![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 38694 |
FusionGeneSummary for TMEM87B_IL1RN |
![]() |
Fusion gene information | Fusion gene name: TMEM87B_IL1RN | Fusion gene ID: 38694 | Hgene | Tgene | Gene symbol | TMEM87B | IL1RN | Gene ID | 84910 | 3557 |
Gene name | transmembrane protein 87B | interleukin 1 receptor antagonist | |
Synonyms | - | DIRA|ICIL-1RA|IL-1RN|IL-1ra|IL-1ra3|IL1F3|IL1RA|IRAP|MVCD4 | |
Cytomap | 2q13 | 2q14.1 | |
Type of gene | protein-coding | protein-coding | |
Description | transmembrane protein 87B | interleukin-1 receptor antagonist proteinIL1 inhibitorintracellular IL-1 receptor antagonist type IIintracellular interleukin-1 receptor antagonist (icIL-1ra)type II interleukin-1 receptor antagonist | |
Modification date | 20180519 | 20180527 | |
UniProtAcc | Q96K49 | P18510 | |
Ensembl transtripts involved in fusion gene | ENST00000283206, ENST00000463427, | ENST00000465812, ENST00000409052, ENST00000361779, ENST00000259206, ENST00000354115, ENST00000409930, | |
Fusion gene scores | * DoF score | 4 X 7 X 9=252 | 7 X 4 X 6=168 |
# samples | 12 | 9 | |
** MAII score | log2(12/252*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/168*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TMEM87B [Title/Abstract] AND IL1RN [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | IL1RN | GO:0034115 | negative regulation of heterotypic cell-cell adhesion | 2139180 |
Tgene | IL1RN | GO:0051384 | response to glucocorticoid | 10443688 |
Tgene | IL1RN | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway | 2137200|2139180 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | STAD | TCGA-BR-4357-01A | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000283206 | ENST00000465812 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
5CDS-3UTR | ENST00000283206 | ENST00000409052 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
5CDS-intron | ENST00000283206 | ENST00000361779 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
5CDS-intron | ENST00000283206 | ENST00000259206 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
5CDS-intron | ENST00000283206 | ENST00000354115 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
5CDS-intron | ENST00000283206 | ENST00000409930 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
3UTR-3UTR | ENST00000463427 | ENST00000465812 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
3UTR-3UTR | ENST00000463427 | ENST00000409052 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
3UTR-intron | ENST00000463427 | ENST00000361779 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
3UTR-intron | ENST00000463427 | ENST00000259206 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
3UTR-intron | ENST00000463427 | ENST00000354115 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
3UTR-intron | ENST00000463427 | ENST00000409930 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
Top |
FusionProtFeatures for TMEM87B_IL1RN |
![]() |
Hgene | Tgene |
TMEM87B | IL1RN |
May be involved in retrograde transport from endosomesto the trans-Golgi network (TGN). {ECO:0000269|PubMed:26157166}. | Inhibits the activity of interleukin-1 by binding toreceptor IL1R1 and preventing its association with the coreceptorIL1RAP for signaling. Has no interleukin-1 like activity. Bindsfunctional interleukin-1 receptor IL1R1 with greater affinity thandecoy receptor IL1R2; however, the physiological relevance of thelatter association is unsure. {ECO:0000269|PubMed:7775431}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for TMEM87B_IL1RN |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for TMEM87B_IL1RN |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TMEM87B | BTNL8, LPAR1, IPPK, TMED6 | IL1RN | IL1R2, IL1R1, TERF2IP, POT1, RELA, SEC22C, FTH1, TBC1D22B, FCF1, CDK15 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for TMEM87B_IL1RN |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | IL1RN | P18510 | DB06372 | Rilonacept | Interleukin-1 receptor antagonist protein | biotech | approved|investigational |
Top |
RelatedDiseases for TMEM87B_IL1RN |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | IL1RN | C0020429 | Hyperalgesia | 4 | CTD_human |
Tgene | IL1RN | C0001973 | Alcoholic Intoxication, Chronic | 2 | PSYGENET |
Tgene | IL1RN | C0003873 | Rheumatoid Arthritis | 2 | CTD_human |
Tgene | IL1RN | C0005586 | Bipolar Disorder | 2 | PSYGENET |
Tgene | IL1RN | C0011206 | Delirium | 2 | PSYGENET |
Tgene | IL1RN | C0027051 | Myocardial Infarction | 2 | CTD_human |
Tgene | IL1RN | C0027540 | Necrosis | 2 | CTD_human |
Tgene | IL1RN | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
Tgene | IL1RN | C0037274 | Dermatologic disorders | 2 | CTD_human |
Tgene | IL1RN | C0001723 | Affective Disorders, Psychotic | 1 | PSYGENET |
Tgene | IL1RN | C0003123 | Anorexia | 1 | CTD_human |
Tgene | IL1RN | C0003165 | Anthracosis | 1 | CTD_human |
Tgene | IL1RN | C0004096 | Asthma | 1 | CTD_human |
Tgene | IL1RN | C0004352 | Autistic Disorder | 1 | CTD_human |
Tgene | IL1RN | C0007786 | Brain Ischemia | 1 | CTD_human |
Tgene | IL1RN | C0009375 | Colonic Neoplasms | 1 | CTD_human |
Tgene | IL1RN | C0011991 | Diarrhea | 1 | CTD_human |
Tgene | IL1RN | C0013415 | Dysthymic Disorder | 1 | PSYGENET |
Tgene | IL1RN | C0015379 | Extravasation of Diagnostic and Therapeutic Materials | 1 | CTD_human |
Tgene | IL1RN | C0016059 | Fibrosis | 1 | CTD_human |
Tgene | IL1RN | C0018099 | Gout | 1 | CTD_human |
Tgene | IL1RN | C0021368 | Inflammation | 1 | CTD_human |
Tgene | IL1RN | C0022658 | Kidney Diseases | 1 | CTD_human |
Tgene | IL1RN | C0023186 | Learning Disorders | 1 | CTD_human |
Tgene | IL1RN | C0027121 | Myositis | 1 | CTD_human |
Tgene | IL1RN | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Tgene | IL1RN | C0030193 | Pain | 1 | CTD_human |
Tgene | IL1RN | C0033687 | Proteinuria | 1 | CTD_human |
Tgene | IL1RN | C0034069 | Pulmonary Fibrosis | 1 | CTD_human |
Tgene | IL1RN | C0036429 | Sclerosis | 1 | CTD_human |
Tgene | IL1RN | C0038220 | Status Epilepticus | 1 | CTD_human |
Tgene | IL1RN | C0038454 | Cerebrovascular accident | 1 | CTD_human |
Tgene | IL1RN | C0085129 | Bronchial Hyperreactivity | 1 | CTD_human |
Tgene | IL1RN | C0162557 | Liver Failure, Acute | 1 | CTD_human |
Tgene | IL1RN | C0311375 | Arsenic Poisoning | 1 | CTD_human |
Tgene | IL1RN | C0333355 | Inflammatory disease of mucous membrane | 1 | CTD_human |
Tgene | IL1RN | C0333641 | Atrophic | 1 | CTD_human |
Tgene | IL1RN | C0524988 | Schnitzler Syndrome | 1 | CTD_human |
Tgene | IL1RN | C0525045 | Mood Disorders | 1 | PSYGENET |
Tgene | IL1RN | C3495559 | Juvenile arthritis | 1 | CTD_human |