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Fusion gene ID: 38546 |
FusionGeneSummary for TMEM219_CPB1 |
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Fusion gene information | Fusion gene name: TMEM219_CPB1 | Fusion gene ID: 38546 | Hgene | Tgene | Gene symbol | TMEM219 | CPB1 | Gene ID | 124446 | 1360 |
Gene name | transmembrane protein 219 | carboxypeptidase B1 | |
Synonyms | IGFBP-3R | CPB|PASP|PCPB | |
Cytomap | 16p11.2 | 3q24 | |
Type of gene | protein-coding | protein-coding | |
Description | insulin-like growth factor-binding protein 3 receptortesticular tissue protein Li 203 | carboxypeptidase Bcarboxypeptidase B1 (tissue)pancreas-specific proteinpancreatic carboxypeptidase Bprocarboxypeptidase Bprotaminasetissue carboxypeptidase B | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q86XT9 | P15086 | |
Ensembl transtripts involved in fusion gene | ENST00000414689, ENST00000279396, ENST00000561899, ENST00000566848, | ENST00000491148, ENST00000282957, ENST00000498639, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 21 X 24 X 3=1512 |
# samples | 1 | 19 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(19/1512*10)=-2.99238681589013 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TMEM219 [Title/Abstract] AND CPB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-A8-A06Z-01A | TMEM219 | chr16 | 29983099 | + | CPB1 | chr3 | 148558489 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000414689 | ENST00000491148 | TMEM219 | chr16 | 29983099 | + | CPB1 | chr3 | 148558489 | + |
intron-3CDS | ENST00000414689 | ENST00000282957 | TMEM219 | chr16 | 29983099 | + | CPB1 | chr3 | 148558489 | + |
intron-intron | ENST00000414689 | ENST00000498639 | TMEM219 | chr16 | 29983099 | + | CPB1 | chr3 | 148558489 | + |
intron-3CDS | ENST00000279396 | ENST00000491148 | TMEM219 | chr16 | 29983099 | + | CPB1 | chr3 | 148558489 | + |
intron-3CDS | ENST00000279396 | ENST00000282957 | TMEM219 | chr16 | 29983099 | + | CPB1 | chr3 | 148558489 | + |
intron-intron | ENST00000279396 | ENST00000498639 | TMEM219 | chr16 | 29983099 | + | CPB1 | chr3 | 148558489 | + |
3UTR-3CDS | ENST00000561899 | ENST00000491148 | TMEM219 | chr16 | 29983099 | + | CPB1 | chr3 | 148558489 | + |
3UTR-3CDS | ENST00000561899 | ENST00000282957 | TMEM219 | chr16 | 29983099 | + | CPB1 | chr3 | 148558489 | + |
3UTR-intron | ENST00000561899 | ENST00000498639 | TMEM219 | chr16 | 29983099 | + | CPB1 | chr3 | 148558489 | + |
intron-3CDS | ENST00000566848 | ENST00000491148 | TMEM219 | chr16 | 29983099 | + | CPB1 | chr3 | 148558489 | + |
intron-3CDS | ENST00000566848 | ENST00000282957 | TMEM219 | chr16 | 29983099 | + | CPB1 | chr3 | 148558489 | + |
intron-intron | ENST00000566848 | ENST00000498639 | TMEM219 | chr16 | 29983099 | + | CPB1 | chr3 | 148558489 | + |
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FusionProtFeatures for TMEM219_CPB1 |
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Hgene | Tgene |
TMEM219 | CPB1 |
Cell death receptor specific for IGFBP3, may mediatecaspase-8-dependent apoptosis upon ligand binding.{ECO:0000269|PubMed:20353938}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TMEM219_CPB1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TMEM219_CPB1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TMEM219 | HLA-DQA1, ITM2B, MCOLN3, BTNL8, ZACN, PON2, NRN1, UPK1A, CHRNA3, TCTN2 | CPB1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMEM219_CPB1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | CPB1 | P15086 | DB04272 | Citric Acid | Carboxypeptidase B | small molecule | approved|nutraceutical|vet_approved |
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RelatedDiseases for TMEM219_CPB1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |