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Fusion gene ID: 38657 |
FusionGeneSummary for TMEM59_SSBP3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMEM59_SSBP3 | Fusion gene ID: 38657 | Hgene | Tgene | Gene symbol | TMEM59 | SSBP3 | Gene ID | 9528 | 23648 |
| Gene name | transmembrane protein 59 | single stranded DNA binding protein 3 | |
| Synonyms | C1orf8|DCF1|HSPC001|PRO195|UNQ169 | CSDP|SSDP|SSDP1 | |
| Cytomap | 1p32.3 | 1p32.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transmembrane protein 59dendritic cell factor 1liver membrane-bound protein | single-stranded DNA-binding protein 3sequence-specific single-stranded-DNA-binding protein | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9BXS4 | Q9BWW4 | |
| Ensembl transtripts involved in fusion gene | ENST00000371348, ENST00000371344, ENST00000234831, ENST00000371341, ENST00000470395, ENST00000371337, | ENST00000326956, ENST00000417664, ENST00000371320, ENST00000371319, ENST00000357475, | |
| Fusion gene scores | * DoF score | 7 X 8 X 5=280 | 11 X 8 X 6=528 |
| # samples | 10 | 10 | |
| ** MAII score | log2(10/280*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/528*10)=-2.40053792958373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TMEM59 [Title/Abstract] AND SSBP3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TMEM59 | GO:0010955 | negative regulation of protein processing | 20427278 |
| Hgene | TMEM59 | GO:0090285 | negative regulation of protein glycosylation in Golgi | 20427278 |
| Hgene | TMEM59 | GO:1903077 | negative regulation of protein localization to plasma membrane | 20427278 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-VQ-A91K-01A | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000371348 | ENST00000326956 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-5UTR | ENST00000371348 | ENST00000417664 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-5UTR | ENST00000371348 | ENST00000371320 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-5UTR | ENST00000371348 | ENST00000371319 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-intron | ENST00000371348 | ENST00000357475 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-5UTR | ENST00000371344 | ENST00000326956 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-5UTR | ENST00000371344 | ENST00000417664 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-5UTR | ENST00000371344 | ENST00000371320 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-5UTR | ENST00000371344 | ENST00000371319 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-intron | ENST00000371344 | ENST00000357475 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-5UTR | ENST00000234831 | ENST00000326956 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-5UTR | ENST00000234831 | ENST00000417664 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-5UTR | ENST00000234831 | ENST00000371320 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-5UTR | ENST00000234831 | ENST00000371319 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-intron | ENST00000234831 | ENST00000357475 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-5UTR | ENST00000371341 | ENST00000326956 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-5UTR | ENST00000371341 | ENST00000417664 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-5UTR | ENST00000371341 | ENST00000371320 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-5UTR | ENST00000371341 | ENST00000371319 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-intron | ENST00000371341 | ENST00000357475 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5UTR-5UTR | ENST00000470395 | ENST00000326956 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5UTR-5UTR | ENST00000470395 | ENST00000417664 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5UTR-5UTR | ENST00000470395 | ENST00000371320 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5UTR-5UTR | ENST00000470395 | ENST00000371319 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5UTR-intron | ENST00000470395 | ENST00000357475 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| intron-5UTR | ENST00000371337 | ENST00000326956 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| intron-5UTR | ENST00000371337 | ENST00000417664 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| intron-5UTR | ENST00000371337 | ENST00000371320 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| intron-5UTR | ENST00000371337 | ENST00000371319 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| intron-intron | ENST00000371337 | ENST00000357475 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
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FusionProtFeatures for TMEM59_SSBP3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TMEM59 | SSBP3 |
| Acts as a regulator of autophagy in response to S.aureusinfection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B orMAP1LC3C). Acts by interacting with ATG16L1, leading to promote afunctional complex between LC3 and ATG16L1 and promoting LC3lipidation and subsequent activation of autophagy(PubMed:27273576, PubMed:23376921). Modulates the O-glycosylationand complex N-glycosylation steps occurring during the Golgimaturation of several proteins such as APP, BACE1, SEAP or PRNP(PubMed:20427278). Inhibits APP transport to the cell surface andfurther shedding (PubMed:20427278). {ECO:0000269|PubMed:20427278,ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:27273576}. | May be involved in transcription regulation of the alpha2(I) collagen gene where it binds to the single-strandedpolypyrimidine sequences in the promoter region. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TMEM59_SSBP3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TMEM59_SSBP3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TMEM59 | RYK, ELAVL1, ATG16L1, CUL7, TYW1, PDE3B, IL20RB, TMEM30A, NTRK1, ERRFI1 | SSBP3 | TAL1, HCLS1, LMX1B, RFC1, SUPT5H, ZNF226, ANKEF1, TRIM33, APP, EPAS1, ARNT2, LDB2, EWSR1, PIN1, YES1, LDB1, IL36RN, TBC1D23, NXT2, IDI2, SSBP2, SSBP4, DIS3, LHX1, ISL2, ISL1, LMO4, LHX9, LHX6, MDC1, CLK1, PCGF1, NANOG, LMO2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMEM59_SSBP3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMEM59_SSBP3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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