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Fusion gene ID: 38446 |
FusionGeneSummary for TMEM150C_SCD5 |
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Fusion gene information | Fusion gene name: TMEM150C_SCD5 | Fusion gene ID: 38446 | Hgene | Tgene | Gene symbol | TMEM150C | SCD5 | Gene ID | 441027 | 79966 |
Gene name | transmembrane protein 150C | stearoyl-CoA desaturase 5 | |
Synonyms | TTN3 | ACOD4|FADS4|HSCD5|SCD2|SCD4 | |
Cytomap | 4q21.22 | 4q21.22 | |
Type of gene | protein-coding | protein-coding | |
Description | transmembrane protein 150Ctentonin 3 | stearoyl-CoA desaturase 5acyl-CoA-desaturase 4stearoyl-CoA 9-desaturasestearoyl-CoA desaturase 2stearoyl-CoA desaturase 4 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | B9EJG8 | Q86SK9 | |
Ensembl transtripts involved in fusion gene | ENST00000515780, ENST00000449862, ENST00000508701, | ENST00000319540, ENST00000273908, ENST00000282709, | |
Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 4 X 2 X 5=40 |
# samples | 2 | 5 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TMEM150C [Title/Abstract] AND SCD5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | SCD5 | GO:0006636 | unsaturated fatty acid biosynthetic process | 15907797 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LGG | TCGA-HT-8564-01A | TMEM150C | chr4 | 83483059 | - | SCD5 | chr4 | 83626566 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000515780 | ENST00000319540 | TMEM150C | chr4 | 83483059 | - | SCD5 | chr4 | 83626566 | - |
intron-3CDS | ENST00000515780 | ENST00000273908 | TMEM150C | chr4 | 83483059 | - | SCD5 | chr4 | 83626566 | - |
intron-3CDS | ENST00000515780 | ENST00000282709 | TMEM150C | chr4 | 83483059 | - | SCD5 | chr4 | 83626566 | - |
5UTR-3CDS | ENST00000449862 | ENST00000319540 | TMEM150C | chr4 | 83483059 | - | SCD5 | chr4 | 83626566 | - |
5UTR-3CDS | ENST00000449862 | ENST00000273908 | TMEM150C | chr4 | 83483059 | - | SCD5 | chr4 | 83626566 | - |
5UTR-3CDS | ENST00000449862 | ENST00000282709 | TMEM150C | chr4 | 83483059 | - | SCD5 | chr4 | 83626566 | - |
5UTR-3CDS | ENST00000508701 | ENST00000319540 | TMEM150C | chr4 | 83483059 | - | SCD5 | chr4 | 83626566 | - |
5UTR-3CDS | ENST00000508701 | ENST00000273908 | TMEM150C | chr4 | 83483059 | - | SCD5 | chr4 | 83626566 | - |
5UTR-3CDS | ENST00000508701 | ENST00000282709 | TMEM150C | chr4 | 83483059 | - | SCD5 | chr4 | 83626566 | - |
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FusionProtFeatures for TMEM150C_SCD5 |
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Hgene | Tgene |
TMEM150C | SCD5 |
Component of a mechanosensitive cation channel. Confersmechanically activated (MA) currents with slow inactivationkinetics. May contribute to proprioception.{ECO:0000250|UniProtKB:Q8C8S3}. | Stearyl-CoA desaturase that utilizes O(2) and electronsfrom reduced cytochrome b5 to introduce the first double bond intosaturated fatty acyl-CoA substrates. Catalyzes the insertion of acis double bond at the delta-9 position into fatty acyl-CoAsubstrates including palmitoyl-CoA and stearoyl-CoA(PubMed:15907797, PubMed:15610069). Gives rise to a mixture of16:1 and 18:1 unsaturated fatty acids.{ECO:0000269|PubMed:15610069, ECO:0000269|PubMed:15907797}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TMEM150C_SCD5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TMEM150C_SCD5 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TMEM150C | SCD5 | CNDP1, PPP2R1A, UQCRC2, TCTN2, TCTN3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMEM150C_SCD5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMEM150C_SCD5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |