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Fusion gene ID: 38671 |
FusionGeneSummary for TMEM63B_EFCAB14 |
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Fusion gene information | Fusion gene name: TMEM63B_EFCAB14 | Fusion gene ID: 38671 | Hgene | Tgene | Gene symbol | TMEM63B | EFCAB14 | Gene ID | 55362 | 9813 |
Gene name | transmembrane protein 63B | EF-hand calcium binding domain 14 | |
Synonyms | C6orf110 | KIAA0494 | |
Cytomap | 6p21.1 | 1p33 | |
Type of gene | protein-coding | protein-coding | |
Description | CSC1-like protein 2 | EF-hand calcium-binding domain-containing protein 14 | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | Q5T3F8 | O75071 | |
Ensembl transtripts involved in fusion gene | ENST00000259746, ENST00000323267, ENST00000527188, | ENST00000544071, ENST00000371933, ENST00000484461, | |
Fusion gene scores | * DoF score | 6 X 4 X 6=144 | 5 X 5 X 2=50 |
# samples | 6 | 5 | |
** MAII score | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/50*10)=0 | |
Context | PubMed: TMEM63B [Title/Abstract] AND EFCAB14 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | UCEC | TCGA-AJ-A3QS-01A | TMEM63B | chr6 | 44095603 | + | EFCAB14 | chr1 | 47157609 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000259746 | ENST00000544071 | TMEM63B | chr6 | 44095603 | + | EFCAB14 | chr1 | 47157609 | - |
intron-3CDS | ENST00000259746 | ENST00000371933 | TMEM63B | chr6 | 44095603 | + | EFCAB14 | chr1 | 47157609 | - |
intron-5UTR | ENST00000259746 | ENST00000484461 | TMEM63B | chr6 | 44095603 | + | EFCAB14 | chr1 | 47157609 | - |
intron-3CDS | ENST00000323267 | ENST00000544071 | TMEM63B | chr6 | 44095603 | + | EFCAB14 | chr1 | 47157609 | - |
intron-3CDS | ENST00000323267 | ENST00000371933 | TMEM63B | chr6 | 44095603 | + | EFCAB14 | chr1 | 47157609 | - |
intron-5UTR | ENST00000323267 | ENST00000484461 | TMEM63B | chr6 | 44095603 | + | EFCAB14 | chr1 | 47157609 | - |
intron-3CDS | ENST00000527188 | ENST00000544071 | TMEM63B | chr6 | 44095603 | + | EFCAB14 | chr1 | 47157609 | - |
intron-3CDS | ENST00000527188 | ENST00000371933 | TMEM63B | chr6 | 44095603 | + | EFCAB14 | chr1 | 47157609 | - |
intron-5UTR | ENST00000527188 | ENST00000484461 | TMEM63B | chr6 | 44095603 | + | EFCAB14 | chr1 | 47157609 | - |
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FusionProtFeatures for TMEM63B_EFCAB14 |
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Hgene | Tgene |
TMEM63B | EFCAB14 |
Acts as an osmosensitive calcium-permeable cationchannel. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TMEM63B_EFCAB14 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TMEM63B_EFCAB14 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TMEM63B | ELAVL1, MAPK14, NRG1, LGALS8, SLC39A4, ATP1A1, ATP2A2, ATP2B1, ATP5A1, ATP5B, ATP5E, ATP5I, ATP6V1A, ATP6V1B2, ATP5O, CAV1, CD97, CLCN7, EMD, FLOT2, GNA11, GOLGA4, HMMR, TNPO1, LGALS3BP, LMNB1, PHB, ABCD3, RAF1, RPN1, SLC1A5, SOAT1, TAP1, TMPO, VDAC2, CXCR4, PABPN1, SLC7A5, OASL, ATP6V0D1, AIFM1, VAPA, ATP6V1G1, SCAMP3, FLOT1, DDX39A, ATP5H, ERLIN1, YME1L1, MAGED2, CKAP4, ERLIN2, PHB2, APOL2, MYOF, DERL2, SARAF, SLC38A2, TMCO1, SLC35F6, CHMP4B, PCID2, C20orf24, SRPRB, ENOPH1, VKORC1, TMEM109, SLC35E1, SGPP1, YIPF5, YIPF4, SLC38A5, ORMDL1, PRKCDBP, PTRF, RABL3, HLA-C, PCDHA3, IL17RB, MTUS2, SLC4A8, ATP2B2, TPRA1, MUC1, ATP6V0A2, PCDHGB4, PTGIR, GPR21, YIPF3, IPPK | EFCAB14 | ELAVL1, CSNK2A2, CSNK2A1, GRAMD3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMEM63B_EFCAB14 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMEM63B_EFCAB14 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |