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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38505

FusionGeneSummary for TMEM182_ARHGAP15

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM182_ARHGAP15
Fusion gene ID: 38505
HgeneTgene
Gene symbol

TMEM182

ARHGAP15

Gene ID

130827

55843

Gene nametransmembrane protein 182Rho GTPase activating protein 15
Synonyms-BM046
Cytomap

2q12.1

2q22.2-q22.3

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 182rho GTPase-activating protein 15rho-type GTPase-activating protein 15
Modification date2018051920180523
UniProtAcc

Q6ZP80

Q53QZ3

Ensembl transtripts involved in fusion geneENST00000409528, ENST00000409173, 
ENST00000412401, ENST00000486293, 
ENST00000409869, ENST00000295095, 
ENST00000473426, 
Fusion gene scores* DoF score5 X 3 X 5=759 X 8 X 5=360
# samples 59
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/360*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMEM182 [Title/Abstract] AND ARHGAP15 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneARHGAP15

GO:0008360

regulation of cell shape

12650940


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-XJ-A83G-01ATMEM182chr2

103353472

+ARHGAP15chr2

144460988

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000409528ENST00000409869TMEM182chr2

103353472

+ARHGAP15chr2

144460988

+
5UTR-intronENST00000409528ENST00000295095TMEM182chr2

103353472

+ARHGAP15chr2

144460988

+
5UTR-intronENST00000409528ENST00000473426TMEM182chr2

103353472

+ARHGAP15chr2

144460988

+
5UTR-intronENST00000409173ENST00000409869TMEM182chr2

103353472

+ARHGAP15chr2

144460988

+
5UTR-intronENST00000409173ENST00000295095TMEM182chr2

103353472

+ARHGAP15chr2

144460988

+
5UTR-intronENST00000409173ENST00000473426TMEM182chr2

103353472

+ARHGAP15chr2

144460988

+
intron-intronENST00000412401ENST00000409869TMEM182chr2

103353472

+ARHGAP15chr2

144460988

+
intron-intronENST00000412401ENST00000295095TMEM182chr2

103353472

+ARHGAP15chr2

144460988

+
intron-intronENST00000412401ENST00000473426TMEM182chr2

103353472

+ARHGAP15chr2

144460988

+
intron-intronENST00000486293ENST00000409869TMEM182chr2

103353472

+ARHGAP15chr2

144460988

+
intron-intronENST00000486293ENST00000295095TMEM182chr2

103353472

+ARHGAP15chr2

144460988

+
intron-intronENST00000486293ENST00000473426TMEM182chr2

103353472

+ARHGAP15chr2

144460988

+

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FusionProtFeatures for TMEM182_ARHGAP15


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMEM182

Q6ZP80

ARHGAP15

Q53QZ3


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TMEM182_ARHGAP15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMEM182_ARHGAP15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMEM182SYNE4, LGALS3ARHGAP15RAC1, SNCA, PRNP, CD93, KDM1A, APP, DHPS


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMEM182_ARHGAP15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMEM182_ARHGAP15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource