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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3850

FusionGeneSummary for BAZ1A_DOCK9

check button Fusion gene summary
Fusion gene informationFusion gene name: BAZ1A_DOCK9
Fusion gene ID: 3850
HgeneTgene
Gene symbol

BAZ1A

DOCK9

Gene ID

11177

23348

Gene namebromodomain adjacent to zinc finger domain 1Adedicator of cytokinesis 9
SynonymsACF1|WALp1|WCRF180|hACF1ZIZ1|ZIZIMIN1
Cytomap

14q13.1-q13.2

13q32.3

Type of geneprotein-codingprotein-coding
Descriptionbromodomain adjacent to zinc finger domain protein 1AATP-dependent chromatin remodeling proteinATP-utilizing chromatin assembly and remodeling factor 1CHRAC subunit ACF1hWALp1williams syndrome transcription factor-related chromatin-remodeling factor dedicator of cytokinesis protein 9cdc42 guanine nucleotide exchange factor zizimin-1zizimin-1
Modification date2018051920180522
UniProtAcc

Q9NRL2

Q9BZ29

Ensembl transtripts involved in fusion geneENST00000358716, ENST00000382422, 
ENST00000360310, ENST00000553853, 
ENST00000376460, ENST00000339416, 
ENST00000448493, ENST00000442173, 
ENST00000461998, 
Fusion gene scores* DoF score5 X 4 X 3=606 X 9 X 4=216
# samples 59
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BAZ1A [Title/Abstract] AND DOCK9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBAZ1A

GO:0006261

DNA-dependent DNA replication

12434153


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW380042BAZ1Achr14

35279442

-DOCK9chr13

99502334

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000358716ENST00000376460BAZ1Achr14

35279442

-DOCK9chr13

99502334

-
intron-3CDSENST00000358716ENST00000339416BAZ1Achr14

35279442

-DOCK9chr13

99502334

-
intron-3CDSENST00000358716ENST00000448493BAZ1Achr14

35279442

-DOCK9chr13

99502334

-
intron-intronENST00000358716ENST00000442173BAZ1Achr14

35279442

-DOCK9chr13

99502334

-
intron-intronENST00000358716ENST00000461998BAZ1Achr14

35279442

-DOCK9chr13

99502334

-
intron-3CDSENST00000382422ENST00000376460BAZ1Achr14

35279442

-DOCK9chr13

99502334

-
intron-3CDSENST00000382422ENST00000339416BAZ1Achr14

35279442

-DOCK9chr13

99502334

-
intron-3CDSENST00000382422ENST00000448493BAZ1Achr14

35279442

-DOCK9chr13

99502334

-
intron-intronENST00000382422ENST00000442173BAZ1Achr14

35279442

-DOCK9chr13

99502334

-
intron-intronENST00000382422ENST00000461998BAZ1Achr14

35279442

-DOCK9chr13

99502334

-
intron-3CDSENST00000360310ENST00000376460BAZ1Achr14

35279442

-DOCK9chr13

99502334

-
intron-3CDSENST00000360310ENST00000339416BAZ1Achr14

35279442

-DOCK9chr13

99502334

-
intron-3CDSENST00000360310ENST00000448493BAZ1Achr14

35279442

-DOCK9chr13

99502334

-
intron-intronENST00000360310ENST00000442173BAZ1Achr14

35279442

-DOCK9chr13

99502334

-
intron-intronENST00000360310ENST00000461998BAZ1Achr14

35279442

-DOCK9chr13

99502334

-
intron-3CDSENST00000553853ENST00000376460BAZ1Achr14

35279442

-DOCK9chr13

99502334

-
intron-3CDSENST00000553853ENST00000339416BAZ1Achr14

35279442

-DOCK9chr13

99502334

-
intron-3CDSENST00000553853ENST00000448493BAZ1Achr14

35279442

-DOCK9chr13

99502334

-
intron-intronENST00000553853ENST00000442173BAZ1Achr14

35279442

-DOCK9chr13

99502334

-
intron-intronENST00000553853ENST00000461998BAZ1Achr14

35279442

-DOCK9chr13

99502334

-

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FusionProtFeatures for BAZ1A_DOCK9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BAZ1A

Q9NRL2

DOCK9

Q9BZ29

Component of the ACF complex, an ATP-dependent chromatinremodeling complex, that regulates spacing of nucleosomes usingATP to generate evenly spaced nucleosomes along the chromatin. TheATPase activity of the complex is regulated by the length offlanking DNA. Also involved in facilitating the DNA replicationprocess. BAZ1A is the accessory, non-catalytic subunit of thecomplex which can enhance and direct the process provided by theATPase subunit, SMARCA5, probably through targetingpericentromeric heterochromatin in late S phase. Moves end-positioned nucleosomes to a predominantly central position. Mayhave a role in nuclear receptor-mediated transcription repression. Component of the histone-fold protein complex CHRACcomplex which facilitates nucleosome sliding by the ACF complexand enhances ACF-mediated chromatin assembly. The C-terminalregions of both CHRAC1 and POLE1 are required for these functions.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BAZ1A_DOCK9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BAZ1A_DOCK9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BAZ1A_DOCK9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BAZ1A_DOCK9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDOCK9C0005586Bipolar Disorder1PSYGENET