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Fusion gene ID: 38494 |
FusionGeneSummary for TMEM178B_RBM28 |
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Fusion gene information | Fusion gene name: TMEM178B_RBM28 | Fusion gene ID: 38494 | Hgene | Tgene | Gene symbol | TMEM178B | RBM28 | Gene ID | 100507421 | 55131 |
Gene name | transmembrane protein 178B | RNA binding motif protein 28 | |
Synonyms | - | ANES | |
Cytomap | 7q34 | 7q32.1 | |
Type of gene | protein-coding | protein-coding | |
Description | transmembrane protein 178B | RNA-binding protein 282810480G15Rik | |
Modification date | 20180329 | 20180523 | |
UniProtAcc | H3BS89 | Q9NW13 | |
Ensembl transtripts involved in fusion gene | ENST00000565468, | ENST00000223073, ENST00000481788, ENST00000415472, | |
Fusion gene scores | * DoF score | 5 X 2 X 5=50 | 3 X 3 X 3=27 |
# samples | 5 | 3 | |
** MAII score | log2(5/50*10)=0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TMEM178B [Title/Abstract] AND RBM28 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | THCA | TCGA-CE-A484-01A | TMEM178B | chr7 | 140912504 | + | RBM28 | chr7 | 127955073 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000565468 | ENST00000223073 | TMEM178B | chr7 | 140912504 | + | RBM28 | chr7 | 127955073 | - |
5CDS-5UTR | ENST00000565468 | ENST00000481788 | TMEM178B | chr7 | 140912504 | + | RBM28 | chr7 | 127955073 | - |
5CDS-5UTR | ENST00000565468 | ENST00000415472 | TMEM178B | chr7 | 140912504 | + | RBM28 | chr7 | 127955073 | - |
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FusionProtFeatures for TMEM178B_RBM28 |
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Hgene | Tgene |
TMEM178B | RBM28 |
Nucleolar component of the spliceosomalribonucleoprotein complexes. {ECO:0000269|PubMed:17081119}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TMEM178B_RBM28 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TMEM178B_RBM28 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TMEM178B | RBM28 | NOP56, SIRT7, CUL3, CUL1, CAND1, RPL5, RPS17, RRP12, DKC1, CTPS1, POLR3F, POLR3G, ZNF622, ESR1, HDAC11, HECW2, LIN28A, TARBP2, BRCA1, OBSL1, EED, RNF2, NOL12, RPL14, RPL8, DHX8, NIFK, NPM1, ZC3H3, PRR11, ILF2, NTRK1, NOP2, PES1, DDX18, NIP7, RRP15, SDAD1, TOP1, IFI16, HNRNPU, KIF11, RPL10, SORT1, FBXW7, ZNF746, RPL30, ZC3HAV1, ZNF2, RPL18, H2AFY2, KIAA0020, KNOP1, GPATCH4, RPL18A, RRP8, WDR46, RPS14, RPL37A, RBM4, PRDM5, MAK16, STAU1, DGCR8, GLTSCR2, ZBTB48, SART3, PDGFB, MECP2, HIST1H1E, SRP68, RBM34, RPL28, CNBP, MTF1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMEM178B_RBM28 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMEM178B_RBM28 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | RBM28 | C2677535 | Alopecia, Neurologic Defects, and Endocrinopathy Syndrome | 1 | CTD_human;ORPHANET;UNIPROT |