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Fusion gene ID: 38736 |
FusionGeneSummary for TMPRSS11B_LCLAT1 |
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Fusion gene information | Fusion gene name: TMPRSS11B_LCLAT1 | Fusion gene ID: 38736 | Hgene | Tgene | Gene symbol | TMPRSS11B | LCLAT1 | Gene ID | 132724 | 253558 |
Gene name | transmembrane serine protease 11B | lysocardiolipin acyltransferase 1 | |
Synonyms | - | 1AGPAT8|AGPAT8|ALCAT1|HSRG1849|LYCAT|UNQ1849 | |
Cytomap | 4q13.2 | 2p23.1 | |
Type of gene | protein-coding | protein-coding | |
Description | transmembrane protease serine 11Bairway trypsin-like protease 5transmembrane protease, serine 11B | lysocardiolipin acyltransferase 11-AGP acyltransferase 81-AGPAT 81-acylglycerol-3-phosphate O-acyltransferase 8acyl-CoA:lysocardiolipin acyltransferase 1 | |
Modification date | 20180523 | 20180527 | |
UniProtAcc | Q86T26 | Q6UWP7 | |
Ensembl transtripts involved in fusion gene | ENST00000332644, | ENST00000379509, ENST00000319406, ENST00000491680, ENST00000359433, ENST00000309052, ENST00000540623, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 2 X 2 X 1=4 |
# samples | 2 | 2 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: TMPRSS11B [Title/Abstract] AND LCLAT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF354474 | TMPRSS11B | chr4 | 69093593 | - | LCLAT1 | chr2 | 30692084 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000332644 | ENST00000379509 | TMPRSS11B | chr4 | 69093593 | - | LCLAT1 | chr2 | 30692084 | - |
intron-intron | ENST00000332644 | ENST00000319406 | TMPRSS11B | chr4 | 69093593 | - | LCLAT1 | chr2 | 30692084 | - |
intron-intron | ENST00000332644 | ENST00000491680 | TMPRSS11B | chr4 | 69093593 | - | LCLAT1 | chr2 | 30692084 | - |
intron-intron | ENST00000332644 | ENST00000359433 | TMPRSS11B | chr4 | 69093593 | - | LCLAT1 | chr2 | 30692084 | - |
intron-intron | ENST00000332644 | ENST00000309052 | TMPRSS11B | chr4 | 69093593 | - | LCLAT1 | chr2 | 30692084 | - |
intron-intron | ENST00000332644 | ENST00000540623 | TMPRSS11B | chr4 | 69093593 | - | LCLAT1 | chr2 | 30692084 | - |
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FusionProtFeatures for TMPRSS11B_LCLAT1 |
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Hgene | Tgene |
TMPRSS11B | LCLAT1 |
Serine protease. {ECO:0000269|PubMed:24498351}. | Acyl-CoA:lysocardiolipin acyltransferase. Possesses bothlysophosphatidylinositol acyltransferase (LPIAT) andlysophosphatidylglycerol acyltransferase (LPGAT) activities.Recognizes both monolysocardiolipin and dilysocardiolipin assubstrates with a preference for linoleoyl-CoA and oleoyl-CoA asacyl donors. Acts as a remodeling enzyme for cardiolipin, a majormembrane polyglycerophospholipid. Converts lysophosphatidic acid(LPA) into phosphatidic acid (PA) with a relatively low activity.Required for establishment of the hematopoietic and endotheliallineages. {ECO:0000269|PubMed:16620771,ECO:0000269|PubMed:19075029}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TMPRSS11B_LCLAT1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TMPRSS11B_LCLAT1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMPRSS11B_LCLAT1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMPRSS11B_LCLAT1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |