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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38587

FusionGeneSummary for TMEM255A_FPR2

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM255A_FPR2
Fusion gene ID: 38587
HgeneTgene
Gene symbol

TMEM255A

FPR2

Gene ID

55026

2358

Gene nametransmembrane protein 255Aformyl peptide receptor 2
SynonymsFAM70AALXR|FMLP-R-II|FMLPX|FPR2A|FPRH1|FPRH2|FPRL1|HM63|LXA4R
Cytomap

Xq24

19q13.41

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 255Afamily with sequence similarity 70, member Aprotein FAM70AN-formyl peptide receptor 2FMLP-R-IFMLP-related receptor ILXA4 receptorRFPformyl peptide receptor-like 1lipoxin A4 receptor (formyl peptide receptor related)
Modification date2018051920180523
UniProtAcc

Q5JRV8

P25090

Ensembl transtripts involved in fusion geneENST00000309720, ENST00000371369, 
ENST00000371352, ENST00000440464, 
ENST00000480821, 		ENST00000340023, 
ENST00000598953, ENST00000598776, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 2 X 2=12
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TMEM255A [Title/Abstract] AND FPR2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFPR2

GO:1904646

cellular response to amyloid-beta

11316806


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-FX-A2QS-01ATMEM255AchrX

119438204

-FPR2chr19

52263285

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000309720ENST00000340023TMEM255AchrX

119438204

-FPR2chr19

52263285

+
5CDS-intronENST00000309720ENST00000598953TMEM255AchrX

119438204

-FPR2chr19

52263285

+
5CDS-intronENST00000309720ENST00000598776TMEM255AchrX

119438204

-FPR2chr19

52263285

+
5CDS-intronENST00000371369ENST00000340023TMEM255AchrX

119438204

-FPR2chr19

52263285

+
5CDS-intronENST00000371369ENST00000598953TMEM255AchrX

119438204

-FPR2chr19

52263285

+
5CDS-intronENST00000371369ENST00000598776TMEM255AchrX

119438204

-FPR2chr19

52263285

+
intron-intronENST00000371352ENST00000340023TMEM255AchrX

119438204

-FPR2chr19

52263285

+
intron-intronENST00000371352ENST00000598953TMEM255AchrX

119438204

-FPR2chr19

52263285

+
intron-intronENST00000371352ENST00000598776TMEM255AchrX

119438204

-FPR2chr19

52263285

+
5CDS-intronENST00000440464ENST00000340023TMEM255AchrX

119438204

-FPR2chr19

52263285

+
5CDS-intronENST00000440464ENST00000598953TMEM255AchrX

119438204

-FPR2chr19

52263285

+
5CDS-intronENST00000440464ENST00000598776TMEM255AchrX

119438204

-FPR2chr19

52263285

+
intron-intronENST00000480821ENST00000340023TMEM255AchrX

119438204

-FPR2chr19

52263285

+
intron-intronENST00000480821ENST00000598953TMEM255AchrX

119438204

-FPR2chr19

52263285

+
intron-intronENST00000480821ENST00000598776TMEM255AchrX

119438204

-FPR2chr19

52263285

+

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FusionProtFeatures for TMEM255A_FPR2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMEM255A

Q5JRV8

FPR2

P25090

Low affinity receptor for N-formyl-methionyl peptides,which are powerful neutrophils chemotactic factors. Binding ofFMLP to the receptor causes activation of neutrophils. Thisresponse is mediated via a G-protein that activates aphosphatidylinositol-calcium second messenger system. Theactivation of LXA4R could result in an anti-inflammatory outcomecounteracting the actions of proinflammatory signals such as LTB4(leukotriene B4).

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TMEM255A_FPR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMEM255A_FPR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMEM255AAPP, SEC24B, WWP2, ITCH, WWP1, COLGALT2, NEDD4, KCTD2, GCA, UBASH3B, ANKRD13DFPR2FUNDC2, REEP6, ATP2B3, SLC38A9, FNDC3A, SLC30A5, RRAGB, ELOVL2, ATP2B4, DOLK, ARL6IP1, RTN2, CERS5, TRIM4, CAMLG, C4orf32, REEP5, MFSD8, SLC7A2, ARAP1, GPR155, RTN4, MOSPD2, TMEM161B, SLC35F2, C6orf47, TMEM208, CHPT1, SLC30A6, ATP8, SLC19A2, GPR89A, LMBRD2, ATP2B2, HSDL1, LRRC8C, GK, SLC35B2, ATP12A, TMEM184B, MFSD5, PTPLB, SLC39A1, ARL6IP5, NOMO3, NCLN, ATP9A, FITM2, DYM, SYNGR2, XPO6, RRAGC, PIGN, ND4, CCDC132, RMND1, NIPA2, ALG10, TUBGCP4, ATP5B, PXMP2, NOMO1, SLC29A1, TMEM245, REEP4, CERS6, ATL2, MZT2B, PDXDC1, LMBR1, TTYH3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMEM255A_FPR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMEM255A_FPR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFPR2C0010346Crohn Disease1CTD_human