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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38729

FusionGeneSummary for TMOD3_MCF2

check button Fusion gene summary
Fusion gene informationFusion gene name: TMOD3_MCF2
Fusion gene ID: 38729
HgeneTgene
Gene symbol

TMOD3

MCF2

Gene ID

29766

4168

Gene nametropomodulin 3MCF.2 cell line derived transforming sequence
SynonymsUTMODARHGEF21|DBL
Cytomap

15q21.2

Xq27.1

Type of geneprotein-codingprotein-coding
Descriptiontropomodulin-3tropomodulin 3 (ubiquitous)ubiquitous tropomodulinproto-oncogene DBLOncogene MCF2 (oncogene DBL)proto-oncogene MCF-2
Modification date2018052320180522
UniProtAcc

Q9NYL9

P10911

Ensembl transtripts involved in fusion geneENST00000308580, ENST00000544199, 
ENST00000561136, 		ENST00000520602, 
ENST00000370576, ENST00000536274, 
ENST00000370578, ENST00000414978, 
ENST00000519895, ENST00000370573, 
ENST00000338585, ENST00000483690, 
Fusion gene scores* DoF score5 X 4 X 4=803 X 3 X 1=9
# samples 53
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TMOD3 [Title/Abstract] AND MCF2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1X13230TMOD3chr15

52122035

+MCF2chrX

138697214

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000308580ENST00000520602TMOD3chr15

52122035

+MCF2chrX

138697214

-
5UTR-3CDSENST00000308580ENST00000370576TMOD3chr15

52122035

+MCF2chrX

138697214

-
5UTR-3CDSENST00000308580ENST00000536274TMOD3chr15

52122035

+MCF2chrX

138697214

-
5UTR-3CDSENST00000308580ENST00000370578TMOD3chr15

52122035

+MCF2chrX

138697214

-
5UTR-3CDSENST00000308580ENST00000414978TMOD3chr15

52122035

+MCF2chrX

138697214

-
5UTR-3CDSENST00000308580ENST00000519895TMOD3chr15

52122035

+MCF2chrX

138697214

-
5UTR-3CDSENST00000308580ENST00000370573TMOD3chr15

52122035

+MCF2chrX

138697214

-
5UTR-3CDSENST00000308580ENST00000338585TMOD3chr15

52122035

+MCF2chrX

138697214

-
5UTR-intronENST00000308580ENST00000483690TMOD3chr15

52122035

+MCF2chrX

138697214

-
intron-3CDSENST00000544199ENST00000520602TMOD3chr15

52122035

+MCF2chrX

138697214

-
intron-3CDSENST00000544199ENST00000370576TMOD3chr15

52122035

+MCF2chrX

138697214

-
intron-3CDSENST00000544199ENST00000536274TMOD3chr15

52122035

+MCF2chrX

138697214

-
intron-3CDSENST00000544199ENST00000370578TMOD3chr15

52122035

+MCF2chrX

138697214

-
intron-3CDSENST00000544199ENST00000414978TMOD3chr15

52122035

+MCF2chrX

138697214

-
intron-3CDSENST00000544199ENST00000519895TMOD3chr15

52122035

+MCF2chrX

138697214

-
intron-3CDSENST00000544199ENST00000370573TMOD3chr15

52122035

+MCF2chrX

138697214

-
intron-3CDSENST00000544199ENST00000338585TMOD3chr15

52122035

+MCF2chrX

138697214

-
intron-intronENST00000544199ENST00000483690TMOD3chr15

52122035

+MCF2chrX

138697214

-
intron-3CDSENST00000561136ENST00000520602TMOD3chr15

52122035

+MCF2chrX

138697214

-
intron-3CDSENST00000561136ENST00000370576TMOD3chr15

52122035

+MCF2chrX

138697214

-
intron-3CDSENST00000561136ENST00000536274TMOD3chr15

52122035

+MCF2chrX

138697214

-
intron-3CDSENST00000561136ENST00000370578TMOD3chr15

52122035

+MCF2chrX

138697214

-
intron-3CDSENST00000561136ENST00000414978TMOD3chr15

52122035

+MCF2chrX

138697214

-
intron-3CDSENST00000561136ENST00000519895TMOD3chr15

52122035

+MCF2chrX

138697214

-
intron-3CDSENST00000561136ENST00000370573TMOD3chr15

52122035

+MCF2chrX

138697214

-
intron-3CDSENST00000561136ENST00000338585TMOD3chr15

52122035

+MCF2chrX

138697214

-
intron-intronENST00000561136ENST00000483690TMOD3chr15

52122035

+MCF2chrX

138697214

-

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FusionProtFeatures for TMOD3_MCF2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMOD3

Q9NYL9

MCF2

P10911

Blocks the elongation and depolymerization of the actinfilaments at the pointed end. The Tmod/TM complex contributes tothe formation of the short actin protofilament, which in turndefines the geometry of the membrane skeleton (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TMOD3_MCF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMOD3_MCF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMOD3USP45, NR4A1, TNFSF11, DUSP23, MAP1LC3B, ELAVL1, ARRB1, ARRB2, ISG15, FBXO25, LRRK2, ATP6V1B1, AHCYL1, PPIL3, NPC1, PSMC4, SULT1A1, HNRNPUL2, PSMB7, CSNK2A1, PAN2, PSMD9, DHX15, PABPC1, PPP1CA, YWHAE, CUL7, CCDC8, DAPK1, ATP6V1B2, MCFD2, PAM16, RUVBL2, SMARCC1, SMARCC2, SNRPD1, CAPZB, DHX9, HSPA5, PSMA1, PSMD3, RAD23A, USP5, XRCC6, HIST1H3E, CAPZA2, CDK2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, IQGAP1, SYNPO, LIMA1, ANLN, MYO5C, MYO19, MYO18A, ZSCAN26, FBXW7, ESR1, CDC5L, CDH1, DUSP19, SCIN, LRRFIP1, POTEI, MYO5B, INF2, ALAS1, SVIL, FLII, LRRFIP2, ACTA2, GSN, LONP2, LRCH3, MEIS2, SPIRE2, COBL, PRPF3, FECH, PHACTR2, ACTBL2, ACTB, TBC1D4, DOCK7, MYO5A, TWF2, ACTC1, SPIRE1, PBX2, PRPF4, ENAH, CSRP2BP, PBX3, FBXO34, SSH1, BDH2, COX15, PARK7, TRIM25, G3BP1, CCND2MCF2MCF2, CDC42, RHOA, TNK2, GNA13, GNB1, HSP90AA1, STUB1, HSPA8, ERCC3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMOD3_MCF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMOD3_MCF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource