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Fusion gene ID: 38554 |
FusionGeneSummary for TMEM232_ANKRA2 |
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Fusion gene information | Fusion gene name: TMEM232_ANKRA2 | Fusion gene ID: 38554 | Hgene | Tgene | Gene symbol | TMEM232 | ANKRA2 | Gene ID | 642987 | 57763 |
Gene name | transmembrane protein 232 | ankyrin repeat family A member 2 | |
Synonyms | - | ANKRA | |
Cytomap | 5q22.1 | 5q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | transmembrane protein 232 | ankyrin repeat family A protein 2RFXANK-like protein 2ankyrin repeat, family A (RFXANK-like), 2 | |
Modification date | 20180403 | 20180523 | |
UniProtAcc | C9JQI7 | Q9H9E1 | |
Ensembl transtripts involved in fusion gene | ENST00000515518, ENST00000429839, ENST00000455884, | ENST00000296785, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 1 X 1 X 1=1 |
# samples | 3 | 1 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: TMEM232 [Title/Abstract] AND ANKRA2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ANKRA2 | GO:0043254 | regulation of protein complex assembly | 25752541 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUSC | TCGA-60-2712-01A | TMEM232 | chr5 | 110002929 | - | ANKRA2 | chr5 | 72858810 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000515518 | ENST00000296785 | TMEM232 | chr5 | 110002929 | - | ANKRA2 | chr5 | 72858810 | - |
5CDS-5UTR | ENST00000429839 | ENST00000296785 | TMEM232 | chr5 | 110002929 | - | ANKRA2 | chr5 | 72858810 | - |
5CDS-5UTR | ENST00000455884 | ENST00000296785 | TMEM232 | chr5 | 110002929 | - | ANKRA2 | chr5 | 72858810 | - |
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FusionProtFeatures for TMEM232_ANKRA2 |
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Hgene | Tgene |
TMEM232 | ANKRA2 |
May regulate the interaction between the 3M complex andthe histone deacetylases HDAC4 and HDAC5 (PubMed:25752541). Mayalso regulate LRP2/megalin (By similarity).{ECO:0000250|UniProtKB:A2ARV4, ECO:0000269|PubMed:25752541}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TMEM232_ANKRA2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TMEM232_ANKRA2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TMEM232 | ANKRA2 | LRP2, HDAC4, HDAC5, HDAC9, AHRR, RFX5, HDAC3, ABL1, MPL, PDE3B, APP, NEK6, CCDC8, RFX7, HUWE1, ZNF462, CUL7, LMNB2, TRIM28, SOGA1, CCAR2, OBSL1, LMNA, CDK4, RFXAP, PRDX2, GTF3C5, FAM83B, PHB2, CDKN2A |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMEM232_ANKRA2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMEM232_ANKRA2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |