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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38499

FusionGeneSummary for TMEM179B_TCEAL3

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM179B_TCEAL3
Fusion gene ID: 38499
HgeneTgene
Gene symbol

TMEM179B

TCEAL3

Gene ID

374395

85012

Gene nametransmembrane protein 179Btranscription elongation factor A like 3
Synonyms-WEX8
Cytomap

11q12.3

Xq22.2

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 179Btranscription elongation factor A protein-like 3TCEA-like protein 3transcription elongation factor A (SII)-like 3transcription elongation factor S-II protein-like 3
Modification date2018052420180523
UniProtAcc

Q7Z7N9

Q969E4

Ensembl transtripts involved in fusion geneENST00000533861, ENST00000333449, 
ENST00000372628, ENST00000243286, 
ENST00000372627, ENST00000477014, 
Fusion gene scores* DoF score5 X 4 X 4=802 X 2 X 2=8
# samples 52
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: TMEM179B [Title/Abstract] AND TCEAL3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB053892TMEM179Bchr11

62557651

-TCEAL3chrX

102864548

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000533861ENST00000372628TMEM179Bchr11

62557651

-TCEAL3chrX

102864548

+
3UTR-3CDSENST00000533861ENST00000243286TMEM179Bchr11

62557651

-TCEAL3chrX

102864548

+
3UTR-3CDSENST00000533861ENST00000372627TMEM179Bchr11

62557651

-TCEAL3chrX

102864548

+
3UTR-intronENST00000533861ENST00000477014TMEM179Bchr11

62557651

-TCEAL3chrX

102864548

+
3UTR-3CDSENST00000333449ENST00000372628TMEM179Bchr11

62557651

-TCEAL3chrX

102864548

+
3UTR-3CDSENST00000333449ENST00000243286TMEM179Bchr11

62557651

-TCEAL3chrX

102864548

+
3UTR-3CDSENST00000333449ENST00000372627TMEM179Bchr11

62557651

-TCEAL3chrX

102864548

+
3UTR-intronENST00000333449ENST00000477014TMEM179Bchr11

62557651

-TCEAL3chrX

102864548

+

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FusionProtFeatures for TMEM179B_TCEAL3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMEM179B

Q7Z7N9

TCEAL3

Q969E4

May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TMEM179B_TCEAL3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMEM179B_TCEAL3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMEM179B_TCEAL3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMEM179B_TCEAL3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource