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Fusion gene ID: 387 |
FusionGeneSummary for ACIN1_DTWD2 |
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Fusion gene information | Fusion gene name: ACIN1_DTWD2 | Fusion gene ID: 387 | Hgene | Tgene | Gene symbol | ACIN1 | DTWD2 | Gene ID | 22985 | 285605 |
Gene name | apoptotic chromatin condensation inducer 1 | DTW domain containing 2 | |
Synonyms | ACINUS|ACN|fSAP152 | - | |
Cytomap | 14q11.2 | 5q23.1 | |
Type of gene | protein-coding | protein-coding | |
Description | apoptotic chromatin condensation inducer in the nucleusfunctional spliceosome-associated protein 152 | DTW domain-containing protein 2 | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | Q9UKV3 | Q8NBA8 | |
Ensembl transtripts involved in fusion gene | ENST00000557515, ENST00000338631, ENST00000357481, ENST00000605057, ENST00000457657, ENST00000262710, ENST00000397341, ENST00000555053, ENST00000555352, | ENST00000304058, ENST00000510708, ENST00000515439, | |
Fusion gene scores | * DoF score | 6 X 6 X 2=72 | 7 X 6 X 4=168 |
# samples | 6 | 7 | |
** MAII score | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ACIN1 [Title/Abstract] AND DTWD2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ACIN1 | GO:0030263 | apoptotic chromosome condensation | 10490026 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE819426 | ACIN1 | chr14 | 23547417 | - | DTWD2 | chr5 | 118309483 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000557515 | ENST00000304058 | ACIN1 | chr14 | 23547417 | - | DTWD2 | chr5 | 118309483 | + |
intron-intron | ENST00000557515 | ENST00000510708 | ACIN1 | chr14 | 23547417 | - | DTWD2 | chr5 | 118309483 | + |
intron-intron | ENST00000557515 | ENST00000515439 | ACIN1 | chr14 | 23547417 | - | DTWD2 | chr5 | 118309483 | + |
intron-intron | ENST00000338631 | ENST00000304058 | ACIN1 | chr14 | 23547417 | - | DTWD2 | chr5 | 118309483 | + |
intron-intron | ENST00000338631 | ENST00000510708 | ACIN1 | chr14 | 23547417 | - | DTWD2 | chr5 | 118309483 | + |
intron-intron | ENST00000338631 | ENST00000515439 | ACIN1 | chr14 | 23547417 | - | DTWD2 | chr5 | 118309483 | + |
intron-intron | ENST00000357481 | ENST00000304058 | ACIN1 | chr14 | 23547417 | - | DTWD2 | chr5 | 118309483 | + |
intron-intron | ENST00000357481 | ENST00000510708 | ACIN1 | chr14 | 23547417 | - | DTWD2 | chr5 | 118309483 | + |
intron-intron | ENST00000357481 | ENST00000515439 | ACIN1 | chr14 | 23547417 | - | DTWD2 | chr5 | 118309483 | + |
intron-intron | ENST00000605057 | ENST00000304058 | ACIN1 | chr14 | 23547417 | - | DTWD2 | chr5 | 118309483 | + |
intron-intron | ENST00000605057 | ENST00000510708 | ACIN1 | chr14 | 23547417 | - | DTWD2 | chr5 | 118309483 | + |
intron-intron | ENST00000605057 | ENST00000515439 | ACIN1 | chr14 | 23547417 | - | DTWD2 | chr5 | 118309483 | + |
intron-intron | ENST00000457657 | ENST00000304058 | ACIN1 | chr14 | 23547417 | - | DTWD2 | chr5 | 118309483 | + |
intron-intron | ENST00000457657 | ENST00000510708 | ACIN1 | chr14 | 23547417 | - | DTWD2 | chr5 | 118309483 | + |
intron-intron | ENST00000457657 | ENST00000515439 | ACIN1 | chr14 | 23547417 | - | DTWD2 | chr5 | 118309483 | + |
intron-intron | ENST00000262710 | ENST00000304058 | ACIN1 | chr14 | 23547417 | - | DTWD2 | chr5 | 118309483 | + |
intron-intron | ENST00000262710 | ENST00000510708 | ACIN1 | chr14 | 23547417 | - | DTWD2 | chr5 | 118309483 | + |
intron-intron | ENST00000262710 | ENST00000515439 | ACIN1 | chr14 | 23547417 | - | DTWD2 | chr5 | 118309483 | + |
intron-intron | ENST00000397341 | ENST00000304058 | ACIN1 | chr14 | 23547417 | - | DTWD2 | chr5 | 118309483 | + |
intron-intron | ENST00000397341 | ENST00000510708 | ACIN1 | chr14 | 23547417 | - | DTWD2 | chr5 | 118309483 | + |
intron-intron | ENST00000397341 | ENST00000515439 | ACIN1 | chr14 | 23547417 | - | DTWD2 | chr5 | 118309483 | + |
intron-intron | ENST00000555053 | ENST00000304058 | ACIN1 | chr14 | 23547417 | - | DTWD2 | chr5 | 118309483 | + |
intron-intron | ENST00000555053 | ENST00000510708 | ACIN1 | chr14 | 23547417 | - | DTWD2 | chr5 | 118309483 | + |
intron-intron | ENST00000555053 | ENST00000515439 | ACIN1 | chr14 | 23547417 | - | DTWD2 | chr5 | 118309483 | + |
intron-intron | ENST00000555352 | ENST00000304058 | ACIN1 | chr14 | 23547417 | - | DTWD2 | chr5 | 118309483 | + |
intron-intron | ENST00000555352 | ENST00000510708 | ACIN1 | chr14 | 23547417 | - | DTWD2 | chr5 | 118309483 | + |
intron-intron | ENST00000555352 | ENST00000515439 | ACIN1 | chr14 | 23547417 | - | DTWD2 | chr5 | 118309483 | + |
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FusionProtFeatures for ACIN1_DTWD2 |
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Hgene | Tgene |
ACIN1 | DTWD2 |
Auxiliary component of the splicing-dependentmultiprotein exon junction complex (EJC) deposited at splicejunction on mRNAs. The EJC is a dynamic structure consisting ofcore proteins and several peripheral nuclear and cytoplasmicassociated factors that join the complex only transiently eitherduring EJC assembly or during subsequent mRNA metabolism.Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJCprior to or during the splicing process and to regulate specificexcision of introns in specific transcription subsets; ACIN1confers RNA-binding to the complex. The ASAP complex can inhibitRNA processing during in vitro splicing reactions. The ASAPcomplex promotes apoptosis and is disassembled after induction ofapoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X(and probably other apoptotic genes); specifically inhibitsformation of proapoptotic isoforms such as Bcl-X(S); the activityis different from the established EJC assembly and function.Induces apoptotic chromatin condensation after activation byCASP3. Regulates cyclin A1, but not cyclin A2, expression inleukemia cells. {ECO:0000269|PubMed:10490026,ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500,ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ACIN1_DTWD2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ACIN1_DTWD2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ACIN1_DTWD2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ACIN1_DTWD2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |