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Fusion gene ID: 38729 |
FusionGeneSummary for TMOD3_MCF2 |
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Fusion gene information | Fusion gene name: TMOD3_MCF2 | Fusion gene ID: 38729 | Hgene | Tgene | Gene symbol | TMOD3 | MCF2 | Gene ID | 29766 | 4168 |
Gene name | tropomodulin 3 | MCF.2 cell line derived transforming sequence | |
Synonyms | UTMOD | ARHGEF21|DBL | |
Cytomap | 15q21.2 | Xq27.1 | |
Type of gene | protein-coding | protein-coding | |
Description | tropomodulin-3tropomodulin 3 (ubiquitous)ubiquitous tropomodulin | proto-oncogene DBLOncogene MCF2 (oncogene DBL)proto-oncogene MCF-2 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q9NYL9 | P10911 | |
Ensembl transtripts involved in fusion gene | ENST00000308580, ENST00000544199, ENST00000561136, | ENST00000520602, ENST00000370576, ENST00000536274, ENST00000370578, ENST00000414978, ENST00000519895, ENST00000370573, ENST00000338585, ENST00000483690, | |
Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 3 X 3 X 1=9 |
# samples | 5 | 3 | |
** MAII score | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TMOD3 [Title/Abstract] AND MCF2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | X13230 | TMOD3 | chr15 | 52122035 | + | MCF2 | chrX | 138697214 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000308580 | ENST00000520602 | TMOD3 | chr15 | 52122035 | + | MCF2 | chrX | 138697214 | - |
5UTR-3CDS | ENST00000308580 | ENST00000370576 | TMOD3 | chr15 | 52122035 | + | MCF2 | chrX | 138697214 | - |
5UTR-3CDS | ENST00000308580 | ENST00000536274 | TMOD3 | chr15 | 52122035 | + | MCF2 | chrX | 138697214 | - |
5UTR-3CDS | ENST00000308580 | ENST00000370578 | TMOD3 | chr15 | 52122035 | + | MCF2 | chrX | 138697214 | - |
5UTR-3CDS | ENST00000308580 | ENST00000414978 | TMOD3 | chr15 | 52122035 | + | MCF2 | chrX | 138697214 | - |
5UTR-3CDS | ENST00000308580 | ENST00000519895 | TMOD3 | chr15 | 52122035 | + | MCF2 | chrX | 138697214 | - |
5UTR-3CDS | ENST00000308580 | ENST00000370573 | TMOD3 | chr15 | 52122035 | + | MCF2 | chrX | 138697214 | - |
5UTR-3CDS | ENST00000308580 | ENST00000338585 | TMOD3 | chr15 | 52122035 | + | MCF2 | chrX | 138697214 | - |
5UTR-intron | ENST00000308580 | ENST00000483690 | TMOD3 | chr15 | 52122035 | + | MCF2 | chrX | 138697214 | - |
intron-3CDS | ENST00000544199 | ENST00000520602 | TMOD3 | chr15 | 52122035 | + | MCF2 | chrX | 138697214 | - |
intron-3CDS | ENST00000544199 | ENST00000370576 | TMOD3 | chr15 | 52122035 | + | MCF2 | chrX | 138697214 | - |
intron-3CDS | ENST00000544199 | ENST00000536274 | TMOD3 | chr15 | 52122035 | + | MCF2 | chrX | 138697214 | - |
intron-3CDS | ENST00000544199 | ENST00000370578 | TMOD3 | chr15 | 52122035 | + | MCF2 | chrX | 138697214 | - |
intron-3CDS | ENST00000544199 | ENST00000414978 | TMOD3 | chr15 | 52122035 | + | MCF2 | chrX | 138697214 | - |
intron-3CDS | ENST00000544199 | ENST00000519895 | TMOD3 | chr15 | 52122035 | + | MCF2 | chrX | 138697214 | - |
