FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 38451

FusionGeneSummary for TMEM158_CELF2

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM158_CELF2
Fusion gene ID: 38451
HgeneTgene
Gene symbol

TMEM158

CELF2

Gene ID

25907

10659

Gene nametransmembrane protein 158 (gene/pseudogene)CUGBP Elav-like family member 2
SynonymsBBP|RIS1|p40BBPBRUNOL3|CELF-2|CUG-BP2|CUGBP2|ETR-3|ETR3|NAPOR
Cytomap

3p21.31

10p14

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 15840 kDa BINP-binding proteinBINP receptorRas induced senescence 1brain injury-derived neurotrophic peptide (BINP) binding proteinbrain specific binding proteinCUGBP Elav-like family member 2CUG triplet repeat RNA-binding protein 2CUG-BP- and ETR-3-like factor 2ELAV-type RNA-binding protein 3KDM2B/CELF2 fusionRNA-binding protein BRUNOL-3bruno-like protein 3neuroblastoma apoptosis-related RNA-binding prote
Modification date2018052320180523
UniProtAcc

Q8WZ71

O95319

Ensembl transtripts involved in fusion geneENST00000503771, ENST00000379261, 
ENST00000416382, ENST00000450189, 
ENST00000542579, ENST00000399850, 
ENST00000417956, ENST00000354440, 
ENST00000427450, ENST00000315874, 
ENST00000608830, ENST00000609692, 
ENST00000354897, ENST00000537122, 
Fusion gene scores* DoF score3 X 3 X 1=96 X 7 X 2=84
# samples 37
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/84*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMEM158 [Title/Abstract] AND CELF2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCELF2

GO:0006376

mRNA splice site selection

11158314


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1T07230TMEM158chr3

45266108

-CELF2chr10

11076249

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000503771ENST00000379261TMEM158chr3

45266108

-CELF2chr10

11076249

-
intron-intronENST00000503771ENST00000416382TMEM158chr3

45266108

-CELF2chr10

11076249

-
intron-intronENST00000503771ENST00000450189TMEM158chr3

45266108

-CELF2chr10

11076249

-
intron-intronENST00000503771ENST00000542579TMEM158chr3

45266108

-CELF2chr10

11076249

-
intron-intronENST00000503771ENST00000399850TMEM158chr3

45266108

-CELF2chr10

11076249

-
intron-intronENST00000503771ENST00000417956TMEM158chr3

45266108

-CELF2chr10

11076249

-
intron-intronENST00000503771ENST00000354440TMEM158chr3

45266108

-CELF2chr10

11076249

-
intron-intronENST00000503771ENST00000427450TMEM158chr3

45266108

-CELF2chr10

11076249

-
intron-intronENST00000503771ENST00000315874TMEM158chr3

45266108

-CELF2chr10

11076249

-
intron-intronENST00000503771ENST00000608830TMEM158chr3

45266108

-CELF2chr10

11076249

-
intron-intronENST00000503771ENST00000609692TMEM158chr3

45266108

-CELF2chr10

11076249

-
intron-intronENST00000503771ENST00000354897TMEM158chr3

45266108

-CELF2chr10

11076249

-
intron-intronENST00000503771ENST00000537122TMEM158chr3

45266108

-CELF2chr10

11076249

-

Top

FusionProtFeatures for TMEM158_CELF2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMEM158

Q8WZ71

CELF2

O95319

Receptor for brain injury-derived neurotrophic peptide(BINP), a synthetic 13-mer peptide. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TMEM158_CELF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TMEM158_CELF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TMEM158_CELF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TMEM158_CELF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCELF2C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneCELF2C0036341Schizophrenia1CTD_human
TgeneCELF2C0038325Stevens-Johnson Syndrome1CTD_human