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Fusion gene ID: 38504 |
FusionGeneSummary for TMEM182_ADAMTS12 |
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Fusion gene information | Fusion gene name: TMEM182_ADAMTS12 | Fusion gene ID: 38504 | Hgene | Tgene | Gene symbol | TMEM182 | ADAMTS12 | Gene ID | 130827 | 81792 |
Gene name | transmembrane protein 182 | ADAM metallopeptidase with thrombospondin type 1 motif 12 | |
Synonyms | - | PRO4389 | |
Cytomap | 2q12.1 | 5p13.3-p13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | transmembrane protein 182 | A disintegrin and metalloproteinase with thrombospondin motifs 12ADAM-TS 12ADAM-TS12ADAMTS-12a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q6ZP80 | P58397 | |
Ensembl transtripts involved in fusion gene | ENST00000409528, ENST00000409173, ENST00000412401, ENST00000486293, | ENST00000504830, ENST00000352040, ENST00000504582, ENST00000515401, | |
Fusion gene scores | * DoF score | 5 X 3 X 5=75 | 7 X 4 X 5=140 |
# samples | 5 | 7 | |
** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/140*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TMEM182 [Title/Abstract] AND ADAMTS12 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ADAMTS12 | GO:0030167 | proteoglycan catabolic process | 17895370 |
Tgene | ADAMTS12 | GO:0032331 | negative regulation of chondrocyte differentiation | 22247065 |
Tgene | ADAMTS12 | GO:0050727 | regulation of inflammatory response | 23019333 |
Tgene | ADAMTS12 | GO:0051603 | proteolysis involved in cellular protein catabolic process | 16611630 |
Tgene | ADAMTS12 | GO:0071773 | cellular response to BMP stimulus | 22247065 |
Tgene | ADAMTS12 | GO:1901509 | regulation of endothelial tube morphogenesis | 17895370 |
Tgene | ADAMTS12 | GO:1902203 | negative regulation of hepatocyte growth factor receptor signaling pathway | 17895370 |
Tgene | ADAMTS12 | GO:1902548 | negative regulation of cellular response to vascular endothelial growth factor stimulus | 17895370 |
Tgene | ADAMTS12 | GO:2001113 | negative regulation of cellular response to hepatocyte growth factor stimulus | 17895370 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUAD | TCGA-93-8067-01A | TMEM182 | chr2 | 103414459 | + | ADAMTS12 | chr5 | 33751653 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000409528 | ENST00000504830 | TMEM182 | chr2 | 103414459 | + | ADAMTS12 | chr5 | 33751653 | - |
Frame-shift | ENST00000409528 | ENST00000352040 | TMEM182 | chr2 | 103414459 | + | ADAMTS12 | chr5 | 33751653 | - |
5CDS-5UTR | ENST00000409528 | ENST00000504582 | TMEM182 | chr2 | 103414459 | + | ADAMTS12 | chr5 | 33751653 | - |
5CDS-5UTR | ENST00000409528 | ENST00000515401 | TMEM182 | chr2 | 103414459 | + | ADAMTS12 | chr5 | 33751653 | - |
Frame-shift | ENST00000409173 | ENST00000504830 | TMEM182 | chr2 | 103414459 | + | ADAMTS12 | chr5 | 33751653 | - |
Frame-shift | ENST00000409173 | ENST00000352040 | TMEM182 | chr2 | 103414459 | + | ADAMTS12 | chr5 | 33751653 | - |
5CDS-5UTR | ENST00000409173 | ENST00000504582 | TMEM182 | chr2 | 103414459 | + | ADAMTS12 | chr5 | 33751653 | - |
5CDS-5UTR | ENST00000409173 | ENST00000515401 | TMEM182 | chr2 | 103414459 | + | ADAMTS12 | chr5 | 33751653 | - |
Frame-shift | ENST00000412401 | ENST00000504830 | TMEM182 | chr2 | 103414459 | + | ADAMTS12 | chr5 | 33751653 | - |
Frame-shift | ENST00000412401 | ENST00000352040 | TMEM182 | chr2 | 103414459 | + | ADAMTS12 | chr5 | 33751653 | - |
5CDS-5UTR | ENST00000412401 | ENST00000504582 | TMEM182 | chr2 | 103414459 | + | ADAMTS12 | chr5 | 33751653 | - |
5CDS-5UTR | ENST00000412401 | ENST00000515401 | TMEM182 | chr2 | 103414459 | + | ADAMTS12 | chr5 | 33751653 | - |
3UTR-3CDS | ENST00000486293 | ENST00000504830 | TMEM182 | chr2 | 103414459 | + | ADAMTS12 | chr5 | 33751653 | - |
3UTR-3CDS | ENST00000486293 | ENST00000352040 | TMEM182 | chr2 | 103414459 | + | ADAMTS12 | chr5 | 33751653 | - |
3UTR-5UTR | ENST00000486293 | ENST00000504582 | TMEM182 | chr2 | 103414459 | + | ADAMTS12 | chr5 | 33751653 | - |
3UTR-5UTR | ENST00000486293 | ENST00000515401 | TMEM182 | chr2 | 103414459 | + | ADAMTS12 | chr5 | 33751653 | - |
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FusionProtFeatures for TMEM182_ADAMTS12 |
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Hgene | Tgene |
TMEM182 | ADAMTS12 |
Metalloprotease that may play a role in the degradationof COMP. Cleaves also alpha-2 macroglobulin and aggregan. Hasanti-tumorigenic properties. {ECO:0000269|PubMed:16611630,ECO:0000269|PubMed:17895370, ECO:0000269|PubMed:18485748}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TMEM182_ADAMTS12 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TMEM182_ADAMTS12 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TMEM182 | SYNE4, LGALS3 | ADAMTS12 | CALM2, MEOX2, MYL6, UBR1, FKBP9, SP3, PPM1A, SNRK, USF2, USF1, RUFY3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMEM182_ADAMTS12 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMEM182_ADAMTS12 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ADAMTS12 | C0036341 | Schizophrenia | 1 | PSYGENET |