intron-3CDS | ENST00000544199 | ENST00000370573 | TMOD3 | chr15 | 52122035 | + | MCF2 | chrX | 138697214 | - |
intron-3CDS | ENST00000544199 | ENST00000338585 | TMOD3 | chr15 | 52122035 | + | MCF2 | chrX | 138697214 | - |
intron-intron | ENST00000544199 | ENST00000483690 | TMOD3 | chr15 | 52122035 | + | MCF2 | chrX | 138697214 | - |
intron-3CDS | ENST00000561136 | ENST00000520602 | TMOD3 | chr15 | 52122035 | + | MCF2 | chrX | 138697214 | - |
intron-3CDS | ENST00000561136 | ENST00000370576 | TMOD3 | chr15 | 52122035 | + | MCF2 | chrX | 138697214 | - |
intron-3CDS | ENST00000561136 | ENST00000536274 | TMOD3 | chr15 | 52122035 | + | MCF2 | chrX | 138697214 | - |
intron-3CDS | ENST00000561136 | ENST00000370578 | TMOD3 | chr15 | 52122035 | + | MCF2 | chrX | 138697214 | - |
intron-3CDS | ENST00000561136 | ENST00000414978 | TMOD3 | chr15 | 52122035 | + | MCF2 | chrX | 138697214 | - |
intron-3CDS | ENST00000561136 | ENST00000519895 | TMOD3 | chr15 | 52122035 | + | MCF2 | chrX | 138697214 | - |
intron-3CDS | ENST00000561136 | ENST00000370573 | TMOD3 | chr15 | 52122035 | + | MCF2 | chrX | 138697214 | - |
intron-3CDS | ENST00000561136 | ENST00000338585 | TMOD3 | chr15 | 52122035 | + | MCF2 | chrX | 138697214 | - |
intron-intron | ENST00000561136 | ENST00000483690 | TMOD3 | chr15 | 52122035 | + | MCF2 | chrX | 138697214 | - |
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FusionProtFeatures for TMOD3_MCF2 |
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Hgene | Tgene |
TMOD3 | MCF2 |
Blocks the elongation and depolymerization of the actinfilaments at the pointed end. The Tmod/TM complex contributes tothe formation of the short actin protofilament, which in turndefines the geometry of the membrane skeleton (By similarity).{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TMOD3_MCF2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TMOD3_MCF2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TMOD3 | USP45, NR4A1, TNFSF11, DUSP23, MAP1LC3B, ELAVL1, ARRB1, ARRB2, ISG15, FBXO25, LRRK2, ATP6V1B1, AHCYL1, PPIL3, NPC1, PSMC4, SULT1A1, HNRNPUL2, PSMB7, CSNK2A1, PAN2, PSMD9, DHX15, PABPC1, PPP1CA, YWHAE, CUL7, CCDC8, DAPK1, ATP6V1B2, MCFD2, PAM16, RUVBL2, SMARCC1, SMARCC2, SNRPD1, CAPZB, DHX9, HSPA5, PSMA1, PSMD3, RAD23A, USP5, XRCC6, HIST1H3E, CAPZA2, CDK2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, IQGAP1, SYNPO, LIMA1, ANLN, MYO5C, MYO19, MYO18A, ZSCAN26, FBXW7, ESR1, CDC5L, CDH1, DUSP19, SCIN, LRRFIP1, POTEI, MYO5B, INF2, ALAS1, SVIL, FLII, LRRFIP2, ACTA2, GSN, LONP2, LRCH3, MEIS2, SPIRE2, COBL, PRPF3, FECH, PHACTR2, ACTBL2, ACTB, TBC1D4, DOCK7, MYO5A, TWF2, ACTC1, SPIRE1, PBX2, PRPF4, ENAH, CSRP2BP, PBX3, FBXO34, SSH1, BDH2, COX15, PARK7, TRIM25, G3BP1, CCND2 | MCF2 | MCF2, CDC42, RHOA, TNK2, GNA13, GNB1, HSP90AA1, STUB1, HSPA8, ERCC3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMOD3_MCF2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMOD3_MCF2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |