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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38546

FusionGeneSummary for TMEM219_CPB1

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM219_CPB1
Fusion gene ID: 38546
HgeneTgene
Gene symbol

TMEM219

CPB1

Gene ID

124446

1360

Gene nametransmembrane protein 219carboxypeptidase B1
SynonymsIGFBP-3RCPB|PASP|PCPB
Cytomap

16p11.2

3q24

Type of geneprotein-codingprotein-coding
Descriptioninsulin-like growth factor-binding protein 3 receptortesticular tissue protein Li 203carboxypeptidase Bcarboxypeptidase B1 (tissue)pancreas-specific proteinpancreatic carboxypeptidase Bprocarboxypeptidase Bprotaminasetissue carboxypeptidase B
Modification date2018051920180523
UniProtAcc

Q86XT9

P15086

Ensembl transtripts involved in fusion geneENST00000414689, ENST00000279396, 
ENST00000561899, ENST00000566848, 
ENST00000491148, ENST00000282957, 
ENST00000498639, 
Fusion gene scores* DoF score1 X 1 X 1=121 X 24 X 3=1512
# samples 119
** MAII scorelog2(1/1*10)=3.32192809488736log2(19/1512*10)=-2.99238681589013
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMEM219 [Title/Abstract] AND CPB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A8-A06Z-01ATMEM219chr16

29983099

+CPB1chr3

148558489

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000414689ENST00000491148TMEM219chr16

29983099

+CPB1chr3

148558489

+
intron-3CDSENST00000414689ENST00000282957TMEM219chr16

29983099

+CPB1chr3

148558489

+
intron-intronENST00000414689ENST00000498639TMEM219chr16

29983099

+CPB1chr3

148558489

+
intron-3CDSENST00000279396ENST00000491148TMEM219chr16

29983099

+CPB1chr3

148558489

+
intron-3CDSENST00000279396ENST00000282957TMEM219chr16

29983099

+CPB1chr3

148558489

+
intron-intronENST00000279396ENST00000498639TMEM219chr16

29983099

+CPB1chr3

148558489

+
3UTR-3CDSENST00000561899ENST00000491148TMEM219chr16

29983099

+CPB1chr3

148558489

+
3UTR-3CDSENST00000561899ENST00000282957TMEM219chr16

29983099

+CPB1chr3

148558489

+
3UTR-intronENST00000561899ENST00000498639TMEM219chr16

29983099

+CPB1chr3

148558489

+
intron-3CDSENST00000566848ENST00000491148TMEM219chr16

29983099

+CPB1chr3

148558489

+
intron-3CDSENST00000566848ENST00000282957TMEM219chr16

29983099

+CPB1chr3

148558489

+
intron-intronENST00000566848ENST00000498639TMEM219chr16

29983099

+CPB1chr3

148558489

+

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FusionProtFeatures for TMEM219_CPB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMEM219

Q86XT9

CPB1

P15086

Cell death receptor specific for IGFBP3, may mediatecaspase-8-dependent apoptosis upon ligand binding.{ECO:0000269|PubMed:20353938}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TMEM219_CPB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMEM219_CPB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMEM219HLA-DQA1, ITM2B, MCOLN3, BTNL8, ZACN, PON2, NRN1, UPK1A, CHRNA3, TCTN2CPB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMEM219_CPB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCPB1P15086DB04272Citric AcidCarboxypeptidase Bsmall moleculeapproved|nutraceutical|vet_approved

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RelatedDiseases for TMEM219_CPB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource