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Fusion gene ID: 38463 |
FusionGeneSummary for TMEM164_NDUFV3 |
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Fusion gene information | Fusion gene name: TMEM164_NDUFV3 | Fusion gene ID: 38463 | Hgene | Tgene | Gene symbol | TMEM164 | NDUFV3 | Gene ID | 84187 | 4731 |
Gene name | transmembrane protein 164 | NADH:ubiquinone oxidoreductase subunit V3 | |
Synonyms | bB360B22.3 | CI-10k|CI-9KD | |
Cytomap | Xq23 | 21q22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | transmembrane protein 164RP13-360B22.2 | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrialNADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDaNADH-ubiquinone oxidoreductase 9 kD subunitNADH-ubiquinone oxidoreductase 9 kDa subunitNADH-ubiquinone oxidoreductase flavoprotein 3, 10k | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | Q5U3C3 | P56181 | |
Ensembl transtripts involved in fusion gene | ENST00000372072, ENST00000372073, ENST00000372068, ENST00000288381, ENST00000464177, | ENST00000460259, ENST00000354250, ENST00000340344, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 1 X 2=4 |
# samples | 2 | 2 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: TMEM164 [Title/Abstract] AND NDUFV3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | KIRC | TCGA-CJ-5681-01A | TMEM164 | chrX | 109416681 | + | NDUFV3 | chr21 | 44328974 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3UTR | ENST00000372072 | ENST00000460259 | TMEM164 | chrX | 109416681 | + | NDUFV3 | chr21 | 44328974 | + |
3UTR-3UTR | ENST00000372072 | ENST00000354250 | TMEM164 | chrX | 109416681 | + | NDUFV3 | chr21 | 44328974 | + |
3UTR-3UTR | ENST00000372072 | ENST00000340344 | TMEM164 | chrX | 109416681 | + | NDUFV3 | chr21 | 44328974 | + |
3UTR-3UTR | ENST00000372073 | ENST00000460259 | TMEM164 | chrX | 109416681 | + | NDUFV3 | chr21 | 44328974 | + |
3UTR-3UTR | ENST00000372073 | ENST00000354250 | TMEM164 | chrX | 109416681 | + | NDUFV3 | chr21 | 44328974 | + |
3UTR-3UTR | ENST00000372073 | ENST00000340344 | TMEM164 | chrX | 109416681 | + | NDUFV3 | chr21 | 44328974 | + |
3UTR-3UTR | ENST00000372068 | ENST00000460259 | TMEM164 | chrX | 109416681 | + | NDUFV3 | chr21 | 44328974 | + |
3UTR-3UTR | ENST00000372068 | ENST00000354250 | TMEM164 | chrX | 109416681 | + | NDUFV3 | chr21 | 44328974 | + |
3UTR-3UTR | ENST00000372068 | ENST00000340344 | TMEM164 | chrX | 109416681 | + | NDUFV3 | chr21 | 44328974 | + |
3UTR-3UTR | ENST00000288381 | ENST00000460259 | TMEM164 | chrX | 109416681 | + | NDUFV3 | chr21 | 44328974 | + |
3UTR-3UTR | ENST00000288381 | ENST00000354250 | TMEM164 | chrX | 109416681 | + | NDUFV3 | chr21 | 44328974 | + |
3UTR-3UTR | ENST00000288381 | ENST00000340344 | TMEM164 | chrX | 109416681 | + | NDUFV3 | chr21 | 44328974 | + |
3UTR-3UTR | ENST00000464177 | ENST00000460259 | TMEM164 | chrX | 109416681 | + | NDUFV3 | chr21 | 44328974 | + |
3UTR-3UTR | ENST00000464177 | ENST00000354250 | TMEM164 | chrX | 109416681 | + | NDUFV3 | chr21 | 44328974 | + |
3UTR-3UTR | ENST00000464177 | ENST00000340344 | TMEM164 | chrX | 109416681 | + | NDUFV3 | chr21 | 44328974 | + |
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FusionProtFeatures for TMEM164_NDUFV3 |
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Hgene | Tgene |
TMEM164 | NDUFV3 |
Accessory subunit of the mitochondrial membranerespiratory chain NADH dehydrogenase (Complex I), that is believednot to be involved in catalysis. Complex I functions in thetransfer of electrons from NADH to the respiratory chain. Theimmediate electron acceptor for the enzyme is believed to beubiquinone. May be the terminally assembled subunit of Complex I.{ECO:0000269|PubMed:27626371}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TMEM164_NDUFV3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TMEM164_NDUFV3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TMEM164 | MOV10, NXF1, NRG1, P2RY12, LPAR1, LRRC8B, KIF2B, APLNR, GPR21, SYP, SLC15A1, SLC9A6, TACR1, SLC22A16, VIPR2, UPK1A | NDUFV3 | PHYHIP, NDUFV2, NDUFS1, SLC25A3, ILF3, SLC25A6, SHMT2, MOV10, NXF1, NDUFS3, TMX2, DNAJC30, PRRT2, NDUFA8, VAPB, NDUFA12, NDUFS4, NDUFS5, NDUFA9, NDUFA11, NDUFS6, NDUFV1, TIMMDC1, CDC42, GRIA2, UBA1, VAPA, GOLT1B, WRAP53, VPS18, NDUFB11, NDUFA13, SSMEM1, SERINC1, NDUFS7, YIPF3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMEM164_NDUFV3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | NDUFV3 | P56181 | DB09270 | Ubidecarenone | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for TMEM164_NDUFV3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TMEM164 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
Tgene | NDUFV3 | C0005586 | Bipolar Disorder | 1 | PSYGENET |