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Fusion gene ID: 38451 |
FusionGeneSummary for TMEM158_CELF2 |
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Fusion gene information | Fusion gene name: TMEM158_CELF2 | Fusion gene ID: 38451 | Hgene | Tgene | Gene symbol | TMEM158 | CELF2 | Gene ID | 25907 | 10659 |
Gene name | transmembrane protein 158 (gene/pseudogene) | CUGBP Elav-like family member 2 | |
Synonyms | BBP|RIS1|p40BBP | BRUNOL3|CELF-2|CUG-BP2|CUGBP2|ETR-3|ETR3|NAPOR | |
Cytomap | 3p21.31 | 10p14 | |
Type of gene | protein-coding | protein-coding | |
Description | transmembrane protein 15840 kDa BINP-binding proteinBINP receptorRas induced senescence 1brain injury-derived neurotrophic peptide (BINP) binding proteinbrain specific binding protein | CUGBP Elav-like family member 2CUG triplet repeat RNA-binding protein 2CUG-BP- and ETR-3-like factor 2ELAV-type RNA-binding protein 3KDM2B/CELF2 fusionRNA-binding protein BRUNOL-3bruno-like protein 3neuroblastoma apoptosis-related RNA-binding prote | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8WZ71 | O95319 | |
Ensembl transtripts involved in fusion gene | ENST00000503771, | ENST00000379261, ENST00000416382, ENST00000450189, ENST00000542579, ENST00000399850, ENST00000417956, ENST00000354440, ENST00000427450, ENST00000315874, ENST00000608830, ENST00000609692, ENST00000354897, ENST00000537122, | |
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 6 X 7 X 2=84 |
# samples | 3 | 7 | |
** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/84*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TMEM158 [Title/Abstract] AND CELF2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CELF2 | GO:0006376 | mRNA splice site selection | 11158314 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | T07230 | TMEM158 | chr3 | 45266108 | - | CELF2 | chr10 | 11076249 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000503771 | ENST00000379261 | TMEM158 | chr3 | 45266108 | - | CELF2 | chr10 | 11076249 | - |
intron-intron | ENST00000503771 | ENST00000416382 | TMEM158 | chr3 | 45266108 | - | CELF2 | chr10 | 11076249 | - |
intron-intron | ENST00000503771 | ENST00000450189 | TMEM158 | chr3 | 45266108 | - | CELF2 | chr10 | 11076249 | - |
intron-intron | ENST00000503771 | ENST00000542579 | TMEM158 | chr3 | 45266108 | - | CELF2 | chr10 | 11076249 | - |
intron-intron | ENST00000503771 | ENST00000399850 | TMEM158 | chr3 | 45266108 | - | CELF2 | chr10 | 11076249 | - |
intron-intron | ENST00000503771 | ENST00000417956 | TMEM158 | chr3 | 45266108 | - | CELF2 | chr10 | 11076249 | - |
intron-intron | ENST00000503771 | ENST00000354440 | TMEM158 | chr3 | 45266108 | - | CELF2 | chr10 | 11076249 | - |
intron-intron | ENST00000503771 | ENST00000427450 | TMEM158 | chr3 | 45266108 | - | CELF2 | chr10 | 11076249 | - |
intron-intron | ENST00000503771 | ENST00000315874 | TMEM158 | chr3 | 45266108 | - | CELF2 | chr10 | 11076249 | - |
intron-intron | ENST00000503771 | ENST00000608830 | TMEM158 | chr3 | 45266108 | - | CELF2 | chr10 | 11076249 | - |
intron-intron | ENST00000503771 | ENST00000609692 | TMEM158 | chr3 | 45266108 | - | CELF2 | chr10 | 11076249 | - |
intron-intron | ENST00000503771 | ENST00000354897 | TMEM158 | chr3 | 45266108 | - | CELF2 | chr10 | 11076249 | - |
intron-intron | ENST00000503771 | ENST00000537122 | TMEM158 | chr3 | 45266108 | - | CELF2 | chr10 | 11076249 | - |
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FusionProtFeatures for TMEM158_CELF2 |
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Hgene | Tgene |
TMEM158 | CELF2 |
Receptor for brain injury-derived neurotrophic peptide(BINP), a synthetic 13-mer peptide. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TMEM158_CELF2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TMEM158_CELF2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMEM158_CELF2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMEM158_CELF2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CELF2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | CELF2 | C0036341 | Schizophrenia | 1 | CTD_human |
Tgene | CELF2 | C0038325 | Stevens-Johnson Syndrome | 1 | CTD_human |