|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 38694 |
FusionGeneSummary for TMEM87B_IL1RN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMEM87B_IL1RN | Fusion gene ID: 38694 | Hgene | Tgene | Gene symbol | TMEM87B | IL1RN | Gene ID | 84910 | 3557 |
| Gene name | transmembrane protein 87B | interleukin 1 receptor antagonist | |
| Synonyms | - | DIRA|ICIL-1RA|IL-1RN|IL-1ra|IL-1ra3|IL1F3|IL1RA|IRAP|MVCD4 | |
| Cytomap | 2q13 | 2q14.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transmembrane protein 87B | interleukin-1 receptor antagonist proteinIL1 inhibitorintracellular IL-1 receptor antagonist type IIintracellular interleukin-1 receptor antagonist (icIL-1ra)type II interleukin-1 receptor antagonist | |
| Modification date | 20180519 | 20180527 | |
| UniProtAcc | Q96K49 | P18510 | |
| Ensembl transtripts involved in fusion gene | ENST00000283206, ENST00000463427, | ENST00000465812, ENST00000409052, ENST00000361779, ENST00000259206, ENST00000354115, ENST00000409930, | |
| Fusion gene scores | * DoF score | 4 X 7 X 9=252 | 7 X 4 X 6=168 |
| # samples | 12 | 9 | |
| ** MAII score | log2(12/252*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/168*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TMEM87B [Title/Abstract] AND IL1RN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | IL1RN | GO:0034115 | negative regulation of heterotypic cell-cell adhesion | 2139180 |
| Tgene | IL1RN | GO:0051384 | response to glucocorticoid | 10443688 |
| Tgene | IL1RN | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway | 2137200|2139180 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-BR-4357-01A | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000283206 | ENST00000465812 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
| 5CDS-3UTR | ENST00000283206 | ENST00000409052 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
| 5CDS-intron | ENST00000283206 | ENST00000361779 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
| 5CDS-intron | ENST00000283206 | ENST00000259206 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
| 5CDS-intron | ENST00000283206 | ENST00000354115 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
| 5CDS-intron | ENST00000283206 | ENST00000409930 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
| 3UTR-3UTR | ENST00000463427 | ENST00000465812 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
| 3UTR-3UTR | ENST00000463427 | ENST00000409052 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
| 3UTR-intron | ENST00000463427 | ENST00000361779 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
| 3UTR-intron | ENST00000463427 | ENST00000259206 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
| 3UTR-intron | ENST00000463427 | ENST00000354115 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
| 3UTR-intron | ENST00000463427 | ENST00000409930 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
Top |
FusionProtFeatures for TMEM87B_IL1RN |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TMEM87B | IL1RN |
| May be involved in retrograde transport from endosomesto the trans-Golgi network (TGN). {ECO:0000269|PubMed:26157166}. | Inhibits the activity of interleukin-1 by binding toreceptor IL1R1 and preventing its association with the coreceptorIL1RAP for signaling. Has no interleukin-1 like activity. Bindsfunctional interleukin-1 receptor IL1R1 with greater affinity thandecoy receptor IL1R2; however, the physiological relevance of thelatter association is unsure. {ECO:0000269|PubMed:7775431}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for TMEM87B_IL1RN |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for TMEM87B_IL1RN |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TMEM87B | BTNL8, LPAR1, IPPK, TMED6 | IL1RN | IL1R2, IL1R1, TERF2IP, POT1, RELA, SEC22C, FTH1, TBC1D22B, FCF1, CDK15 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for TMEM87B_IL1RN |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | IL1RN | P18510 | DB06372 | Rilonacept | Interleukin-1 receptor antagonist protein | biotech | approved|investigational |
Top |
RelatedDiseases for TMEM87B_IL1RN |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | IL1RN | C0020429 | Hyperalgesia | 4 | CTD_human |
| Tgene | IL1RN | C0001973 | Alcoholic Intoxication, Chronic | 2 | PSYGENET |
| Tgene | IL1RN | C0003873 | Rheumatoid Arthritis | 2 | CTD_human |
| Tgene | IL1RN | C0005586 | Bipolar Disorder | 2 | PSYGENET |
| Tgene | IL1RN | C0011206 | Delirium | 2 | PSYGENET |
| Tgene | IL1RN | C0027051 | Myocardial Infarction | 2 | CTD_human |
| Tgene | IL1RN | C0027540 | Necrosis | 2 | CTD_human |
| Tgene | IL1RN | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
| Tgene | IL1RN | C0037274 | Dermatologic disorders | 2 | CTD_human |
| Tgene | IL1RN | C0001723 | Affective Disorders, Psychotic | 1 | PSYGENET |
| Tgene | IL1RN | C0003123 | Anorexia | 1 | CTD_human |
| Tgene | IL1RN | C0003165 | Anthracosis | 1 | CTD_human |
| Tgene | IL1RN | C0004096 | Asthma | 1 | CTD_human |
| Tgene | IL1RN | C0004352 | Autistic Disorder | 1 | CTD_human |
| Tgene | IL1RN | C0007786 | Brain Ischemia | 1 | CTD_human |
| Tgene | IL1RN | C0009375 | Colonic Neoplasms | 1 | CTD_human |
| Tgene | IL1RN | C0011991 | Diarrhea | 1 | CTD_human |
| Tgene | IL1RN | C0013415 | Dysthymic Disorder | 1 | PSYGENET |
| Tgene | IL1RN | C0015379 | Extravasation of Diagnostic and Therapeutic Materials | 1 | CTD_human |
| Tgene | IL1RN | C0016059 | Fibrosis | 1 | CTD_human |
| Tgene | IL1RN | C0018099 | Gout | 1 | CTD_human |
| Tgene | IL1RN | C0021368 | Inflammation | 1 | CTD_human |
| Tgene | IL1RN | C0022658 | Kidney Diseases | 1 | CTD_human |
| Tgene | IL1RN | C0023186 | Learning Disorders | 1 | CTD_human |
| Tgene | IL1RN | C0027121 | Myositis | 1 | CTD_human |
| Tgene | IL1RN | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Tgene | IL1RN | C0030193 | Pain | 1 | CTD_human |
| Tgene | IL1RN | C0033687 | Proteinuria | 1 | CTD_human |
| Tgene | IL1RN | C0034069 | Pulmonary Fibrosis | 1 | CTD_human |
| Tgene | IL1RN | C0036429 | Sclerosis | 1 | CTD_human |
| Tgene | IL1RN | C0038220 | Status Epilepticus | 1 | CTD_human |
| Tgene | IL1RN | C0038454 | Cerebrovascular accident | 1 | CTD_human |
| Tgene | IL1RN | C0085129 | Bronchial Hyperreactivity | 1 | CTD_human |
| Tgene | IL1RN | C0162557 | Liver Failure, Acute | 1 | CTD_human |
| Tgene | IL1RN | C0311375 | Arsenic Poisoning | 1 | CTD_human |
| Tgene | IL1RN | C0333355 | Inflammatory disease of mucous membrane | 1 | CTD_human |
| Tgene | IL1RN | C0333641 | Atrophic | 1 | CTD_human |
| Tgene | IL1RN | C0524988 | Schnitzler Syndrome | 1 | CTD_human |
| Tgene | IL1RN | C0525045 | Mood Disorders | 1 | PSYGENET |
| Tgene | IL1RN | C3495559 | Juvenile arthritis | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|