FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 38450

FusionGeneSummary for TMEM154_SLC39A11

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM154_SLC39A11
Fusion gene ID: 38450
HgeneTgene
Gene symbol

TMEM154

SLC39A11

Gene ID

201799

201266

Gene nametransmembrane protein 154solute carrier family 39 member 11
Synonyms-C17orf26|ZIP-11|ZIP11
Cytomap

4q31.3

17q24.3-q25.1

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 154zinc transporter ZIP11Zrt- and Irt-like protein 11solute carrier family 39 (metal ion transporter), member 11
Modification date2018040220180523
UniProtAcc

Q6P9G4

Q8N1S5

Ensembl transtripts involved in fusion geneENST00000304385, ENST00000504064, 
ENST00000255559, ENST00000542342, 
ENST00000579988, ENST00000579732, 
Fusion gene scores* DoF score1 X 1 X 1=112 X 6 X 7=504
# samples 112
** MAII scorelog2(1/1*10)=3.32192809488736log2(12/504*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMEM154 [Title/Abstract] AND SLC39A11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI028092TMEM154chr4

153559676

+SLC39A11chr17

70831428

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000304385ENST00000255559TMEM154chr4

153559676

+SLC39A11chr17

70831428

-
intron-intronENST00000304385ENST00000542342TMEM154chr4

153559676

+SLC39A11chr17

70831428

-
intron-intronENST00000304385ENST00000579988TMEM154chr4

153559676

+SLC39A11chr17

70831428

-
intron-intronENST00000304385ENST00000579732TMEM154chr4

153559676

+SLC39A11chr17

70831428

-
intron-intronENST00000504064ENST00000255559TMEM154chr4

153559676

+SLC39A11chr17

70831428

-
intron-intronENST00000504064ENST00000542342TMEM154chr4

153559676

+SLC39A11chr17

70831428

-
intron-intronENST00000504064ENST00000579988TMEM154chr4

153559676

+SLC39A11chr17

70831428

-
intron-intronENST00000504064ENST00000579732TMEM154chr4

153559676

+SLC39A11chr17

70831428

-

Top

FusionProtFeatures for TMEM154_SLC39A11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMEM154

Q6P9G4

SLC39A11

Q8N1S5

Functions as a cellular zinc transporter.{ECO:0000250|UniProtKB:Q8BWY7}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TMEM154_SLC39A11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TMEM154_SLC39A11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TMEM154_SLC39A11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TMEM154_SLC39A11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource