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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38476

FusionGeneSummary for TMEM170A_TMEM170A

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM170A_TMEM170A
Fusion gene ID: 38476
HgeneTgene
Gene symbol

TMEM170A

TMEM170A

Gene ID

124491

124491

Gene nametransmembrane protein 170Atransmembrane protein 170A
SynonymsTMEM170TMEM170
Cytomap

16q23.1

16q23.1

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 170Atransmembrane protein 170transmembrane protein 170Atransmembrane protein 170
Modification date2018032920180329
UniProtAcc

Q8WVE7

Q8WVE7

Ensembl transtripts involved in fusion geneENST00000357613, ENST00000569540, 
ENST00000561878, ENST00000567796, 
ENST00000566980, ENST00000569276, 
ENST00000357613, ENST00000569540, 
ENST00000561878, ENST00000567796, 
ENST00000566980, ENST00000569276, 
Fusion gene scores* DoF score6 X 6 X 5=1801 X 2 X 1=2
# samples 72
** MAII scorelog2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/2*10)=3.32192809488736
Context

PubMed: TMEM170A [Title/Abstract] AND TMEM170A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA225763TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
ChiTaRS3.1AA259184TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000357613ENST00000357613TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-3UTRENST00000357613ENST00000569540TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-intronENST00000357613ENST00000561878TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-intronENST00000357613ENST00000567796TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-intronENST00000357613ENST00000566980TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-intronENST00000357613ENST00000569276TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-3UTRENST00000569540ENST00000357613TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-3UTRENST00000569540ENST00000569540TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-intronENST00000569540ENST00000561878TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-intronENST00000569540ENST00000567796TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-intronENST00000569540ENST00000566980TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-intronENST00000569540ENST00000569276TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-3UTRENST00000561878ENST00000357613TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-3UTRENST00000561878ENST00000569540TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-intronENST00000561878ENST00000561878TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-intronENST00000561878ENST00000567796TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-intronENST00000561878ENST00000566980TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-intronENST00000561878ENST00000569276TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-3UTRENST00000567796ENST00000357613TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-3UTRENST00000567796ENST00000569540TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-intronENST00000567796ENST00000561878TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-intronENST00000567796ENST00000567796TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-intronENST00000567796ENST00000566980TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-intronENST00000567796ENST00000569276TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-3UTRENST00000566980ENST00000357613TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-3UTRENST00000566980ENST00000569540TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-intronENST00000566980ENST00000561878TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-intronENST00000566980ENST00000567796TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-intronENST00000566980ENST00000566980TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-intronENST00000566980ENST00000569276TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-3UTRENST00000569276ENST00000357613TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-3UTRENST00000569276ENST00000569540TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-intronENST00000569276ENST00000561878TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-intronENST00000569276ENST00000567796TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-intronENST00000569276ENST00000566980TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-intronENST00000569276ENST00000569276TMEM170Achr16

75479503

-TMEM170Achr16

75479808

-
intron-3UTRENST00000357613ENST00000357613TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-intronENST00000357613ENST00000569540TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-intronENST00000357613ENST00000561878TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-intronENST00000357613ENST00000567796TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-intronENST00000357613ENST00000566980TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-intronENST00000357613ENST00000569276TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-3UTRENST00000569540ENST00000357613TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-intronENST00000569540ENST00000569540TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-intronENST00000569540ENST00000561878TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-intronENST00000569540ENST00000567796TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-intronENST00000569540ENST00000566980TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-intronENST00000569540ENST00000569276TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-3UTRENST00000561878ENST00000357613TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-intronENST00000561878ENST00000569540TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-intronENST00000561878ENST00000561878TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-intronENST00000561878ENST00000567796TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-intronENST00000561878ENST00000566980TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-intronENST00000561878ENST00000569276TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-3UTRENST00000567796ENST00000357613TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-intronENST00000567796ENST00000569540TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-intronENST00000567796ENST00000561878TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-intronENST00000567796ENST00000567796TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-intronENST00000567796ENST00000566980TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-intronENST00000567796ENST00000569276TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-3UTRENST00000566980ENST00000357613TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-intronENST00000566980ENST00000569540TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-intronENST00000566980ENST00000561878TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-intronENST00000566980ENST00000567796TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-intronENST00000566980ENST00000566980TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-intronENST00000566980ENST00000569276TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-3UTRENST00000569276ENST00000357613TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-intronENST00000569276ENST00000569540TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-intronENST00000569276ENST00000561878TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-intronENST00000569276ENST00000567796TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-intronENST00000569276ENST00000566980TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+
intron-intronENST00000569276ENST00000569276TMEM170Achr16

75479808

+TMEM170Achr16

75479503

+

Top

FusionProtFeatures for TMEM170A_TMEM170A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMEM170A

Q8WVE7

TMEM170A

Q8WVE7

Acts as a regulator of endoplasmic reticulum (ER) andnuclear envelope (NE) morphogenesis. Affects the ratio betweentubular ER and ER sheets by promoting sheet formation at theexpense of tubules. Influences NE expansion, nuclear pore complexformation and proper localization of inner nuclear membraneproteins (PubMed:26906412). {ECO:0000269|PubMed:26906412}. Acts as a regulator of endoplasmic reticulum (ER) andnuclear envelope (NE) morphogenesis. Affects the ratio betweentubular ER and ER sheets by promoting sheet formation at theexpense of tubules. Influences NE expansion, nuclear pore complexformation and proper localization of inner nuclear membraneproteins (PubMed:26906412). {ECO:0000269|PubMed:26906412}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TMEM170A_TMEM170A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMEM170A_TMEM170A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMEM170A_TMEM170A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMEM170A_TMEM170A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource