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Center for Computational Systems Medicine
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FusionGeneSummary

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Fusion gene ID: 38695

FusionGeneSummary for TMEM87B_MERTK

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM87B_MERTK
Fusion gene ID: 38695
HgeneTgene
Gene symbol

TMEM87B

MERTK

Gene ID

84910

10461

Gene nametransmembrane protein 87BMER proto-oncogene, tyrosine kinase
Synonyms-MER|RP38|Tyro12|c-Eyk|c-mer
Cytomap

2q13

2q13

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 87Btyrosine-protein kinase MerMER receptor tyrosine kinaseSTK kinasec-mer proto-oncogene tyrosine kinaseproto-oncogene c-Merreceptor tyrosine kinase MerTK
Modification date2018051920180523
UniProtAcc

Q96K49

Q12866

Ensembl transtripts involved in fusion geneENST00000283206, ENST00000463427, 
ENST00000295408, ENST00000421804, 
ENST00000409780, 
Fusion gene scores* DoF score4 X 7 X 9=2525 X 7 X 10=350
# samples 1213
** MAII scorelog2(12/252*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/350*10)=-1.42884329880387
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMEM87B [Title/Abstract] AND MERTK [Title/Abstract] AND fusion [Title/Abstract]

Diverse, Biologically Relevant, and Targetable Gene Rearrangements in Triple-Negative Breast Cancer and Other Malignancies (pmid: 27231203)
Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Kinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMERTK

GO:0050766

positive regulation of phagocytosis

18395422


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVACCTCGA-OR-A5K5-01ATMEM87Bchr2

112817614

+MERTKchr2

112785928

+
TCGARVBLCATCGA-XF-A9SU-01ATMEM87Bchr2

112834859

+MERTKchr2

112765960

+
TCGARVBRCATCGA-AO-A0J2-01ATMEM87Bchr2

112813333

+MERTKchr2

112785928

+
TCGALDBRCATCGA-A2-A0D0-01ATMEM87Bchr2

112813333

+MERTKchr2

112751828

+
TCGALDCESCTCGA-C5-A7X5-01ATMEM87Bchr2

112813333

+MERTKchr2

112751828

+
TCGARVLUADTCGA-50-5072-01ATMEM87Bchr2

112813333

+MERTKchr2

112751828

+
TCGARVLUSCTCGA-85-A511-01ATMEM87Bchr2

112813333

+MERTKchr2

112751828

+
TCGALDOVTCGA-61-1725-01ATMEM87Bchr2

112821830

+MERTKchr2

112776990

+
TCGALDSTADTCGA-VQ-AA6D-01ATMEM87Bchr2

112817614

+MERTKchr2

112765960

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000283206ENST00000295408TMEM87Bchr2

112817614

+MERTKchr2

112785928

+
Frame-shiftENST00000283206ENST00000421804TMEM87Bchr2

112817614

+MERTKchr2

112785928

+
In-frameENST00000283206ENST00000409780TMEM87Bchr2

112817614

+MERTKchr2

112785928

+
intron-3CDSENST00000463427ENST00000295408TMEM87Bchr2

112817614

+MERTKchr2

112785928

+
intron-3CDSENST00000463427ENST00000421804TMEM87Bchr2

112817614

+MERTKchr2

112785928

+
intron-3CDSENST00000463427ENST00000409780TMEM87Bchr2

112817614

+MERTKchr2

112785928

+
In-frameENST00000283206ENST00000295408TMEM87Bchr2

112834859

+MERTKchr2

112765960

+
In-frameENST00000283206ENST00000421804TMEM87Bchr2

112834859

+MERTKchr2

112765960

+
In-frameENST00000283206ENST00000409780TMEM87Bchr2

112834859

+MERTKchr2

112765960

+
intron-3CDSENST00000463427ENST00000295408TMEM87Bchr2

112834859

+MERTKchr2

112765960

+
intron-3CDSENST00000463427ENST00000421804TMEM87Bchr2

112834859

+MERTKchr2

112765960

+
intron-3CDSENST00000463427ENST00000409780TMEM87Bchr2

112834859

+MERTKchr2

112765960

+
Frame-shiftENST00000283206ENST00000295408TMEM87Bchr2

112813333

+MERTKchr2

112785928

+
In-frameENST00000283206ENST00000421804TMEM87Bchr2

112813333

+MERTKchr2

112785928

+
Frame-shiftENST00000283206ENST00000409780TMEM87Bchr2

112813333

+MERTKchr2

112785928

+
intron-3CDSENST00000463427ENST00000295408TMEM87Bchr2

112813333

+MERTKchr2

112785928

+
intron-3CDSENST00000463427ENST00000421804TMEM87Bchr2

112813333

+MERTKchr2

112785928

+
intron-3CDSENST00000463427ENST00000409780TMEM87Bchr2

112813333

+MERTKchr2

112785928

+
In-frameENST00000283206ENST00000295408TMEM87Bchr2

112813333

+MERTKchr2

112751828

+
In-frameENST00000283206ENST00000421804TMEM87Bchr2

112813333

+MERTKchr2

112751828

+
In-frameENST00000283206ENST00000409780TMEM87Bchr2

112813333

+MERTKchr2

112751828

+
intron-3CDSENST00000463427ENST00000295408TMEM87Bchr2

112813333

+MERTKchr2

112751828

+
intron-3CDSENST00000463427ENST00000421804TMEM87Bchr2

112813333

+MERTKchr2

112751828

+
intron-3CDSENST00000463427ENST00000409780TMEM87Bchr2

112813333

+MERTKchr2

112751828

+
In-frameENST00000283206ENST00000295408TMEM87Bchr2

112821830

+MERTKchr2

112776990

+
In-frameENST00000283206ENST00000421804TMEM87Bchr2

112821830

+MERTKchr2

112776990

+
In-frameENST00000283206ENST00000409780TMEM87Bchr2

112821830

+MERTKchr2

112776990

+
intron-3CDSENST00000463427ENST00000295408TMEM87Bchr2

112821830

+MERTKchr2

112776990

+
intron-3CDSENST00000463427ENST00000421804TMEM87Bchr2

112821830

+MERTKchr2

112776990

+
intron-3CDSENST00000463427ENST00000409780TMEM87Bchr2

112821830

+MERTKchr2

112776990

+
In-frameENST00000283206ENST00000295408TMEM87Bchr2

112817614

+MERTKchr2

112765960

+
In-frameENST00000283206ENST00000421804TMEM87Bchr2

112817614

+MERTKchr2

112765960

+
In-frameENST00000283206ENST00000409780TMEM87Bchr2

112817614

+MERTKchr2

112765960

+
intron-3CDSENST00000463427ENST00000295408TMEM87Bchr2

112817614

+MERTKchr2

112765960

+
intron-3CDSENST00000463427ENST00000421804TMEM87Bchr2

112817614

+MERTKchr2

112765960

+
intron-3CDSENST00000463427ENST00000409780TMEM87Bchr2

112817614

+MERTKchr2

112765960

+

Top

FusionProtFeatures for TMEM87B_MERTK


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMEM87B

Q96K49

MERTK

Q12866

May be involved in retrograde transport from endosomesto the trans-Golgi network (TGN). {ECO:0000269|PubMed:26157166}. Receptor tyrosine kinase that transduces signals fromthe extracellular matrix into the cytoplasm by binding to severalligands including LGALS3, TUB, TULP1 or GAS6. Regulates manyphysiological processes including cell survival, migration,differentiation, and phagocytosis of apoptotic cells(efferocytosis). Ligand binding at the cell surface inducesautophosphorylation of MERTK on its intracellular domain thatprovides docking sites for downstream signaling molecules.Following activation by ligand, interacts with GRB2 or PLCG2 andinduces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTKsignaling plays a role in various processes such as macrophageclearance of apoptotic cells, platelet aggregation, cytoskeletonreorganization and engulfment. Functions in the retinal pigmentepithelium (RPE) as a regulator of rod outer segments fragmentsphagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response byactivating STAT1, which selectively induces production ofsuppressors of cytokine signaling SOCS1 and SOCS3.{ECO:0000269|PubMed:17005688}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMERTKchr2:112813333chr2:112751828ENST00000295408+719587_8584321000DomainProtein kinase
TgeneMERTKchr2:112813333chr2:112751828ENST00000421804+720587_858432951DomainProtein kinase
TgeneMERTKchr2:112813333chr2:112751828ENST00000295408+719593_6014321000Nucleotide bindingATP
TgeneMERTKchr2:112813333chr2:112751828ENST00000421804+720593_601432951Nucleotide bindingATP
TgeneMERTKchr2:112813333chr2:112751828ENST00000295408+719527_9994321000Topological domainCytoplasmic
TgeneMERTKchr2:112813333chr2:112751828ENST00000421804+720527_999432951Topological domainCytoplasmic
TgeneMERTKchr2:112813333chr2:112751828ENST00000295408+719506_5264321000TransmembraneHelical
TgeneMERTKchr2:112813333chr2:112751828ENST00000421804+720506_526432951TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEM87Bchr2:112813333chr2:112751828ENST00000283206+119236_24755556Topological domainCytoplasmic
HgeneTMEM87Bchr2:112813333chr2:112751828ENST00000283206+119269_29955556Topological domainLumenal
HgeneTMEM87Bchr2:112813333chr2:112751828ENST00000283206+119321_32255556Topological domainCytoplasmic
HgeneTMEM87Bchr2:112813333chr2:112751828ENST00000283206+119344_35055556Topological domainLumenal
HgeneTMEM87Bchr2:112813333chr2:112751828ENST00000283206+119372_39655556Topological domainCytoplasmic
HgeneTMEM87Bchr2:112813333chr2:112751828ENST00000283206+119418_42955556Topological domainLumenal
HgeneTMEM87Bchr2:112813333chr2:112751828ENST00000283206+11943_21455556Topological domainLumenal
HgeneTMEM87Bchr2:112813333chr2:112751828ENST00000283206+119451_55555556Topological domainCytoplasmic
HgeneTMEM87Bchr2:112817614chr2:112765960ENST00000283206+219236_24775556Topological domainCytoplasmic
HgeneTMEM87Bchr2:112817614chr2:112765960ENST00000283206+219269_29975556Topological domainLumenal
HgeneTMEM87Bchr2:112817614chr2:112765960ENST00000283206+219321_32275556Topological domainCytoplasmic
HgeneTMEM87Bchr2:112817614chr2:112765960ENST00000283206+219344_35075556Topological domainLumenal
HgeneTMEM87Bchr2:112817614chr2:112765960ENST00000283206+219372_39675556Topological domainCytoplasmic
HgeneTMEM87Bchr2:112817614chr2:112765960ENST00000283206+219418_42975556Topological domainLumenal
HgeneTMEM87Bchr2:112817614chr2:112765960ENST00000283206+21943_21475556Topological domainLumenal
HgeneTMEM87Bchr2:112817614chr2:112765960ENST00000283206+219451_55575556Topological domainCytoplasmic
HgeneTMEM87Bchr2:112821830chr2:112776990ENST00000283206+319236_247106556Topological domainCytoplasmic
HgeneTMEM87Bchr2:112821830chr2:112776990ENST00000283206+319269_299106556Topological domainLumenal
HgeneTMEM87Bchr2:112821830chr2:112776990ENST00000283206+319321_322106556Topological domainCytoplasmic
HgeneTMEM87Bchr2:112821830chr2:112776990ENST00000283206+319344_350106556Topological domainLumenal
HgeneTMEM87Bchr2:112821830chr2:112776990ENST00000283206+319372_396106556Topological domainCytoplasmic
HgeneTMEM87Bchr2:112821830chr2:112776990ENST00000283206+319418_429106556Topological domainLumenal
HgeneTMEM87Bchr2:112821830chr2:112776990ENST00000283206+31943_214106556Topological domainLumenal
HgeneTMEM87Bchr2:112821830chr2:112776990ENST00000283206+319451_555106556Topological domainCytoplasmic
HgeneTMEM87Bchr2:112834859chr2:112765960ENST00000283206+619236_247197556Topological domainCytoplasmic
HgeneTMEM87Bchr2:112834859chr2:112765960ENST00000283206+619269_299197556Topological domainLumenal
HgeneTMEM87Bchr2:112834859chr2:112765960ENST00000283206+619321_322197556Topological domainCytoplasmic
HgeneTMEM87Bchr2:112834859chr2:112765960ENST00000283206+619344_350197556Topological domainLumenal
HgeneTMEM87Bchr2:112834859chr2:112765960ENST00000283206+619372_396197556Topological domainCytoplasmic
HgeneTMEM87Bchr2:112834859chr2:112765960ENST00000283206+619418_429197556Topological domainLumenal
HgeneTMEM87Bchr2:112834859chr2:112765960ENST00000283206+61943_214197556Topological domainLumenal
HgeneTMEM87Bchr2:112834859chr2:112765960ENST00000283206+619451_555197556Topological domainCytoplasmic
HgeneTMEM87Bchr2:112813333chr2:112751828ENST00000283206+119215_23555556TransmembraneHelical%3B Name%3D1
HgeneTMEM87Bchr2:112813333chr2:112751828ENST00000283206+119248_26855556TransmembraneHelical%3B Name%3D2
HgeneTMEM87Bchr2:112813333chr2:112751828ENST00000283206+119300_32055556TransmembraneHelical%3B Name%3D3
HgeneTMEM87Bchr2:112813333chr2:112751828ENST00000283206+119323_34355556TransmembraneHelical%3B Name%3D4
HgeneTMEM87Bchr2:112813333chr2:112751828ENST00000283206+119351_37155556TransmembraneHelical%3B Name%3D5
HgeneTMEM87Bchr2:112813333chr2:112751828ENST00000283206+119397_41755556TransmembraneHelical%3B Name%3D6
HgeneTMEM87Bchr2:112813333chr2:112751828ENST00000283206+119430_45055556TransmembraneHelical%3B Name%3D7
HgeneTMEM87Bchr2:112817614chr2:112765960ENST00000283206+219215_23575556TransmembraneHelical%3B Name%3D1
HgeneTMEM87Bchr2:112817614chr2:112765960ENST00000283206+219248_26875556TransmembraneHelical%3B Name%3D2
HgeneTMEM87Bchr2:112817614chr2:112765960ENST00000283206+219300_32075556TransmembraneHelical%3B Name%3D3
HgeneTMEM87Bchr2:112817614chr2:112765960ENST00000283206+219323_34375556TransmembraneHelical%3B Name%3D4
HgeneTMEM87Bchr2:112817614chr2:112765960ENST00000283206+219351_37175556TransmembraneHelical%3B Name%3D5
HgeneTMEM87Bchr2:112817614chr2:112765960ENST00000283206+219397_41775556TransmembraneHelical%3B Name%3D6
HgeneTMEM87Bchr2:112817614chr2:112765960ENST00000283206+219430_45075556TransmembraneHelical%3B Name%3D7
HgeneTMEM87Bchr2:112821830chr2:112776990ENST00000283206+319215_235106556TransmembraneHelical%3B Name%3D1
HgeneTMEM87Bchr2:112821830chr2:112776990ENST00000283206+319248_268106556TransmembraneHelical%3B Name%3D2
HgeneTMEM87Bchr2:112821830chr2:112776990ENST00000283206+319300_320106556TransmembraneHelical%3B Name%3D3
HgeneTMEM87Bchr2:112821830chr2:112776990ENST00000283206+319323_343106556TransmembraneHelical%3B Name%3D4
HgeneTMEM87Bchr2:112821830chr2:112776990ENST00000283206+319351_371106556TransmembraneHelical%3B Name%3D5
HgeneTMEM87Bchr2:112821830chr2:112776990ENST00000283206+319397_417106556TransmembraneHelical%3B Name%3D6
HgeneTMEM87Bchr2:112821830chr2:112776990ENST00000283206+319430_450106556TransmembraneHelical%3B Name%3D7
HgeneTMEM87Bchr2:112834859chr2:112765960ENST00000283206+619215_235197556TransmembraneHelical%3B Name%3D1
HgeneTMEM87Bchr2:112834859chr2:112765960ENST00000283206+619248_268197556TransmembraneHelical%3B Name%3D2
HgeneTMEM87Bchr2:112834859chr2:112765960ENST00000283206+619300_320197556TransmembraneHelical%3B Name%3D3
HgeneTMEM87Bchr2:112834859chr2:112765960ENST00000283206+619323_343197556TransmembraneHelical%3B Name%3D4
HgeneTMEM87Bchr2:112834859chr2:112765960ENST00000283206+619351_371197556TransmembraneHelical%3B Name%3D5
HgeneTMEM87Bchr2:112834859chr2:112765960ENST00000283206+619397_417197556TransmembraneHelical%3B Name%3D6
HgeneTMEM87Bchr2:112834859chr2:112765960ENST00000283206+619430_450197556TransmembraneHelical%3B Name%3D7
TgeneMERTKchr2:112813333chr2:112751828ENST00000295408+719197_2734321000DomainNote=Ig-like C2-type 2
TgeneMERTKchr2:112813333chr2:112751828ENST00000295408+719286_3814321000DomainFibronectin type-III 1
TgeneMERTKchr2:112813333chr2:112751828ENST00000295408+719386_4844321000DomainFibronectin type-III 2
TgeneMERTKchr2:112813333chr2:112751828ENST00000295408+71981_1864321000DomainNote=Ig-like C2-type 1
TgeneMERTKchr2:112813333chr2:112751828ENST00000421804+720197_273432951DomainNote=Ig-like C2-type 2
TgeneMERTKchr2:112813333chr2:112751828ENST00000421804+720286_381432951DomainFibronectin type-III 1
TgeneMERTKchr2:112813333chr2:112751828ENST00000421804+720386_484432951DomainFibronectin type-III 2
TgeneMERTKchr2:112813333chr2:112751828ENST00000421804+72081_186432951DomainNote=Ig-like C2-type 1
TgeneMERTKchr2:112817614chr2:112765960ENST00000295408+1219197_2736221000DomainNote=Ig-like C2-type 2
TgeneMERTKchr2:112817614chr2:112765960ENST00000295408+1219286_3816221000DomainFibronectin type-III 1
TgeneMERTKchr2:112817614chr2:112765960ENST00000295408+1219386_4846221000DomainFibronectin type-III 2
TgeneMERTKchr2:112817614chr2:112765960ENST00000295408+1219587_8586221000DomainProtein kinase
TgeneMERTKchr2:112817614chr2:112765960ENST00000295408+121981_1866221000DomainNote=Ig-like C2-type 1
TgeneMERTKchr2:112817614chr2:112765960ENST00000421804+1220197_273622951DomainNote=Ig-like C2-type 2
TgeneMERTKchr2:112817614chr2:112765960ENST00000421804+1220286_381622951DomainFibronectin type-III 1
TgeneMERTKchr2:112817614chr2:112765960ENST00000421804+1220386_484622951DomainFibronectin type-III 2
TgeneMERTKchr2:112817614chr2:112765960ENST00000421804+1220587_858622951DomainProtein kinase
TgeneMERTKchr2:112817614chr2:112765960ENST00000421804+122081_186622951DomainNote=Ig-like C2-type 1
TgeneMERTKchr2:112821830chr2:112776990ENST00000295408+1419197_2736931000DomainNote=Ig-like C2-type 2
TgeneMERTKchr2:112821830chr2:112776990ENST00000295408+1419286_3816931000DomainFibronectin type-III 1
TgeneMERTKchr2:112821830chr2:112776990ENST00000295408+1419386_4846931000DomainFibronectin type-III 2
TgeneMERTKchr2:112821830chr2:112776990ENST00000295408+1419587_8586931000DomainProtein kinase
TgeneMERTKchr2:112821830chr2:112776990ENST00000295408+141981_1866931000DomainNote=Ig-like C2-type 1
TgeneMERTKchr2:112821830chr2:112776990ENST00000421804+1420197_273693951DomainNote=Ig-like C2-type 2
TgeneMERTKchr2:112821830chr2:112776990ENST00000421804+1420286_381693951DomainFibronectin type-III 1
TgeneMERTKchr2:112821830chr2:112776990ENST00000421804+1420386_484693951DomainFibronectin type-III 2
TgeneMERTKchr2:112821830chr2:112776990ENST00000421804+1420587_858693951DomainProtein kinase
TgeneMERTKchr2:112821830chr2:112776990ENST00000421804+142081_186693951DomainNote=Ig-like C2-type 1
TgeneMERTKchr2:112834859chr2:112765960ENST00000295408+1219197_2736221000DomainNote=Ig-like C2-type 2
TgeneMERTKchr2:112834859chr2:112765960ENST00000295408+1219286_3816221000DomainFibronectin type-III 1
TgeneMERTKchr2:112834859chr2:112765960ENST00000295408+1219386_4846221000DomainFibronectin type-III 2
TgeneMERTKchr2:112834859chr2:112765960ENST00000295408+1219587_8586221000DomainProtein kinase
TgeneMERTKchr2:112834859chr2:112765960ENST00000295408+121981_1866221000DomainNote=Ig-like C2-type 1
TgeneMERTKchr2:112834859chr2:112765960ENST00000421804+1220197_273622951DomainNote=Ig-like C2-type 2
TgeneMERTKchr2:112834859chr2:112765960ENST00000421804+1220286_381622951DomainFibronectin type-III 1
TgeneMERTKchr2:112834859chr2:112765960ENST00000421804+1220386_484622951DomainFibronectin type-III 2
TgeneMERTKchr2:112834859chr2:112765960ENST00000421804+1220587_858622951DomainProtein kinase
TgeneMERTKchr2:112834859chr2:112765960ENST00000421804+122081_186622951DomainNote=Ig-like C2-type 1
TgeneMERTKchr2:112817614chr2:112765960ENST00000295408+1219593_6016221000Nucleotide bindingATP
TgeneMERTKchr2:112817614chr2:112765960ENST00000421804+1220593_601622951Nucleotide bindingATP
TgeneMERTKchr2:112821830chr2:112776990ENST00000295408+1419593_6016931000Nucleotide bindingATP
TgeneMERTKchr2:112821830chr2:112776990ENST00000421804+1420593_601693951Nucleotide bindingATP
TgeneMERTKchr2:112834859chr2:112765960ENST00000295408+1219593_6016221000Nucleotide bindingATP
TgeneMERTKchr2:112834859chr2:112765960ENST00000421804+1220593_601622951Nucleotide bindingATP
TgeneMERTKchr2:112813333chr2:112751828ENST00000295408+71921_5054321000Topological domainExtracellular
TgeneMERTKchr2:112813333chr2:112751828ENST00000421804+72021_505432951Topological domainExtracellular
TgeneMERTKchr2:112817614chr2:112765960ENST00000295408+121921_5056221000Topological domainExtracellular
TgeneMERTKchr2:112817614chr2:112765960ENST00000295408+1219527_9996221000Topological domainCytoplasmic
TgeneMERTKchr2:112817614chr2:112765960ENST00000421804+122021_505622951Topological domainExtracellular
TgeneMERTKchr2:112817614chr2:112765960ENST00000421804+1220527_999622951Topological domainCytoplasmic
TgeneMERTKchr2:112821830chr2:112776990ENST00000295408+141921_5056931000Topological domainExtracellular
TgeneMERTKchr2:112821830chr2:112776990ENST00000295408+1419527_9996931000Topological domainCytoplasmic
TgeneMERTKchr2:112821830chr2:112776990ENST00000421804+142021_505693951Topological domainExtracellular
TgeneMERTKchr2:112821830chr2:112776990ENST00000421804+1420527_999693951Topological domainCytoplasmic
TgeneMERTKchr2:112834859chr2:112765960ENST00000295408+121921_5056221000Topological domainExtracellular
TgeneMERTKchr2:112834859chr2:112765960ENST00000295408+1219527_9996221000Topological domainCytoplasmic
TgeneMERTKchr2:112834859chr2:112765960ENST00000421804+122021_505622951Topological domainExtracellular
TgeneMERTKchr2:112834859chr2:112765960ENST00000421804+1220527_999622951Topological domainCytoplasmic
TgeneMERTKchr2:112817614chr2:112765960ENST00000295408+1219506_5266221000TransmembraneHelical
TgeneMERTKchr2:112817614chr2:112765960ENST00000421804+1220506_526622951TransmembraneHelical
TgeneMERTKchr2:112821830chr2:112776990ENST00000295408+1419506_5266931000TransmembraneHelical
TgeneMERTKchr2:112821830chr2:112776990ENST00000421804+1420506_526693951TransmembraneHelical
TgeneMERTKchr2:112834859chr2:112765960ENST00000295408+1219506_5266221000TransmembraneHelical
TgeneMERTKchr2:112834859chr2:112765960ENST00000421804+1220506_526622951TransmembraneHelical


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FusionGeneSequence for TMEM87B_MERTK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMEM87B_MERTK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMEM87BBTNL8, LPAR1, IPPK, TMED6MERTKGAS6, IKBKG, NEDD4L, ITGB5, MERTK, TNK2, HSP90AA1, SKI


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMEM87B_MERTK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMEM87B_MERTK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMERTKC0017661IGA Glomerulonephritis1CTD_human
TgeneMERTKC0034065Pulmonary Embolism1CTD_human
TgeneMERTKC0035334Retinitis Pigmentosa1CTD_human;HPO;ORPHANET
TgeneMERTKC0040038Thromboembolism1CTD_human
TgeneMERTKC0040053Thrombosis1CTD_human
TgeneMERTKC3151228RETINITIS PIGMENTOSA 38 (disorder)1UNIPROT