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Fusion gene ID: 38696 |
FusionGeneSummary for TMEM87B_PVT1 |
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Fusion gene information | Fusion gene name: TMEM87B_PVT1 | Fusion gene ID: 38696 | Hgene | Tgene | Gene symbol | TMEM87B | PVT1 | Gene ID | 84910 | 5820 |
Gene name | transmembrane protein 87B | Pvt1 oncogene | |
Synonyms | - | LINC00079|MIR1204HG|MYC|NCRNA00079|onco-lncRNA-100 | |
Cytomap | 2q13 | 8q24.21 | |
Type of gene | protein-coding | ncRNA | |
Description | transmembrane protein 87B | CXCR4/PVT1 fusionHIST1H2BD/PVT1 fusionMIR1204, MIR1205, MIR1206 and MIR1207 hostOncogene PVT-1 (MYC activator)PVT1/CASC8 fusionPVT1/CCDC26 fusionPVT1/IFRD1 fusionPVT1/IRF2BP2 fusionPVT1/LINC00824 fusionPVT1/MYC fusionPVT1/NFIL3 fusionPVT1/NSMCE | |
Modification date | 20180519 | 20180520 | |
UniProtAcc | Q96K49 | ||
Ensembl transtripts involved in fusion gene | ENST00000283206, ENST00000463427, | ENST00000408388, | |
Fusion gene scores | * DoF score | 4 X 7 X 9=252 | 15 X 10 X 9=1350 |
# samples | 12 | 17 | |
** MAII score | log2(12/252*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(17/1350*10)=-2.98935275580049 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TMEM87B [Title/Abstract] AND PVT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | ACC | TCGA-OR-A5J7-01A | TMEM87B | chr2 | 112838695 | + | PVT1 | chr8 | 128902835 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000283206 | ENST00000408388 | TMEM87B | chr2 | 112838695 | + | PVT1 | chr8 | 128902835 | + |
intron-intron | ENST00000463427 | ENST00000408388 | TMEM87B | chr2 | 112838695 | + | PVT1 | chr8 | 128902835 | + |
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FusionProtFeatures for TMEM87B_PVT1 |
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Hgene | Tgene |
TMEM87B | PVT1 |
May be involved in retrograde transport from endosomesto the trans-Golgi network (TGN). {ECO:0000269|PubMed:26157166}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TMEM87B_PVT1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TMEM87B_PVT1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TMEM87B | BTNL8, LPAR1, IPPK, TMED6 | PVT1 | TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMEM87B_PVT1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMEM87B_PVT1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PVT1 | C0019829 | Hodgkin Disease | 1 | CTD_human |
Tgene | PVT1 | C0162538 | Immunoglobulin A deficiency (disorder) | 1 | CTD_human |