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Fusion gene ID: 38465 |
FusionGeneSummary for TMEM165_KIAA1211 |
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Fusion gene information | Fusion gene name: TMEM165_KIAA1211 | Fusion gene ID: 38465 | Hgene | Tgene | Gene symbol | TMEM165 | KIAA1211 | Gene ID | 55858 | 57482 |
Gene name | transmembrane protein 165 | KIAA1211 | |
Synonyms | CDG2K|FT27|GDT1|TMPT27|TPARL | - | |
Cytomap | 4q12 | 4q12 | |
Type of gene | protein-coding | protein-coding | |
Description | transmembrane protein 165TPA regulated locustransmembrane protein PT27transmembrane protein TPARL | uncharacterized protein KIAA1211 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q9HC07 | Q6ZU35 | |
Ensembl transtripts involved in fusion gene | ENST00000506198, ENST00000381334, ENST00000542052, ENST00000514904, | ENST00000264229, ENST00000541073, ENST00000504228, ENST00000505410, | |
Fusion gene scores | * DoF score | 3 X 2 X 4=24 | 6 X 4 X 4=96 |
# samples | 4 | 6 | |
** MAII score | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TMEM165 [Title/Abstract] AND KIAA1211 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TMEM165 | GO:0032472 | Golgi calcium ion transport | 23569283 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | HNSC | TCGA-QK-A8Z8-01A | TMEM165 | chr4 | 56290810 | + | KIAA1211 | chr4 | 57138487 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000506198 | ENST00000264229 | TMEM165 | chr4 | 56290810 | + | KIAA1211 | chr4 | 57138487 | + |
5CDS-intron | ENST00000506198 | ENST00000541073 | TMEM165 | chr4 | 56290810 | + | KIAA1211 | chr4 | 57138487 | + |
5CDS-intron | ENST00000506198 | ENST00000504228 | TMEM165 | chr4 | 56290810 | + | KIAA1211 | chr4 | 57138487 | + |
5CDS-intron | ENST00000506198 | ENST00000505410 | TMEM165 | chr4 | 56290810 | + | KIAA1211 | chr4 | 57138487 | + |
5CDS-5UTR | ENST00000381334 | ENST00000264229 | TMEM165 | chr4 | 56290810 | + | KIAA1211 | chr4 | 57138487 | + |
5CDS-intron | ENST00000381334 | ENST00000541073 | TMEM165 | chr4 | 56290810 | + | KIAA1211 | chr4 | 57138487 | + |
5CDS-intron | ENST00000381334 | ENST00000504228 | TMEM165 | chr4 | 56290810 | + | KIAA1211 | chr4 | 57138487 | + |
5CDS-intron | ENST00000381334 | ENST00000505410 | TMEM165 | chr4 | 56290810 | + | KIAA1211 | chr4 | 57138487 | + |
5CDS-5UTR | ENST00000542052 | ENST00000264229 | TMEM165 | chr4 | 56290810 | + | KIAA1211 | chr4 | 57138487 | + |
5CDS-intron | ENST00000542052 | ENST00000541073 | TMEM165 | chr4 | 56290810 | + | KIAA1211 | chr4 | 57138487 | + |
5CDS-intron | ENST00000542052 | ENST00000504228 | TMEM165 | chr4 | 56290810 | + | KIAA1211 | chr4 | 57138487 | + |
5CDS-intron | ENST00000542052 | ENST00000505410 | TMEM165 | chr4 | 56290810 | + | KIAA1211 | chr4 | 57138487 | + |
3UTR-5UTR | ENST00000514904 | ENST00000264229 | TMEM165 | chr4 | 56290810 | + | KIAA1211 | chr4 | 57138487 | + |
3UTR-intron | ENST00000514904 | ENST00000541073 | TMEM165 | chr4 | 56290810 | + | KIAA1211 | chr4 | 57138487 | + |
3UTR-intron | ENST00000514904 | ENST00000504228 | TMEM165 | chr4 | 56290810 | + | KIAA1211 | chr4 | 57138487 | + |
3UTR-intron | ENST00000514904 | ENST00000505410 | TMEM165 | chr4 | 56290810 | + | KIAA1211 | chr4 | 57138487 | + |
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FusionProtFeatures for TMEM165_KIAA1211 |
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Hgene | Tgene |
TMEM165 | KIAA1211 |
May function as a calcium/proton transporter involved incalcium and in lysosomal pH homeostasis. Therefore, it may play anindirect role in protein glycosylation.{ECO:0000269|PubMed:22683087, ECO:0000269|PubMed:23569283}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TMEM165_KIAA1211 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TMEM165_KIAA1211 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TMEM165 | CUL3, RPLP1, MTHFD1, RPS26, CALU, REL, AHSP, CDK1, CNOT2, CDK2AP1, SMC3, GPATCH8, SMC6, USP43, UBXN8, ERRFI1, PTAR1, ARPC2, ATP2C1, UBE4B, PPME1, WDR62, VPS35, TRIM25 | KIAA1211 | UBC, CAPZA2, NTRK1, FLNA, MYO19, MYO18A, GLI1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMEM165_KIAA1211 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMEM165_KIAA1211 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TMEM165 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | TMEM165 | C3553571 | CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIk | 1 | ORPHANET;UNIPROT |