![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 38650 |
FusionGeneSummary for TMEM57_KAT6B |
![]() |
Fusion gene information | Fusion gene name: TMEM57_KAT6B | Fusion gene ID: 38650 | Hgene | Tgene | Gene symbol | TMEM57 | KAT6B | Gene ID | 23522 |
Gene name | lysine acetyltransferase 6B | ||
Synonyms | GTPTS|MORF|MOZ2|MYST4|ZC2HC6B|qkf|querkopf | ||
Cytomap | 10q22.2 | ||
Type of gene | protein-coding | ||
Description | histone acetyltransferase KAT6BK(lysine) acetyltransferase 6BMOZ, YBF2/SAS3, SAS2 and TIP60 protein 4MOZ-related factorMYST histone acetyltransferase (monocytic leukemia) 4MYST-4histone acetyltransferase MORFhistone acetyltransferase MOZ2histone a | ||
Modification date | 20180523 | ||
UniProtAcc | Q8WYB5 | ||
Ensembl transtripts involved in fusion gene | ENST00000399763, ENST00000399766, ENST00000374343, ENST00000470035, | ENST00000372725, ENST00000372724, ENST00000287239, ENST00000372714, ENST00000372711, ENST00000490365, | |
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 4 X 5 X 2=40 |
# samples | 3 | 5 | |
** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TMEM57 [Title/Abstract] AND KAT6B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | KAT6B | GO:0016573 | histone acetylation | 11965546 |
Tgene | KAT6B | GO:0043966 | histone H3 acetylation | 16387653 |
Tgene | KAT6B | GO:0045892 | negative regulation of transcription, DNA-templated | 10497217 |
Tgene | KAT6B | GO:0045893 | positive regulation of transcription, DNA-templated | 10497217|11965546 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AJ299264 | TMEM57 | chr1 | 25793487 | + | KAT6B | chr10 | 76785513 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000399763 | ENST00000372725 | TMEM57 | chr1 | 25793487 | + | KAT6B | chr10 | 76785513 | + |
intron-intron | ENST00000399763 | ENST00000372724 | TMEM57 | chr1 | 25793487 | + | KAT6B | chr10 | 76785513 | + |
intron-intron | ENST00000399763 | ENST00000287239 | TMEM57 | chr1 | 25793487 | + | KAT6B | chr10 | 76785513 | + |
intron-intron | ENST00000399763 | ENST00000372714 | TMEM57 | chr1 | 25793487 | + | KAT6B | chr10 | 76785513 | + |
intron-intron | ENST00000399763 | ENST00000372711 | TMEM57 | chr1 | 25793487 | + | KAT6B | chr10 | 76785513 | + |
intron-3UTR | ENST00000399763 | ENST00000490365 | TMEM57 | chr1 | 25793487 | + | KAT6B | chr10 | 76785513 | + |
intron-intron | ENST00000399766 | ENST00000372725 | TMEM57 | chr1 | 25793487 | + | KAT6B | chr10 | 76785513 | + |
intron-intron | ENST00000399766 | ENST00000372724 | TMEM57 | chr1 | 25793487 | + | KAT6B | chr10 | 76785513 | + |
intron-intron | ENST00000399766 | ENST00000287239 | TMEM57 | chr1 | 25793487 | + | KAT6B | chr10 | 76785513 | + |
intron-intron | ENST00000399766 | ENST00000372714 | TMEM57 | chr1 | 25793487 | + | KAT6B | chr10 | 76785513 | + |
intron-intron | ENST00000399766 | ENST00000372711 | TMEM57 | chr1 | 25793487 | + | KAT6B | chr10 | 76785513 | + |
intron-3UTR | ENST00000399766 | ENST00000490365 | TMEM57 | chr1 | 25793487 | + | KAT6B | chr10 | 76785513 | + |
intron-intron | ENST00000374343 | ENST00000372725 | TMEM57 | chr1 | 25793487 | + | KAT6B | chr10 | 76785513 | + |
intron-intron | ENST00000374343 | ENST00000372724 | TMEM57 | chr1 | 25793487 | + | KAT6B | chr10 | 76785513 | + |
intron-intron | ENST00000374343 | ENST00000287239 | TMEM57 | chr1 | 25793487 | + | KAT6B | chr10 | 76785513 | + |
intron-intron | ENST00000374343 | ENST00000372714 | TMEM57 | chr1 | 25793487 | + | KAT6B | chr10 | 76785513 | + |
intron-intron | ENST00000374343 | ENST00000372711 | TMEM57 | chr1 | 25793487 | + | KAT6B | chr10 | 76785513 | + |
intron-3UTR | ENST00000374343 | ENST00000490365 | TMEM57 | chr1 | 25793487 | + | KAT6B | chr10 | 76785513 | + |
intron-intron | ENST00000470035 | ENST00000372725 | TMEM57 | chr1 | 25793487 | + | KAT6B | chr10 | 76785513 | + |
intron-intron | ENST00000470035 | ENST00000372724 | TMEM57 | chr1 | 25793487 | + | KAT6B | chr10 | 76785513 | + |
intron-intron | ENST00000470035 | ENST00000287239 | TMEM57 | chr1 | 25793487 | + | KAT6B | chr10 | 76785513 | + |
intron-intron | ENST00000470035 | ENST00000372714 | TMEM57 | chr1 | 25793487 | + | KAT6B | chr10 | 76785513 | + |
intron-intron | ENST00000470035 | ENST00000372711 | TMEM57 | chr1 | 25793487 | + | KAT6B | chr10 | 76785513 | + |
intron-3UTR | ENST00000470035 | ENST00000490365 | TMEM57 | chr1 | 25793487 | + | KAT6B | chr10 | 76785513 | + |
Top |
FusionProtFeatures for TMEM57_KAT6B |
![]() |
Hgene | Tgene |
TMEM57 | KAT6B |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Histone acetyltransferase which may be involved in bothpositive and negative regulation of transcription. Required forRUNX2-dependent transcriptional activation. May be involved incerebral cortex development. Component of the MOZ/MORF complexwhich has a histone H3 acetyltransferase activity.{ECO:0000269|PubMed:10497217, ECO:0000269|PubMed:11965546,ECO:0000269|PubMed:16387653}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for TMEM57_KAT6B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for TMEM57_KAT6B |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for TMEM57_KAT6B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for TMEM57_KAT6B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | KAT6B | C0853193 | Bipolar I disorder | 1 | PSYGENET |
Tgene | KAT6B | C3495559 | Juvenile arthritis | 1 | CTD_human |