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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38709

FusionGeneSummary for TMEM98_GRM5

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM98_GRM5
Fusion gene ID: 38709
HgeneTgene
Gene symbol

TMEM98

GRM5

Gene ID

26022

2915

Gene nametransmembrane protein 98glutamate metabotropic receptor 5
SynonymsTADA1GPRC1E|MGLUR5|PPP1R86|mGlu5
Cytomap

17q11.2

11q14.2-q14.3

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 98metabotropic glutamate receptor 5glutamate receptor, metabotropic 5protein phosphatase 1, regulatory subunit 86
Modification date2018052320180523
UniProtAcc

Q9Y2Y6

P41594

Ensembl transtripts involved in fusion geneENST00000394642, ENST00000579849, 
ENST00000578289, 		ENST00000455756, 
ENST00000418177, ENST00000305447, 
ENST00000305432, ENST00000393297, 
ENST00000393294, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 2 X 3=24
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TMEM98 [Title/Abstract] AND GRM5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A7-A2KD-01ATMEM98chr17

31263465

+GRM5chr11

88301160

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000394642ENST00000455756TMEM98chr17

31263465

+GRM5chr11

88301160

-
Frame-shiftENST00000394642ENST00000418177TMEM98chr17

31263465

+GRM5chr11

88301160

-
Frame-shiftENST00000394642ENST00000305447TMEM98chr17

31263465

+GRM5chr11

88301160

-
Frame-shiftENST00000394642ENST00000305432TMEM98chr17

31263465

+GRM5chr11

88301160

-
Frame-shiftENST00000394642ENST00000393297TMEM98chr17

31263465

+GRM5chr11

88301160

-
5CDS-intronENST00000394642ENST00000393294TMEM98chr17

31263465

+GRM5chr11

88301160

-
Frame-shiftENST00000579849ENST00000455756TMEM98chr17

31263465

+GRM5chr11

88301160

-
Frame-shiftENST00000579849ENST00000418177TMEM98chr17

31263465

+GRM5chr11

88301160

-
Frame-shiftENST00000579849ENST00000305447TMEM98chr17

31263465

+GRM5chr11

88301160

-
Frame-shiftENST00000579849ENST00000305432TMEM98chr17

31263465

+GRM5chr11

88301160

-
Frame-shiftENST00000579849ENST00000393297TMEM98chr17

31263465

+GRM5chr11

88301160

-
5CDS-intronENST00000579849ENST00000393294TMEM98chr17

31263465

+GRM5chr11

88301160

-
Frame-shiftENST00000578289ENST00000455756TMEM98chr17

31263465

+GRM5chr11

88301160

-
Frame-shiftENST00000578289ENST00000418177TMEM98chr17

31263465

+GRM5chr11

88301160

-
Frame-shiftENST00000578289ENST00000305447TMEM98chr17

31263465

+GRM5chr11

88301160

-
Frame-shiftENST00000578289ENST00000305432TMEM98chr17

31263465

+GRM5chr11

88301160

-
Frame-shiftENST00000578289ENST00000393297TMEM98chr17

31263465

+GRM5chr11

88301160

-
5CDS-intronENST00000578289ENST00000393294TMEM98chr17

31263465

+GRM5chr11

88301160

-

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FusionProtFeatures for TMEM98_GRM5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMEM98

Q9Y2Y6

GRM5

P41594

G-protein coupled receptor for glutamate. Ligand bindingcauses a conformation change that triggers signaling via guaninenucleotide-binding proteins (G proteins) and modulates theactivity of down-stream effectors. Signaling activates aphosphatidylinositol-calcium second messenger system and generatesa calcium-activated chloride current. Plays an important role inthe regulation of synaptic plasticity and the modulation of theneural network activity. {ECO:0000269|PubMed:7908515,ECO:0000269|Ref.8}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TMEM98_GRM5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMEM98_GRM5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMEM98RABEPK, TNNT1GRM5SIAH1, CALM1, PRKCA, HOMER1, CEP104, EVC2, PRKCD, PRKCZ


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMEM98_GRM5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGRM5P41594DB06201RufinamideMetabotropic glutamate receptor 5small moleculeapproved
TgeneGRM5P41594DB00659AcamprosateMetabotropic glutamate receptor 5small moleculeapproved|investigational

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RelatedDiseases for TMEM98_GRM5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTMEM98C4014848NANOPHTHALMOS 41UNIPROT
TgeneGRM5C0036341Schizophrenia3PSYGENET
TgeneGRM5C0041696Unipolar Depression3PSYGENET
TgeneGRM5C1269683Major Depressive Disorder3PSYGENET
TgeneGRM5C0038220Status Epilepticus2CTD_human
TgeneGRM5C1263846Attention deficit hyperactivity disorder2CTD_human
TgeneGRM5C0005586Bipolar Disorder1PSYGENET
TgeneGRM5C0011882Diabetic Neuropathies1CTD_human
TgeneGRM5C0014556Epilepsy, Temporal Lobe1CTD_human
TgeneGRM5C0027796Neuralgia1CTD_human
TgeneGRM5C0236736Cocaine-Related Disorders1CTD_human
TgeneGRM5C0236969Substance-Related Disorders1CTD_human