|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 3854 |
FusionGeneSummary for BAZ1A_RNF115 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BAZ1A_RNF115 | Fusion gene ID: 3854 | Hgene | Tgene | Gene symbol | BAZ1A | RNF115 | Gene ID | 11177 | 27246 |
| Gene name | bromodomain adjacent to zinc finger domain 1A | ring finger protein 115 | |
| Synonyms | ACF1|WALp1|WCRF180|hACF1 | BCA2|ZNF364 | |
| Cytomap | 14q13.1-q13.2 | 1q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | bromodomain adjacent to zinc finger domain protein 1AATP-dependent chromatin remodeling proteinATP-utilizing chromatin assembly and remodeling factor 1CHRAC subunit ACF1hWALp1williams syndrome transcription factor-related chromatin-remodeling factor | E3 ubiquitin-protein ligase RNF115RING-type E3 ubiquitin transferase RNF115rabring 7zinc finger protein 364 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9NRL2 | Q9Y4L5 | |
| Ensembl transtripts involved in fusion gene | ENST00000358716, ENST00000382422, ENST00000360310, ENST00000553853, | ENST00000369291, | |
| Fusion gene scores | * DoF score | 5 X 4 X 3=60 | 4 X 3 X 3=36 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/36*10)=0.473931188332412 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: BAZ1A [Title/Abstract] AND RNF115 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | BAZ1A | GO:0006261 | DNA-dependent DNA replication | 12434153 |
| Tgene | RNF115 | GO:0051865 | protein autoubiquitination | 16288031 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-63-6202-01A | BAZ1A | chr14 | 35343698 | - | RNF115 | chr1 | 145646115 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000358716 | ENST00000369291 | BAZ1A | chr14 | 35343698 | - | RNF115 | chr1 | 145646115 | + |
| In-frame | ENST00000382422 | ENST00000369291 | BAZ1A | chr14 | 35343698 | - | RNF115 | chr1 | 145646115 | + |
| Frame-shift | ENST00000360310 | ENST00000369291 | BAZ1A | chr14 | 35343698 | - | RNF115 | chr1 | 145646115 | + |
| intron-3CDS | ENST00000553853 | ENST00000369291 | BAZ1A | chr14 | 35343698 | - | RNF115 | chr1 | 145646115 | + |
Top |
FusionProtFeatures for BAZ1A_RNF115 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BAZ1A | RNF115 |
