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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38671

FusionGeneSummary for TMEM63B_EFCAB14

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM63B_EFCAB14
Fusion gene ID: 38671
HgeneTgene
Gene symbol

TMEM63B

EFCAB14

Gene ID

55362

9813

Gene nametransmembrane protein 63BEF-hand calcium binding domain 14
SynonymsC6orf110KIAA0494
Cytomap

6p21.1

1p33

Type of geneprotein-codingprotein-coding
DescriptionCSC1-like protein 2EF-hand calcium-binding domain-containing protein 14
Modification date2018051920180522
UniProtAcc

Q5T3F8

O75071

Ensembl transtripts involved in fusion geneENST00000259746, ENST00000323267, 
ENST00000527188, 
ENST00000544071, 
ENST00000371933, ENST00000484461, 
Fusion gene scores* DoF score6 X 4 X 6=1445 X 5 X 2=50
# samples 65
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/50*10)=0
Context

PubMed: TMEM63B [Title/Abstract] AND EFCAB14 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDUCECTCGA-AJ-A3QS-01ATMEM63Bchr6

44095603

+EFCAB14chr1

47157609

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000259746ENST00000544071TMEM63Bchr6

44095603

+EFCAB14chr1

47157609

-
intron-3CDSENST00000259746ENST00000371933TMEM63Bchr6

44095603

+EFCAB14chr1

47157609

-
intron-5UTRENST00000259746ENST00000484461TMEM63Bchr6

44095603

+EFCAB14chr1

47157609

-
intron-3CDSENST00000323267ENST00000544071TMEM63Bchr6

44095603

+EFCAB14chr1

47157609

-
intron-3CDSENST00000323267ENST00000371933TMEM63Bchr6

44095603

+EFCAB14chr1

47157609

-
intron-5UTRENST00000323267ENST00000484461TMEM63Bchr6

44095603

+EFCAB14chr1

47157609

-
intron-3CDSENST00000527188ENST00000544071TMEM63Bchr6

44095603

+EFCAB14chr1

47157609

-
intron-3CDSENST00000527188ENST00000371933TMEM63Bchr6

44095603

+EFCAB14chr1

47157609

-
intron-5UTRENST00000527188ENST00000484461TMEM63Bchr6

44095603

+EFCAB14chr1

47157609

-

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FusionProtFeatures for TMEM63B_EFCAB14


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMEM63B

Q5T3F8

EFCAB14

O75071

Acts as an osmosensitive calcium-permeable cationchannel. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TMEM63B_EFCAB14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMEM63B_EFCAB14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMEM63BELAVL1, MAPK14, NRG1, LGALS8, SLC39A4, ATP1A1, ATP2A2, ATP2B1, ATP5A1, ATP5B, ATP5E, ATP5I, ATP6V1A, ATP6V1B2, ATP5O, CAV1, CD97, CLCN7, EMD, FLOT2, GNA11, GOLGA4, HMMR, TNPO1, LGALS3BP, LMNB1, PHB, ABCD3, RAF1, RPN1, SLC1A5, SOAT1, TAP1, TMPO, VDAC2, CXCR4, PABPN1, SLC7A5, OASL, ATP6V0D1, AIFM1, VAPA, ATP6V1G1, SCAMP3, FLOT1, DDX39A, ATP5H, ERLIN1, YME1L1, MAGED2, CKAP4, ERLIN2, PHB2, APOL2, MYOF, DERL2, SARAF, SLC38A2, TMCO1, SLC35F6, CHMP4B, PCID2, C20orf24, SRPRB, ENOPH1, VKORC1, TMEM109, SLC35E1, SGPP1, YIPF5, YIPF4, SLC38A5, ORMDL1, PRKCDBP, PTRF, RABL3, HLA-C, PCDHA3, IL17RB, MTUS2, SLC4A8, ATP2B2, TPRA1, MUC1, ATP6V0A2, PCDHGB4, PTGIR, GPR21, YIPF3, IPPKEFCAB14ELAVL1, CSNK2A2, CSNK2A1, GRAMD3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMEM63B_EFCAB14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMEM63B_EFCAB14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource