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Fusion gene ID: 38737 |
FusionGeneSummary for TMPRSS11B_TSN |
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Fusion gene information | Fusion gene name: TMPRSS11B_TSN | Fusion gene ID: 38737 | Hgene | Tgene | Gene symbol | TMPRSS11B | TSN | Gene ID | 132724 | 7247 |
Gene name | transmembrane serine protease 11B | translin | |
Synonyms | - | BCLF-1|C3PO|RCHF1|REHF-1|TBRBP|TRSLN | |
Cytomap | 4q13.2 | 2q14.3 | |
Type of gene | protein-coding | protein-coding | |
Description | transmembrane protease serine 11Bairway trypsin-like protease 5transmembrane protease, serine 11B | translincomponent 3 of promoter of RISCrecombination hotspot associated factorrecombination hotspot-binding proteintestis brain-RNA binding protein | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q86T26 | Q15631 | |
Ensembl transtripts involved in fusion gene | ENST00000332644, | ENST00000389682, ENST00000498545, ENST00000536142, ENST00000409193, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 5 X 6 X 1=30 |
# samples | 2 | 6 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(6/30*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TMPRSS11B [Title/Abstract] AND TSN [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW969521 | TMPRSS11B | chr4 | 69107567 | - | TSN | chr2 | 122524894 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000332644 | ENST00000389682 | TMPRSS11B | chr4 | 69107567 | - | TSN | chr2 | 122524894 | - |
intron-intron | ENST00000332644 | ENST00000498545 | TMPRSS11B | chr4 | 69107567 | - | TSN | chr2 | 122524894 | - |
intron-intron | ENST00000332644 | ENST00000536142 | TMPRSS11B | chr4 | 69107567 | - | TSN | chr2 | 122524894 | - |
intron-intron | ENST00000332644 | ENST00000409193 | TMPRSS11B | chr4 | 69107567 | - | TSN | chr2 | 122524894 | - |
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FusionProtFeatures for TMPRSS11B_TSN |
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Hgene | Tgene |
TMPRSS11B | TSN |
Serine protease. {ECO:0000269|PubMed:24498351}. | DNA-binding protein that specifically recognizesconsensus sequences at the breakpoint junctions in chromosomaltranslocations, mostly involving immunoglobulin (Ig)/T-cellreceptor gene segments. Seems to recognize single-stranded DNAends generated by staggered breaks occurring at recombination hotspots. Exhibits both single-stranded and double-strandedendoribonuclease activity. May act as an activator of RNA-inducedsilencing complex (RISC) by facilitating endonucleolytic cleavageof the siRNA passenger strand. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TMPRSS11B_TSN |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TMPRSS11B_TSN |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMPRSS11B_TSN |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMPRSS11B_TSN |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |