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Fusion gene ID: 38643 |
FusionGeneSummary for TMEM54_TRIM62 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMEM54_TRIM62 | Fusion gene ID: 38643 | Hgene | Tgene | Gene symbol | TMEM54 | TRIM62 | Gene ID | 113452 | 55223 |
| Gene name | transmembrane protein 54 | tripartite motif containing 62 | |
| Synonyms | BCLP|CAC-1|CAC1 | DEAR1 | |
| Cytomap | 1p35.1 | 1p35.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transmembrane protein 54beta-casein-like proteinprotein CAC-1 | E3 ubiquitin-protein ligase TRIM62RING-type E3 ubiquitin transferase TRIM62ductal epithelium-associated RING Chromosome 1tripartite motif-containing protein 62 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q969K7 | Q9BVG3 | |
| Ensembl transtripts involved in fusion gene | ENST00000373463, ENST00000329151, ENST00000475208, | ENST00000291416, ENST00000543586, ENST00000485148, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 1 X 1 X 1=1 |
| # samples | 2 | 1 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: TMEM54 [Title/Abstract] AND TRIM62 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TRIM62 | GO:0032897 | negative regulation of viral transcription | 18248090 |
| Tgene | TRIM62 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 23077300 |
| Tgene | TRIM62 | GO:0046596 | regulation of viral entry into host cell | 18248090 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | CESC | TCGA-DS-A1OC-01A | TMEM54 | chr1 | 33363727 | - | TRIM62 | chr1 | 33631167 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000373463 | ENST00000291416 | TMEM54 | chr1 | 33363727 | - | TRIM62 | chr1 | 33631167 | - |
| In-frame | ENST00000373463 | ENST00000543586 | TMEM54 | chr1 | 33363727 | - | TRIM62 | chr1 | 33631167 | - |
| 5CDS-5UTR | ENST00000373463 | ENST00000485148 | TMEM54 | chr1 | 33363727 | - | TRIM62 | chr1 | 33631167 | - |
| In-frame | ENST00000329151 | ENST00000291416 | TMEM54 | chr1 | 33363727 | - | TRIM62 | chr1 | 33631167 | - |
| In-frame | ENST00000329151 | ENST00000543586 | TMEM54 | chr1 | 33363727 | - | TRIM62 | chr1 | 33631167 | - |
| 5CDS-5UTR | ENST00000329151 | ENST00000485148 | TMEM54 | chr1 | 33363727 | - | TRIM62 | chr1 | 33631167 | - |
| 5UTR-3CDS | ENST00000475208 | ENST00000291416 | TMEM54 | chr1 | 33363727 | - | TRIM62 | chr1 | 33631167 | - |
| 5UTR-3CDS | ENST00000475208 | ENST00000543586 | TMEM54 | chr1 | 33363727 | - | TRIM62 | chr1 | 33631167 | - |
| 5UTR-5UTR | ENST00000475208 | ENST00000485148 | TMEM54 | chr1 | 33363727 | - | TRIM62 | chr1 | 33631167 | - |
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FusionProtFeatures for TMEM54_TRIM62 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TMEM54 | TRIM62 |
| E3 ubiquitin ligase whose activity is dependent on E2ubiquitin-conjugating enzyme UBE2D2.{ECO:0000269|PubMed:23402750}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TMEM54 | chr1:33363727 | chr1:33631167 | ENST00000329151 | - | 2 | 5 | 22_42 | 70 | 170 | Transmembrane | Helical |
| Hgene | TMEM54 | chr1:33363727 | chr1:33631167 | ENST00000373463 | - | 2 | 6 | 22_42 | 70 | 223 | Transmembrane | Helical |
| Tgene | >TRIM62 | chr1:33363727 | chr1:33631167 | ENST00000291416 | - | 0 | 5 | 277_475 | 136 | 476 | Domain | B30.2/SPRY |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TMEM54 | chr1:33363727 | chr1:33631167 | ENST00000329151 | - | 2 | 5 | 100_120 | 70 | 170 | Transmembrane | Helical |
| Hgene | >TMEM54 | chr1:33363727 | chr1:33631167 | ENST00000329151 | - | 2 | 5 | 155_175 | 70 | 170 | Transmembrane | Helical |
| Hgene | >TMEM54 | chr1:33363727 | chr1:33631167 | ENST00000329151 | - | 2 | 5 | 62_82 | 70 | 170 | Transmembrane | Helical |
| Hgene | >TMEM54 | chr1:33363727 | chr1:33631167 | ENST00000373463 | - | 2 | 6 | 100_120 | 70 | 223 | Transmembrane | Helical |
| Hgene | >TMEM54 | chr1:33363727 | chr1:33631167 | ENST00000373463 | - | 2 | 6 | 155_175 | 70 | 223 | Transmembrane | Helical |
| Hgene | >TMEM54 | chr1:33363727 | chr1:33631167 | ENST00000373463 | - | 2 | 6 | 62_82 | 70 | 223 | Transmembrane | Helical |
| Tgene | TRIM62 | chr1:33363727 | chr1:33631167 | ENST00000291416 | - | 0 | 5 | 127_241 | 136 | 476 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | TRIM62 | chr1:33363727 | chr1:33631167 | ENST00000291416 | - | 0 | 5 | 11_54 | 136 | 476 | Zinc finger | RING-type |
| Tgene | TRIM62 | chr1:33363727 | chr1:33631167 | ENST00000291416 | - | 0 | 5 | 88_128 | 136 | 476 | Zinc finger | B box-type |
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FusionGeneSequence for TMEM54_TRIM62 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TMEM54_ENST00000373463_chr1_33363727_-_TRIM62_ENST00000291416_chr1_33631167_-_410aa MCLRLGGLSVGDFRKVLMKTGLVLVVLGHVSFITAALFHGTVLRYVGTPQDAVALQYCVVNILSVTSAIVRELKDQLQALQDSEREHTEA LQLLKRQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQERLAETDRHTFLA GVASLSERLKGKIHETNLTYEDFPTSKYTGPLQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDV EVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGNQYSACTEPWTRLNVRDKLDKVGVFLDYDQGL >In-frame_TMEM54_ENST00000373463_chr1_33363727_-_TRIM62_ENST00000543586_chr1_33631167_-_410aa MCLRLGGLSVGDFRKVLMKTGLVLVVLGHVSFITAALFHGTVLRYVGTPQDAVALQYCVVNILSVTSAIVRELKDQLQALQDSEREHTEA LQLLKRQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQERLAETDRHTFLA GVASLSERLKGKIHETNLTYEDFPTSKYTGPLQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDV EVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGNQYSACTEPWTRLNVRDKLDKVGVFLDYDQGL >In-frame_TMEM54_ENST00000329151_chr1_33363727_-_TRIM62_ENST00000291416_chr1_33631167_-_410aa MCLRLGGLSVGDFRKVLMKTGLVLVVLGHVSFITAALFHGTVLRYVGTPQDAVALQYCVVNILSVTSAIVRELKDQLQALQDSEREHTEA LQLLKRQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQERLAETDRHTFLA GVASLSERLKGKIHETNLTYEDFPTSKYTGPLQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDV EVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGNQYSACTEPWTRLNVRDKLDKVGVFLDYDQGL >In-frame_TMEM54_ENST00000329151_chr1_33363727_-_TRIM62_ENST00000543586_chr1_33631167_-_410aa MCLRLGGLSVGDFRKVLMKTGLVLVVLGHVSFITAALFHGTVLRYVGTPQDAVALQYCVVNILSVTSAIVRELKDQLQALQDSEREHTEA LQLLKRQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQERLAETDRHTFLA GVASLSERLKGKIHETNLTYEDFPTSKYTGPLQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDV EVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGNQYSACTEPWTRLNVRDKLDKVGVFLDYDQGL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TMEM54_ENST00000373463_chr1_33363727_-_TRIM62_ENST00000291416_chr1_33631167_-_1230nt ATGTGTCTGCGCCTCGGAGGCCTGAGTGTGGGCGACTTCCGGAAGGTGCTGATGAAGACAGGCCTGGTGCTGGTGGTGCTGGGCCATGTG AGCTTCATCACAGCTGCCCTGTTCCATGGCACAGTGCTGCGCTACGTGGGCACCCCTCAAGATGCGGTGGCTCTGCAGTACTGCGTGGTC AACATCCTCTCTGTCACTTCCGCCATCGTGAGGGAGCTGAAGGACCAACTTCAGGCCCTTCAAGACAGCGAGCGGGAACACACCGAAGCG CTGCAGCTGCTCAAGCGACAACTGGCGGAGACCAAGTCTTCCACCAAGAGCCTGCGGACCACTATCGGCGAGGCCTTCGAGCGGCTGCAC CGGCTGCTGCGTGAACGCCAGAAGGCCATGCTAGAGGAGCTGGAGGCGGACACGGCCCGCACGCTGACCGACATCGAGCAGAAAGTCCAG CGCTACAGCCAGCAGCTGCGCAAGGTCCAGGAGGGAGCCCAGATCCTGCAGGAGCGGCTGGCTGAAACCGACCGGCACACCTTCCTGGCT GGGGTGGCCTCACTGTCCGAGCGGCTCAAGGGAAAAATCCATGAGACCAACCTCACATATGAAGACTTCCCGACCTCCAAGTACACAGGC CCCCTGCAGTACACCATCTGGAAGTCCCTGTTCCAGGACATCCACCCAGTGCCAGCCGCCCTAACCCTGGACCCGGGCACAGCCCACCAG CGCCTGATCCTGTCGGACGACTGCACCATTGTGGCTTACGGCAACTTGCACCCACAGCCACTGCAGGACTCGCCAAAGCGCTTCGATGTG GAGGTGTCGGTGCTGGGTTCTGAAGCCTTCAGTAGTGGCGTCCACTACTGGGAGGTGGTGGTGGCGGAGAAGACCCAGTGGGTGATCGGG CTGGCACACGAAGCCGCAAGCCGCAAGGGCAGCATCCAGATCCAGCCCAGCCGCGGCTTCTACTGCATCGTGATGCACGATGGCAACCAG TACAGCGCCTGCACGGAGCCCTGGACGCGGCTTAACGTCCGGGACAAGCTTGACAAGGTGGGTGTCTTCCTGGACTATGACCAAGGCTTG CTCATCTTCTACAATGCTGATGACATGTCCTGGCTCTACACCTTCCGCGAGAAGTTCCCTGGCAAGCTCTGCTCTTACTTCAGCCCTGGC >In-frame_TMEM54_ENST00000373463_chr1_33363727_-_TRIM62_ENST00000543586_chr1_33631167_-_1230nt ATGTGTCTGCGCCTCGGAGGCCTGAGTGTGGGCGACTTCCGGAAGGTGCTGATGAAGACAGGCCTGGTGCTGGTGGTGCTGGGCCATGTG AGCTTCATCACAGCTGCCCTGTTCCATGGCACAGTGCTGCGCTACGTGGGCACCCCTCAAGATGCGGTGGCTCTGCAGTACTGCGTGGTC AACATCCTCTCTGTCACTTCCGCCATCGTGAGGGAGCTGAAGGACCAACTTCAGGCCCTTCAAGACAGCGAGCGGGAACACACCGAAGCG CTGCAGCTGCTCAAGCGACAACTGGCGGAGACCAAGTCTTCCACCAAGAGCCTGCGGACCACTATCGGCGAGGCCTTCGAGCGGCTGCAC CGGCTGCTGCGTGAACGCCAGAAGGCCATGCTAGAGGAGCTGGAGGCGGACACGGCCCGCACGCTGACCGACATCGAGCAGAAAGTCCAG CGCTACAGCCAGCAGCTGCGCAAGGTCCAGGAGGGAGCCCAGATCCTGCAGGAGCGGCTGGCTGAAACCGACCGGCACACCTTCCTGGCT GGGGTGGCCTCACTGTCCGAGCGGCTCAAGGGAAAAATCCATGAGACCAACCTCACATATGAAGACTTCCCGACCTCCAAGTACACAGGC CCCCTGCAGTACACCATCTGGAAGTCCCTGTTCCAGGACATCCACCCAGTGCCAGCCGCCCTAACCCTGGACCCGGGCACAGCCCACCAG CGCCTGATCCTGTCGGACGACTGCACCATTGTGGCTTACGGCAACTTGCACCCACAGCCACTGCAGGACTCGCCAAAGCGCTTCGATGTG GAGGTGTCGGTGCTGGGTTCTGAAGCCTTCAGTAGTGGCGTCCACTACTGGGAGGTGGTGGTGGCGGAGAAGACCCAGTGGGTGATCGGG CTGGCACACGAAGCCGCAAGCCGCAAGGGCAGCATCCAGATCCAGCCCAGCCGCGGCTTCTACTGCATCGTGATGCACGATGGCAACCAG TACAGCGCCTGCACGGAGCCCTGGACGCGGCTTAACGTCCGGGACAAGCTTGACAAGGTGGGTGTCTTCCTGGACTATGACCAAGGCTTG CTCATCTTCTACAATGCTGATGACATGTCCTGGCTCTACACCTTCCGCGAGAAGTTCCCTGGCAAGCTCTGCTCTTACTTCAGCCCTGGC >In-frame_TMEM54_ENST00000329151_chr1_33363727_-_TRIM62_ENST00000291416_chr1_33631167_-_1230nt ATGTGTCTGCGCCTCGGAGGCCTGAGTGTGGGCGACTTCCGGAAGGTGCTGATGAAGACAGGCCTGGTGCTGGTGGTGCTGGGCCATGTG AGCTTCATCACAGCTGCCCTGTTCCATGGCACAGTGCTGCGCTACGTGGGCACCCCTCAAGATGCGGTGGCTCTGCAGTACTGCGTGGTC AACATCCTCTCTGTCACTTCCGCCATCGTGAGGGAGCTGAAGGACCAACTTCAGGCCCTTCAAGACAGCGAGCGGGAACACACCGAAGCG CTGCAGCTGCTCAAGCGACAACTGGCGGAGACCAAGTCTTCCACCAAGAGCCTGCGGACCACTATCGGCGAGGCCTTCGAGCGGCTGCAC CGGCTGCTGCGTGAACGCCAGAAGGCCATGCTAGAGGAGCTGGAGGCGGACACGGCCCGCACGCTGACCGACATCGAGCAGAAAGTCCAG CGCTACAGCCAGCAGCTGCGCAAGGTCCAGGAGGGAGCCCAGATCCTGCAGGAGCGGCTGGCTGAAACCGACCGGCACACCTTCCTGGCT GGGGTGGCCTCACTGTCCGAGCGGCTCAAGGGAAAAATCCATGAGACCAACCTCACATATGAAGACTTCCCGACCTCCAAGTACACAGGC CCCCTGCAGTACACCATCTGGAAGTCCCTGTTCCAGGACATCCACCCAGTGCCAGCCGCCCTAACCCTGGACCCGGGCACAGCCCACCAG CGCCTGATCCTGTCGGACGACTGCACCATTGTGGCTTACGGCAACTTGCACCCACAGCCACTGCAGGACTCGCCAAAGCGCTTCGATGTG GAGGTGTCGGTGCTGGGTTCTGAAGCCTTCAGTAGTGGCGTCCACTACTGGGAGGTGGTGGTGGCGGAGAAGACCCAGTGGGTGATCGGG CTGGCACACGAAGCCGCAAGCCGCAAGGGCAGCATCCAGATCCAGCCCAGCCGCGGCTTCTACTGCATCGTGATGCACGATGGCAACCAG TACAGCGCCTGCACGGAGCCCTGGACGCGGCTTAACGTCCGGGACAAGCTTGACAAGGTGGGTGTCTTCCTGGACTATGACCAAGGCTTG CTCATCTTCTACAATGCTGATGACATGTCCTGGCTCTACACCTTCCGCGAGAAGTTCCCTGGCAAGCTCTGCTCTTACTTCAGCCCTGGC >In-frame_TMEM54_ENST00000329151_chr1_33363727_-_TRIM62_ENST00000543586_chr1_33631167_-_1230nt ATGTGTCTGCGCCTCGGAGGCCTGAGTGTGGGCGACTTCCGGAAGGTGCTGATGAAGACAGGCCTGGTGCTGGTGGTGCTGGGCCATGTG AGCTTCATCACAGCTGCCCTGTTCCATGGCACAGTGCTGCGCTACGTGGGCACCCCTCAAGATGCGGTGGCTCTGCAGTACTGCGTGGTC AACATCCTCTCTGTCACTTCCGCCATCGTGAGGGAGCTGAAGGACCAACTTCAGGCCCTTCAAGACAGCGAGCGGGAACACACCGAAGCG CTGCAGCTGCTCAAGCGACAACTGGCGGAGACCAAGTCTTCCACCAAGAGCCTGCGGACCACTATCGGCGAGGCCTTCGAGCGGCTGCAC CGGCTGCTGCGTGAACGCCAGAAGGCCATGCTAGAGGAGCTGGAGGCGGACACGGCCCGCACGCTGACCGACATCGAGCAGAAAGTCCAG CGCTACAGCCAGCAGCTGCGCAAGGTCCAGGAGGGAGCCCAGATCCTGCAGGAGCGGCTGGCTGAAACCGACCGGCACACCTTCCTGGCT GGGGTGGCCTCACTGTCCGAGCGGCTCAAGGGAAAAATCCATGAGACCAACCTCACATATGAAGACTTCCCGACCTCCAAGTACACAGGC CCCCTGCAGTACACCATCTGGAAGTCCCTGTTCCAGGACATCCACCCAGTGCCAGCCGCCCTAACCCTGGACCCGGGCACAGCCCACCAG CGCCTGATCCTGTCGGACGACTGCACCATTGTGGCTTACGGCAACTTGCACCCACAGCCACTGCAGGACTCGCCAAAGCGCTTCGATGTG GAGGTGTCGGTGCTGGGTTCTGAAGCCTTCAGTAGTGGCGTCCACTACTGGGAGGTGGTGGTGGCGGAGAAGACCCAGTGGGTGATCGGG CTGGCACACGAAGCCGCAAGCCGCAAGGGCAGCATCCAGATCCAGCCCAGCCGCGGCTTCTACTGCATCGTGATGCACGATGGCAACCAG TACAGCGCCTGCACGGAGCCCTGGACGCGGCTTAACGTCCGGGACAAGCTTGACAAGGTGGGTGTCTTCCTGGACTATGACCAAGGCTTG CTCATCTTCTACAATGCTGATGACATGTCCTGGCTCTACACCTTCCGCGAGAAGTTCCCTGGCAAGCTCTGCTCTTACTTCAGCCCTGGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TMEM54_ENST00000373463_chr1_33363727_-_TRIM62_ENST00000291416_chr1_33631167_-_3125nt CGAGCGCGACGGTGCGGGGCGCGCGGGCGACGGGCCAGCGGGATGGGAGCAGGGTCCCCCGGCGGCCCGCAGCCTCGGGAGCCGCGCTGA AGCCGGGGGCGGGACCAGCGCGGAGCCGACATGTGTCTGCGCCTCGGAGGCCTGAGTGTGGGCGACTTCCGGAAGGTGCTGATGAAGACA GGCCTGGTGCTGGTGGTGCTGGGCCATGTGAGCTTCATCACAGCTGCCCTGTTCCATGGCACAGTGCTGCGCTACGTGGGCACCCCTCAA GATGCGGTGGCTCTGCAGTACTGCGTGGTCAACATCCTCTCTGTCACTTCCGCCATCGTGAGGGAGCTGAAGGACCAACTTCAGGCCCTT CAAGACAGCGAGCGGGAACACACCGAAGCGCTGCAGCTGCTCAAGCGACAACTGGCGGAGACCAAGTCTTCCACCAAGAGCCTGCGGACC ACTATCGGCGAGGCCTTCGAGCGGCTGCACCGGCTGCTGCGTGAACGCCAGAAGGCCATGCTAGAGGAGCTGGAGGCGGACACGGCCCGC ACGCTGACCGACATCGAGCAGAAAGTCCAGCGCTACAGCCAGCAGCTGCGCAAGGTCCAGGAGGGAGCCCAGATCCTGCAGGAGCGGCTG GCTGAAACCGACCGGCACACCTTCCTGGCTGGGGTGGCCTCACTGTCCGAGCGGCTCAAGGGAAAAATCCATGAGACCAACCTCACATAT GAAGACTTCCCGACCTCCAAGTACACAGGCCCCCTGCAGTACACCATCTGGAAGTCCCTGTTCCAGGACATCCACCCAGTGCCAGCCGCC CTAACCCTGGACCCGGGCACAGCCCACCAGCGCCTGATCCTGTCGGACGACTGCACCATTGTGGCTTACGGCAACTTGCACCCACAGCCA CTGCAGGACTCGCCAAAGCGCTTCGATGTGGAGGTGTCGGTGCTGGGTTCTGAAGCCTTCAGTAGTGGCGTCCACTACTGGGAGGTGGTG GTGGCGGAGAAGACCCAGTGGGTGATCGGGCTGGCACACGAAGCCGCAAGCCGCAAGGGCAGCATCCAGATCCAGCCCAGCCGCGGCTTC TACTGCATCGTGATGCACGATGGCAACCAGTACAGCGCCTGCACGGAGCCCTGGACGCGGCTTAACGTCCGGGACAAGCTTGACAAGGTG GGTGTCTTCCTGGACTATGACCAAGGCTTGCTCATCTTCTACAATGCTGATGACATGTCCTGGCTCTACACCTTCCGCGAGAAGTTCCCT GGCAAGCTCTGCTCTTACTTCAGCCCTGGCCAGAGCCACGCCAATGGCAAGAACGTTCAGCCGCTGCGGATCAACACCGTCCGCATCTAG TCCAGGCAGAAGGAGACCACAACCTCCTGGGACCACTGCCACCTGCAAGAGCCCTGCCCAGGAGATAGAAGACCTGGACTCCAGCCCACC GTGGCCACTGGAGACCTCAGGCCAGTTGTTTACCCTCCAGCCTCCAGTCTGTAAAATGGAGGTTGCATTCCCTACTTCCTAAACTCTCTT CCAGCATCGATGTTCTGTAGCTCTGACCTTGATAGGGATACAGCTTTGATCCAAGGATGTGACATGGCTTCTCCTCAGGGCAACCCCTGC CCAACCCTCATCCCCATCTTCTCAGGGGCAGGGGACTACCTTCCAGTGTCTCCCTCCAGCCCAGCCCTGACCTCAGGAAGTGTCAGAGCA TGGCCAGTAGTTGGCAGCCCGAAAGACACACAGCACCCTCTTATGTCCCATGGCCTAAGACTTACCCCTGACCAAGCTAGTGATGGGCCA TTTACCCTTGACCCCAGTCCACAGTGGTCACAGGTAGTACCTGGTCCTAGGGTTGCCTGAGAGCCAACCTCTCCTGCCACCCCCACACCA AGAACTATATGGTTCCTACTTCTCCCACTGATCTGCTGGTCAGTGATGATGCTGTGGCCTGTGGAAGGCACCTGGTAGTTGAGTCCACAC ATTATAGTCATGTGCCACCACCTTCCTGCCCACAGGCCGAGGGACAGGGTGAGGGTATACCCAAAGCTGATGCAGAGCCCATTAGCCTAA AAGCAACTGCAGGACAAGCCTCCCTGGATGATCGAGGTCCCCAGTAGCTCTGAACAAGAGTCCAGCCAACCCTCTTCAGCCAGGCCTCTG TGACCTGCTAGGGTGCAGGAGGCTTCCAGAAGCAGTTGTTGTAATTAGGACCCAAGCACTGGGAGGGGCTGTTGGCTGGACCCCTTGTCA GACTTGGCATCTATCTCAGTTAGGATCCTGCTGCAGAAAACAAGAGCCACTTGTAGCTGGTTTAATTAGACAAGGATTTACTACCTGGCC CCTGGTGGCTTGCAAAATTGTTGGAAGAGCTGGAGAAGCAGACTCTGCTGAATTTCCAGGAACTCCCAGCGCCAGATTCATCATGTCTGT TGTGACCAGGAAAGCTGCCCCCATCTGCAGGAAGCCACTATGCCAGAAAGCTGCTGACTGCAGAACTAGGCTCCCTCTGCCACGGTCCGT GCCAGCCAATAGATGTCCTGAGGCCTGCCCCTCTCCCACTTCACTCAGTTCCCAAATCTAAATTTTTACAAGAGATTCTGTTTGGGGGAA CTTAAGTCAGATCCAGAACCTTGGCTGCAAGGGAGTCTGGGAAATGTCATTTCCCTAGAAGGAAGTTAGGGTGGGTGGAGCAAGCCCCAC CTGCGTTTTTCTGCCACAGCATCCAATCGTGAAGAACTCGGGAGAGGGTGGAGTCCACATCTAGGGTTGTCCTGCCCCTTGGCTCTATCC CTGCCCAGAGGTGGGAACTGGAGGAGTGGGCTGCAAGACTGAGCCTAAATGTCTCCCCGGCCTTGACTTTTCTTTCTAGTCCTGGGGCCT AGATTCTGCACTTGGGGTCTCTGACACAACACACCATCCCAAAGTAGCCGGAAGAGCTAAACACAGGGGGTTCTTAAAATGGCTGCCCCC GCCACCCGGGCCTCCCTTGGGCAAAAGGAATTGTCAGCCCTACCCCAACCCTTCAACTACCAGAATCTGGGCCACCCCAGCAGTATTTTT >In-frame_TMEM54_ENST00000373463_chr1_33363727_-_TRIM62_ENST00000543586_chr1_33631167_-_1825nt CGAGCGCGACGGTGCGGGGCGCGCGGGCGACGGGCCAGCGGGATGGGAGCAGGGTCCCCCGGCGGCCCGCAGCCTCGGGAGCCGCGCTGA AGCCGGGGGCGGGACCAGCGCGGAGCCGACATGTGTCTGCGCCTCGGAGGCCTGAGTGTGGGCGACTTCCGGAAGGTGCTGATGAAGACA GGCCTGGTGCTGGTGGTGCTGGGCCATGTGAGCTTCATCACAGCTGCCCTGTTCCATGGCACAGTGCTGCGCTACGTGGGCACCCCTCAA GATGCGGTGGCTCTGCAGTACTGCGTGGTCAACATCCTCTCTGTCACTTCCGCCATCGTGAGGGAGCTGAAGGACCAACTTCAGGCCCTT CAAGACAGCGAGCGGGAACACACCGAAGCGCTGCAGCTGCTCAAGCGACAACTGGCGGAGACCAAGTCTTCCACCAAGAGCCTGCGGACC ACTATCGGCGAGGCCTTCGAGCGGCTGCACCGGCTGCTGCGTGAACGCCAGAAGGCCATGCTAGAGGAGCTGGAGGCGGACACGGCCCGC ACGCTGACCGACATCGAGCAGAAAGTCCAGCGCTACAGCCAGCAGCTGCGCAAGGTCCAGGAGGGAGCCCAGATCCTGCAGGAGCGGCTG GCTGAAACCGACCGGCACACCTTCCTGGCTGGGGTGGCCTCACTGTCCGAGCGGCTCAAGGGAAAAATCCATGAGACCAACCTCACATAT GAAGACTTCCCGACCTCCAAGTACACAGGCCCCCTGCAGTACACCATCTGGAAGTCCCTGTTCCAGGACATCCACCCAGTGCCAGCCGCC CTAACCCTGGACCCGGGCACAGCCCACCAGCGCCTGATCCTGTCGGACGACTGCACCATTGTGGCTTACGGCAACTTGCACCCACAGCCA CTGCAGGACTCGCCAAAGCGCTTCGATGTGGAGGTGTCGGTGCTGGGTTCTGAAGCCTTCAGTAGTGGCGTCCACTACTGGGAGGTGGTG GTGGCGGAGAAGACCCAGTGGGTGATCGGGCTGGCACACGAAGCCGCAAGCCGCAAGGGCAGCATCCAGATCCAGCCCAGCCGCGGCTTC TACTGCATCGTGATGCACGATGGCAACCAGTACAGCGCCTGCACGGAGCCCTGGACGCGGCTTAACGTCCGGGACAAGCTTGACAAGGTG GGTGTCTTCCTGGACTATGACCAAGGCTTGCTCATCTTCTACAATGCTGATGACATGTCCTGGCTCTACACCTTCCGCGAGAAGTTCCCT GGCAAGCTCTGCTCTTACTTCAGCCCTGGCCAGAGCCACGCCAATGGCAAGAACGTTCAGCCGCTGCGGATCAACACCGTCCGCATCTAG TCCAGGCAGAAGGAGACCACAACCTCCTGGGACCACTGCCACCTGCAAGAGCCCTGCCCAGGAGATAGAAGACCTGGACTCCAGCCCACC GTGGCCACTGGAGACCTCAGGCCAGTTGTTTACCCTCCAGCCTCCAGTCTGTAAAATGGAGGTTGCATTCCCTACTTCCTAAACTCTCTT CCAGCATCGATGTTCTGTAGCTCTGACCTTGATAGGGATACAGCTTTGATCCAAGGATGTGACATGGCTTCTCCTCAGGGCAACCCCTGC CCAACCCTCATCCCCATCTTCTCAGGGGCAGGGGACTACCTTCCAGTGTCTCCCTCCAGCCCAGCCCTGACCTCAGGAAGTGTCAGAGCA TGGCCAGTAGTTGGCAGCCCGAAAGACACACAGCACCCTCTTATGTCCCATGGCCTAAGACTTACCCCTGACCAAGCTAGTGATGGGCCA >In-frame_TMEM54_ENST00000329151_chr1_33363727_-_TRIM62_ENST00000291416_chr1_33631167_-_3156nt GCCCAGCCCCGGGCTCCGGGCGGGAAGTGGGCGAGCGCGACGGTGCGGGGCGCGCGGGCGACGGGCCAGCGGGATGGGAGCAGGGTCCCC CGGCGGCCCGCAGCCTCGGGAGCCGCGCTGAAGCCGGGGGCGGGACCAGCGCGGAGCCGACATGTGTCTGCGCCTCGGAGGCCTGAGTGT GGGCGACTTCCGGAAGGTGCTGATGAAGACAGGCCTGGTGCTGGTGGTGCTGGGCCATGTGAGCTTCATCACAGCTGCCCTGTTCCATGG CACAGTGCTGCGCTACGTGGGCACCCCTCAAGATGCGGTGGCTCTGCAGTACTGCGTGGTCAACATCCTCTCTGTCACTTCCGCCATCGT GAGGGAGCTGAAGGACCAACTTCAGGCCCTTCAAGACAGCGAGCGGGAACACACCGAAGCGCTGCAGCTGCTCAAGCGACAACTGGCGGA GACCAAGTCTTCCACCAAGAGCCTGCGGACCACTATCGGCGAGGCCTTCGAGCGGCTGCACCGGCTGCTGCGTGAACGCCAGAAGGCCAT GCTAGAGGAGCTGGAGGCGGACACGGCCCGCACGCTGACCGACATCGAGCAGAAAGTCCAGCGCTACAGCCAGCAGCTGCGCAAGGTCCA GGAGGGAGCCCAGATCCTGCAGGAGCGGCTGGCTGAAACCGACCGGCACACCTTCCTGGCTGGGGTGGCCTCACTGTCCGAGCGGCTCAA GGGAAAAATCCATGAGACCAACCTCACATATGAAGACTTCCCGACCTCCAAGTACACAGGCCCCCTGCAGTACACCATCTGGAAGTCCCT GTTCCAGGACATCCACCCAGTGCCAGCCGCCCTAACCCTGGACCCGGGCACAGCCCACCAGCGCCTGATCCTGTCGGACGACTGCACCAT TGTGGCTTACGGCAACTTGCACCCACAGCCACTGCAGGACTCGCCAAAGCGCTTCGATGTGGAGGTGTCGGTGCTGGGTTCTGAAGCCTT CAGTAGTGGCGTCCACTACTGGGAGGTGGTGGTGGCGGAGAAGACCCAGTGGGTGATCGGGCTGGCACACGAAGCCGCAAGCCGCAAGGG CAGCATCCAGATCCAGCCCAGCCGCGGCTTCTACTGCATCGTGATGCACGATGGCAACCAGTACAGCGCCTGCACGGAGCCCTGGACGCG GCTTAACGTCCGGGACAAGCTTGACAAGGTGGGTGTCTTCCTGGACTATGACCAAGGCTTGCTCATCTTCTACAATGCTGATGACATGTC CTGGCTCTACACCTTCCGCGAGAAGTTCCCTGGCAAGCTCTGCTCTTACTTCAGCCCTGGCCAGAGCCACGCCAATGGCAAGAACGTTCA GCCGCTGCGGATCAACACCGTCCGCATCTAGTCCAGGCAGAAGGAGACCACAACCTCCTGGGACCACTGCCACCTGCAAGAGCCCTGCCC AGGAGATAGAAGACCTGGACTCCAGCCCACCGTGGCCACTGGAGACCTCAGGCCAGTTGTTTACCCTCCAGCCTCCAGTCTGTAAAATGG AGGTTGCATTCCCTACTTCCTAAACTCTCTTCCAGCATCGATGTTCTGTAGCTCTGACCTTGATAGGGATACAGCTTTGATCCAAGGATG TGACATGGCTTCTCCTCAGGGCAACCCCTGCCCAACCCTCATCCCCATCTTCTCAGGGGCAGGGGACTACCTTCCAGTGTCTCCCTCCAG CCCAGCCCTGACCTCAGGAAGTGTCAGAGCATGGCCAGTAGTTGGCAGCCCGAAAGACACACAGCACCCTCTTATGTCCCATGGCCTAAG ACTTACCCCTGACCAAGCTAGTGATGGGCCATTTACCCTTGACCCCAGTCCACAGTGGTCACAGGTAGTACCTGGTCCTAGGGTTGCCTG AGAGCCAACCTCTCCTGCCACCCCCACACCAAGAACTATATGGTTCCTACTTCTCCCACTGATCTGCTGGTCAGTGATGATGCTGTGGCC TGTGGAAGGCACCTGGTAGTTGAGTCCACACATTATAGTCATGTGCCACCACCTTCCTGCCCACAGGCCGAGGGACAGGGTGAGGGTATA CCCAAAGCTGATGCAGAGCCCATTAGCCTAAAAGCAACTGCAGGACAAGCCTCCCTGGATGATCGAGGTCCCCAGTAGCTCTGAACAAGA GTCCAGCCAACCCTCTTCAGCCAGGCCTCTGTGACCTGCTAGGGTGCAGGAGGCTTCCAGAAGCAGTTGTTGTAATTAGGACCCAAGCAC TGGGAGGGGCTGTTGGCTGGACCCCTTGTCAGACTTGGCATCTATCTCAGTTAGGATCCTGCTGCAGAAAACAAGAGCCACTTGTAGCTG GTTTAATTAGACAAGGATTTACTACCTGGCCCCTGGTGGCTTGCAAAATTGTTGGAAGAGCTGGAGAAGCAGACTCTGCTGAATTTCCAG GAACTCCCAGCGCCAGATTCATCATGTCTGTTGTGACCAGGAAAGCTGCCCCCATCTGCAGGAAGCCACTATGCCAGAAAGCTGCTGACT GCAGAACTAGGCTCCCTCTGCCACGGTCCGTGCCAGCCAATAGATGTCCTGAGGCCTGCCCCTCTCCCACTTCACTCAGTTCCCAAATCT AAATTTTTACAAGAGATTCTGTTTGGGGGAACTTAAGTCAGATCCAGAACCTTGGCTGCAAGGGAGTCTGGGAAATGTCATTTCCCTAGA AGGAAGTTAGGGTGGGTGGAGCAAGCCCCACCTGCGTTTTTCTGCCACAGCATCCAATCGTGAAGAACTCGGGAGAGGGTGGAGTCCACA