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Fusion gene ID: 3852 |
FusionGeneSummary for BAZ1A_MYO1E |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BAZ1A_MYO1E | Fusion gene ID: 3852 | Hgene | Tgene | Gene symbol | BAZ1A | MYO1E | Gene ID | 11177 | 4643 |
| Gene name | bromodomain adjacent to zinc finger domain 1A | myosin IE | |
| Synonyms | ACF1|WALp1|WCRF180|hACF1 | FSGS6|HuncM-IC|MYO1C | |
| Cytomap | 14q13.1-q13.2 | 15q22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | bromodomain adjacent to zinc finger domain protein 1AATP-dependent chromatin remodeling proteinATP-utilizing chromatin assembly and remodeling factor 1CHRAC subunit ACF1hWALp1williams syndrome transcription factor-related chromatin-remodeling factor | unconventional myosin-IeMYO1E variant proteinmyosin-ICunconventional myosin 1E | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9NRL2 | Q12965 | |
| Ensembl transtripts involved in fusion gene | ENST00000358716, ENST00000382422, ENST00000360310, ENST00000553853, | ENST00000288235, ENST00000558814, | |
| Fusion gene scores | * DoF score | 5 X 4 X 3=60 | 4 X 5 X 3=60 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: BAZ1A [Title/Abstract] AND MYO1E [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | BAZ1A | GO:0006261 | DNA-dependent DNA replication | 12434153 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE005282 | BAZ1A | chr14 | 35234114 | - | MYO1E | chr15 | 59515304 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000358716 | ENST00000288235 | BAZ1A | chr14 | 35234114 | - | MYO1E | chr15 | 59515304 | + |
| intron-5UTR | ENST00000358716 | ENST00000558814 | BAZ1A | chr14 | 35234114 | - | MYO1E | chr15 | 59515304 | + |
| intron-3CDS | ENST00000382422 | ENST00000288235 | BAZ1A | chr14 | 35234114 | - | MYO1E | chr15 | 59515304 | + |
| intron-5UTR | ENST00000382422 | ENST00000558814 | BAZ1A | chr14 | 35234114 | - | MYO1E | chr15 | 59515304 | + |
| intron-3CDS | ENST00000360310 | ENST00000288235 | BAZ1A | chr14 | 35234114 | - | MYO1E | chr15 | 59515304 | + |
| intron-5UTR | ENST00000360310 | ENST00000558814 | BAZ1A | chr14 | 35234114 | - | MYO1E | chr15 | 59515304 | + |
| intron-3CDS | ENST00000553853 | ENST00000288235 | BAZ1A | chr14 | 35234114 | - | MYO1E | chr15 | 59515304 | + |
| intron-5UTR | ENST00000553853 | ENST00000558814 | BAZ1A | chr14 | 35234114 | - | MYO1E | chr15 | 59515304 | + |
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FusionProtFeatures for BAZ1A_MYO1E |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BAZ1A | MYO1E |
| Component of the ACF complex, an ATP-dependent chromatinremodeling complex, that regulates spacing of nucleosomes usingATP to generate evenly spaced nucleosomes along the chromatin. TheATPase activity of the complex is regulated by the length offlanking DNA. Also involved in facilitating the DNA replicationprocess. BAZ1A is the accessory, non-catalytic subunit of thecomplex which can enhance and direct the process provided by theATPase subunit, SMARCA5, probably through targetingpericentromeric heterochromatin in late S phase. Moves end-positioned nucleosomes to a predominantly central position. Mayhave a role in nuclear receptor-mediated transcription repression. Component of the histone-fold protein complex CHRACcomplex which facilitates nucleosome sliding by the ACF complexand enhances ACF-mediated chromatin assembly. The C-terminalregions of both CHRAC1 and POLE1 are required for these functions. | Myosins are actin-based motor molecules with ATPaseactivity. Unconventional myosins serve in intracellular movements.Their highly divergent tails bind to membranous compartments,which are then moved relative to actin filaments. Binds tomembranes containing anionic phospholipids via its tail domain.Required for normal morphology of the glomerular basementmembrane, normal development of foot processes by kidney podocytesand normal kidney function. In dendritic cells, may control themovement of class II-containing cytoplasmic vesicles along theactin cytoskeleton by connecting them with the actin network viaARL14EP and ARL14. {ECO:0000269|PubMed:11940582,ECO:0000269|PubMed:17257598, ECO:0000269|PubMed:20860408}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for BAZ1A_MYO1E |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for BAZ1A_MYO1E |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BAZ1A_MYO1E |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BAZ1A_MYO1E |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | MYO1E | C3279905 | FOCAL SEGMENTAL GLOMERULOSCLEROSIS 6 | 1 | UNIPROT |
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