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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38650

FusionGeneSummary for TMEM57_KAT6B

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM57_KAT6B
Fusion gene ID: 38650
HgeneTgene
Gene symbol

TMEM57

KAT6B

Gene ID

23522

Gene namelysine acetyltransferase 6B
SynonymsGTPTS|MORF|MOZ2|MYST4|ZC2HC6B|qkf|querkopf
Cytomap

10q22.2

Type of geneprotein-coding
Descriptionhistone acetyltransferase KAT6BK(lysine) acetyltransferase 6BMOZ, YBF2/SAS3, SAS2 and TIP60 protein 4MOZ-related factorMYST histone acetyltransferase (monocytic leukemia) 4MYST-4histone acetyltransferase MORFhistone acetyltransferase MOZ2histone a
Modification date20180523
UniProtAcc

Q8WYB5

Ensembl transtripts involved in fusion geneENST00000399763, ENST00000399766, 
ENST00000374343, ENST00000470035, 
ENST00000372725, ENST00000372724, 
ENST00000287239, ENST00000372714, 
ENST00000372711, ENST00000490365, 
Fusion gene scores* DoF score3 X 3 X 1=94 X 5 X 2=40
# samples 35
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TMEM57 [Title/Abstract] AND KAT6B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneKAT6B

GO:0016573

histone acetylation

11965546

TgeneKAT6B

GO:0043966

histone H3 acetylation

16387653

TgeneKAT6B

GO:0045892

negative regulation of transcription, DNA-templated

10497217

TgeneKAT6B

GO:0045893

positive regulation of transcription, DNA-templated

10497217|11965546


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AJ299264TMEM57chr1

25793487

+KAT6Bchr10

76785513

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000399763ENST00000372725TMEM57chr1

25793487

+KAT6Bchr10

76785513

+
intron-intronENST00000399763ENST00000372724TMEM57chr1

25793487

+KAT6Bchr10

76785513

+
intron-intronENST00000399763ENST00000287239TMEM57chr1

25793487

+KAT6Bchr10

76785513

+
intron-intronENST00000399763ENST00000372714TMEM57chr1

25793487

+KAT6Bchr10

76785513

+
intron-intronENST00000399763ENST00000372711TMEM57chr1

25793487

+KAT6Bchr10

76785513

+
intron-3UTRENST00000399763ENST00000490365TMEM57chr1

25793487

+KAT6Bchr10

76785513

+
intron-intronENST00000399766ENST00000372725TMEM57chr1

25793487

+KAT6Bchr10

76785513

+
intron-intronENST00000399766ENST00000372724TMEM57chr1

25793487

+KAT6Bchr10

76785513

+
intron-intronENST00000399766ENST00000287239TMEM57chr1

25793487

+KAT6Bchr10

76785513

+
intron-intronENST00000399766ENST00000372714TMEM57chr1

25793487

+KAT6Bchr10

76785513

+
intron-intronENST00000399766ENST00000372711TMEM57chr1

25793487

+KAT6Bchr10

76785513

+
intron-3UTRENST00000399766ENST00000490365TMEM57chr1

25793487

+KAT6Bchr10

76785513

+
intron-intronENST00000374343ENST00000372725TMEM57chr1

25793487

+KAT6Bchr10

76785513

+
intron-intronENST00000374343ENST00000372724TMEM57chr1

25793487

+KAT6Bchr10

76785513

+
intron-intronENST00000374343ENST00000287239TMEM57chr1

25793487

+KAT6Bchr10

76785513

+
intron-intronENST00000374343ENST00000372714TMEM57chr1

25793487

+KAT6Bchr10

76785513

+
intron-intronENST00000374343ENST00000372711TMEM57chr1

25793487

+KAT6Bchr10

76785513

+
intron-3UTRENST00000374343ENST00000490365TMEM57chr1

25793487

+KAT6Bchr10

76785513

+
intron-intronENST00000470035ENST00000372725TMEM57chr1

25793487

+KAT6Bchr10

76785513

+
intron-intronENST00000470035ENST00000372724TMEM57chr1

25793487

+KAT6Bchr10

76785513

+
intron-intronENST00000470035ENST00000287239TMEM57chr1

25793487

+KAT6Bchr10

76785513

+
intron-intronENST00000470035ENST00000372714TMEM57chr1

25793487

+KAT6Bchr10

76785513

+
intron-intronENST00000470035ENST00000372711TMEM57chr1

25793487

+KAT6Bchr10

76785513

+
intron-3UTRENST00000470035ENST00000490365TMEM57chr1

25793487

+KAT6Bchr10

76785513

+

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FusionProtFeatures for TMEM57_KAT6B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMEM57

KAT6B

Q8WYB5

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Histone acetyltransferase which may be involved in bothpositive and negative regulation of transcription. Required forRUNX2-dependent transcriptional activation. May be involved incerebral cortex development. Component of the MOZ/MORF complexwhich has a histone H3 acetyltransferase activity.{ECO:0000269|PubMed:10497217, ECO:0000269|PubMed:11965546,ECO:0000269|PubMed:16387653}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TMEM57_KAT6B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMEM57_KAT6B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMEM57_KAT6B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMEM57_KAT6B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneKAT6BC0853193Bipolar I disorder1PSYGENET
TgeneKAT6BC3495559Juvenile arthritis1CTD_human