TCTAGGGTTGTCCTGCCCCTTGGCTCTATCCCTGCCCAGAGGTGGGAACTGGAGGAGTGGGCTGCAAGACTGAGCCTAAATGTCTCCCCG GCCTTGACTTTTCTTTCTAGTCCTGGGGCCTAGATTCTGCACTTGGGGTCTCTGACACAACACACCATCCCAAAGTAGCCGGAAGAGCTA AACACAGGGGGTTCTTAAAATGGCTGCCCCCGCCACCCGGGCCTCCCTTGGGCAAAAGGAATTGTCAGCCCTACCCCAACCCTTCAACTA CCAGAATCTGGGCCACCCCAGCAGTATTTTTATTTAAAATGTTGCCCATTTTATGAGTTATGATCAATTTGTATTAAATTAAAGTTACAG >In-frame_TMEM54_ENST00000329151_chr1_33363727_-_TRIM62_ENST00000543586_chr1_33631167_-_1856nt GCCCAGCCCCGGGCTCCGGGCGGGAAGTGGGCGAGCGCGACGGTGCGGGGCGCGCGGGCGACGGGCCAGCGGGATGGGAGCAGGGTCCCC CGGCGGCCCGCAGCCTCGGGAGCCGCGCTGAAGCCGGGGGCGGGACCAGCGCGGAGCCGACATGTGTCTGCGCCTCGGAGGCCTGAGTGT GGGCGACTTCCGGAAGGTGCTGATGAAGACAGGCCTGGTGCTGGTGGTGCTGGGCCATGTGAGCTTCATCACAGCTGCCCTGTTCCATGG CACAGTGCTGCGCTACGTGGGCACCCCTCAAGATGCGGTGGCTCTGCAGTACTGCGTGGTCAACATCCTCTCTGTCACTTCCGCCATCGT GAGGGAGCTGAAGGACCAACTTCAGGCCCTTCAAGACAGCGAGCGGGAACACACCGAAGCGCTGCAGCTGCTCAAGCGACAACTGGCGGA GACCAAGTCTTCCACCAAGAGCCTGCGGACCACTATCGGCGAGGCCTTCGAGCGGCTGCACCGGCTGCTGCGTGAACGCCAGAAGGCCAT GCTAGAGGAGCTGGAGGCGGACACGGCCCGCACGCTGACCGACATCGAGCAGAAAGTCCAGCGCTACAGCCAGCAGCTGCGCAAGGTCCA GGAGGGAGCCCAGATCCTGCAGGAGCGGCTGGCTGAAACCGACCGGCACACCTTCCTGGCTGGGGTGGCCTCACTGTCCGAGCGGCTCAA GGGAAAAATCCATGAGACCAACCTCACATATGAAGACTTCCCGACCTCCAAGTACACAGGCCCCCTGCAGTACACCATCTGGAAGTCCCT GTTCCAGGACATCCACCCAGTGCCAGCCGCCCTAACCCTGGACCCGGGCACAGCCCACCAGCGCCTGATCCTGTCGGACGACTGCACCAT TGTGGCTTACGGCAACTTGCACCCACAGCCACTGCAGGACTCGCCAAAGCGCTTCGATGTGGAGGTGTCGGTGCTGGGTTCTGAAGCCTT CAGTAGTGGCGTCCACTACTGGGAGGTGGTGGTGGCGGAGAAGACCCAGTGGGTGATCGGGCTGGCACACGAAGCCGCAAGCCGCAAGGG CAGCATCCAGATCCAGCCCAGCCGCGGCTTCTACTGCATCGTGATGCACGATGGCAACCAGTACAGCGCCTGCACGGAGCCCTGGACGCG GCTTAACGTCCGGGACAAGCTTGACAAGGTGGGTGTCTTCCTGGACTATGACCAAGGCTTGCTCATCTTCTACAATGCTGATGACATGTC CTGGCTCTACACCTTCCGCGAGAAGTTCCCTGGCAAGCTCTGCTCTTACTTCAGCCCTGGCCAGAGCCACGCCAATGGCAAGAACGTTCA GCCGCTGCGGATCAACACCGTCCGCATCTAGTCCAGGCAGAAGGAGACCACAACCTCCTGGGACCACTGCCACCTGCAAGAGCCCTGCCC AGGAGATAGAAGACCTGGACTCCAGCCCACCGTGGCCACTGGAGACCTCAGGCCAGTTGTTTACCCTCCAGCCTCCAGTCTGTAAAATGG AGGTTGCATTCCCTACTTCCTAAACTCTCTTCCAGCATCGATGTTCTGTAGCTCTGACCTTGATAGGGATACAGCTTTGATCCAAGGATG TGACATGGCTTCTCCTCAGGGCAACCCCTGCCCAACCCTCATCCCCATCTTCTCAGGGGCAGGGGACTACCTTCCAGTGTCTCCCTCCAG CCCAGCCCTGACCTCAGGAAGTGTCAGAGCATGGCCAGTAGTTGGCAGCCCGAAAGACACACAGCACCCTCTTATGTCCCATGGCCTAAG |
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FusionGenePPI for TMEM54_TRIM62 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TMEM54 | CDK2, RARA, HDAC1, PEX19, RBBP8, CREB3, LMNA | TRIM62 | SKIL, SMAD2, SMAD3, SFN, SNAP29, CCDC94, CNTROB, CARD9, UBE2D2, NRGN, NUP88 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMEM54_TRIM62 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMEM54_TRIM62 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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