hgene | >TMPRSS11D | chr4:68749644 | chr4:57677960 | ENST00000283916 | - | 1 | 10 | 1_20 | 2 | 419 | Topological domain | Cytoplasmic |
Hgene | >TMPRSS11D | chr4:68749644 | chr4:57677960 | ENST00000283916 | - | 1 | 10 | 42_418 | 2 | 419 | Topological domain | Extracellular |
Hgene | >TMPRSS11D | chr4:68749644 | chr4:57677960 | ENST00000283916 | - | 1 | 10 | 21_41 | 2 | 419 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
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FusionGeneSequence for TMPRSS11D_SPINK2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_TMPRSS11D_ENST00000283916_chr4_68749644_-_SPINK2_ENST00000248701_chr4_57677960_-_54aa >In-frame_TMPRSS11D_ENST00000283916_chr4_68749644_-_SPINK2_ENST00000506738_chr4_57677960_-_54aa >In-frame_TMPRSS11D_ENST00000283916_chr4_68749644_-_SPINK2_ENST00000504762_chr4_57677960_-_54aa |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_TMPRSS11D_ENST00000283916_chr4_68749644_-_SPINK2_ENST00000248701_chr4_57677960_-_164nt ATGTATAGCCAAACTGCTCTCAGTATAGATTACCAGGATGTCCCAGACACTTTAACCCTGTGTGTGGCAGTGACATGTCCACTTATGCCA >In-frame_TMPRSS11D_ENST00000283916_chr4_68749644_-_SPINK2_ENST00000506738_chr4_57677960_-_164nt ATGTATAGCCAAACTGCTCTCAGTATAGATTACCAGGATGTCCCAGACACTTTAACCCTGTGTGTGGCAGTGACATGTCCACTTATGCCA >In-frame_TMPRSS11D_ENST00000283916_chr4_68749644_-_SPINK2_ENST00000504762_chr4_57677960_-_164nt ATGTATAGCCAAACTGCTCTCAGTATAGATTACCAGGATGTCCCAGACACTTTAACCCTGTGTGTGGCAGTGACATGTCCACTTATGCCA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_TMPRSS11D_ENST00000283916_chr4_68749644_-_SPINK2_ENST00000248701_chr4_57677960_-_541nt ACTATAGATCACACGTAATACATGAGAGTCATTCATTTGAGTGGGAATCTCAAAGCAGTTGAGTAGGCAGAAAAAAGAACCTCTTCATTA AGGATTAAAATGTATAGCCAAACTGCTCTCAGTATAGATTACCAGGATGTCCCAGACACTTTAACCCTGTGTGTGGCAGTGACATGTCCA CTTATGCCAATGAATGTACTCTGTGCATGAAAATCAGGGAAGGTGGTCATAATATTAAAATCATTCGAAATGGACCCTGCTGATGGAGCA GTTTACAGAAAAGAAGATGGAGAGACCACCTTCACTGGCAGACTAGATAAATTGCATTTCCCCTTTTTCTCTTTTCCTGTGTTTCTTTAC ATGAGATTTGTTAACACACATTTTCTGAGAGCAGGTATGGAAGACAGCCATGTGTAGTGATGGATAATTTAAAGAAAAAAAGAATCCTTG TTTCTTGGCTTTTGCTCCTGGAGTTAAGCTTACTGCCCAGGTGACTTGTGCATTGCTTTATTTAGTTGAAATAAAATCAGCATTGAATTC >In-frame_TMPRSS11D_ENST00000283916_chr4_68749644_-_SPINK2_ENST00000506738_chr4_57677960_-_541nt ACTATAGATCACACGTAATACATGAGAGTCATTCATTTGAGTGGGAATCTCAAAGCAGTTGAGTAGGCAGAAAAAAGAACCTCTTCATTA AGGATTAAAATGTATAGCCAAACTGCTCTCAGTATAGATTACCAGGATGTCCCAGACACTTTAACCCTGTGTGTGGCAGTGACATGTCCA CTTATGCCAATGAATGTACTCTGTGCATGAAAATCAGGGAAGGTGGTCATAATATTAAAATCATTCGAAATGGACCCTGCTGATGGAGCA GTTTACAGAAAAGAAGATGGAGAGACCACCTTCACTGGCAGACTAGATAAATTGCATTTCCCCTTTTTCTCTTTTCCTGTGTTTCTTTAC ATGAGATTTGTTAACACACATTTTCTGAGAGCAGGTATGGAAGACAGCCATGTGTAGTGATGGATAATTTAAAGAAAAAAAGAATCCTTG TTTCTTGGCTTTTGCTCCTGGAGTTAAGCTTACTGCCCAGGTGACTTGTGCATTGCTTTATTTAGTTGAAATAAAATCAGCATTGAATTC >In-frame_TMPRSS11D_ENST00000283916_chr4_68749644_-_SPINK2_ENST00000504762_chr4_57677960_-_530nt ACTATAGATCACACGTAATACATGAGAGTCATTCATTTGAGTGGGAATCTCAAAGCAGTTGAGTAGGCAGAAAAAAGAACCTCTTCATTA AGGATTAAAATGTATAGCCAAACTGCTCTCAGTATAGATTACCAGGATGTCCCAGACACTTTAACCCTGTGTGTGGCAGTGACATGTCCA CTTATGCCAATGAATGTACTCTGTGCATGAAAATCAGGGAAGGTGGTCATAATATTAAAATCATTCGAAATGGACCCTGCTGATGGAGCA GTTTACAGAAAAGAAGATGGAGAGACCACCTTCACTGGCAGACTAGATAAATTGCATTTCCCCTTTTTCTCTTTTCCTGTGTTTCTTTAC ATGAGATTTGTTAACACACATTTTCTGAGAGCAGGTATGGAAGACAGCCATGTGTAGTGATGGATAATTTAAAGAAAAAAAGAATCCTTG |
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FusionGenePPI for TMPRSS11D_SPINK2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TMPRSS11D | SPINK2 | KRTAP5-9, ADAMTSL4, KRTAP10-3, NOTCH2NL, MAPK8IP2, GCHFR, ATP5S, NUDT8, MIPEP, DCAF15, CTTNBP2NL, PRTFDC1, UBR2, PDP2, IDE, PMPCB, RSPRY1, PMPCA, MOB4, STRIP1, IKBIP, STRN, UBR1, STRN3, STRN4, ATP6V1D |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMPRSS11D_SPINK2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMPRSS11D_SPINK2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |