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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38737

FusionGeneSummary for TMPRSS11B_TSN

check button Fusion gene summary
Fusion gene informationFusion gene name: TMPRSS11B_TSN
Fusion gene ID: 38737
HgeneTgene
Gene symbol

TMPRSS11B

TSN

Gene ID

132724

7247

Gene nametransmembrane serine protease 11Btranslin
Synonyms-BCLF-1|C3PO|RCHF1|REHF-1|TBRBP|TRSLN
Cytomap

4q13.2

2q14.3

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protease serine 11Bairway trypsin-like protease 5transmembrane protease, serine 11Btranslincomponent 3 of promoter of RISCrecombination hotspot associated factorrecombination hotspot-binding proteintestis brain-RNA binding protein
Modification date2018052320180523
UniProtAcc

Q86T26

Q15631

Ensembl transtripts involved in fusion geneENST00000332644, ENST00000389682, 
ENST00000498545, ENST00000536142, 
ENST00000409193, 
Fusion gene scores* DoF score2 X 2 X 1=45 X 6 X 1=30
# samples 26
** MAII scorelog2(2/4*10)=2.32192809488736log2(6/30*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TMPRSS11B [Title/Abstract] AND TSN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW969521TMPRSS11Bchr4

69107567

-TSNchr2

122524894

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000332644ENST00000389682TMPRSS11Bchr4

69107567

-TSNchr2

122524894

-
intron-intronENST00000332644ENST00000498545TMPRSS11Bchr4

69107567

-TSNchr2

122524894

-
intron-intronENST00000332644ENST00000536142TMPRSS11Bchr4

69107567

-TSNchr2

122524894

-
intron-intronENST00000332644ENST00000409193TMPRSS11Bchr4

69107567

-TSNchr2

122524894

-

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FusionProtFeatures for TMPRSS11B_TSN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMPRSS11B

Q86T26

TSN

Q15631

Serine protease. {ECO:0000269|PubMed:24498351}. DNA-binding protein that specifically recognizesconsensus sequences at the breakpoint junctions in chromosomaltranslocations, mostly involving immunoglobulin (Ig)/T-cellreceptor gene segments. Seems to recognize single-stranded DNAends generated by staggered breaks occurring at recombination hotspots. Exhibits both single-stranded and double-strandedendoribonuclease activity. May act as an activator of RNA-inducedsilencing complex (RISC) by facilitating endonucleolytic cleavageof the siRNA passenger strand.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TMPRSS11B_TSN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMPRSS11B_TSN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMPRSS11B_TSN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMPRSS11B_TSN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource