|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 38566 |
FusionGeneSummary for TMEM242_PREP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMEM242_PREP | Fusion gene ID: 38566 | Hgene | Tgene | Gene symbol | TMEM242 | PREP | Gene ID | 729515 | 5550 |
| Gene name | transmembrane protein 242 | prolyl endopeptidase | |
| Synonyms | BM033|C6orf35 | PE|PEP | |
| Cytomap | 6q25.3 | 6q21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transmembrane protein 242UPF0463 transmembrane protein C6orf35 | prolyl endopeptidasedJ355L5.1 (prolyl endopeptidase)post-proline cleaving enzymeprolyl oligopeptidase | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9NWH2 | P48147 | |
| Ensembl transtripts involved in fusion gene | ENST00000400788, ENST00000367144, | ENST00000369110, | |
| Fusion gene scores | * DoF score | 3 X 1 X 3=9 | 6 X 3 X 6=108 |
| # samples | 3 | 6 | |
| ** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TMEM242 [Title/Abstract] AND PREP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | THCA | TCGA-CE-A13K-01A | TMEM242 | chr6 | 157739814 | - | PREP | chr6 | 105845802 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000400788 | ENST00000369110 | TMEM242 | chr6 | 157739814 | - | PREP | chr6 | 105845802 | - |
| intron-3CDS | ENST00000367144 | ENST00000369110 | TMEM242 | chr6 | 157739814 | - | PREP | chr6 | 105845802 | - |
Top |
FusionProtFeatures for TMEM242_PREP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TMEM242 | PREP |
| Cleaves peptide bonds on the C-terminal side of prolylresidues within peptides that are up to approximately 30 aminoacids long. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TMEM242 | chr6:157739814 | chr6:105845802 | ENST00000400788 | - | 3 | 4 | 30_50 | 109 | 142 | Transmembrane | Helical |
| Hgene | TMEM242 | chr6:157739814 | chr6:105845802 | ENST00000400788 | - | 3 | 4 | 82_102 | 109 | 142 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for TMEM242_PREP |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TMEM242_ENST00000400788_chr6_157739814_-_PREP_ENST00000369110_chr6_105845802_-_805aa METAGAATGQPASGLEAPGSTNDRLFLVKGGIFLGTVAAAGMLAGFITTLSLAKKKSPEWFNKGSMATAALPESGSSLALRALGWGSLYA WCGVGVISFAVWKALGVHSVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIRGLYKERMTELYDYPKYSCHFKKGKRY FYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILSDDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCM AWTHDGKGMFYNSYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAELSDDGRYVLLSIREGCDPVNRLWYCDL QQESSGIAGILKWVKLIDNFEGEYDYVTNEGTVFTFKTNRQSPNYRVINIDFRDPEESKWKVLVPEHEKDVLEWIACVRSNFLVLCYLHD VKNILQLHDLTTGALLKTFPLDVGSIVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPRVFREVTVKGIDASDYQTVQIFYPSKD GTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISITPNYSVSRLIFVRHMGGILAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEY LIKEGYTSPKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYGCSDSKQHFEWLVKYSPLHNVKLPEAD |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TMEM242_ENST00000400788_chr6_157739814_-_PREP_ENST00000369110_chr6_105845802_-_2415nt ATGGAGACAGCGGGCGCTGCAACTGGGCAGCCGGCCTCTGGGCTGGAGGCTCCGGGGTCCACGAATGACCGGCTTTTCCTGGTTAAAGGT GGAATTTTCCTTGGTACCGTTGCTGCAGCGGGAATGCTAGCTGGATTTATTACAACATTATCATTGGCTAAAAAGAAAAGCCCTGAATGG TTCAATAAGGGAAGTATGGCCACGGCTGCATTACCGGAAAGCGGGTCTTCCCTTGCCTTGCGAGCTCTGGGCTGGGGCTCCCTGTATGCA TGGTGTGGGGTTGGTGTGATTAGCTTCGCAGTCTGGAAAGCTTTAGGAGTTCACAGTGTACAGGATTATCATGGTCATAAAATTTGTGAC CCTTACGCCTGGCTTGAAGACCCCGACAGTGAACAGACTAAGGCCTTTGTGGAGGCCCAGAATAAGATTACTGTGCCATTTCTTGAGCAG TGTCCCATCAGAGGTTTATACAAAGAGAGAATGACTGAACTATATGATTATCCCAAGTATAGTTGCCACTTCAAGAAAGGAAAACGGTAT TTTTATTTTTACAATACAGGTTTGCAGAACCAGCGAGTATTATATGTACAGGATTCCTTAGAGGGTGAGGCCAGAGTGTTCCTGGACCCC AACATACTGTCTGACGATGGCACAGTGGCACTCCGAGGTTATGCGTTCAGCGAAGATGGTGAATATTTTGCCTATGGTCTGAGTGCCAGT GGCTCAGACTGGGTGACAATCAAGTTCATGAAAGTTGATGGTGCCAAAGAGCTTCCAGATGTGCTTGAAAGAGTCAAGTTCAGCTGTATG GCCTGGACCCATGATGGGAAGGGAATGTTCTACAACTCATACCCTCAACAGGATGGAAAAAGTGATGGCACAGAGACATCTACCAATCTC CACCAAAAGCTCTACTACCATGTCTTGGGAACCGATCAGTCAGAAGATATTTTGTGTGCTGAGTTTCCTGATGAACCTAAATGGATGGGT GGAGCTGAGTTATCTGATGATGGCCGCTATGTCTTGTTATCAATAAGGGAAGGATGTGATCCAGTAAACCGACTCTGGTACTGTGACCTA CAGCAGGAATCCAGTGGCATCGCGGGAATCCTGAAGTGGGTAAAACTGATTGACAACTTTGAAGGGGAATATGACTACGTGACCAATGAG GGGACGGTGTTCACATTCAAGACGAATCGCCAGTCTCCCAACTATCGCGTGATCAACATTGACTTCAGGGATCCTGAAGAGTCTAAGTGG AAAGTACTTGTTCCTGAGCATGAGAAAGATGTCTTAGAATGGATAGCTTGTGTCAGGTCCAACTTCTTGGTCTTATGCTACCTCCATGAC GTCAAGAACATTCTGCAGCTCCATGACCTGACTACTGGTGCTCTCCTTAAGACCTTCCCGCTCGATGTCGGCAGCATTGTAGGGTACAGC GGTCAGAAGAAGGACACTGAAATCTTCTATCAGTTTACTTCCTTTTTATCTCCAGGTATCATTTATCACTGTGATCTTACCAAAGAGGAG CTGGAGCCAAGAGTTTTCCGAGAGGTGACCGTAAAAGGAATTGATGCTTCTGATTACCAGACAGTCCAGATTTTCTACCCTAGCAAGGAT GGTACGAAGATTCCAATGTTCATTGTGCATAAAAAAGGCATAAAATTGGATGGCTCTCATCCAGCTTTCTTATATGGCTATGGCGGCTTC AACATATCCATCACACCCAACTACAGTGTTTCCAGGCTTATTTTTGTGAGACACATGGGTGGTATCCTGGCAGTGGCCAACATCAGAGGA GGTGGCGAATATGGAGAGACGTGGCATAAAGGTGGTATCTTGGCCAACAAACAAAACTGCTTTGATGACTTTCAGTGTGCTGCTGAGTAT CTGATCAAGGAAGGTTACACATCTCCCAAGAGGCTGACTATTAATGGAGGTTCAAATGGAGGCCTCTTAGTGGCTGCTTGTGCAAATCAG AGACCTGACCTCTTTGGTTGTGTTATTGCCCAAGTTGGAGTAATGGACATGCTGAAGTTTCATAAATATACCATCGGCCATGCTTGGACC ACTGATTATGGGTGCTCGGACAGCAAACAACACTTTGAATGGCTTGTCAAATACTCTCCATTGCATAATGTGAAGTTACCAGAAGCAGAT GACATCCAGTACCCGTCCATGCTGCTCCTCACTGCTGACCATGATGACCGCGTGGTCCCGCTTCACTCCCTGAAGTTCATTGCCACCCTT CAGTACATCGTGGGCCGCAGCAGGAAGCAAAGCAACCCCCTGCTTATCCACGTGGACACCAAGGCGGGCCACGGGGCGGGGAAGCCCACA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TMEM242_ENST00000400788_chr6_157739814_-_PREP_ENST00000369110_chr6_105845802_-_3096nt AGATTGCACAGGAGGAGGCGGTAGCGGAACCTTTCTCCTCCGCCTGGTTCTCGCTTCCACCCGGGCCCAGTTGGGGACGGACGCACTAGA GGCGACCTAAACATGGAGACAGCGGGCGCTGCAACTGGGCAGCCGGCCTCTGGGCTGGAGGCTCCGGGGTCCACGAATGACCGGCTTTTC CTGGTTAAAGGTGGAATTTTCCTTGGTACCGTTGCTGCAGCGGGAATGCTAGCTGGATTTATTACAACATTATCATTGGCTAAAAAGAAA AGCCCTGAATGGTTCAATAAGGGAAGTATGGCCACGGCTGCATTACCGGAAAGCGGGTCTTCCCTTGCCTTGCGAGCTCTGGGCTGGGGC TCCCTGTATGCATGGTGTGGGGTTGGTGTGATTAGCTTCGCAGTCTGGAAAGCTTTAGGAGTTCACAGTGTACAGGATTATCATGGTCAT AAAATTTGTGACCCTTACGCCTGGCTTGAAGACCCCGACAGTGAACAGACTAAGGCCTTTGTGGAGGCCCAGAATAAGATTACTGTGCCA TTTCTTGAGCAGTGTCCCATCAGAGGTTTATACAAAGAGAGAATGACTGAACTATATGATTATCCCAAGTATAGTTGCCACTTCAAGAAA GGAAAACGGTATTTTTATTTTTACAATACAGGTTTGCAGAACCAGCGAGTATTATATGTACAGGATTCCTTAGAGGGTGAGGCCAGAGTG TTCCTGGACCCCAACATACTGTCTGACGATGGCACAGTGGCACTCCGAGGTTATGCGTTCAGCGAAGATGGTGAATATTTTGCCTATGGT CTGAGTGCCAGTGGCTCAGACTGGGTGACAATCAAGTTCATGAAAGTTGATGGTGCCAAAGAGCTTCCAGATGTGCTTGAAAGAGTCAAG TTCAGCTGTATGGCCTGGACCCATGATGGGAAGGGAATGTTCTACAACTCATACCCTCAACAGGATGGAAAAAGTGATGGCACAGAGACA TCTACCAATCTCCACCAAAAGCTCTACTACCATGTCTTGGGAACCGATCAGTCAGAAGATATTTTGTGTGCTGAGTTTCCTGATGAACCT AAATGGATGGGTGGAGCTGAGTTATCTGATGATGGCCGCTATGTCTTGTTATCAATAAGGGAAGGATGTGATCCAGTAAACCGACTCTGG TACTGTGACCTACAGCAGGAATCCAGTGGCATCGCGGGAATCCTGAAGTGGGTAAAACTGATTGACAACTTTGAAGGGGAATATGACTAC GTGACCAATGAGGGGACGGTGTTCACATTCAAGACGAATCGCCAGTCTCCCAACTATCGCGTGATCAACATTGACTTCAGGGATCCTGAA GAGTCTAAGTGGAAAGTACTTGTTCCTGAGCATGAGAAAGATGTCTTAGAATGGATAGCTTGTGTCAGGTCCAACTTCTTGGTCTTATGC TACCTCCATGACGTCAAGAACATTCTGCAGCTCCATGACCTGACTACTGGTGCTCTCCTTAAGACCTTCCCGCTCGATGTCGGCAGCATT GTAGGGTACAGCGGTCAGAAGAAGGACACTGAAATCTTCTATCAGTTTACTTCCTTTTTATCTCCAGGTATCATTTATCACTGTGATCTT ACCAAAGAGGAGCTGGAGCCAAGAGTTTTCCGAGAGGTGACCGTAAAAGGAATTGATGCTTCTGATTACCAGACAGTCCAGATTTTCTAC CCTAGCAAGGATGGTACGAAGATTCCAATGTTCATTGTGCATAAAAAAGGCATAAAATTGGATGGCTCTCATCCAGCTTTCTTATATGGC TATGGCGGCTTCAACATATCCATCACACCCAACTACAGTGTTTCCAGGCTTATTTTTGTGAGACACATGGGTGGTATCCTGGCAGTGGCC AACATCAGAGGAGGTGGCGAATATGGAGAGACGTGGCATAAAGGTGGTATCTTGGCCAACAAACAAAACTGCTTTGATGACTTTCAGTGT GCTGCTGAGTATCTGATCAAGGAAGGTTACACATCTCCCAAGAGGCTGACTATTAATGGAGGTTCAAATGGAGGCCTCTTAGTGGCTGCT TGTGCAAATCAGAGACCTGACCTCTTTGGTTGTGTTATTGCCCAAGTTGGAGTAATGGACATGCTGAAGTTTCATAAATATACCATCGGC CATGCTTGGACCACTGATTATGGGTGCTCGGACAGCAAACAACACTTTGAATGGCTTGTCAAATACTCTCCATTGCATAATGTGAAGTTA CCAGAAGCAGATGACATCCAGTACCCGTCCATGCTGCTCCTCACTGCTGACCATGATGACCGCGTGGTCCCGCTTCACTCCCTGAAGTTC ATTGCCACCCTTCAGTACATCGTGGGCCGCAGCAGGAAGCAAAGCAACCCCCTGCTTATCCACGTGGACACCAAGGCGGGCCACGGGGCG GGGAAGCCCACAGCCAAAGTGATAGAGGAAGTCTCAGACATGTTTGCGTTCATCGCGCGGTGCCTGAACGTCGACTGGATTCCATAAACA GTTTTCGTGCTTCCTCCTGACAGCGACAGAAAACCTCAAGGGCTTTCCCACGTTGACACCAAGAAACCACTGGGCATAATGCTTCCCCAC GGGAACATTATTCCTGCACTCACAGGCTACAGTTGAACAGAACTGCCGTGGGAATTTTATCTTTTTTAGGCTTCTCCTTTTTAGCAAGGC CTTGGTGTTTCTTTTTCCACCCTGTCTAGGCACATGTGGTTTTTTGGTGTTTTTTTTAAGGGCATGTTGGGATAAATAGCTAAATGGCAA CAAACACATTGTGAATATTAGATTGCTGAATTAAGGATCATAGTCGGGCATACTTATCTATATCCATAACCTCTATATCTTTAAATAAAT GTGAGAACTGTTCTCATGGAGAAGACTTCTTTGCAACAATAATAAATGTTATTTAAGAATGACAGGCTTTTACTTCCGGTTTCTTCATAT TGAGGGGCAACTCCAGAAGTGGAGTTTTCTGTGAGAATAAAGCATTTCACCTTTCTGCAACAAGTTAGTTTTCAAGCAGTTAAGTCATAG |
Top |
FusionGenePPI for TMEM242_PREP |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TMEM242 | VKORC1, GGT7, RNF5, SLC22A9, SLC2A12, TMEM63A, TRIM25 | PREP | SIRT7, TARS, BRCA1, SGOL2, AIP, GLO1, HSPA4, HSPD1, HSPH1, KCNAB2, PABPC4, ALDOA, ALDOC, CTH, GDI2, ISYNA1, ME1, OAT, PABPC1, QDPR, NTRK1, SUCO, MTG2, NSMAF, RHPN1, KIF3A, SNCA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for TMEM242_PREP |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for TMEM242_PREP |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | PREP | C0002622 | Amnesia | 1 | CTD_human |
| Tgene | PREP | C0002624 | Retrograde amnesia | 1 | CTD_human |
| Tgene | PREP | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Tgene | PREP | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Tgene | PREP | C0338831 | Manic | 1 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|