| Component of the ACF complex, an ATP-dependent chromatinremodeling complex, that regulates spacing of nucleosomes usingATP to generate evenly spaced nucleosomes along the chromatin. TheATPase activity of the complex is regulated by the length offlanking DNA. Also involved in facilitating the DNA replicationprocess. BAZ1A is the accessory, non-catalytic subunit of thecomplex which can enhance and direct the process provided by theATPase subunit, SMARCA5, probably through targetingpericentromeric heterochromatin in late S phase. Moves end-positioned nucleosomes to a predominantly central position. Mayhave a role in nuclear receptor-mediated transcription repression. Component of the histone-fold protein complex CHRACcomplex which facilitates nucleosome sliding by the ACF complexand enhances ACF-mediated chromatin assembly. The C-terminalregions of both CHRAC1 and POLE1 are required for these functions. | E3 ubiquitin-protein ligase that mediates E2-dependent,'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substratesand may play a role in diverse biological processes. Through theirpolyubiquitination, may play a role in the endosomal traffickingand degradation of membrane receptors including EGFR, FLT3, METand CXCR4. {ECO:0000269|PubMed:16288031,ECO:0000269|PubMed:18819927, ECO:0000303|PubMed:23418353}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for BAZ1A_RNF115 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_BAZ1A_ENST00000382422_chr14_35343698_-_RNF115_ENST00000369291_chr1_145646115_+_308aa MPLLHRKPFVRQKPPADLRPDEEVFYCKVTNEIFRHYENIYVPDVNQALLKKXQMIPVFXVVAAVGXTIPQQHILQSFGAIWITRCFFKI LDPFXVAVHWTKIIEPMKGVTRLTLTSGEQDLHGCHWVGDTDLEEVLVLTDLQLLKEYYNTSLQDSLQILPFLDLHTLFPGAGCCTPTLG TMPGVRQGLMPLXPSFXDNWKTQALPQLTRKRSHLFQQXQXLRNKLIWVXSVQYAKKITQLKRKSGSYLAITSFTAVVLCRGXNCMTHVL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_BAZ1A_ENST00000382422_chr14_35343698_-_RNF115_ENST00000369291_chr1_145646115_+_926nt ATGCCGCTGCTACACCGAAAGCCGTTTGTGAGACAGAAGCCGCCCGCGGACCTGCGGCCCGACGAGGAAGTTTTCTACTGTAAAGTCACC AACGAGATCTTCCGCCACTACGAGAATATATATGTCCCAGATGTGAATCAGGCTTTATTGAAGAAGTGACAGATGATTCCAGTTTTTTAG GTGGTGGCGGCAGTCGGATAGACAATACCACAACAACACATTTTGCAGAGCTTTGGGGCCATTTGGATCACACGATGTTTTTTCAAGATT TTAGACCCTTTCTAAGTAGCAGTCCACTGGACCAAGATAATAGAGCCAATGAAAGGGGTCACCAGACTCACACTGACTTCTGGGGAGCAA GACCTCCACGGTTGCCATTGGGTCGGAGATACAGATCTCGAGGAAGTTCTCGTCCTGACAGATCTCCAGCTATTGAAGGAATACTACAAC ACATCTTTGCAGGATTCTTTGCAAATTCTGCCATTCCTGGATCTCCACACCCTTTTTCCTGGAGCGGGATGCTGCACTCCAACCCTGGGG ACTATGCCTGGGGTCAGACAGGGCTTGATGCCATTGTAACCCAGCTTTTAGGACAACTGGAAAACACAGGCCCTCCCCCAGCTGACAAGG AAAAGATCACATCTCTTCCAACAGTGACAGTAACTCAGGAACAAGTTGATATGGGTTTAGAGTGTCCAGTATGCAAAGAAGATTACACAG TTGAAGAGGAAGTCCGGCAGTTACCTTGCAATCACTTCTTTCACAGCAGTTGTATTGTGCCGTGGCTAGAACTGCATGACACATGTCCTG TATGTAGGAAGAGCTTAAATGGTGAGGACTCTACTCGGCAAAGCCAGAGCACTGAGGCCTCTGCAAGCAACAGATTTAGCAATGACAGTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_BAZ1A_ENST00000382422_chr14_35343698_-_RNF115_ENST00000369291_chr1_145646115_+_9252nt CCCGCACTGCCCCCCGCGGCGGGGCGTCCTGCCCCATTGTGAGGCGGCGGCAGGACGAGAGGAGGTAGGGCGCGCTCGGGGGGCAGGGGC GGCGGCGGCTCCGCTCGCTCGACACCCGGGCAGCGGCAGGAACGAACTCGGCTCCGGTAGCGGCCGCGGCGCGTCAGTCACACAAAAGGC AGCCGAGCTTCTCCCAGCGCGCGGACCGGCCCACGCTGCCGCCGAGGGCTCCCCACCTTACCGGCTTTCCTTTCCCTCCAATTTTGATAG GGAAGCGGGGCCGGCGCGGGCGGCCGAGGGTCCAGGCGAGCCCGCGGGCGGACGGGAGATGCCGCTGCTACACCGAAAGCCGTTTGTGAG ACAGAAGCCGCCCGCGGACCTGCGGCCCGACGAGGAAGTTTTCTACTGTAAAGTCACCAACGAGATCTTCCGCCACTACGAGAATATATA TGTCCCAGATGTGAATCAGGCTTTATTGAAGAAGTGACAGATGATTCCAGTTTTTTAGGTGGTGGCGGCAGTCGGATAGACAATACCACA ACAACACATTTTGCAGAGCTTTGGGGCCATTTGGATCACACGATGTTTTTTCAAGATTTTAGACCCTTTCTAAGTAGCAGTCCACTGGAC CAAGATAATAGAGCCAATGAAAGGGGTCACCAGACTCACACTGACTTCTGGGGAGCAAGACCTCCACGGTTGCCATTGGGTCGGAGATAC AGATCTCGAGGAAGTTCTCGTCCTGACAGATCTCCAGCTATTGAAGGAATACTACAACACATCTTTGCAGGATTCTTTGCAAATTCTGCC ATTCCTGGATCTCCACACCCTTTTTCCTGGAGCGGGATGCTGCACTCCAACCCTGGGGACTATGCCTGGGGTCAGACAGGGCTTGATGCC ATTGTAACCCAGCTTTTAGGACAACTGGAAAACACAGGCCCTCCCCCAGCTGACAAGGAAAAGATCACATCTCTTCCAACAGTGACAGTA ACTCAGGAACAAGTTGATATGGGTTTAGAGTGTCCAGTATGCAAAGAAGATTACACAGTTGAAGAGGAAGTCCGGCAGTTACCTTGCAAT CACTTCTTTCACAGCAGTTGTATTGTGCCGTGGCTAGAACTGCATGACACATGTCCTGTATGTAGGAAGAGCTTAAATGGTGAGGACTCT ACTCGGCAAAGCCAGAGCACTGAGGCCTCTGCAAGCAACAGATTTAGCAATGACAGTCAGCTACATGACCGATGGACTTTCTGAAGCTAA AGACCACACCTGAATCAGGGCTGTGGTAATCATCTTACCATAGCTGTAAATTGTATCAAAACAAAAAATTAGTAGATGGATTTAGGAATA TGTAAGAAACTCAACACATAATATAAATGCAATGAATGTTTTTCTTCTTTAAATTTAAAGTTAGTATCTACAGATGGAATTGTATCTACA ACCAAATGCCTCTTATCCCTGAATTCAGAGTGATAATTTTATAAGTGTGAAACTTAATTATGTAGGGCTCCCCCCGTCTGAATAGAATTA ATTCCTTAAAGTCTAGTTAGGGTCCTGCTGTCTGTCATGTTGCCTTGTAACGGATGTTTCCACCTCCTTCTCCAACCTCTACCCCACCAT TAGTGTATTTTACTATAAAAACAGTGGAACCACAGCCCTAAAGTCCTGCTGATATAAAGTCCTTTTGTCTTAATTGTATTTAAAAAAAAA AAAAAACTACTCTTGATCACATTAGCTATGAGGCGAGGTCAAATTCAGGTATCTAAGACTAATGATTTTGTTTTGTCTTGATCCCCAGAG AGCAAATCAAAGAAAAATTACAGCAAGAAGAGAAAAGTGGTTTATCATTGTGTGCTTTGGTTTTCTTATTTTAATTTTTTTTGTTTTTTT TTTTTGAGATGGAGTCTCGCTCTGTCGCCTAGGCTGGAGTGCAGTGGCACGATCTTGGCTCATTGCAAACTCTGCCTCCTGAGTTCAAGC GATTCTCCTACCTCAGCCTCCAGAGTAGCTGGGACCACAGGCATTTGTTACCATGCCCAGCTAATTTTTTGTATATTTAGTAGAGATGGG GTTTCACCGTGTTAGCCAGGATGGTCTCAATCTCCTGACCTTGTGCTCCGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGA GCCACTGCGCCTGGCCTCTTATTTTAATTTTTAAAGACTACTTCAGTTGATGCAGTTTCCCAAGAAACCTACATAACATATATTGGGAGC CTTATGTTGATAGGAATCTGATTCCCATTCCTTTTTGGGAATGAGTTGGGCAGCATACAGGCACAGAAAGACAGATGTTTGAGACCTTTG CTTCTGAGATTTTAAAAAATGATTACCGCTGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGCGGATCAC AAGGTCAAGAGATCAAGACCAGCCTGGCCAACAAGGTAAAACCTTGTCTCTACTAAAAATATAAAATTAGCTGGGCCTGGTGGTGCATGC CTGTAATCCCAGCTACTCATGAGGCTGAGGTGGGAGAATCGCTTGAACCCAGGAGGTGGAGGTTGCGGTGAGCCGGATCATACCAATGCA CTCCAGTCTGGGCAACAAGAGCGAAACTCCATCTCAAAAAAAAAAAAAAAATCCCCAACTCACTGCTTTTTTTGTTTGTTTCTGTCGCCT AGGCTGGAGTGCAGTGGCACGATCTCAGCTCACCACAGCCTCGACCTCCCAGGCTCAAGTGATCCTCCCACCTCAGCCTACCAAGTGGCT GGGACTACAGGCGTGTGCCACCATGCCTGGGTAATTTTTGTATTTTTGTAGAGATAGGGTTTTGCCGTGTTGCCCAGGCTGGTCTCAAAC TCCTGGGCTCAAGTGATCTGCCTGCCTCAACCTCTCAAAGTGCTCAACTCATTGTTTACTGTCTTTTTTCCTAGTAATCTTAAAATAATT TGCCTCACAGAAATAGAGACAGTAAGTGTCTGCAGCCAGTTCACTGTTTTTGGTAATTCATTGGTCTTCAGGAGTTAAGATTTTACATTG TCACATTTTAATTTTTAAGCCTATTTTTCATCTCTGAAACTTTCCTTTTCTCCTTGGTTCTGGCTATACTTGGACTCAAACTGATCAGTG TGATCATGTCCAAAACAGCTTGGCCTGGAAGAGGTAGGCCTTATTTTTTCAGCCTAGTAGTGTCCCATGCACATGCTCTTTGTAGCATTC AAGTGTTTAACATTGGATAAATTAAGAAGGTCAAGAATGTTGTTGAAACTTCAAGGTCTCAAAAGGAAATGATGGGGACATAGAACAACT GTTGGTGTACCAAAAAAAGGTACAGAGGGGCACCATTTGTATTGTCACACAACAATGATCAGAATGATCAGTTTAGAATGATCAGAACAA AAACACCACTCTTTAATGGGTCTTTTTCTTGGCTAGAAGTCTTTCCTCAGTTTTTGTTGACTATCATACGCTGATTTGTGGGTGACGGAA GGGGGCTAGAGATAACGTTTCTCTGTACTTTGGTAAAGGATGAAGGAGTCAGAGAGGGAACAGAAAAAGTGAGAGAGTGGCCTGCTGAAA TAATAGCCTGCCTCTAAAAGTTGTGACCAGAAAGTATGATTCATTTGGGCCCAGAGGGAATAAAATATGTTTTTTCATATACCTCCCATA TTACACCTCTGTAGTGATTGTTTATTTGGGGAATGAGATCTACTTACTGTGCGTTGCCCCTGAAATGTAGCTTGAGAATACACACTGGTT TTGAATTGGGGAGGAGGATGGAAGGAAATTAGAGGTGTATTATGAATATTTGGCCACTACTTAGATGGAGGAAGGCTATGTTGAACTTGG GACACATTGCAGTTTTCAAGTACACAATATCAGTTGTCTCAGAAAAATCATGACAGCCTGGACATATTTGCTTGTCAGTGTCTGGAGATG CCAGGACAGGCAGTTGTAGTTTTACGTACAGATAGAGAACCAATGCCTAGAGAACTAGAAAGGATCTGAGTAGCTTTAAAAAGGGTGGAA ACAAAGTACTGGATAGGGGTCTGCCTTTTTATACACAGTATAGCAAACAGCATCAGACAAAGTTACATGAAGTTTTCTTCACTTTTTTTG CTCTGATGGATAGAGGATGTGAGACTCATTTTACTGTTTCCCAGACCTGTCCCACTTAATGGATCTGTTGTGTTTCTTCTTATAATGGCA GGCACCTCAGATGTCCAGGTTAATTTATGTTGAGGAGTTAGGATTCTTCAGGGATTTATTATTATTATTATTATTATTTATTTATTTATT TATTTATTTATTTATTTTTTGAGATGGAGGCTTGCTCTGTCGCCTAGGCTGGAGTGCAGTGGCGCAATCTCAGCTCACTGCAACCTCCAC CTCCTGGGTTCCAGCGATTCTTCTGCCTTAGCCTCCCAAGCAGCTGGGATTACAGGCACCTGCCACCATGCCCAGCTAATTTTTTATATG TTTAGTAGAGACAAGGTTTTACCTTGTTGGCCAGGCTGGTCTTGAACTCTAGACCTCAGGTGATCTGCCAGTCGTGGCCTCCCAAAGTGC TGGGATTACAGACGGGAGCCACCATGCCCAGCCTGAGATTTATTATAAGGAATTGGTTCACACAATAATGGAGTTTGAGAAATCCCAAGA TCTGCAGTGGGCCAGCTAGAGATCCAGGAGAGCTGATGGTGTAGTTCCAGTCTGAAGGCCAGCTTGGATACCCTAGAAGAGCTGATGTTT CTGTTCCAGTTCAGAGGCAGGAAAAGACTGAGGTCTTAGTTCAAGCAGTCAGGCAGGAGGACTTCTCCCTTACTTGTTCTATTCAGACCT TCAACTGATTGGATGAGGGCCACTTACATTAGGGAGGGCCATGTGCTGTATTCAGTCTACTGACTGAAATGTTAGTCTCTTCCAAAAACA CCCTCACAGACACACCCAGAATACTGTATGACCAAATATCTGGGCATCATGTGGCCTAGTCAAGTTGACACATAAGATTAACCATCACAA TGAGGAAAAACAGAAATGATACATGTATACAGAGTGCTCCTCATCCCAATTAAGTTTCACCAAGTTAATAATGTGTCTCTATGAGAAGTG GTTCACCATGTTGGTCAGGCTGTTTTCAAACTCCTGACCTCAGGTGACCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGA GCTAGCACTCCCAGCCGACAGGTGCTTCTTAAATGTTTTCTTTGAGCAGGAATTGGTCCAGGAATTGGTTCTCAAGTTAGAAGGAAAATT TGAGGGGAAGAACTTGTTTTTTCTCCAATCAGTCTCTGATTAAATAGTTATTAGGAAAAACTCCTTGCTTATGTCTTTGTATTGCACATT TTTATATATGTATATATGTGTAAATAGAGATATTTATATATTCACAGACAAACACGTGTATGCACATTTCACAATGGAGGAAGAAGGGAT ATGGTGTGCACTGAGGTAAAGTGAGCAGGGATACAGAAGAGAGCTGGAGCCTCACAGTCTGATTCTCTCATTGTACATAACCTTTAGGGT CTTTGTTTCCCTGAGTTCTCTGGTATGGGGCACTGTTGGCTTGGGCTGGTACCCTGTTATTCTCTGTGATGAAGGGATTCACTGGAGGTA AAAACGTAATCATTTCCAAAGGTTGAGAATAAATGACTTTGAGGAAAGGGTGTTCATTATCCGTTGCTTCTATATTATAATCAGTTGAAC TACAATACGGTTATCTATTGATTTTTTTTAATTTTTCTGACAAATTATTGACACCAAATTGAATAATTCATGACCTGCATGCTTCAGCTT CTTTCTCCCTGGTTTCCAGGTGCTATTCCCTCAAGAAATGCAAATTAAATATGTCGGTCTTAATAAATCAGGAGGGAAGCATAGTCTGTG TCTGTTTTAAATGACAACAACAACAAAACAGCTTTGGGGTTTAAGAAGTGGAAGACACATTTTTATTTTTTTGAGACACAATCTCACTCT TTCGCCCAGGCTGGAGTGCAGTGGCGTGATCTCAGGTCACTGCAACCTCCCGCTCCTGGGTTCAAGCGATTCTCTTGCCTCAGCCTCCCA AGTAGCTGGGATTACAGGCACGTGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTTGCCATGTTGCCCAGGCTGG TCTCGAACTCCTGATGTCAAGTGATCACCGACCTCAGCATCCCAAAGTGCTGGGATTACAGGCATTAGCCACCACGCCCAGGTGAGAAGA CAGATTTTAAGAGAAGGAGCAGGGCTGGTATCTGAATAGGTATTTGGATGTTAGGGGAAAACCCTTTTTGGCCTCTGTGGTAGAGCGATC GGAAGGTAAAAGTGCTGTTTACAAGAATAATCCATTGGAGATCTGGGGATTGGGGACGACTTATAGGATAGAGTCCTCTTGTTGAGAATT TCCCGAATGAATCTCATGTAGGTTCTGTCACAGTAAGATGGAGGAAAACTTTGATGGGGTAAGTATCACAAGTGGCTGTCCTATAGGGGG AAATCCTAGCCTGCAGTAATGTCAGTGTCTCAGTATTCAGCCAGCGAGCCACTGAGCTGCTCCAGGGGTTTAAAATAGAATGCATAGAAT ACAATGTATACAGCTGGTGATGCTTTCCAGGATCAAAATAGAGCCCTTGTCTGATCCCATTGACATTGTAAGGTTTCGATCTCTCATACC TGCCACAGACAAGTACATTGTAGGCATTCAACTTTTAAGGTTTTATACATGCAAACTTTATGTTTTCCTGCCACACTACACTTGGTGTCC ACAGAAGTGTAGTTTGTATGTTGCCTCTTCTTCCTCTTTCAACCAGAACACTTAGATCTGTGATCATAGGATGTAAGCCTGTGATTCTTT ACTTTTTCTAATAAGAAATACAATTTTCAAGATCCAAAAATTATTAGATTCTTGGCTGGGCATTGTGGCTCATGCCTGTAATCTCAGCAT TTTGGAAGGCTGAGGCAGGCAGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGGCAGCACAATAAAACACCATGTCTACTAAAAATA CAAAAATTAGCCAGGTGTGGTGGCATGCACCTGTAGTCCCAGCTACTTGGGAGGCTGAGGAGGGAGAATCGTTTGAACCAAGGAGGCAGA GGTTGTAGTGAGCCAAGATTGTGCCACTGCACTCCAGGGCAACAGAGAGAGACCCTGTCTCAAAACAAAAACCCCCAAATTATTAGATTC CCTTCCAACAACTTGATAGCCATATTATTAGTATTTTTGATTAAAGAATACATAACAAAAAGCTGCTATGATTTCAGTAATGCTTTTAAG TTAATTTATTAGTCACACCAGAATCTACATCCAATTGAAATATATACAAATATTTGAAAGATATTTATTCAGGCTGAAGATTATGGTATA TAGATTCCTTCTGATAACCTCATGGCCTCACAGGTTCAAAACCCGTGTTTGTGAATCACTCATACAGATTGGGGCTAAGATGCGTGTCCA GAAAACCACCTATTATGCATGAAAATTTGTAGGCTTATTTGAAGGCAATTGTATCAACACATTTTGAAAGCCAAGACACAAGTATTTTAA GTTTCTGTTTAACCAAGTCTCGAGATAAGCAGAGTAAATAAACTCTTTAGAAGCAAGACTCAGTTGGTATGTACAAAGTGGGATTGCTTT GTATATATTCCGCTTAGTTTGAGTCAGAGCTAGTAATCTGATGCTCTTAAATGTCTTCATAAACTTGGGCAGTGATGTTTCCTTTCTGTG ATTATGTGTCACAGATTTTTATATGTGGACTATAATTAGTATAGTACAATGGCTGAAACTTTTCCTATAGTTGGATATATCTTCTGAGAC TTCCAGTGATTGTATAATGTTGAGTAGCTCCAGAAGATTATTTGAATAGTAAAAACAAAAGACATCTCTACCTATGTGAGTTTATTATTT AGTTAGAAACACAGAACTAACTATTTAAAACAGGTAGAGAAAGATTAAGATGAATGTGATGTAGTGGAGAAAGCTTTGGAGACTTTGGAG TCAGAACTCAAATGGCTCTAGGTCCCAAATCCAGACTCTCATTTTGATTCTCAGAACAATTCTGTGGAAAGAGAAGATACAATAGGCAAT ATCCCTTTTTACAGATAGGTAAACAGAAATAGCATCTCAAAACCTCATTTGCACTGGGTGAGGTGGCTCACGCCTGTAATCCCAGCACTT TGGGAGGCTGAGGCGGGTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACCAAAAACACA AAAATTAGCCAGGCATGGTGGTGCATGCCTGTAATCCCAGCTACTTGGGAGACTGAGGCAGGAGAATTGCTTGAACCCGGGAGGTGGAGG TTGCAGTGAGCTGAGATCATGCCACTGCACTCCAGCCTGGGCAACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAATTCATTTGCC CAATGACAAATAGCTGGTATGTTGCAGAGCCAGAATTTGAATCCAGGTCTTTTTGCCTCCATGGCTAGTCCTTTTATCTCCATGGGATAC AGTCTAAAATCCTTAGTTTGAGGTTCAAGACTATCACTAATAAGAGTCTTACTCATCTACTTCAGCCATATCTCTTTCCGTTCCCACAAA CCTTAGCTCCCACATTTGGCAGGTCCTTGCCAAGGAGCACAGGTAAAGTGTCTCTTTCCTTTTAATGGCTCACCATGGAGCTGTAGCTAA ATTTCTGTGCTCTTACCCCTTTATTCATGTAGTTCCTCCTATCAGGAATATCCTGCCCACTCTCTGCTTAACTATGACAAGAGGTCATCT GTCCAAAGAGAAAGAAGAGAGTTTGTGGATTTAGGAGAAAAGAAAATACTCCAAATACTGCTATGGGCATTTATTTAAAAAGAGAAATGA CCAAAGAGGTTAACAAGTATTTAGATGAAGCTGGGCAGTTGTAGTCTGTGGTGCTCTTGGTCTGCACAAATCTTCCTCTTCCTCCAGCAG TGCTGTATGGATGTTGTTGAATGTTGAGGTCTGTCTGCATTTTCTCATTTTCATGCCAAGTCAATCACTGGATCTGGCTGTCTTCCTTTC |
Top |
FusionGenePPI for BAZ1A_RNF115 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| BAZ1A | SMARCA5, POLE3, BAZ1B, SATB1, SMARCA2, CHRAC1, NCOR1, XRCC5, XRCC6, SMARCAD1, ELAVL1, GRK5, RBBP4, SMAD9, SMAD2, CCDC8, SUMO2, SRPK2, RHOA, CCDC22, UGGT1, MAX, TEAD2, FOXE1, HIST1H4A, H2AFX, HIST1H3A, HIST1H2BB, FOXL1, BMI1, CAPN6, MECP2, MTNR1A | RNF115 | UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E3, UBE2W, ELAVL1, RAD23A, SFN, ATN1, CDK10, CST3, DOCK4, FOLR3, MFAP4, IGHA1, HRAS, UBE2I, RPL18A, UBC, RNF115, AKT1, RAB7A, RAB7B, APP, UBE2N, EGFR, PFDN5, MYC, TTR, MDM4, DAZAP2, YWHAB, DNAJB2, HERC2, FBXW11, BAG6, TAX1BP1, PSEN2, GABRD, KDELR1, H2AFX, RAD51 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for BAZ1A_RNF115 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for BAZ1A_RNF115 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | RNF115 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|