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Fusion gene ID: 38505 |
FusionGeneSummary for TMEM182_ARHGAP15 |
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Fusion gene information | Fusion gene name: TMEM182_ARHGAP15 | Fusion gene ID: 38505 | Hgene | Tgene | Gene symbol | TMEM182 | ARHGAP15 | Gene ID | 130827 | 55843 |
Gene name | transmembrane protein 182 | Rho GTPase activating protein 15 | |
Synonyms | - | BM046 | |
Cytomap | 2q12.1 | 2q22.2-q22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | transmembrane protein 182 | rho GTPase-activating protein 15rho-type GTPase-activating protein 15 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q6ZP80 | Q53QZ3 | |
Ensembl transtripts involved in fusion gene | ENST00000409528, ENST00000409173, ENST00000412401, ENST00000486293, | ENST00000409869, ENST00000295095, ENST00000473426, | |
Fusion gene scores | * DoF score | 5 X 3 X 5=75 | 9 X 8 X 5=360 |
# samples | 5 | 9 | |
** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/360*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TMEM182 [Title/Abstract] AND ARHGAP15 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ARHGAP15 | GO:0008360 | regulation of cell shape | 12650940 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-XJ-A83G-01A | TMEM182 | chr2 | 103353472 | + | ARHGAP15 | chr2 | 144460988 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-intron | ENST00000409528 | ENST00000409869 | TMEM182 | chr2 | 103353472 | + | ARHGAP15 | chr2 | 144460988 | + |
5UTR-intron | ENST00000409528 | ENST00000295095 | TMEM182 | chr2 | 103353472 | + | ARHGAP15 | chr2 | 144460988 | + |
5UTR-intron | ENST00000409528 | ENST00000473426 | TMEM182 | chr2 | 103353472 | + | ARHGAP15 | chr2 | 144460988 | + |
5UTR-intron | ENST00000409173 | ENST00000409869 | TMEM182 | chr2 | 103353472 | + | ARHGAP15 | chr2 | 144460988 | + |
5UTR-intron | ENST00000409173 | ENST00000295095 | TMEM182 | chr2 | 103353472 | + | ARHGAP15 | chr2 | 144460988 | + |
5UTR-intron | ENST00000409173 | ENST00000473426 | TMEM182 | chr2 | 103353472 | + | ARHGAP15 | chr2 | 144460988 | + |
intron-intron | ENST00000412401 | ENST00000409869 | TMEM182 | chr2 | 103353472 | + | ARHGAP15 | chr2 | 144460988 | + |
intron-intron | ENST00000412401 | ENST00000295095 | TMEM182 | chr2 | 103353472 | + | ARHGAP15 | chr2 | 144460988 | + |
intron-intron | ENST00000412401 | ENST00000473426 | TMEM182 | chr2 | 103353472 | + | ARHGAP15 | chr2 | 144460988 | + |
intron-intron | ENST00000486293 | ENST00000409869 | TMEM182 | chr2 | 103353472 | + | ARHGAP15 | chr2 | 144460988 | + |
intron-intron | ENST00000486293 | ENST00000295095 | TMEM182 | chr2 | 103353472 | + | ARHGAP15 | chr2 | 144460988 | + |
intron-intron | ENST00000486293 | ENST00000473426 | TMEM182 | chr2 | 103353472 | + | ARHGAP15 | chr2 | 144460988 | + |
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FusionProtFeatures for TMEM182_ARHGAP15 |
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Hgene | Tgene |
TMEM182 | ARHGAP15 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TMEM182_ARHGAP15 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TMEM182_ARHGAP15 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TMEM182 | SYNE4, LGALS3 | ARHGAP15 | RAC1, SNCA, PRNP, CD93, KDM1A, APP, DHPS |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMEM182_ARHGAP15 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMEM182_ARHGAP15 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |