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Fusion gene ID: 38499 |
FusionGeneSummary for TMEM179B_TCEAL3 |
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Fusion gene information | Fusion gene name: TMEM179B_TCEAL3 | Fusion gene ID: 38499 | Hgene | Tgene | Gene symbol | TMEM179B | TCEAL3 | Gene ID | 374395 | 85012 |
Gene name | transmembrane protein 179B | transcription elongation factor A like 3 | |
Synonyms | - | WEX8 | |
Cytomap | 11q12.3 | Xq22.2 | |
Type of gene | protein-coding | protein-coding | |
Description | transmembrane protein 179B | transcription elongation factor A protein-like 3TCEA-like protein 3transcription elongation factor A (SII)-like 3transcription elongation factor S-II protein-like 3 | |
Modification date | 20180524 | 20180523 | |
UniProtAcc | Q7Z7N9 | Q969E4 | |
Ensembl transtripts involved in fusion gene | ENST00000533861, ENST00000333449, | ENST00000372628, ENST00000243286, ENST00000372627, ENST00000477014, | |
Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 2 X 2 X 2=8 |
# samples | 5 | 2 | |
** MAII score | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: TMEM179B [Title/Abstract] AND TCEAL3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CB053892 | TMEM179B | chr11 | 62557651 | - | TCEAL3 | chrX | 102864548 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000533861 | ENST00000372628 | TMEM179B | chr11 | 62557651 | - | TCEAL3 | chrX | 102864548 | + |
3UTR-3CDS | ENST00000533861 | ENST00000243286 | TMEM179B | chr11 | 62557651 | - | TCEAL3 | chrX | 102864548 | + |
3UTR-3CDS | ENST00000533861 | ENST00000372627 | TMEM179B | chr11 | 62557651 | - | TCEAL3 | chrX | 102864548 | + |
3UTR-intron | ENST00000533861 | ENST00000477014 | TMEM179B | chr11 | 62557651 | - | TCEAL3 | chrX | 102864548 | + |
3UTR-3CDS | ENST00000333449 | ENST00000372628 | TMEM179B | chr11 | 62557651 | - | TCEAL3 | chrX | 102864548 | + |
3UTR-3CDS | ENST00000333449 | ENST00000243286 | TMEM179B | chr11 | 62557651 | - | TCEAL3 | chrX | 102864548 | + |
3UTR-3CDS | ENST00000333449 | ENST00000372627 | TMEM179B | chr11 | 62557651 | - | TCEAL3 | chrX | 102864548 | + |
3UTR-intron | ENST00000333449 | ENST00000477014 | TMEM179B | chr11 | 62557651 | - | TCEAL3 | chrX | 102864548 | + |
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FusionProtFeatures for TMEM179B_TCEAL3 |
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Hgene | Tgene |
TMEM179B | TCEAL3 |
May be involved in transcriptional regulation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TMEM179B_TCEAL3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TMEM179B_TCEAL3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMEM179B_TCEAL3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMEM179B_TCEAL3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |